Details for: ADA
Associated with
Other Information
Genular Protein ID: 1289082863
Symbol: ADA_HUMAN
Name: Adenosine deaminase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6090454
Title: Human adenosine deaminase. cDNA and complete primary amino acid sequence.
PubMed ID: 6090454
PubMed ID: 6546794
Title: Sequence of human adenosine deaminase cDNA including the coding region and a small intron.
PubMed ID: 6546794
PubMed ID: 3839456
Title: Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.
PubMed ID: 3839456
PubMed ID: 3028473
Title: Complete sequence and structure of the gene for human adenosine deaminase.
PubMed ID: 3028473
DOI: 10.1021/bi00373a017
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 6688808
Title: Molecular cloning of human adenosine deaminase gene sequences.
PubMed ID: 6688808
PubMed ID: 8452534
Title: Demonstration of adenosine deaminase activity in human fibroblast lysosomes.
PubMed ID: 8452534
DOI: 10.1042/bj2900457
PubMed ID: 8101391
Title: Direct association of adenosine deaminase with a T cell activation antigen, CD26.
PubMed ID: 8101391
PubMed ID: 7907293
Title: Binding of adenosine deaminase to the lymphocyte surface via CD26.
PubMed ID: 7907293
PubMed ID: 10951221
Title: Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides.
PubMed ID: 10951221
PubMed ID: 11772392
Title: Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction.
PubMed ID: 11772392
PubMed ID: 15016824
Title: Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.
PubMed ID: 15016824
PubMed ID: 14691230
Title: N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding.
PubMed ID: 14691230
DOI: 10.1110/ps.03352504
PubMed ID: 16670267
Title: Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26.
PubMed ID: 16670267
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 20959412
Title: Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells.
PubMed ID: 20959412
DOI: 10.1189/jlb.1009696
PubMed ID: 21919946
Title: Adenosine deaminase activity in fertile and infertile men.
PubMed ID: 21919946
PubMed ID: 23193172
Title: The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors.
PubMed ID: 23193172
DOI: 10.1096/fj.12-212621
PubMed ID: 2166947
Title: Hot spot mutations in adenosine deaminase deficiency.
PubMed ID: 2166947
PubMed ID: 8031011
Title: An Asp8Asn substitution results in the adenosine deaminase (ADA) genetic polymorphism (ADA 2 allozyme): occurrence on different chromosomal backgrounds and apparent intragenic crossover.
PubMed ID: 8031011
PubMed ID: 6208479
Title: Structure of adenosine deaminase mRNAs from normal and adenosine deaminase-deficient human cell lines.
PubMed ID: 6208479
PubMed ID: 3839802
Title: Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency.
PubMed ID: 3839802
DOI: 10.1172/jci112050
PubMed ID: 3182793
Title: Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts.
PubMed ID: 3182793
PubMed ID: 2783588
Title: Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency.
PubMed ID: 2783588
DOI: 10.1172/jci113909
PubMed ID: 1284479
Title: Identification of two new missense mutations (R156C and S291L) in two ADA-SCID patients unusual for response to therapy with partial exchange transfusions.
PubMed ID: 1284479
PubMed ID: 8227344
Title: Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype.
PubMed ID: 8227344
DOI: 10.1172/jci116833
PubMed ID: 8299233
Title: Homozygosity for a missense mutation (G20R) associated with neonatal onset adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID).
PubMed ID: 8299233
PubMed ID: 8589684
Title: Three new adenosine deaminase mutations that define a splicing enhancer and cause severe and partial phenotypes: implications for evolution of a CpG hotspot and expression of a transduced ADA cDNA.
PubMed ID: 8589684
PubMed ID: 7599635
Title: Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5' splice site.
PubMed ID: 7599635
PubMed ID: 9225964
Title: Two newly identified mutations (Thr233Ile and Leu152Met) in partially adenosine deaminase-deficient (ADA-) individuals that result in differing biochemical and metabolic phenotypes.
PubMed ID: 9225964
PubMed ID: 9361033
Title: An adenosine deaminase (ADA) allele contains two newly identified deleterious mutations (Y97C and L106V) that interact to abolish enzyme activity.
PubMed ID: 9361033
PubMed ID: 10200056
Title: Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del.
PubMed ID: 10200056
PubMed ID: 16221767
Title: A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans.
PubMed ID: 16221767
PubMed ID: 18772397
Title: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
PubMed ID: 18772397
PubMed ID: 21734253
Title: Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans.
PubMed ID: 21734253
PubMed ID: 26166670
Title: The Role of G22 A Adenosine Deaminase 1 Gene Polymorphism and the Activities of ADA Isoenzymes in Fertile and Infertile Men.
PubMed ID: 26166670
Sequence Information:
- Length: 363
- Mass: 40764
- Checksum: 786BC5085CA9AFCB
- Sequence:
MAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI GMDKPLTLPD FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA EGDLTPDEVV ALVGQGLQEG ERDFGVKARS ILCCMRHQPN WSPKVVELCK KYQQQTVVAI DLAGDETIPG SSLLPGHVQA YQEAVKSGIH RTVHAGEVGS AEVVKEAVDI LKTERLGHGY HTLEDQALYN RLRQENMHFE ICPWSSYLTG AWKPDTEHAV IRLKNDQANY SLNTDDPLIF KSTLDTDYQM TKRDMGFTEE EFKRLNINAA KSSFLPEDEK RELLDLLYKA YGMPPSASAG QNL
Genular Protein ID: 440028438
Symbol: F5GWI4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 339
- Mass: 38293
- Checksum: 04B0ABF8FDAFF9BF
- Sequence:
MAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI GMDKPLTLPD FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA EGDLTPDEVV ALVGQGLQEG ERDFGVKARS ILCCMRHQPN WSPKVVELCK KYQQQTVVAI DLAGDETIPG SSLLPGHVQA YQAVDILKTE RLGHGYHTLE DQALYNRLRQ ENMHFEICPW SSYLTGAWKP DTEHAVIRLK NDQANYSLNT DDPLIFKSTL DTDYQMTKRD MGFTEEEFKR LNINAAKSSF LPEDEKRELL DLLYKAYGMP PSASAGQNL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.