Details for: PARP2
Associated with
Other Information
Genular Protein ID: 3941221550
Symbol: PARP2_HUMAN
Name: NAD(+) ADP-ribosyltransferase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10364231
Title: PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.
PubMed ID: 10364231
PubMed ID: 10329013
Title: A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues.
PubMed ID: 10329013
PubMed ID: 10338144
Title: pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans.
PubMed ID: 10338144
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11948190
Title: Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.
PubMed ID: 11948190
PubMed ID: 20106667
Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.
PubMed ID: 20106667
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 27067600
Title: HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity.
PubMed ID: 27067600
PubMed ID: 28190768
Title: Serine ADP-ribosylation depends on HPF1.
PubMed ID: 28190768
PubMed ID: 25043379
Title: Family-wide analysis of poly(ADP-ribose) polymerase activity.
PubMed ID: 25043379
DOI: 10.1038/ncomms5426
PubMed ID: 27471034
Title: Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.
PubMed ID: 27471034
DOI: 10.1093/nar/gkw675
PubMed ID: 30104678
Title: PARP2 mediates branched poly ADP-ribosylation in response to DNA damage.
PubMed ID: 30104678
PubMed ID: 29361132
Title: Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation.
PubMed ID: 29361132
DOI: 10.1093/nar/gkx1318
PubMed ID: 33275888
Title: The oncogenic helicase ALC1 regulates PARP inhibitor potency by trapping PARP2 at DNA breaks.
PubMed ID: 33275888
PubMed ID: 34732825
Title: Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
PubMed ID: 34732825
PubMed ID: 34486521
Title: Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
PubMed ID: 34486521
DOI: 10.7554/elife.71420
PubMed ID: 34874266
Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
PubMed ID: 34874266
DOI: 10.7554/elife.71502
PubMed ID: 34795260
Title: HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.
PubMed ID: 34795260
PubMed ID: 35349716
Title: PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.
PubMed ID: 35349716
DOI: 10.1093/nar/gkac188
PubMed ID: 20092359
Title: Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
PubMed ID: 20092359
DOI: 10.1021/bi902079y
PubMed ID: 26626480
Title: PARP-1 activation requires local unfolding of an autoinhibitory domain.
PubMed ID: 26626480
PubMed ID: 26704974
Title: PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.
PubMed ID: 26704974
DOI: 10.1093/nar/gkv1376
PubMed ID: 30321391
Title: Structural basis for DNA break recognition by ARTD2/PARP2.
PubMed ID: 30321391
DOI: 10.1093/nar/gky927
PubMed ID: 32028527
Title: HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
PubMed ID: 32028527
PubMed ID: 32939087
Title: Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.
PubMed ID: 32939087
PubMed ID: 33141820
Title: Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
PubMed ID: 33141820
PubMed ID: 34108479
Title: Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition.
PubMed ID: 34108479
Sequence Information:
- Length: 583
- Mass: 66206
- Checksum: 5B7AE8AE531836AF
- Sequence:
MAARRRRSTG GGRARALNES KRVNNGNTAP EDSSPAKKTR RCQRQESKKM PVAGGKANKD RTEDKQDGMP GRSWASKRVS ESVKALLLKG KAPVDPECTA KVGKAHVYCE GNDVYDVMLN QTNLQFNNNK YYLIQLLEDD AQRNFSVWMR WGRVGKMGQH SLVACSGNLN KAKEIFQKKF LDKTKNNWED REKFEKVPGK YDMLQMDYAT NTQDEEETKK EESLKSPLKP ESQLDLRVQE LIKLICNVQA MEEMMMEMKY NTKKAPLGKL TVAQIKAGYQ SLKKIEDCIR AGQHGRALME ACNEFYTRIP HDFGLRTPPL IRTQKELSEK IQLLEALGDI EIAIKLVKTE LQSPEHPLDQ HYRNLHCALR PLDHESYEFK VISQYLQSTH APTHSDYTMT LLDLFEVEKD GEKEAFREDL HNRMLLWHGS RMSNWVGILS HGLRIAPPEA PITGYMFGKG IYFADMSSKS ANYCFASRLK NTGLLLLSEV ALGQCNELLE ANPKAEGLLQ GKHSTKGLGK MAPSSAHFVT LNGSTVPLGP ASDTGILNPD GYTLNYNEYI VYNPNQVRMR YLLKVQFNFL QLW
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.