Gene CDH6 - ENSG00000113361 | NCBI Gene ID: 1004

Details for: CDH6

Gene ID: 1004

Symbol: CDH6

Ensembl ID: ENSG00000113361

Description: cadherin 6

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Adherens junction
(GO:0005912)
Adherens junction organization
(GO:0034332)
Cadherin binding
(GO:0045296)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium ion binding
(GO:0005509)
Catenin complex
(GO:0016342)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell junction assembly
(GO:0007043)
Cell adhesion
(GO:0007155)
Cell junction
(GO:0030054)
Cell morphogenesis
(GO:0000902)
Glutamatergic synapse
(GO:0098978)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Multicellular organism development
(GO:0007275)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Synaptic membrane adhesion
(GO:0099560)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.51
Marker Score: 7712
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.24
Marker Score: 7950
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.09
Marker Score: 19670
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.07
Marker Score: 2217
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.03
Marker Score: 1931
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.96
Marker Score: 2250
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.9
Marker Score: 7882
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.84
Marker Score: 1735
Cell Name: contractile cell (CL0000183)
Fold Change: 1.82
Marker Score: 986
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.73
Marker Score: 16425
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1157
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.56
Marker Score: 13360
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168555
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 861
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.35
Marker Score: 5658
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.31
Marker Score: 3079
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.22
Marker Score: 768
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.19
Marker Score: 1439
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.16
Marker Score: 1795
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4791
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.13
Marker Score: 409
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.1
Marker Score: 2083.5
Cell Name: kidney cell (CL1000497)
Fold Change: 1.08
Marker Score: 720
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.05
Marker Score: 749
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.05
Marker Score: 2137
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.04
Marker Score: 64158
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.03
Marker Score: 1591
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1
Marker Score: 1127
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71791
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48016
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.98
Marker Score: 2050
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: supporting cell (CL0000630)
Fold Change: 0.96
Marker Score: 1807
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.95
Marker Score: 14920
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.95
Marker Score: 392
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5342
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.89
Marker Score: 282
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.89
Marker Score: 408
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5281
Cell Name: pericyte (CL0000669)
Fold Change: 0.86
Marker Score: 501
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.83
Marker Score: 637
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.83
Marker Score: 394
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.82
Marker Score: 495
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.82
Marker Score: 868
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.81
Marker Score: 792
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.8
Marker Score: 8299
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.8
Marker Score: 278
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.73
Marker Score: 785
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.7
Marker Score: 1349
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.69
Marker Score: 202
Cell Name: neuron (CL0000540)
Fold Change: 0.68
Marker Score: 2781
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.67
Marker Score: 824
Cell Name: muscle cell (CL0000187)
Fold Change: 0.66
Marker Score: 188
Cell Name: podocyte (CL0000653)
Fold Change: 0.65
Marker Score: 241.5
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.63
Marker Score: 157
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.62
Marker Score: 163
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.6
Marker Score: 349
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.59
Marker Score: 378
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.58
Marker Score: 341
Cell Name: neural cell (CL0002319)
Fold Change: 0.57
Marker Score: 277
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.57
Marker Score: 162
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.55
Marker Score: 20235
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.53
Marker Score: 252.5
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.53
Marker Score: 235
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.53
Marker Score: 154
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.53
Marker Score: 657
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.52
Marker Score: 152
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.51
Marker Score: 174
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.5
Marker Score: 130
Cell Name: glial cell (CL0000125)
Fold Change: 0.5
Marker Score: 550
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.5
Marker Score: 328
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.49
Marker Score: 662
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.49
Marker Score: 16964
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.48
Marker Score: 328
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.48
Marker Score: 218
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.47
Marker Score: 120
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.47
Marker Score: 664
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.45
Marker Score: 151
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.45
Marker Score: 443
Cell Name: motor neuron (CL0000100)
Fold Change: 0.44
Marker Score: 260
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.43
Marker Score: 181
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.43
Marker Score: 229
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.43
Marker Score: 113
Cell Name: melanocyte (CL0000148)
Fold Change: 0.42
Marker Score: 170
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.42
Marker Score: 8341
Cell Name: astrocyte (CL0000127)
Fold Change: 0.42
Marker Score: 361
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.42
Marker Score: 130
Cell Name: Unknown (CL0000003)
Fold Change: 0.41
Marker Score: 1263

Hover over a box to see details here...

**Key characteristics** * CDH6 is a cell adhesion molecule that is expressed in high levels in epithelial cells. * It is a transmembrane protein that is composed of a extracellular domain and a cytoplasmic domain. * The extracellular domain is responsible for binding to other cadherins, while the cytoplasmic domain is responsible for interacting with other cell adhesion molecules and signaling pathways. * CDH6 is a key protein in cell-cell adhesion and is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. **Pathways and functions** * CDH6 is involved in cell-cell adhesion, which is essential for the formation and maintenance of tissues and organs. * It is involved in the organization of adherens junctions, which are cell-cell contacts that hold tissues and organs together. * CDH6 is also involved in the regulation of Notch signaling, a key signaling pathway in the development of the nervous system. * The expression of CDH6 is upregulated in a variety of human cancers, suggesting that it may play a role in tumor growth and metastasis. **Clinical significance** CDH6 is a promising target for cancer immunotherapy. Inhibition of CDH6 has been shown to inhibit tumor growth in animal models, suggesting that it may be a useful therapeutic agent for cancer patients.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cadherin-6

Genular Protein ID: 62915032

Symbol: CADH6_HUMAN

Name: Cadherin-6

UniProtKB Accession Codes:

P55285 A8K5H5 Q9BWS0

Database IDs:

Citations:

PubMed ID: 7743525

Title: Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells.

PubMed ID: 7743525

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 790
Mass: 88309
Checksum: C175004FC8A61100
Sequence:

MRTYRYFLLL FWVGQPYPTL STPLSKRTSG FPAKKRALEL SGNSKNELNR SKRSWMWNQF 
FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL FIINENTGDI QATKRLDREE 
KPVYILRAQA INRRTGRPVE PESEFIIKIH DINDNEPIFT KEVYTATVPE MSDVGTFVVQ 
VTATDADDPT YGNSAKVVYS ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQVVIQAKD 
MGGQMGGLSG TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN 
AEIEYSITDG EGLDMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS NPYVEPRFLY 
LGPFKDSATV RIVVEDVDEP PVFSKLAYIL QIREDAQINT TIGSVTAQDP DAARNPVKYS 
VDRHTDMDRI FNIDSGNGSI FTSKLLDRET LLWHNITVIA TEINNPKQSS RVPLYIKVLD 
VNDNAPEFAE FYETFVCEKA KADQLIQTLH AVDKDDPYSG HQFSFSLAPE AASGSNFTIQ 
DNKDNTAGIL TRKNGYNRHE MSTYLLPVVI SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC 
HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE DIRDNIVSYN 
DEGGGEEDTQ AFDIGTLRNP EAIEDNKLRR DIVPEALFLP RRTPTARDNT DVRDFINQRL 
KENDTDPTAP PYDSLATYAY EGTGSVADSL SSLESVTTDA DQDYDYLSDW GPRFKKLADM 
YGGVDSDKDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CDH6

Associated with

Cells (max top 100)

Other Information

Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells. PubMed ID: 7743525

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. PubMed ID: 2059658

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569