Details for: CDH3

Gene ID: 1001

Symbol: CDH3

Ensembl ID: ENSG00000062038

Description: cadherin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 74.6407
    Cell Significance Index: -11.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.9951
    Cell Significance Index: -11.9200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.3203
    Cell Significance Index: 38.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7031
    Cell Significance Index: 36.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4450
    Cell Significance Index: 68.3300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.0350
    Cell Significance Index: 16.8300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.9077
    Cell Significance Index: 11.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8855
    Cell Significance Index: 49.5800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.8144
    Cell Significance Index: 29.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6562
    Cell Significance Index: 45.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5921
    Cell Significance Index: 20.3900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.5804
    Cell Significance Index: 13.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4041
    Cell Significance Index: 163.6400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 1.0755
    Cell Significance Index: 15.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6997
    Cell Significance Index: 15.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6734
    Cell Significance Index: 128.1500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.6268
    Cell Significance Index: 9.5200
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.4956
    Cell Significance Index: 2.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4951
    Cell Significance Index: 60.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4575
    Cell Significance Index: 91.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4489
    Cell Significance Index: 245.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4142
    Cell Significance Index: 148.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3876
    Cell Significance Index: 171.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3870
    Cell Significance Index: 26.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3826
    Cell Significance Index: 37.8500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3501
    Cell Significance Index: 4.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3459
    Cell Significance Index: 312.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3213
    Cell Significance Index: 16.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3164
    Cell Significance Index: 14.0000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.3125
    Cell Significance Index: 1.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2569
    Cell Significance Index: 9.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2498
    Cell Significance Index: 45.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2477
    Cell Significance Index: 6.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2022
    Cell Significance Index: 32.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1858
    Cell Significance Index: 11.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1651
    Cell Significance Index: 11.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1500
    Cell Significance Index: 9.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1331
    Cell Significance Index: 8.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1251
    Cell Significance Index: 2.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1232
    Cell Significance Index: 16.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1183
    Cell Significance Index: 5.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1004
    Cell Significance Index: 12.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0767
    Cell Significance Index: 0.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0665
    Cell Significance Index: 13.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0413
    Cell Significance Index: 0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0173
    Cell Significance Index: 2.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0156
    Cell Significance Index: 23.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0147
    Cell Significance Index: 27.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0111
    Cell Significance Index: 15.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0093
    Cell Significance Index: 17.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0080
    Cell Significance Index: 5.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0072
    Cell Significance Index: 0.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0063
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0049
    Cell Significance Index: 0.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0028
    Cell Significance Index: 0.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0018
    Cell Significance Index: 0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0031
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0064
    Cell Significance Index: -0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0112
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0141
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0146
    Cell Significance Index: -10.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0207
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0210
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0217
    Cell Significance Index: -13.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0249
    Cell Significance Index: -1.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0274
    Cell Significance Index: -7.8900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0370
    Cell Significance Index: -0.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0397
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0413
    Cell Significance Index: -7.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0487
    Cell Significance Index: -1.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0519
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0622
    Cell Significance Index: -7.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0634
    Cell Significance Index: -13.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0716
    Cell Significance Index: -1.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0956
    Cell Significance Index: -12.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1006
    Cell Significance Index: -11.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1053
    Cell Significance Index: -10.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1065
    Cell Significance Index: -11.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1120
    Cell Significance Index: -5.2200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1212
    Cell Significance Index: -1.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1399
    Cell Significance Index: -11.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1462
    Cell Significance Index: -11.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1580
    Cell Significance Index: -9.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1681
    Cell Significance Index: -4.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1807
    Cell Significance Index: -9.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1854
    Cell Significance Index: -11.9600
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1877
    Cell Significance Index: -1.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1881
    Cell Significance Index: -3.7200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.1917
    Cell Significance Index: -0.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2123
    Cell Significance Index: -6.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2200
    Cell Significance Index: -11.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2214
    Cell Significance Index: -7.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2291
    Cell Significance Index: -7.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2379
    Cell Significance Index: -7.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2389
    Cell Significance Index: -8.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2660
    Cell Significance Index: -5.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: Cadherin 3 is a type-1 cadherin, characterized by a unique extracellular domain with a short cytoplasmic tail. 2. **Expression**: CDH3 is expressed in a variety of epithelial tissues, including skin, respiratory tract, gastrointestinal tract, and reproductive organs. 3. **Function**: Cadherin 3 mediates calcium-dependent cell-cell adhesion, influencing cell proliferation, differentiation, and survival. 4. **Regulation**: CDH3 is regulated by various signaling pathways, including the Wnt/β-catenin and Notch pathways. **Pathways and Functions** 1. **Adherens Junction Formation**: CDH3 plays a crucial role in the formation and maintenance of adherens junctions, which are essential for cell-cell adhesion and tissue structure. 2. **Cell Proliferation and Differentiation**: Cadherin 3 regulates cell proliferation and differentiation by modulating the activity of key signaling pathways, including the Wnt/β-catenin and Notch pathways. 3. **Cell Survival**: CDH3 has been implicated in the regulation of cell survival, with evidence suggesting that it modulates apoptosis and autophagy. 4. **Tissue Homeostasis**: Cadherin 3 contributes to tissue homeostasis by regulating the balance between cell proliferation and differentiation, ensuring the maintenance of tissue architecture and function. **Clinical Significance** 1. **Cancer**: Alterations in CDH3 expression have been observed in various types of cancer, including breast, lung, and prostate cancer, suggesting its potential as a diagnostic and therapeutic target. 2. **Skin Disorders**: CDH3 mutations have been associated with skin disorders, such as epidermolysis bullosa simplex, highlighting its importance in skin development and homeostasis. 3. **Respiratory Diseases**: Cadherin 3 has been implicated in respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD), suggesting its role in airway epithelial cell function and homeostasis. 4. **Neurological Disorders**: CDH3 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its potential role in neuronal cell-cell interactions and tissue homeostasis. In conclusion, CDH3 is a critical gene that plays a pivotal role in cell adhesion, development, and tissue homeostasis. Its dysregulation has been implicated in various diseases, making it an attractive target for therapeutic intervention. Further research is needed to fully elucidate the mechanisms by which CDH3 regulates cell-cell interactions and tissue homeostasis, with the ultimate goal of developing novel therapeutic strategies for the treatment of diseases associated with CDH3 dysfunction.

