Details for: CDH5

Gene ID: 1003

Symbol: CDH5

Ensembl ID: ENSG00000179776

Description: cadherin 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.84
    Marker Score: 33713
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.59
    Marker Score: 9121
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.52
    Marker Score: 5099
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.74
    Marker Score: 1549
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.7
    Marker Score: 2544
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.53
    Marker Score: 2178
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.32
    Marker Score: 3364
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.17
    Marker Score: 526
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.93
    Marker Score: 1154
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.66
    Marker Score: 3320
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.61
    Marker Score: 375
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.57
    Marker Score: 1415
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1509
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169068
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.46
    Marker Score: 341
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.45
    Marker Score: 1558
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.36
    Marker Score: 1366
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.31
    Marker Score: 315
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.31
    Marker Score: 409
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.28
    Marker Score: 1146
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.23
    Marker Score: 261
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.17
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2162
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2130
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251805
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1
    Marker Score: 220
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 398
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.96
    Marker Score: 243
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.95
    Marker Score: 1609
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.95
    Marker Score: 467
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5334
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9
    Marker Score: 413
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13808
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.86
    Marker Score: 865
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.86
    Marker Score: 535
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.84
    Marker Score: 896.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 632
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.74
    Marker Score: 204
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.65
    Marker Score: 1132
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.63
    Marker Score: 314
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.61
    Marker Score: 162.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 278
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 346
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 458
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.53
    Marker Score: 207
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.44
    Marker Score: 122
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.42
    Marker Score: 524.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 179
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.41
    Marker Score: 114
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 154.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.35
    Marker Score: 401
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.34
    Marker Score: 229
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 96.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 185
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.26
    Marker Score: 176
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.26
    Marker Score: 4140
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.24
    Marker Score: 60
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.22
    Marker Score: 50
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.22
    Marker Score: 177
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.21
    Marker Score: 1422
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.21
    Marker Score: 183
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2
    Marker Score: 78.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.19
    Marker Score: 230
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.18
    Marker Score: 110
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.15
    Marker Score: 145.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.15
    Marker Score: 167
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.15
    Marker Score: 144
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.14
    Marker Score: 54
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.14
    Marker Score: 72

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Other Information

**Key characteristics:** - CDH5 is a type of cadherin, a family of cell adhesion molecules that are crucial for the formation and maintenance of tissue architecture. - It is expressed in a variety of cell types, including endothelial cells, epithelial cells, and immune cells. - It is a transmembrane protein with a extracellular domain and a cytoplasmic domain. - The extracellular domain is responsible for binding to other cadherins and other cell adhesion molecules, while the cytoplasmic domain is involved in signal transduction. **Pathways and functions:** - CDH5 plays a critical role in cell-cell adhesion by interacting with other cadherins and cell adhesion molecules. - It is involved in the organization of cell-cell junctions, which are essential for tissue integrity and signaling. - It is also involved in regulating vascular permeability, as it can open or close blood vessels depending on the local signaling environment. - CDH5 is involved in various signaling pathways, including the adherens junction pathway, the beta-catenin binding pathway, the Bmp receptor binding pathway, and the cadherin binding pathway. - It is a key regulator of vascular endothelial growth factor (VEGF) signaling, as it is a key factor that is required for the migration and survival of endothelial cells. **Clinical significance:** - Mutations in CDH5 have been linked to various human diseases, including cardiovascular disease, stroke, and cancer. - In cardiovascular disease, mutations in CDH5 have been linked to the development of atherosclerosis and heart failure. - In stroke, mutations in CDH5 have been linked to the formation of blood clots and the development of ischemic stroke. - In cancer, mutations in CDH5 have been linked to the progression of tumors and the development of metastasis.

Genular Protein ID: 1027313521

Symbol: CADH5_HUMAN

Name: Cadherin-5

UniProtKB Accession Codes:

P33151 Q4VAI5 Q4VAI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 17 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 50 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7627717

Title: Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin.

PubMed ID: 7627717

DOI: 10.1161/01.atv.15.8.1229

PubMed ID: 9219219

Title: Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.

PubMed ID: 9219219

DOI: 10.3109/10739689709146790

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

PubMed ID: 1522121

Title: A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

PubMed ID: 1522121

DOI: 10.1083/jcb.118.6.1511

PubMed ID: 15980433

Title: G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function.

PubMed ID: 15980433

DOI: 10.1074/jbc.m502844200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19996314

Title: Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.

PubMed ID: 19996314

DOI: 10.1074/jbc.m109.060301

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 21183689

Title: Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation.

