Details for: CDH4

Gene ID: 1002

Symbol: CDH4

Ensembl ID: ENSG00000179242

Description: cadherin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 224.5006
    Cell Significance Index: -34.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.9586
    Cell Significance Index: -34.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8646
    Cell Significance Index: -34.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.7347
    Cell Significance Index: 1698.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5829
    Cell Significance Index: -10.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.7100
    Cell Significance Index: 119.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.6149
    Cell Significance Index: 99.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6276
    Cell Significance Index: 99.7900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.5951
    Cell Significance Index: 22.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3892
    Cell Significance Index: 77.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3251
    Cell Significance Index: 81.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2943
    Cell Significance Index: 31.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2405
    Cell Significance Index: 248.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1522
    Cell Significance Index: 796.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8902
    Cell Significance Index: 25.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7167
    Cell Significance Index: 48.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5425
    Cell Significance Index: 17.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3842
    Cell Significance Index: 55.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3659
    Cell Significance Index: 69.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2871
    Cell Significance Index: 259.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1913
    Cell Significance Index: 18.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0854
    Cell Significance Index: 8.7200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0497
    Cell Significance Index: 0.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0429
    Cell Significance Index: 6.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0111
    Cell Significance Index: -20.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0123
    Cell Significance Index: -18.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0187
    Cell Significance Index: -25.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0249
    Cell Significance Index: -4.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0436
    Cell Significance Index: -27.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0471
    Cell Significance Index: -34.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0524
    Cell Significance Index: -1.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0541
    Cell Significance Index: -40.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0609
    Cell Significance Index: -33.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0626
    Cell Significance Index: -1.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0661
    Cell Significance Index: -37.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0672
    Cell Significance Index: -30.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0700
    Cell Significance Index: -12.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0803
    Cell Significance Index: -1.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0985
    Cell Significance Index: -28.3400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1121
    Cell Significance Index: -1.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1131
    Cell Significance Index: -3.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1317
    Cell Significance Index: -14.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1508
    Cell Significance Index: -1.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1771
    Cell Significance Index: -22.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1826
    Cell Significance Index: -31.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1952
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1961
    Cell Significance Index: -41.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2029
    Cell Significance Index: -24.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2202
    Cell Significance Index: -25.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2342
    Cell Significance Index: -4.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2355
    Cell Significance Index: -32.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2366
    Cell Significance Index: -18.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2659
    Cell Significance Index: -7.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2787
    Cell Significance Index: -36.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3282
    Cell Significance Index: -8.2100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3287
    Cell Significance Index: -2.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3306
    Cell Significance Index: -38.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3309
    Cell Significance Index: -34.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3386
    Cell Significance Index: -39.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3565
    Cell Significance Index: -6.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3724
    Cell Significance Index: -25.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3790
    Cell Significance Index: -12.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4030
    Cell Significance Index: -8.0900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4603
    Cell Significance Index: -5.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4619
    Cell Significance Index: -9.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4652
    Cell Significance Index: -15.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4873
    Cell Significance Index: -36.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4886
    Cell Significance Index: -29.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5663
    Cell Significance Index: -6.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6024
    Cell Significance Index: -26.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6173
    Cell Significance Index: -32.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6231
    Cell Significance Index: -40.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6234
    Cell Significance Index: -13.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6260
    Cell Significance Index: -32.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6492
    Cell Significance Index: -40.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6572
    Cell Significance Index: -14.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6614
    Cell Significance Index: -23.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6768
    Cell Significance Index: -14.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6953
    Cell Significance Index: -32.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7020
    Cell Significance Index: -33.0000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7383
    Cell Significance Index: -9.5800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7507
    Cell Significance Index: -4.4600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7631
    Cell Significance Index: -15.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.7750
    Cell Significance Index: -8.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8011
    Cell Significance Index: -16.7200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8519
    Cell Significance Index: -8.0800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8926
    Cell Significance Index: -21.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9347
    Cell Significance Index: -20.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9581
    Cell Significance Index: -12.0900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9836
    Cell Significance Index: -19.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9910
    Cell Significance Index: -51.4800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.0042
    Cell Significance Index: -31.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0057
    Cell Significance Index: -36.9200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0066
    Cell Significance Index: -6.8200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.0132
    Cell Significance Index: -9.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0271
    Cell Significance Index: -35.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.0924
    Cell Significance Index: -12.4100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.1456
    Cell Significance Index: -13.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1689
    Cell Significance Index: -34.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Cadherin 4 is a type of calcium-dependent cell adhesion molecule (CADM) that mediates homophilic and heterophilic cell-cell adhesion. It is composed of four extracellular cadherin domains, which interact with other cadherin molecules to form a complex that facilitates cell-cell adhesion. Cadherin 4 is also involved in the organization of adherens junctions, which are essential for maintaining tissue structure and function. **Pathways and Functions:** Cadherin 4 is involved in various signaling pathways that regulate cell behavior, including: 1. **Adherens junction organization**: Cadherin 4 plays a crucial role in the formation and maintenance of adherens junctions, which are essential for maintaining tissue structure and function. 2. **Axon extension and guidance**: Cadherin 4 is involved in the regulation of axon extension and guidance, which are critical processes in neural development and function. 3. **Cell-cell communication**: Cadherin 4 facilitates cell-cell communication by mediating the exchange of signaling molecules between adjacent cells. 4. **Cell morphogenesis**: Cadherin 4 is involved in regulating cell shape and morphology, which is essential for tissue development and function. **Clinical Significance:** Cadherin 4 has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: Cadherin 4 has been linked to neurological disorders such as autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Cancer**: Cadherin 4 has been found to be overexpressed in certain types of cancer, including breast cancer and colon cancer. 3. **Gastrointestinal disorders**: Cadherin 4 has been implicated in gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome. In conclusion, cadherin 4 is a complex adhesion molecule that plays a critical role in maintaining tissue structure and function. Its involvement in various signaling pathways and diseases highlights its importance in understanding the molecular mechanisms underlying human disease. Further research is needed to fully elucidate the functions and clinical significance of cadherin 4. **Proteins:** The human CADH4 gene encodes a single protein, Cadherin-4, which consists of four extracellular cadherin domains. The protein is highly conserved across species, with high sequence identity between human and mouse. The protein is also highly expressed in various tissues, including neural and non-neural tissues. **Significantly Expressed Cells:** Cadherin 4 is significantly expressed in various cell types, including: 1. **Inhibitory interneurons**: Cadherin 4 is expressed in inhibitory interneurons, which are critical for regulating neural circuit function. 2. **Astrocytes**: Cadherin 4 is expressed in astrocytes, which are involved in maintaining neural tissue structure and function. 3. **Retinal cone cells**: Cadherin 4 is expressed in retinal cone cells, which are critical for visual function. 4. **Enterocytes**: Cadherin 4 is expressed in enterocytes, which are involved in maintaining gastrointestinal tissue structure and function. In summary, cadherin 4 is a complex adhesion molecule that plays a critical role in maintaining tissue structure and function. Its involvement in various signaling pathways and diseases highlights its importance in understanding the molecular mechanisms underlying human disease. Further research is needed to fully elucidate the functions and clinical significance of cadherin 4.

