Details for: HCN4
Associated with
Other Information
Genular Protein ID: 2215846694
Symbol: HCN4_HUMAN
Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10228147
Title: Two pacemaker channels from human heart with profoundly different activation kinetics.
PubMed ID: 10228147
PubMed ID: 10430953
Title: Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.
PubMed ID: 10430953
PubMed ID: 19165230
Title: Role of HCN4 channel in preventing ventricular arrhythmia.
PubMed ID: 19165230
DOI: 10.1038/jhg.2008.16
PubMed ID: 20829353
Title: Structural basis for the cAMP-dependent gating in the human HCN4 channel.
PubMed ID: 20829353
PubMed ID: 22006928
Title: Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
PubMed ID: 22006928
PubMed ID: 23103389
Title: Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel.
PubMed ID: 23103389
PubMed ID: 15123648
Title: Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.
PubMed ID: 15123648
PubMed ID: 16407510
Title: Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.
PubMed ID: 16407510
DOI: 10.1056/nejmoa052475
PubMed ID: 20662977
Title: A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.
PubMed ID: 20662977
PubMed ID: 30127718
Title: A loss-of-function HCN4 mutation associated with familial benign myoclonic epilepsy in infancy causes increased neuronal excitability.
PubMed ID: 30127718
Sequence Information:
- Length: 1203
- Mass: 129042
- Checksum: 7EFDD2D69CF1F9D9
- Sequence:
MDKLPPSMRK RLYSLPQQVG AKAWIMDEEE DAEEEGAGGR QDPSRRSIRL RPLPSPSPSA AAGGTESRSS ALGAADSEGP ARGAGKSSTN GDCRRFRGSL ASLGSRGGGS GGTGSGSSHG HLHDSAEERR LIAEGDASPG EDRTPPGLAA EPERPGASAQ PAASPPPPQQ PPQPASASCE QPSVDTAIKV EGGAAAGDQI LPEAEVRLGQ AGFMQRQFGA MLQPGVNKFS LRMFGSQKAV EREQERVKSA GFWIIHPYSD FRFYWDLTML LLMVGNLIII PVGITFFKDE NTTPWIVFNV VSDTFFLIDL VLNFRTGIVV EDNTEIILDP QRIKMKYLKS WFMVDFISSI PVDYIFLIVE TRIDSEVYKT ARALRIVRFT KILSLLRLLR LSRLIRYIHQ WEEIFHMTYD LASAVVRIVN LIGMMLLLCH WDGCLQFLVP MLQDFPDDCW VSINNMVNNS WGKQYSYALF KAMSHMLCIG YGRQAPVGMS DVWLTMLSMI VGATCYAMFI GHATALIQSL DSSRRQYQEK YKQVEQYMSF HKLPPDTRQR IHDYYEHRYQ GKMFDEESIL GELSEPLREE IINFNCRKLV ASMPLFANAD PNFVTSMLTK LRFEVFQPGD YIIREGTIGK KMYFIQHGVV SVLTKGNKET KLADGSYFGE ICLLTRGRRT ASVRADTYCR LYSLSVDNFN EVLEEYPMMR RAFETVALDR LDRIGKKNSI LLHKVQHDLN SGVFNYQENE IIQQIVQHDR EMAHCAHRVQ AAASATPTPT PVIWTPLIQA PLQAAAATTS VAIALTHHPR LPAAIFRPPP GSGLGNLGAG QTPRHLKRLQ SLIPSALGSA SPASSPSQVD TPSSSSFHIQ QLAGFSAPAG LSPLLPSSSS SPPPGACGSP SAPTPSAGVA ATTIAGFGHF HKALGGSLSS SDSPLLTPLQ PGARSPQAAQ PSPAPPGARG GLGLPEHFLP PPPSSRSPSS SPGQLGQPPG ELSLGLATGP LSTPETPPRQ PEPPSLVAGA SGGASPVGFT PRGGLSPPGH SPGPPRTFPS APPRASGSHG SLLLPPASSP PPPQVPQRRG TPPLTPGRLT QDLKLISASQ PALPQDGAQT LRRASPHSSG ESMAAFPLFP RAGGGSGGSG SSGGLGPPGR PYGAIPGQHV TLPRKTSSGS LPPPLSLFGA RATSSGGPPL TAGPQREPGA RPEPVRSKLP SNL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.