Details for: SH2B3

Gene ID: 10019

Symbol: SH2B3

Ensembl ID: ENSG00000111252

Description: SH2B adaptor protein 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.51
    Marker Score: 472
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.46
    Marker Score: 471
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.44
    Marker Score: 718
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.38
    Marker Score: 1,574
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.36
    Marker Score: 1,254
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.31
    Marker Score: 535
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.29
    Marker Score: 1,559
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.28
    Marker Score: 2,604
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.28
    Marker Score: 1,277
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,927
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.18
    Marker Score: 712
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.14
    Marker Score: 29,135
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 656
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.12
    Marker Score: 2,694
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.08
    Marker Score: 60,512
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.06
    Marker Score: 2,073
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,729
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,747
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,972
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.99
    Marker Score: 22,087
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.98
    Marker Score: 1,130
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.98
    Marker Score: 922
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.95
    Marker Score: 237
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.91
    Marker Score: 2,363
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.91
    Marker Score: 2,147
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,717
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.89
    Marker Score: 54,836
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.89
    Marker Score: 1,290
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,974
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,253
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.86
    Marker Score: 1,330
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.82
    Marker Score: 453
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.82
    Marker Score: 2,042
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.8
    Marker Score: 4,878
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8
    Marker Score: 4,802
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.79
    Marker Score: 776
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.79
    Marker Score: 881
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.79
    Marker Score: 6,779
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.78
    Marker Score: 1,427
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.78
    Marker Score: 373
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.78
    Marker Score: 204
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.77
    Marker Score: 7,289
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.77
    Marker Score: 1,532
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.76
    Marker Score: 522
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1,225
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3,128
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.74
    Marker Score: 469
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,189
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.74
    Marker Score: 505
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.73
    Marker Score: 12,961
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.72
    Marker Score: 26,484
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.72
    Marker Score: 455
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.71
    Marker Score: 6,269
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.71
    Marker Score: 6,685
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.69
    Marker Score: 1,735
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.69
    Marker Score: 413
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.68
    Marker Score: 285
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.68
    Marker Score: 1,299
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.67
    Marker Score: 262
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.67
    Marker Score: 445
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.66
    Marker Score: 2,760
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.66
    Marker Score: 594
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.66
    Marker Score: 328
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.66
    Marker Score: 272
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.66
    Marker Score: 232
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.65
    Marker Score: 178
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.64
    Marker Score: 578
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.64
    Marker Score: 2,270
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.63
    Marker Score: 147
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.63
    Marker Score: 675
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.63
    Marker Score: 761
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.63
    Marker Score: 152
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.62
    Marker Score: 12,380
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.62
    Marker Score: 628
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.62
    Marker Score: 257
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.61
    Marker Score: 2,547
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.6
    Marker Score: 575
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.6
    Marker Score: 592
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.6
    Marker Score: 155
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6,158
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.59
    Marker Score: 2,490
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.59
    Marker Score: 354
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.58
    Marker Score: 202
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.58
    Marker Score: 295
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.58
    Marker Score: 364
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.58
    Marker Score: 21,973
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.58
    Marker Score: 199
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.56
    Marker Score: 134

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SH2B3 is a member of the SH2B family of adaptor proteins, which are known for their ability to bind to phosphotyrosine-containing peptides and regulate signaling pathways. The SH2B3 protein contains a SH2 domain, which is responsible for its ability to bind to phosphotyrosine-containing peptides, as well as an SH3 domain, which mediates interactions with other proteins. SH2B3 is highly phosphorylated, which allows it to interact with a wide range of signaling molecules, including receptor tyrosine kinases, cytokine receptors, and other adaptor proteins. **Pathways and Functions** SH2B3 is involved in a wide range of signaling pathways, including: 1. **Cytokine signaling**: SH2B3 regulates the activity of cytokine receptors, including those involved in the response to interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and stem cell factor (SCF). 2. **Chemokine signaling**: SH2B3 regulates the activity of chemokine receptors, including those involved in the response to chemokines such as CXCL12 and CCL2. 3. **Hematopoiesis**: SH2B3 is involved in the regulation of hematopoietic stem cell differentiation, proliferation, and survival. 4. **Immune cell development**: SH2B3 regulates the development and function of immune cells, including T cells, B cells, and myeloid cells. 5. **Platelet production**: SH2B3 is involved in the regulation of megakaryocyte development and platelet production. **Clinical Significance** Dysregulation of SH2B3 has been implicated in various diseases, including: 1. **Hematological disorders**: SH2B3 mutations have been associated with hematological disorders, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). 2. **Immune system disorders**: SH2B3 dysregulation has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: SH2B3 is overexpressed in various types of cancer, including breast cancer and lung cancer, and is associated with poor prognosis. 4. **Neurological disorders**: SH2B3 is involved in the regulation of neuronal development and function, and dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SH2B3 is a critical adaptor protein involved in various cellular processes, including immune system function, hematopoiesis, and cell signaling. Dysregulation of SH2B3 has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the role of SH2B3 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 4196209216

Symbol: SH2B3_HUMAN

Name: SH2B adapter protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10799879

Title: Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation.

PubMed ID: 10799879

DOI: 10.4049/jimmunol.164.10.5199

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17554260

Title: Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

PubMed ID: 17554260

DOI: 10.1038/ng2068

PubMed ID: 18311140

Title: Newly identified genetic risk variants for celiac disease related to the immune response.

PubMed ID: 18311140

DOI: 10.1038/ng.102

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 20843259

Title: LNK mutations in JAK2 mutation-negative erythrocytosis.