Genular Protein ID: 733022415

Symbol: CADH3_HUMAN

Name: Cadherin-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2793940

Title: Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues.

PubMed ID: 2793940

DOI: 10.1083/jcb.109.4.1787

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9815605

Title: P-cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer.

PubMed ID: 9815605

PubMed ID: 2702654

Title: Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.

PubMed ID: 2702654

PubMed ID: 16007225

Title: Adhesion signaling by a novel mitotic substrate of src kinases.

PubMed ID: 16007225

DOI: 10.1038/sj.onc.1208582

PubMed ID: 11544476

Title: Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin.

PubMed ID: 11544476

DOI: 10.1038/ng716

PubMed ID: 17052462

Title: Crystal structure of a beta-catenin/BCL9/Tcf4 complex.

PubMed ID: 17052462

DOI: 10.1016/j.molcel.2006.09.001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 12445216

Title: A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy.

PubMed ID: 12445216

DOI: 10.1046/j.1523-1747.2002.19528.x

PubMed ID: 15805154

Title: Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome).

PubMed ID: 15805154

DOI: 10.1136/jmg.2004.027821

Sequence Information:

  • Length: 829
  • Mass: 91418
  • Checksum: 7C03C8536CD98C7B
  • Sequence:
  • MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA LGKVFMGCPG 
    QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR ILRRHKRDWV VAPISVPENG 
    KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA DSPPEGVFAV EKETGWLLLN KPLDREEIAK 
    YELFGHAVSE NGASVEDPMN ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT 
    DEDDAIYTYN GVVAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA 
    TDMDGDGSTT TAVAVVEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT VTDLDAPNSP 
    AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA KNQHTLYVEV TNEAPFVLKL 
    PTSTATIVVH VEDVNEAPVF VPPSKVVEVQ EGIPTGEPVC VYTAEDPDKE NQKISYRILR 
    DPAGWLAMDP DSGQVTAVGT LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID 
    VNDHGPVPEP RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD 
    TVVLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP WKGGFILPVL 
    GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY YGEEGGGEED QDYDITQLHR 
    GLEARPEVVL RNDVAPTIIP TPMYRPRPAN PDEIGNFIIE NLKAANTDPT APPYDTLLVF 
    DYEGSGSDAA SLSSLTSSAS DQDQDYDYLN EWGSRFKKLA DMYGGGEDD

Genular Protein ID: 43648192

Symbol: B4DLF0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 774
  • Mass: 85633
  • Checksum: F07B43E029140C73
  • Sequence:
  • MGCPGQEPAL FSTDNDDFTV RNGETVQERR SLKERNPLKI FPSKRILRRH KRDWVVAPIS 
    VPENGKGPFP QRLNQLKSNK DRDTKIFYSI TGPGADSPPE GVFAVEKETG WLLLNKPLDR 
    EEIAKYELFG HAVSENGASV EDPMNISIIV TDQNDHKPKF TQDTFRGSVL EGVLPGTSVM 
    QVTATDEDDA IYTYNGVVAY SIHSQEPKDP HDLMFTIHRS TGTISVISSG LDREKVPEYT 
    LTIQATDMDG DGSTTTAVAV VEILDANDNA PMFDPQKYEA HVPENAVGHE VQRLTVTDLD 
    APNSPAWRAT YLIMGGDDGD HFTITTHPES NQGILTTRKG LDFEAKNQHT LYVEVTNEAP 
    FVLKLPTSTA TIVVHVEDVN EAPVFVPPSK VVEVQEGIPT GEPVCVYTAE DPDKENQKIS 
    YRILRDPAGW LAMDPDSGQV TAVGTLDRED EQFVRNNIYE VMVLAMDNGS PPTTGTGTLL 
    LTLIDVNDHG PVPEPRQITI CNQSPVRHVL NITDKDLSPH TSPFQAQLTD DSDIYWTAEV 
    NEEGDTVVLS LKKFLKQDTY DVHLSLSDHG NKEQLTVIRA TVCDCHGHVE TCPGPWKGGF 
    ILPVLGAVLA LLFLLLVLLL LVRKKRKIKE PLLLPEDDTR DNVFYYGEEG GGEEDQDYDI 
    TQLHRGLEAR PEVVLRNDVA PTIIPTPMYR PRPANPDEIG NFIIENLKAA NTDPTAPPYD 
    TLLVFDYEGS GSDAASLSSL TSSASDQDQD YDYLNEWGSR FKKLADMYGG GEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.