Details for: HDAC6
Associated with
Other Information
Genular Protein ID: 4108119930
Symbol: HDAC6_HUMAN
Name: Histone deacetylase 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10220385
Title: Three proteins define a class of human histone deacetylases related to yeast Hda1p.
PubMed ID: 10220385
PubMed ID: 10048485
Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10048485
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11533236
Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
PubMed ID: 11533236
PubMed ID: 11948178
Title: Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.
PubMed ID: 11948178
PubMed ID: 12032081
Title: The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
PubMed ID: 12032081
PubMed ID: 12354939
Title: Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.
PubMed ID: 12354939
PubMed ID: 12024216
PubMed ID: 12620231
Title: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
PubMed ID: 12620231
PubMed ID: 17604723
Title: HEF1-dependent Aurora A activation induces disassembly of the primary cilium.
PubMed ID: 17604723
PubMed ID: 17872950
Title: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.
PubMed ID: 17872950
PubMed ID: 17846173
Title: Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.
PubMed ID: 17846173
PubMed ID: 17516032
Title: Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.
PubMed ID: 17516032
PubMed ID: 19081074
Title: A BBSome subunit links ciliogenesis, microtubule stability and acetylation.
PubMed ID: 19081074
PubMed ID: 19033385
Title: The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.
PubMed ID: 19033385
DOI: 10.1242/jcs.035006
PubMed ID: 20102703
Title: Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation.
PubMed ID: 20102703
PubMed ID: 19893491
Title: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.
PubMed ID: 19893491
PubMed ID: 20308065
Title: TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.
PubMed ID: 20308065
PubMed ID: 23093407
Title: Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration.
PubMed ID: 23093407
PubMed ID: 20181727
Title: A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia.
PubMed ID: 20181727
DOI: 10.1093/hmg/ddq083
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24413532
Title: Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.
PubMed ID: 24413532
PubMed ID: 24687993
Title: Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.
PubMed ID: 24687993
DOI: 10.1096/fj.13-246470
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25422469
Title: Disruption of FAT10-MAD2 binding inhibits tumor progression.
PubMed ID: 25422469
PubMed ID: 26246421
Title: Deacetylation of alpha-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
PubMed ID: 26246421
DOI: 10.1038/srep12917
PubMed ID: 31505170
Title: Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.
PubMed ID: 31505170
PubMed ID: 30538141
Title: ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion.
PubMed ID: 30538141
Sequence Information:
- Length: 1215
- Mass: 131419
- Checksum: 6F17731268A33114
- Sequence:
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG DPKGEMAATP AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH TLLGDPCPML ESPGAPCRSA QASVSCALEA LEPFWEVLVR STETVERDNM EEDNVEESEE EGPWEPPVLP ILTWPVLQSR TGLVYDQNMM NHCNLWDSHH PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH SAEYVGHLRA TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQTISGHA LRILIVDWDV HHGNGTQHMF EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT VNVAWNGPRM GDADYLAAWH RLVLPIAYEF NPELVLVSAG FDAARGDPLG GCQVSPEGYA HLTHLLMGLA SGRIILILEG GYNLTSISES MAACTRSLLG DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE DREGPSSSKL VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KVTSASFGEE STPGQTNSET AVVALTQDQP SEAATGGATL AQTISEAAIG GAMLGQTTSE EAVGGATPDQ TTSEETVGGA ILDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME GATLDQTTSE EAPGGTELIQ TPLASSTDHQ TPPTSPVQGT TPQISPSTLI GSLRTLELGS ESQGASESQA PGEENLLGEA AGGQDMADSM LMQGSRGLTD QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ ENWVCLSCYQ VYCGRYINGH MLQHHGNSGH PLVLSYIDLS AWCYYCQAYV HHQALLDVKN IAHQNKFGED MPHPH
