Details for: KCNE3

Gene ID: 10008

Symbol: KCNE3

Ensembl ID: ENSG00000175538

Description: potassium voltage-gated channel subfamily E regulatory subunit 3

Associated with

  • Cardiac conduction
    (R-HSA-5576891)
  • Muscle contraction
    (R-HSA-397014)
  • Phase 2 - plateau phase
    (R-HSA-5576893)
  • Phase 3 - rapid repolarisation
    (R-HSA-5576890)
  • Basolateral part of cell
    (GO:1990794)
  • Cytoplasm
    (GO:0005737)
  • Delayed rectifier potassium channel activity
    (GO:0005251)
  • Dendrite
    (GO:0030425)
  • Intracellular chloride ion homeostasis
    (GO:0030644)
  • Membrane raft
    (GO:0045121)
  • Membrane repolarization during action potential
    (GO:0086011)
  • Membrane repolarization during ventricular cardiac muscle cell action potential
    (GO:0098915)
  • Negative regulation of delayed rectifier potassium channel activity
    (GO:1902260)
  • Negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
    (GO:1905025)
  • Negative regulation of potassium ion export across plasma membrane
    (GO:1903765)
  • Negative regulation of voltage-gated potassium channel activity
    (GO:1903817)
  • Neuronal cell body membrane
    (GO:0032809)
  • Perikaryon
    (GO:0043204)
  • Plasma membrane
    (GO:0005886)
  • Potassium channel regulator activity
    (GO:0015459)
  • Potassium ion export across plasma membrane
    (GO:0097623)
  • Protein binding
    (GO:0005515)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Sodium ion transport
    (GO:0006814)
  • Transmembrane transporter binding
    (GO:0044325)
  • Ventricular cardiac muscle cell action potential
    (GO:0086005)
  • Vesicle
    (GO:0031982)
  • Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
    (GO:1902282)
  • Voltage-gated potassium channel complex
    (GO:0008076)

Other Information

Genular Protein ID: 1946696385

Symbol: KCNE3_HUMAN

Name: Potassium voltage-gated channel subfamily E member 3

UniProtKB Accession Codes:

Q9Y6H6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 EMBL 3 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 24 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 7 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11104781

Title: Structural determinants of KvLQT1 control by the KCNE family of proteins.

PubMed ID: 11104781

DOI: 10.1074/jbc.m010713200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10646604

Title: A constitutively open potassium channel formed by KCNQ1 and KCNE3.

PubMed ID: 10646604

DOI: 10.1038/35003200

PubMed ID: 11207363

Title: MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis.

PubMed ID: 11207363

DOI: 10.1016/s0092-8674(01)00207-0

PubMed ID: 11874988

Title: Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism.

PubMed ID: 11874988

DOI: 10.1096/fj.01-0520hyp

PubMed ID: 12954870

Title: MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain.

PubMed ID: 12954870

DOI: 10.1523/jneurosci.23-22-08077.2003

PubMed ID: 20533308

Title: Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting.

PubMed ID: 20533308

DOI: 10.1002/jcp.22265

PubMed ID: 12414843

Title: A mutation in the KCNE3 potassium channel gene is associated with susceptibility to thyrotoxic hypokalemic periodic paralysis.

PubMed ID: 12414843

DOI: 10.1210/jc.2002-020698

PubMed ID: 14504341

Title: Lack of association of the potassium channel-associated peptide MiRP2-R83H variant with periodic paralysis.

PubMed ID: 14504341

DOI: 10.1212/01.wnl.0000082392.66713.e3

PubMed ID: 15037716

Title: Periodic paralysis mutation MiRP2-R83H in controls: Interpretations and general recommendation.

PubMed ID: 15037716

DOI: 10.1212/01.wnl.0000119392.29624.88

PubMed ID: 19122847

Title: Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome.

PubMed ID: 19122847

DOI: 10.1161/circep.107.748103

PubMed ID: 19306396

Title: Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome.

PubMed ID: 19306396

DOI: 10.1002/humu.20834

Sequence Information:

  • Length: 103
  • Mass: 11710
  • Checksum: 5235385E8D08BF10
  • Sequence:
    • METTNGTETW YESLHAVLKA LNATLHSNLL CRPGPGLGPD NQTEERRASL PGRDDNSYMY 
ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV SMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.