CDH5 | ENSG00000179776 | NCBI 1003

Details for: CDH5

Gene ID: 1003

Symbol: CDH5

Ensembl ID: ENSG00000179776

Description: cadherin 5

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Adherens junction
(GO:0005912)
Adherens junction organization
(GO:0034332)
Beta-catenin binding
(GO:0008013)
Bicellular tight junction
(GO:0005923)
Bicellular tight junction assembly
(GO:0070830)
Blood vessel endothelial cell migration
(GO:0043534)
Blood vessel maturation
(GO:0001955)
Bmp receptor binding
(GO:0070700)
Cadherin binding
(GO:0045296)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium ion binding
(GO:0005509)
Catenin complex
(GO:0016342)
Cell-cell adhesion
(GO:0098609)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell junction
(GO:0005911)
Cell-cell junction assembly
(GO:0007043)
Cell junction
(GO:0030054)
Cell morphogenesis
(GO:0000902)
Cell surface
(GO:0009986)
External side of plasma membrane
(GO:0009897)
Fibrinogen binding
(GO:0070051)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Intracellular calcium ion homeostasis
(GO:0006874)
Maintenance of blood-brain barrier
(GO:0035633)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of microtubule polymerization
(GO:0031115)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of establishment of endothelial barrier
(GO:1903142)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein dephosphorylation
(GO:0035307)
Protein binding
(GO:0005515)
Protein localization to bicellular tight junction
(GO:1902396)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of establishment of cell polarity
(GO:2000114)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of vascular permeability
(GO:0043114)
Signaling receptor binding
(GO:0005102)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Transmembrane transporter binding
(GO:0044325)
Vascular endothelial growth factor receptor 2 binding
(GO:0043184)
Vasculature development
(GO:0001944)

Other Information

Proteins

Cadherin-5
Q59EA3_HUMAN

Genular Protein ID: 1027313521

Symbol: CADH5_HUMAN

Name: Cadherin-5

UniProtKB Accession Codes:

P33151 Q4VAI5 Q4VAI6

Database IDs:

Citations:

PubMed ID: 7627717

Title: Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin.

PubMed ID: 7627717

DOI: 10.1161/01.atv.15.8.1229

PubMed ID: 9219219

Title: Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.

PubMed ID: 9219219

DOI: 10.3109/10739689709146790

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

PubMed ID: 1522121

Title: A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

PubMed ID: 1522121

DOI: 10.1083/jcb.118.6.1511

PubMed ID: 15980433

Title: G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function.

PubMed ID: 15980433

DOI: 10.1074/jbc.m502844200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19996314

Title: Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.

PubMed ID: 19996314

DOI: 10.1074/jbc.m109.060301

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 21183689

Title: Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation.

PubMed ID: 21183689

DOI: 10.1182/blood-2010-04-281956

PubMed ID: 21269602

Title: Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin.

PubMed ID: 21269602

DOI: 10.1016/j.jmb.2011.01.031

PubMed ID: 27466317

Title: VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.

PubMed ID: 27466317

DOI: 10.1091/mbc.e16-02-0127

Sequence Information:

Length: 784
Mass: 87528
Checksum: 6DBEBFC4DA6899D1
Sequence:

MQRLMMLLAT SGACLGLLAV AAVAAAGANP AQRDTHSLLP THRRQKRDWI WNQMHIDEEK 
NTSLPHHVGK IKSSVSRKNA KYLLKGEYVG KVFRVDAETG DVFAIERLDR ENISEYHLTA 
VIVDKDTGEN LETPSSFTIK VHDVNDNWPV FTHRLFNASV PESSAVGTSV ISVTAVDADD 
PTVGDHASVM YQILKGKEYF AIDNSGRIIT ITKSLDREKQ ARYEIVVEAR DAQGLRGDSG 
TATVLVTLQD INDNFPFFTQ TKYTFVVPED TRVGTSVGSL FVEDPDEPQN RMTKYSILRG 
DYQDAFTIET NPAHNEGIIK PMKPLDYEYI QQYSFIVEAT DPTIDLRYMS PPAGNRAQVI 
INITDVDEPP IFQQPFYHFQ LKENQKKPLI GTVLAMDPDA ARHSIGYSIR RTSDKGQFFR 
VTKKGDIYNE KELDREVYPW YNLTVEAKEL DSTGTPTGKE SIVQVHIEVL DENDNAPEFA 
KPYQPKVCEN AVHGQLVLQI SAIDKDITPR NVKFKFILNT ENNFTLTDNH DNTANITVKY 
GQFDREHTKV HFLPVVISDN GMPSRTGTST LTVAVCKCNE QGEFTFCEDM AAQVGVSIQA 
VVAILLCILT ITVITLLIFL RRRLRKQARA HGKSVPEIHE QLVTYDEEGG GEMDTTSYDV 
SVLNSVRRGG AKPPRPALDA RPSLYAQVQK PPRHAPGAHG GPGEMAAMIE VKKDEADHDG 
DGPPYDTLHI YGYEGSESIA ESLSSLGTDS SDSDVDYDFL NDWGPRFKML AELYGSDPRE 
ELLY

Genular Protein ID: 1213500267

Symbol: Q59EA3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EA3

Database IDs:

Sequence Information:

Length: 807
Mass: 89924
Checksum: 3A1A28EAE185E0F6
Sequence:

TDRQSNGTET SLSPQARSVP PGKMQRLMML LATSGACLGL LAVAAVAAAG ANPAQRDTHS 
LLPTHRRQKR DWIWNQMHID EEKNTSLPHH VGKIKSSVSR KNAKYLLKGE YVGKVFRVDA 
ETGDVFAIER LDRENISEYH LTAVIVDKDT GENLETPSSF TIKVHDVNDN WPVFTHRLFN 
ASVPESSAVG TSVISVTAVD ADDPTVGDHA SVMYQILKGK EYFAIDNSGR IITITKSLDR 
EKQARYEIVV EARDAQGLRG DSGTATVLVT LQDINDNFPF FTQTKYTFVV PEDTRVGTSV 
GSLFVEDPDE PQNRMTKYSI LRGDYQDAFT IETNPAHNEG IIKPMKPLDY EYIQQYSFIV 
EATDPTIDLR YMSPPAGNRA QVIINITDVD EPPIFQQPFY HFQLKENQKK PLIGTVLAMD 
PDAARHSIGY SIRRTSDKGQ FFRVTKKGDI YNEKELDREV YPWYNLTVEA KELDSTGTPT 
GKESIVQVHI EVLDENDNAP EFAKPYQPKV CENAVHGQLV LQISAIDKDI TPRNVKFKFI 
LNTENNFTLT DNHDNTANIT VKYGQFDREH TKVHFLPVVI SDNGMPSRTG TSTLTVAVCK 
CNEQGEFTFC EDMAAQVGVS IQAVVAILLC ILTITVITLL IFLRRRLRKQ ARAHGKSVPE 
IHEQLVTYDE EGGGEMDTTS YDVSVLNSVR RGGAKPPRPA LDARPSLYAQ VQKPPRHAPG 
AHGGPGEMAA MIEVKKDEAD HDGDGPPYDT LHIYGYEGSE SIAESLSSLG TDSSDSDVDY 
DFLNDWGPRF KMLAELYGSD PREELLY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDH5

Associated with

Other Information

Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. PubMed ID: 7627717

Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. PubMed ID: 9219219

Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. PubMed ID: 10861224

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. PubMed ID: 2059658

A novel endothelial-specific membrane protein is a marker of cell-cell contacts. PubMed ID: 1522121

G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. PubMed ID: 15980433

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

A strategy for precise and large scale identification of core fucosylated glycoproteins. PubMed ID: 19139490

Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. PubMed ID: 19996314

CCM1 regulates vascular-lumen organization by inducing endothelial polarity. PubMed ID: 20332120

Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. PubMed ID: 21183689

Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin. PubMed ID: 21269602

VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. PubMed ID: 27466317