Genular Protein ID: 659728241
Symbol: Q9BRX7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15772651
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 146
- Mass: 16399
- Checksum: 6A2C1261CE1F83EB
- Sequence:
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHR
Genular Protein ID: 3011025104
Symbol: B4DZH6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1229
- Mass: 132781
- Checksum: C9565F32C7CF6EC9
- Sequence:
MSGANRGRGQ ASSTMTSTGQ DSTTTRQRRS RQNPQSPPQD SSVTSKRNIK KGAVPRSIPN LAEVKKKGKM KKLGQAMEED LIVGLQGMDL NLEAEALAGT GLVLDEQLNE FHCLWDDSFP EGPERLHAIK EQLIQEGLLD RCVSFQARFA EKEELMLVHS LEYIDLMETT QYMNEGELRV LADTYDSVYL HPNSYSCACL ASGSVLRLVD AVLGAEIRNG MAIIRPPGHH AQHSLMDGYC MFNHVAVAAR YAQQKHRIRR VLIVDWDVHH GQGTQFTFDQ DPSVLYFSIH RYEQGRFWPH LKASNWSTTG FGQGQGYTIN VPWNQVGMRD ADYIAAFLHV LLPVALEFQP QLVLVAAGFD ALQGDPKGEM AATPAGFAQL THLLMGLAGG KLILSLEGGY NLRALAEGVS ASLHTLLGDP CPMLESPGAP CRSAQASVSC ALEALEPFWE VLVRSTETVE RDNMEEDNVE ESEEEGPWEP PVLPILTWPV LQSRTGLVYD QNMMNHCNLW DSHHPEVPQR ILRIMCRLEE LGLAGRCLTL TPRPATEAEL LTCHSAEYVG HLRATEKMKT RELHRESSNF DSIYICPSTF ACAQLATGAA CRLVEAVLSG EVLNGAAVVR PPGHHAEQDA ACGFCFFNSV AVAARHAQTI SGHALRILIV DWDVHHGNGT QHMFEDDPSV LYVSLHRYDH GTFFPMGDEG ASSQIGRAAG TGFTVNVAWN GPRMGDADYL AAWHRLVLPI AYEFNPELVL VSAGFDAARG DPLGGCQVSP EGYAHLTHLL MGLASGRIIL ILEGGYNLTS ISESMAACTR SLLGDPPPLL TLPRPPLSGA LASITETIQV HRRYWRSLRV MKVEDREGPS SSKLVTKKAP QPAKPRLAER MTTREKKVLE AGMGKVTSAS FGEESTPGQT NSETAVVALT QDQPSEAATG GATLAQTISE AAIGGAMLGQ TTSEEAVGGA TPDQTTSEET VGGAILDQTT SEDAVGGATL GQTTSEEAVG GATLAQTTSE AAMEGATLDQ TTSEEAPGGT ELIQTPLASS TDHQTPPTSP VQGTTPQISP STLIGSLRTL ELGSESQGAS ESQAPGEENL LGEAAGGQDM ADSMLMQGSR GLTDQAIFYA VTPLPWCPHL VAVCPIPAAG LDVTQPCGDC GTIQENWVCL SCYQVYCGRY INGHMLQHHG NSGHPLVLSY IDLSAWCYYC QAYVHHQALL DVKNIAHQNK FGEDMPHPH
Genular Protein ID: 92444804
Symbol: Q9NSW6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1209
- Mass: 130804
- Checksum: A2BD1739B3EFACE0
- Sequence:
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHRMETT QYMNEGELRV LADTYDSVYL HPNSYSCACL ASGSVLRLVD AVLGAEIRNG MAIIRPPGHH AQHSLMDGYC MFNHVAVAAR YAQQKHRIRR VLIVDWDVHH GQGTQFTFDQ DPSVLYFSIH RYEQGRFWPH LKASNWSTTG FGQGQGYTIN VPWNQVGMRD ADYIAAFLHV LLPVALEFQP QLVLVAAGFD ALQGDPKGEM AATPAGFAQL THLLMGLAGG KLILSLEGGY NLRALAEGVS ASLHTLLGDP CPMLESPGAP CRSAQTSVSC ALEALEPFWE VLVRSTETVE RDNMEEDNVE ESEEEGPWEP PVLPILTWPV LQSRTGLVYD QNMMNHCNLW DSHHPEVPQR ILRIMCRLEE LGLAGRCLTL TPRPATEAEL LTCHSAEYVG HLRATEKMKT RELHRESSNF DSIYICPSTF ACAQLATGAA CRLVEAVLSG EVLNGAAVVR PPGHHAEQDA ACGFCFFNSV AVAARHAQTI SGHALRILIV DWDVHHGNGT QHMFEDDPSV LYVSLHRYDH GTFFPMGDEG ASSQIGRAAG TGFTVNVAWN GPRMGDADYL AAWHRLVLPI AYEFNPELVL VSAGFDAARG DPLGGCQVSP EGYAHLTHLL MGLASGRIIL ILEGGYNLTS ISESMAACTR SLLGDPPPLL TLPRPPLSGA LASITETIQV HRRYWRCLRV MKVEDREGPS SSKLDTKKAP QPAKPRLAER MTTREKKVLE AGMGKVTSAS FGEESTPGQT NSETAVVALT QDQPSEAATG GATLAQTISE AAIGGAMLGQ TTSEEAVGGA TPDQTTSEET VGGAILDQTT SEDAVGGATL GQTTSEEAVG GATLAQTTSE AAMEGATLDQ TTSEEAPGGT ELIQTPLASS TDHQTPPTSP VQGTTPQISP STLIGSLRTL ELGSESQGAS ESQAPGEENL LGEAAGGQDM ADSMLMQGSR GLTDQAIFYA VTPLPWCPHL VAVCPIPAAG LDVTQPCGDC GTIQENWVCL SCYQVYCGRY INGHMLQHHG NSGHPLVLSY IDLSAWCYYC QAYVHHQALL DVKNIAHQNK FGEDMPHPH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.