HDAC5 | ENSG00000108840 | NCBI 10014

Details for: HDAC5

Gene ID: 10014

Symbol: HDAC5

Ensembl ID: ENSG00000108840

Description: histone deacetylase 5

Associated with

Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Pip3 activates akt signaling
(R-HSA-1257604)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signal transduction
(R-HSA-162582)
B cell activation
(GO:0042113)
B cell differentiation
(GO:0030183)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to lipopolysaccharide
(GO:0071222)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Golgi apparatus
(GO:0005794)
Histone deacetylase activity
(GO:0004407)
Histone deacetylase binding
(GO:0042826)
Histone deacetylase complex
(GO:0000118)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Metal ion binding
(GO:0046872)
Negative regulation of cell migration involved in sprouting angiogenesis
(GO:0090051)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase c binding
(GO:0005080)
Protein lysine deacetylase activity
(GO:0033558)
Regulation of myotube differentiation
(GO:0010830)
Regulation of protein binding
(GO:0043393)
Response to activity
(GO:0014823)
Response to cocaine
(GO:0042220)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription corepressor binding
(GO:0001222)

Other Information

Proteins

Histone deacetylase 5

Genular Protein ID: 704421138

Symbol: HDAC5_HUMAN

Name: Histone deacetylase 5

UniProtKB Accession Codes:

Q9UQL6 C9JFV9 O60340 O60528 Q96DY4

Database IDs:

Citations:

PubMed ID: 10220385

Title: Three proteins define a class of human histone deacetylases related to yeast Hda1p.

PubMed ID: 10220385

DOI: 10.1073/pnas.96.9.4868

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9610721

Title: Characterization of human colon cancer antigens recognized by autologous antibodies.

PubMed ID: 9610721

DOI: 10.1002/(sici)1097-0215(19980529)76:5<652::aid-ijc7>3.0.co;2-p

PubMed ID: 11018260

Title: Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5).

PubMed ID: 11018260

DOI: 10.1016/s0167-4781(00)00191-3

PubMed ID: 10898795

Title: BCoR, a novel corepressor involved in BCL-6 repression.

PubMed ID: 10898795

PubMed ID: 11081517

Title: Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.

PubMed ID: 11081517

DOI: 10.1038/35040593

PubMed ID: 11114197

Title: Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.

PubMed ID: 11114197

DOI: 10.1073/pnas.260501497

PubMed ID: 11509672

Title: Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.

PubMed ID: 11509672

DOI: 10.1128/mcb.21.18.6312-6321.2001

PubMed ID: 12354939

Title: Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.

PubMed ID: 12354939

DOI: 10.1073/pnas.172511699

PubMed ID: 12504096

Title: Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers.

PubMed ID: 12504096

DOI: 10.1016/s0006-291x(02)02873-5

PubMed ID: 17373667

Title: Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases.

PubMed ID: 17373667

DOI: 10.1002/ijc.22673

PubMed ID: 17872950

Title: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.

PubMed ID: 17872950

DOI: 10.1074/jbc.m703735200

PubMed ID: 18184930

Title: AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5.

PubMed ID: 18184930

DOI: 10.2337/db07-0843

PubMed ID: 18332134

Title: Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis.

PubMed ID: 18332134

DOI: 10.1074/jbc.m800264200

PubMed ID: 19666599

Title: Human BAHD1 promotes heterochromatic gene silencing.

PubMed ID: 19666599

DOI: 10.1073/pnas.0901259106

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20188095

Title: Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.

PubMed ID: 20188095

DOI: 10.1016/j.febslet.2010.02.057

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22649097

Title: Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

PubMed ID: 22649097

DOI: 10.1126/scisignal.2002979

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24413532

Title: Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.

PubMed ID: 24413532

DOI: 10.1158/0008-5472.can-13-2020

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25752541

Title: Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

PubMed ID: 25752541

DOI: 10.1016/j.str.2015.02.001

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28167758

Title: MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.

