ACOT8 | ENSG00000101473 | NCBI 10005

Details for: ACOT8

Gene ID: 10005

Symbol: ACOT8

Ensembl ID: ENSG00000101473

Description: acyl-CoA thioesterase 8

Associated with

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
(R-HSA-2046104)
Alpha-linolenic acid (ala) metabolism
(R-HSA-2046106)
Beta-oxidation of pristanoyl-coa
(R-HSA-389887)
Beta-oxidation of very long chain fatty acids
(R-HSA-390247)
Bile acid and bile salt metabolism
(R-HSA-194068)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Peroxisomal lipid metabolism
(R-HSA-390918)
Peroxisomal protein import
(R-HSA-9033241)
Protein localization
(R-HSA-9609507)
Synthesis of bile acids and bile salts
(R-HSA-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-HSA-193368)
Acetoacetyl-coa hydrolase activity
(GO:0047603)
Acetyl-coa hydrolase activity
(GO:0003986)
Acyl-coa hydrolase activity
(GO:0016289)
Acyl-coa metabolic process
(GO:0006637)
Alpha-linolenic acid metabolic process
(GO:0036109)
Bile acid biosynthetic process
(GO:0006699)
Carboxylic ester hydrolase activity
(GO:0052689)
Choloyl-coa hydrolase activity
(GO:0033882)
Cytosol
(GO:0005829)
Dicarboxylic acid catabolic process
(GO:0043649)
Fatty acid beta-oxidation using acyl-coa oxidase
(GO:0033540)
Fatty acid catabolic process
(GO:0009062)
Fatty acyl-coa hydrolase activity
(GO:0047617)
Hydroxymethylglutaryl-coa hydrolase activity
(GO:0047994)
Long-chain fatty acyl-coa hydrolase activity
(GO:0052816)
Medium-chain fatty acyl-coa hydrolase activity
(GO:0052815)
Negative regulation of cd4 production
(GO:0045225)
Peroxisomal matrix
(GO:0005782)
Peroxisome fission
(GO:0016559)
Protein binding
(GO:0005515)
Succinyl-coa hydrolase activity
(GO:0004778)

Other Information

Proteins

Acyl-coenzyme A thioesterase 8

Genular Protein ID: 2581957923

Symbol: ACOT8_HUMAN

Name: Acyl-coenzyme A thioesterase 8

UniProtKB Accession Codes:

O14734 O15261 Q17RX4

Database IDs:

Citations:

PubMed ID: 9299485

Title: A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef.

PubMed ID: 9299485

DOI: 10.1006/bbrc.1997.7217

PubMed ID: 9153233

Title: Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation.

PubMed ID: 9153233

DOI: 10.1074/jbc.272.21.13779

PubMed ID: 10092594

Title: Identification of peroxisomal acyl-CoA thioesterases in yeast and humans.

PubMed ID: 10092594

DOI: 10.1074/jbc.274.14.9216

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10944470

Title: Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase.

PubMed ID: 10944470

DOI: 10.1006/bbrc.2000.3285

PubMed ID: 15194431

Title: Overexpression of human acyl-CoA thioesterase upregulates peroxisome biogenesis.

PubMed ID: 15194431

DOI: 10.1016/j.yexcr.2004.02.029

PubMed ID: 11755680

Title: The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism.

PubMed ID: 11755680

DOI: 10.1016/s0163-7827(01)00017-0

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 319
Mass: 35914
Checksum: 8345C6E5EABF3326
Sequence:

MSSPQAPEDG QGCGDRGDPP GDLRSVLVTT VLNLEPLDED LFRGRHYWVP AKRLFGGQIV 
GQALVAAAKS VSEDVHVHSL HCYFVRAGDP KLPVLYQVER TRTGSSFSVR SVKAVQHGKP 
IFICQASFQQ AQPSPMQHQF SMPTVPPPEE LLDCETLIDQ YLRDPNLQKR YPLALNRIAA 
QEVPIEIKPV NPSPLSQLQR MEPKQMFWVR ARGYIGEGDM KMHCCVAAYI SDYAFLGTAL 
LPHQWQHKVH FMVSLDHSMW FHAPFRADHW MLYECESPWA GGSRGLVHGR LWRQDGVLAV 
TCAQEGVIRV KPQVSESKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACOT8

Associated with

Other Information

A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef. PubMed ID: 9299485

Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. PubMed ID: 9153233

Identification of peroxisomal acyl-CoA thioesterases in yeast and humans. PubMed ID: 10092594

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. PubMed ID: 10944470

Overexpression of human acyl-CoA thioesterase upregulates peroxisome biogenesis. PubMed ID: 15194431

The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism. PubMed ID: 11755680

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712