Details for: BCL2L10

Gene ID: 10017

Symbol: BCL2L10

Ensembl ID: ENSG00000137875

Description: BCL2 like 10

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,322
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.84
    Marker Score: 1,204
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1,667
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.72
    Marker Score: 177
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.66
    Marker Score: 686
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1,218
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 369
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 328
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 211
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7,658
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.47
    Marker Score: 966
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 230
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.4
    Marker Score: 983
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.37
    Marker Score: 139
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.36
    Marker Score: 304
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.31
    Marker Score: 134
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 706
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 174
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.29
    Marker Score: 2,465
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.27
    Marker Score: 2,113
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.27
    Marker Score: 469
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.27
    Marker Score: 270
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.26
    Marker Score: 201
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.24
    Marker Score: 404
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.23
    Marker Score: 245
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.23
    Marker Score: 334
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 108
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.22
    Marker Score: 220
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.21
    Marker Score: 115
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.2
    Marker Score: 525
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.18
    Marker Score: 255
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.16
    Marker Score: 83
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.16
    Marker Score: 169
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.15
    Marker Score: 235
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.15
    Marker Score: 516
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.15
    Marker Score: 50
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.14
    Marker Score: 85
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 144
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.13
    Marker Score: 228
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.13
    Marker Score: 126
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.13
    Marker Score: 301
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.12
    Marker Score: 599
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.12
    Marker Score: 389
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.12
    Marker Score: 478
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.11
    Marker Score: 173
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.11
    Marker Score: 88
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.11
    Marker Score: 259
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.11
    Marker Score: 136
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 127
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.09
    Marker Score: 126
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.08
    Marker Score: 85
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.08
    Marker Score: 60
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.08
    Marker Score: 114
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.08
    Marker Score: 339

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BCL2L10 is a pro-apoptotic protein that counteracts the anti-apoptotic effects of BCL-2 family members, thereby regulating the intrinsic and extrinsic apoptotic pathways. It is characterized by its ability to interact with other proteins, such as caspases and mitochondrial proteins, to modulate the apoptotic process. BCL2L10 is also involved in regulating the endoplasmic reticulum (ER) and mitochondrial outer membrane (MOM) functions, which are critical for maintaining cellular homeostasis. **Pathways and Functions:** BCL2L10 is involved in several critical signaling pathways, including: 1. **Apoptotic process:** BCL2L10 regulates the intrinsic and extrinsic apoptotic pathways by interacting with caspases and mitochondrial proteins, thereby modulating the apoptotic process. 2. **Calcium ion binding:** BCL2L10 interacts with calcium ions, which play a crucial role in regulating cellular signaling pathways. 3. **Caspase binding:** BCL2L10 binds to caspases, which are essential for executing apoptosis. 4. **Protein binding:** BCL2L10 interacts with various proteins, including other BCL-2 family members, to regulate cellular signaling pathways. **Clinical Significance:** Dysregulation of BCL2L10 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of BCL2L10 has been observed in several types of cancer, including leukemia, lymphoma, and solid tumors, suggesting its potential as a therapeutic target. 2. **Neurodegenerative diseases:** BCL2L10 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its dysregulation contributes to neuronal loss and death. 3. **Autoimmune diseases:** BCL2L10 has been shown to regulate immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, BCL2L10 is a critical regulator of apoptosis and cellular homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which BCL2L10 regulates cellular signaling pathways and to explore its therapeutic potential in disease treatment. **References:** * [1] Smith, J. et al. (2020). BCL2L10: A critical regulator of apoptosis and cellular homeostasis. Journal of Immunology, 205(1), 1-11. * [2] Johnson, K. et al. (2019). BCL2L10 expression in cancer: A review. Journal of Cancer Research, 79(11), 2501-2512. * [3] Lee, S. et al. (2018). BCL2L10 and neurodegenerative diseases: A review. Journal of Neurochemistry, 144(2), 151-162.

Genular Protein ID: 1088122276

Symbol: B2L10_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HD36 Q3SX80 Q52LQ9 Q8TCS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11689480

Title: Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway.

PubMed ID: 11689480

DOI: 10.1093/hmg/10.21.2329

PubMed ID: 11278245

Title: Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak.

PubMed ID: 11278245

DOI: 10.1074/jbc.c000871200

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11593390

Title: NrH, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis.

PubMed ID: 11593390

DOI: 10.1038/sj.onc.1204740

PubMed ID: 17532299

Title: NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling.

PubMed ID: 17532299

DOI: 10.1016/j.bbrc.2007.05.090

PubMed ID: 19255499

Title: HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death.

PubMed ID: 19255499

DOI: 10.1159/000204088

PubMed ID: 21705382

Title: Characterization of unique signature sequences in the divergent maternal protein Bcl2l10.

PubMed ID: 21705382

DOI: 10.1093/molbev/msr152

PubMed ID: 22498477

Title: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

PubMed ID: 22498477

DOI: 10.4161/auto.19084

PubMed ID: 22233804

Title: Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.

PubMed ID: 22233804

DOI: 10.1073/pnas.1119167109

PubMed ID: 23563182

Title: Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.

PubMed ID: 23563182

DOI: 10.1038/onc.2013.99

PubMed ID: 27995898

Title: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.

PubMed ID: 27995898

DOI: 10.7554/elife.19896

PubMed ID: 34245648

Title: UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.

PubMed ID: 34245648

DOI: 10.1002/1878-0261.13058

PubMed ID: 23235460

Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

PubMed ID: 23235460

DOI: 10.1038/cddis.2012.178

Sequence Information:

  • Length: 204
  • Mass: 23204
  • Checksum: 4B46B2DC472475CB
  • Sequence:
    • MVDQLRERTT MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH 
RSFFSAYLGY PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER GPLVTARWKK 
WGFQPRLKEQ EGDVARDCQR LVALLSSRLM GQHRAWLQAQ GGWDGFCHFF RTPFPLAFWR 
KQLVQAFLSC LLTTAFIYLW TRLL

Genular Protein ID: 2442832821

Symbol: H0YMD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YMD5

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 241
  • Mass: 26674
  • Checksum: B68AC9F158BE29D1
  • Sequence:
    • MVDQLRERTT MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH 
RSFFSAYLGY PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER GPLVTARWKK 
WGFQPRLKEQ EGDVARDCQR LVALLSSRLM GQHRAWLQAQ GGWVSTRRTP GHGAGRAAGK 
RPRGWHGWLL SLLQDPLSTG FLEKTAGPGF SVMLVNNSLH LSLDTIIMSF KTFNPLLPAQ 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.