Details for: CDH2

Gene ID: 1000

Symbol: CDH2

Ensembl ID: ENSG00000170558

Description: cadherin 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 5.99
    Marker Score: 4,506
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.96
    Marker Score: 110,819
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.75
    Marker Score: 24,893
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.45
    Marker Score: 23,910
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.06
    Marker Score: 30,627
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.92
    Marker Score: 13,142
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.86
    Marker Score: 5,186
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.67
    Marker Score: 4,441
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.36
    Marker Score: 14,015
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.33
    Marker Score: 112,558
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.29
    Marker Score: 58,340
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.26
    Marker Score: 11,587
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.96
    Marker Score: 4,162
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.94
    Marker Score: 6,750
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.87
    Marker Score: 3,982
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.78
    Marker Score: 1,556
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.75
    Marker Score: 58,659
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.68
    Marker Score: 1,565
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.66
    Marker Score: 1,552
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.65
    Marker Score: 52,768
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.65
    Marker Score: 773
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.52
    Marker Score: 1,463
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.45
    Marker Score: 8,011
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.33
    Marker Score: 2,900
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.31
    Marker Score: 1,111
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.29
    Marker Score: 881
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.27
    Marker Score: 86,329
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.26
    Marker Score: 9,471
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.15
    Marker Score: 9,944
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.13
    Marker Score: 6,066
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.1
    Marker Score: 694
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.1
    Marker Score: 31,370
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.08
    Marker Score: 1,243
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.06
    Marker Score: 1,358
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.03
    Marker Score: 8,435
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.01
    Marker Score: 123,568
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.97
    Marker Score: 15,124
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18,152
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.89
    Marker Score: 69,706
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.88
    Marker Score: 532
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.88
    Marker Score: 3,919
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.87
    Marker Score: 7,223
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,999
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.81
    Marker Score: 548
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.78
    Marker Score: 10,560
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.77
    Marker Score: 7,194
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.76
    Marker Score: 16,551
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.76
    Marker Score: 829
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.72
    Marker Score: 1,927
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.7
    Marker Score: 22,642
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.65
    Marker Score: 1,763
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.65
    Marker Score: 2,035
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.64
    Marker Score: 2,046
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.62
    Marker Score: 16,759
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.61
    Marker Score: 481
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.6
    Marker Score: 2,690
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.59
    Marker Score: 853
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.59
    Marker Score: 1,374
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.59
    Marker Score: 3,795
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.58
    Marker Score: 3,714
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.57
    Marker Score: 9,430
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2,397
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.53
    Marker Score: 1,442
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.51
    Marker Score: 5,863
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.48
    Marker Score: 5,248
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.47
    Marker Score: 984
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,447
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.45
    Marker Score: 9,342
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.44
    Marker Score: 1,555
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.4
    Marker Score: 6,059
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.4
    Marker Score: 881
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.39
    Marker Score: 503
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21,213
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.35
    Marker Score: 7,256
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.33
    Marker Score: 448
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.3
    Marker Score: 546
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.29
    Marker Score: 1,416
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2,537
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.24
    Marker Score: 650
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.22
    Marker Score: 2,067
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.21
    Marker Score: 12,131
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.2
    Marker Score: 405
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.19
    Marker Score: 1,488
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.18
    Marker Score: 444
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.18
    Marker Score: 698
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.16
    Marker Score: 382
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.16
    Marker Score: 694
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.14
    Marker Score: 388
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.14
    Marker Score: 311
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.13
    Marker Score: 545
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.09
    Marker Score: 350
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.09
    Marker Score: 3,101
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.07
    Marker Score: 36,900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 433
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.02
    Marker Score: 2,403
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,789
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1
    Marker Score: 1,055
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,014
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell-cell adhesion**: CDH2 is a transmembrane protein that mediates calcium-dependent cell-cell adhesion via its extracellular domain, which interacts with the cytoplasmic domain of β-catenin and actin filaments. 2. **Cell junction formation**: CDH2 forms adherens junctions with other cells, which are composed of the cytoplasmic domain of CDH2, β-catenin, and actin filaments. 3. **Tissue morphogenesis**: CDH2 plays a crucial role in tissue morphogenesis, including the development of the cerebral cortex, brain, and cardiovascular system. 4. **Regulation of cellular processes**: CDH2 regulates various cellular processes, including cell migration, proliferation, and differentiation, through its interaction with other proteins and signaling pathways. **Pathways and Functions** 1. **Adherens junction organization**: CDH2 is essential for the formation and maintenance of adherens junctions, which are critical for maintaining tissue structure and function. 2. **Apical-basal polarity**: CDH2 helps establish apical-basal polarity in epithelial cells, which is essential for maintaining tissue structure and function. 3. **Calcium-dependent signaling**: CDH2 mediates calcium-dependent signaling pathways, which are involved in various cellular processes, including cell migration and proliferation. 4. **Wnt signaling pathway regulation**: CDH2 negatively regulates the canonical Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation and differentiation. **Clinical Significance** 1. **Cancer**: CDH2 is frequently downregulated in various types of cancer, including breast, lung, and colon cancer, which is associated with a poor prognosis. 2. **Cardiovascular disease**: CDH2 is involved in the development of cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 3. **Neurological disorders**: CDH2 is implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Regenerative medicine**: CDH2 is being explored as a potential target for regenerative medicine, including tissue engineering and stem cell therapy. In conclusion, CDH2 is a critical protein that plays a significant role in maintaining tissue integrity and regulating various cellular processes. Alterations in CDH2 expression have been implicated in various diseases, and its dysregulation has significant clinical implications. Further research is needed to fully understand the mechanisms by which CDH2 regulates cellular processes and to develop therapeutic strategies to target CDH2 in disease prevention and treatment.