Genular Protein ID: 2590644067

Symbol: CADH4_HUMAN

Name: Cadherin-4

UniProtKB Accession Codes:

P55283 B3KWB8 G3V1P8 Q2M208 Q5VZ44 Q9BZ05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

Sequence Information:

  • Length: 916
  • Mass: 100281
  • Checksum: E4512F94E58046D7
  • Sequence:
    • MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE GEKLLQVKFS 
SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF TVTAWDSQTA EKWDAVVRLL 
VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD TLLPWPQHQN ANGLRRRKRD WVIPPINVPE 
NSRGPFPQQL VRIRSDKDND IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH 
ASYHLRAHAV DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT 
ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE KVQQYTVIVQ 
ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE VPENRVETVV ANLTVMDRDQ 
PHSPNWNAVY RIISGDPSGH FSVRTDPVTN EGMVTVVKAV DYELNRAFML TVMVSNQAPL 
ASGIQMSFQS TAGVTISIMD INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ 
AVRYSKLSDP ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT 
LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE LPFVPAAVRK 
NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL SNTSIIKVKV CPCDDNGDCT 
TIGAVAAAGL GTGAIVAILI CILILLTMVL LFVMWMKRRE KERHTKQLLI DPEDDVRDNI 
LKYDEEGGGE EDQDYDLSQL QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG 
DIGDFINEGL RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG 
PRFKKLADMY GGGEED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.