PubMed ID: 21183689

DOI: 10.1182/blood-2010-04-281956

PubMed ID: 21269602

Title: Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin.

PubMed ID: 21269602

DOI: 10.1016/j.jmb.2011.01.031

PubMed ID: 27466317

Title: VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.

PubMed ID: 27466317

DOI: 10.1091/mbc.e16-02-0127

Sequence Information:

  • Length: 784
  • Mass: 87528
  • Checksum: 6DBEBFC4DA6899D1
  • Sequence:
    • MQRLMMLLAT SGACLGLLAV AAVAAAGANP AQRDTHSLLP THRRQKRDWI WNQMHIDEEK 
NTSLPHHVGK IKSSVSRKNA KYLLKGEYVG KVFRVDAETG DVFAIERLDR ENISEYHLTA 
VIVDKDTGEN LETPSSFTIK VHDVNDNWPV FTHRLFNASV PESSAVGTSV ISVTAVDADD 
PTVGDHASVM YQILKGKEYF AIDNSGRIIT ITKSLDREKQ ARYEIVVEAR DAQGLRGDSG 
TATVLVTLQD INDNFPFFTQ TKYTFVVPED TRVGTSVGSL FVEDPDEPQN RMTKYSILRG 
DYQDAFTIET NPAHNEGIIK PMKPLDYEYI QQYSFIVEAT DPTIDLRYMS PPAGNRAQVI 
INITDVDEPP IFQQPFYHFQ LKENQKKPLI GTVLAMDPDA ARHSIGYSIR RTSDKGQFFR 
VTKKGDIYNE KELDREVYPW YNLTVEAKEL DSTGTPTGKE SIVQVHIEVL DENDNAPEFA 
KPYQPKVCEN AVHGQLVLQI SAIDKDITPR NVKFKFILNT ENNFTLTDNH DNTANITVKY 
GQFDREHTKV HFLPVVISDN GMPSRTGTST LTVAVCKCNE QGEFTFCEDM AAQVGVSIQA 
VVAILLCILT ITVITLLIFL RRRLRKQARA HGKSVPEIHE QLVTYDEEGG GEMDTTSYDV 
SVLNSVRRGG AKPPRPALDA RPSLYAQVQK PPRHAPGAHG GPGEMAAMIE VKKDEADHDG 
DGPPYDTLHI YGYEGSESIA ESLSSLGTDS SDSDVDYDFL NDWGPRFKML AELYGSDPRE 
ELLY

Genular Protein ID: 1213500267

Symbol: Q59EA3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EA3

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 2 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 807
  • Mass: 89924
  • Checksum: 3A1A28EAE185E0F6
  • Sequence:
    • TDRQSNGTET SLSPQARSVP PGKMQRLMML LATSGACLGL LAVAAVAAAG ANPAQRDTHS 
LLPTHRRQKR DWIWNQMHID EEKNTSLPHH VGKIKSSVSR KNAKYLLKGE YVGKVFRVDA 
ETGDVFAIER LDRENISEYH LTAVIVDKDT GENLETPSSF TIKVHDVNDN WPVFTHRLFN 
ASVPESSAVG TSVISVTAVD ADDPTVGDHA SVMYQILKGK EYFAIDNSGR IITITKSLDR 
EKQARYEIVV EARDAQGLRG DSGTATVLVT LQDINDNFPF FTQTKYTFVV PEDTRVGTSV 
GSLFVEDPDE PQNRMTKYSI LRGDYQDAFT IETNPAHNEG IIKPMKPLDY EYIQQYSFIV 
EATDPTIDLR YMSPPAGNRA QVIINITDVD EPPIFQQPFY HFQLKENQKK PLIGTVLAMD 
PDAARHSIGY SIRRTSDKGQ FFRVTKKGDI YNEKELDREV YPWYNLTVEA KELDSTGTPT 
GKESIVQVHI EVLDENDNAP EFAKPYQPKV CENAVHGQLV LQISAIDKDI TPRNVKFKFI 
LNTENNFTLT DNHDNTANIT VKYGQFDREH TKVHFLPVVI SDNGMPSRTG TSTLTVAVCK 
CNEQGEFTFC EDMAAQVGVS IQAVVAILLC ILTITVITLL IFLRRRLRKQ ARAHGKSVPE 
IHEQLVTYDE EGGGEMDTTS YDVSVLNSVR RGGAKPPRPA LDARPSLYAQ VQKPPRHAPG 
AHGGPGEMAA MIEVKKDEAD HDGDGPPYDT LHIYGYEGSE SIAESLSSLG TDSSDSDVDY 
DFLNDWGPRF KMLAELYGSD PREELLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.