PubMed ID: 20843259

DOI: 10.1056/nejmc1006966

Sequence Information:

  • Length: 575
  • Mass: 63225
  • Checksum: EE30B9E21E0009E5
  • Sequence:
  • MNGPALQPSS PSSAPSASPA AAPRGWSEFC ELHAVAAARE LARQYWLFAR EHPQHAPLRA 
    ELVSLQFTDL FQRYFCREVR DGRAPGRDYR DTGRGPPAKA EASPEPGPGP AAPGLPKARS 
    SEELAPPRPP GPCSFQHFRR SLRHIFRRRS AGELPAAHTA AAPGTPGEAA ETPARPGLAK 
    KFLPWSLARE PPPEALKEAV LRYSLADEAS MDSGARWQRG RLALRRAPGP DGPDRVLELF 
    DPPKSSRPKL QAACSSIQEV RWCTRLEMPD NLYTFVLKVK DRTDIIFEVG DEQQLNSWMA 
    ELSECTGRGL ESTEAEMHIP SALEPSTSSS PRGSTDSLNQ GASPGGLLDP ACQKTDHFLS 
    CYPWFHGPIS RVKAAQLVQL QGPDAHGVFL VRQSETRRGE YVLTFNFQGI AKHLRLSLTE 
    RGQCRVQHLH FPSVVDMLHH FQRSPIPLEC GAACDVRLSS YVVVVSQPPG SCNTVLFPFS 
    LPHWDSESLP HWGSELGLPH LSSSGCPRGL SPEGLPGRSS PPEQIFHLVP SPEELANSLQ 
    HLEHEPVNRA RDSDYEMDSS SRSHLRAIDN QYTPL

Genular Protein ID: 238447371

Symbol: F5GYM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 373
  • Mass: 41449
  • Checksum: 5D8D8631D492A527
  • Sequence:
  • MGFPVLCRGW RRTWPGCASW LGAPPPQKPL LSPLLLNHRS SKSSRPKLQA ACSSIQEVRW 
    CTRLEMPDNL YTFVLKVKDR TDIIFEVGDE QQLNSWMAEL SECTGRGLES TEAEMHIPSA 
    LEPSTSSSPR GSTDSLNQGA SPGGLLDPAC QKTDHFLSCY PWFHGPISRV KAAQLVQLQG 
    PDAHGVFLVR QSETRRGEYV LTFNFQGIAK HLRLSLTERG QCRVQHLHFP SVVDMLHHFQ 
    RSPIPLECGA ACDVRLSSYV VVVSQPPGSC NTVLFPFSLP HWDSESLPHW GSELGLPHLS 
    SSGCPRGLSP EGLPGRSSPP EQIFHLVPSP EELANSLQHL EHEPVNRARD SDYEMDSSSR 
    SHLRAIDNQY TPL

Genular Protein ID: 3422645948

Symbol: B7Z7K6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 373
  • Mass: 41419
  • Checksum: 5EAEF760D5C08657
  • Sequence:
  • MGFPVLCRGW RRTWPGCASW LGAPPPQKPL LSPLLLNHRS SKSSRPKLQA ACSSIQEVRR 
    CTRLEMPDNL YTFVLKVKDR TDIIFEVGDE QQLNSWMAEL SECTGRGLES TEAEMHIPSA 
    LEPSTSSSPR GSTDSLNQGA SPGGLLDPAC QKTDHFLSCY PWFHGPISRV KAAQLVQLQG 
    PDAHGVFLVR QSETRRGEYV LTFNFQGIAK HLRLSLTERG QCRVQHLHFP SVVDMLHHFQ 
    RSPIPLECGA ACDVRLSSYV VVVSQPPGSC NTVLFPFSLP HWDSESLPHW GSELGLPHLS 
    SSGCPRGLSP EGLPGRSSPP EQIFHLVPSP EELANSLQHL EHEPVNRARD SDYEMDSSSR 
    SHLRAIDNQY TPL

Genular Protein ID: 1056086978

Symbol: Q96BA5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 51
  • Mass: 5376
  • Checksum: EA64553DA38B6F62
  • Sequence:
  • MEFLLSTGLE CSGAILAHCN LHLPGSSDSA STSQVAGITS TSHHAWLILY F

Genular Protein ID: 18656636

Symbol: Q59H48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 439
  • Mass: 48574
  • Checksum: 7663AF5531A10B84
  • Sequence:
  • HFRRSLRHIF RRRSAGELPA AHTAAAPGTP GEAAETPARP GLAKKFLPWS LAREPPPEAL 
    KEAVLRYSLA DEASMDSGAR WQRGRLALRR APGPDGPDRV LELFDPPKSS RPKLQAACSS 
    IQEVRRCTRL EMPDNLYTFV LKVKDRTDII FEVGDEQQLN SWMAELSECT GRGLESTEAE 
    MHIPSALEPS TSSSPRGSTD SLNQGASPGG LLDPACQKTD HFLSCYPWFH GPISRVKAAQ 
    LVQLQGPDAH GVFLVRQSET RRGEYVLTFN FQGIAKHLRL SLTERGQCRV QHLHFPSVVD 
    MLHHFQRSPI PLECGAACDV RLSSYVVVVS QPPGSCNTVL FPFSLPHWDS ESLPHWGSEL 
    GLPHLSSSGC PRGLSPEGLP GRSSPPEQIF HLVPSPEELA NSLQHLEHEP VNRARDSDYE 
    MDSSSRSHLR AIDNQYTPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.