FRAT1 | ENSG00000165879 | NCBI 10023

Details for: FRAT1

Gene ID: 10023

Symbol: FRAT1

Ensembl ID: ENSG00000165879

Description: FRAT regulator of WNT signaling pathway 1

Associated with

Beta-catenin phosphorylation cascade
(R-HSA-196299)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Beta-catenin destruction complex disassembly
(GO:1904886)
Canonical wnt signaling pathway
(GO:0060070)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Intracellular membrane-bounded organelle
(GO:0043231)
Molecular function inhibitor activity
(GO:0140678)
Nucleus
(GO:0005634)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Protein binding
(GO:0005515)
Regulation of protein export from nucleus
(GO:0046825)

Other Information

Proteins

Proto-oncogene FRAT1

Genular Protein ID: 1007816618

Symbol: FRAT1_HUMAN

Name: Proto-oncogene FRAT1

UniProtKB Accession Codes:

Q92837 Q5JTI1 Q8NE74 Q8TDW9

Database IDs:

Citations:

PubMed ID: 9034327

Title: Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.

PubMed ID: 9034327

DOI: 10.1093/emboj/16.3.441

PubMed ID: 11894125

Title: Molecular cloning and expression of proto-oncogene FRAT1 in human cancer.

PubMed ID: 11894125

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12556519

Title: Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.

PubMed ID: 12556519

DOI: 10.1074/jbc.m213265200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 11738041

Title: The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

PubMed ID: 11738041

DOI: 10.1016/s0969-2126(01)00679-7

Sequence Information:

Length: 279
Mass: 29093
Checksum: 629AFD6CEA1DC0BD
Sequence:

MPCRREEEEE AGEEAEGEEE EEDSFLLLQQ SVALGSSGEV DRLVAQIGET LQLDAAQHSP 
ASPCGPPGAP LRAPGPLAAA VPADKARSPA VPLLLPPALA ETVGPAPPGV LRCALGDRGR 
VRGRAAPYCV AELATGPSAL SPLPPQADLD GPPGAGKQGI PQPLSGPCRR GWLRGAAASR 
RLQQRRGSQP ETRTGDDDPH RLLQQLVLSG NLIKEAVRRL HSRRLQLRAK LPQRPLLGPL 
SAPVHEPPSP RSPRAACSDP GASGRAQLRT GDGVLVPGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FRAT1

Associated with

Other Information

Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. PubMed ID: 9034327

Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. PubMed ID: 11894125

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. PubMed ID: 12556519

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. PubMed ID: 11738041