Genular Protein ID: 1163920042

Symbol: CADH2_HUMAN

Name: Cadherin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2216790

Title: Human N-cadherin: nucleotide and deduced amino acid sequence.

PubMed ID: 2216790

DOI: 10.1093/nar/18.19.5896

PubMed ID: 1500442

Title: Extrajunctional distribution of N-cadherin in cultured human endothelial cells.

PubMed ID: 1500442

DOI: 10.1242/jcs.102.1.7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2384753

Title: N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene.

PubMed ID: 2384753

DOI: 10.1111/j.1471-4159.1990.tb04563.x

PubMed ID: 7959764

Title: Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2.

PubMed ID: 7959764

DOI: 10.1006/geno.1994.1358

PubMed ID: 16007225

Title: Adhesion signaling by a novel mitotic substrate of src kinases.

PubMed ID: 16007225

DOI: 10.1038/sj.onc.1208582

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 28169360

Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.

PubMed ID: 28169360

DOI: 10.1038/srep42125

PubMed ID: 32341084

Title: Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin and Regulates Neuron Migration during Brain Development.

PubMed ID: 32341084

DOI: 10.1128/mcb.00539-19

PubMed ID: 28280076

Title: Identification of cadherin 2 (CDH2) mutations in arrhythmogenic right ventricular cardiomyopathy.

PubMed ID: 28280076

DOI: 10.1161/circgenetics.116.001605

PubMed ID: 28326674

Title: Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy.

PubMed ID: 28326674

DOI: 10.1111/chd.12462

PubMed ID: 31585109

Title: De novo pathogenic variants in N-cadherin cause a syndromic neurodevelopmental disorder with corpus collosum, axon, cardiac, ocular, and genital defects.

PubMed ID: 31585109

DOI: 10.1016/j.ajhg.2019.09.005

PubMed ID: 31650526

Title: Novel variants in CDH2 are associated with a new syndrome including Peters anomaly.

PubMed ID: 31650526

DOI: 10.1111/cge.13660

PubMed ID: 34702855

Title: CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice.

PubMed ID: 34702855

DOI: 10.1038/s41467-021-26426-1

Sequence Information:

  • Length: 906
  • Mass: 99809
  • Checksum: 7267E2A00489DF94
  • Sequence:
  • MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF 
    SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK 
    LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL 
    VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV 
    DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 
    NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 
    GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY 
    RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 
    TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 
    ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 
    NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 
    FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 
    GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 
    EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 
    KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 
    YGGGDD

Genular Protein ID: 407073305

Symbol: C9J126_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 821
  • Mass: 90673
  • Checksum: 3E288C4557CA8D30
  • Sequence:
  • MVYAVRSFPL SSEHAKFLIY AQDKETQEKW QVAVKLSLKP TLTEESVKES AEVEEIVFPR 
    QFSKHSGHLQ RQKRDWVIPP INLPENSRGP FPQELVRIRS DRDKNLSLRY SVTGPGADQP 
    PTGIFIINPI SGQLSVTKPL DREQIARFHL RAHAVDINGN QVENPIDIVI NVIDMNDNRP 
    EFLHQVWNGT VPEGSKPGTY VMTVTAIDAD DPNALNGMLR YRIVSQAPST PSPNMFTINN 
    ETGDIITVAA GLDREKVQQY TLIIQATDME GNPTYGLSNT ATAVITVTDV NDNPPEFTAM 
    TFYGEVPENR VDIIVANLTV TDKDQPHTPA WNAVYRISGG DPTGRFAIQT DPNSNDGLVT 
    VVKPIDFETN RMFVLTVAAE NQVPLAKGIQ HPPQSTATVS VTVIDVNENP YFAPNPKIIR 
    QEEGLHAGTM LTTFTAQDPD RYMQQNIRYT KLSDPANWLK IDPVNGQITT IAVLDRESPN 
    VKNNIYNATF LASDNGIPPM SGTGTLQIYL LDINDNAPQV LPQEAETCET PDPNSINITA 
    LDYDIDPNAG PFAFDLPLSP VTIKRNWTIT RLNGDFAQLN LKIKFLEAGI YEVPIIITDS 
    GNPPKSNISI LRVKVCQCDS NGDCTDVDRI VGAGLGTGAI IAILLCIIIL LILVLMFVVW 
    MKRRDKERQA KQLLIDPEDD VRDNILKYDE EGGGEEDQDY DLSQLQQPDT VEPDAIKPVG 
    IRRMDERPIH AEPQYPVRSA APHPGDIGDF INEGLKAADN DPTAPPYDSL LVFDYEGSGS 
    TAGSLSSLNS SSSGGEQDYD YLNDWGPRFK KLADMYGGGD D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.