PubMed ID: 28167758

DOI: 10.1073/pnas.1621425114

Sequence Information:

Length: 1122
Mass: 121978
Checksum: CF4BE774E3588FEC
Sequence:

MNSPNESDGM SGREPSLEIL PRTSLHSIPV TVEVKPVLPR AMPSSMGGGG GGSPSPVELR 
GALVGSVDPT LREQQLQQEL LALKQQQQLQ KQLLFAEFQK QHDHLTRQHE VQLQKHLKQQ 
QEMLAAKQQQ EMLAAKRQQE LEQQRQREQQ RQEELEKQRL EQQLLILRNK EKSKESAIAS 
TEVKLRLQEF LLSKSKEPTP GGLNHSLPQH PKCWGAHHAS LDQSSPPQSG PPGTPPSYKL 
PLPGPYDSRD DFPLRKTASE PNLKVRSRLK QKVAERRSSP LLRRKDGTVI STFKKRAVEI 
TGAGPGASSV CNSAPGSGPS SPNSSHSTIA ENGFTGSVPN IPTEMLPQHR ALPLDSSPNQ 
FSLYTSPSLP NISLGLQATV TVTNSHLTAS PKLSTQQEAE RQALQSLRQG GTLTGKFMST 
SSIPGCLLGV ALEGDGSPHG HASLLQHVLL LEQARQQSTL IAVPLHGQSP LVTGERVATS 
MRTVGKLPRH RPLSRTQSSP LPQSPQALQQ LVMQQQHQQF LEKQKQQQLQ LGKILTKTGE 
LPRQPTTHPE ETEEELTEQQ EVLLGEGALT MPREGSTESE STQEDLEEED EEDDGEEEED 
CIQVKDEEGE SGAEEGPDLE EPGAGYKKLF SDAQPLQPLQ VYQAPLSLAT VPHQALGRTQ 
SSPAAPGGMK SPPDQPVKHL FTTGVVYDTF MLKHQCMCGN THVHPEHAGR IQSIWSRLQE 
TGLLSKCERI RGRKATLDEI QTVHSEYHTL LYGTSPLNRQ KLDSKKLLGP ISQKMYAVLP 
CGGIGVDSDT VWNEMHSSSA VRMAVGCLLE LAFKVAAGEL KNGFAIIRPP GHHAEESTAM 
GFCFFNSVAI TAKLLQQKLN VGKVLIVDWD IHHGNGTQQA FYNDPSVLYI SLHRYDNGNF 
FPGSGAPEEV GGGPGVGYNV NVAWTGGVDP PIGDVEYLTA FRTVVMPIAH EFSPDVVLVS 
AGFDAVEGHL SPLGGYSVTA RCFGHLTRQL MTLAGGRVVL ALEGGHDLTA ICDASEACVS 
ALLSVELQPL DEAVLQQKPN INAVATLEKV IEIQSKHWSC VQKFAAGLGR SLREAQAGET 
EEAETVSAMA LLSVGAEQAQ AAAAREHSPR PAEEPMEQEP AL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HDAC5

Associated with

Other Information

Three proteins define a class of human histone deacetylases related to yeast Hda1p. PubMed ID: 10220385

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of human colon cancer antigens recognized by autologous antibodies. PubMed ID: 9610721

Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5). PubMed ID: 11018260

BCoR, a novel corepressor involved in BCL-6 repression. PubMed ID: 10898795

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. PubMed ID: 11081517

Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. PubMed ID: 11114197

Identification of a signal-responsive nuclear export sequence in class II histone deacetylases. PubMed ID: 11509672

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. PubMed ID: 12354939

Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers. PubMed ID: 12504096

Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. PubMed ID: 17373667

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. PubMed ID: 17872950

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. PubMed ID: 18184930

Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. PubMed ID: 18332134

Human BAHD1 promotes heterochromatic gene silencing. PubMed ID: 19666599

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. PubMed ID: 20188095

Initial characterization of the human central proteome. PubMed ID: 21269460

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. PubMed ID: 22649097

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1. PubMed ID: 24413532

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. PubMed ID: 25752541

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases. PubMed ID: 28167758