Details for: CDH6

Gene ID: 1004

Symbol: CDH6

Ensembl ID: ENSG00000113361

Description: cadherin 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 200.0704
    Cell Significance Index: -31.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.8512
    Cell Significance Index: -25.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.1705
    Cell Significance Index: -28.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.1930
    Cell Significance Index: 43.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.0039
    Cell Significance Index: 132.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.6469
    Cell Significance Index: 100.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.6458
    Cell Significance Index: 746.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5214
    Cell Significance Index: 12.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9426
    Cell Significance Index: 189.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8285
    Cell Significance Index: 37.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5517
    Cell Significance Index: 105.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5022
    Cell Significance Index: 28.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4141
    Cell Significance Index: 286.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3543
    Cell Significance Index: 319.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2844
    Cell Significance Index: 155.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2417
    Cell Significance Index: 23.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2115
    Cell Significance Index: 24.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1646
    Cell Significance Index: 309.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1382
    Cell Significance Index: 22.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1130
    Cell Significance Index: 40.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1090
    Cell Significance Index: 167.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0789
    Cell Significance Index: 1.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0378
    Cell Significance Index: 23.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0359
    Cell Significance Index: 22.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0197
    Cell Significance Index: 36.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0123
    Cell Significance Index: 0.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0029
    Cell Significance Index: 3.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0048
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0146
    Cell Significance Index: -1.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0264
    Cell Significance Index: -0.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0300
    Cell Significance Index: -16.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0386
    Cell Significance Index: -28.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0438
    Cell Significance Index: -33.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0473
    Cell Significance Index: -6.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0732
    Cell Significance Index: -21.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0776
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0786
    Cell Significance Index: -13.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0838
    Cell Significance Index: -16.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0840
    Cell Significance Index: -17.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0871
    Cell Significance Index: -5.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0912
    Cell Significance Index: -9.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0921
    Cell Significance Index: -11.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1360
    Cell Significance Index: -24.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1451
    Cell Significance Index: -10.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1554
    Cell Significance Index: -17.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1764
    Cell Significance Index: -18.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1777
    Cell Significance Index: -5.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1882
    Cell Significance Index: -23.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1987
    Cell Significance Index: -27.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2040
    Cell Significance Index: -7.0900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2093
    Cell Significance Index: -1.6000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2106
    Cell Significance Index: -1.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2293
    Cell Significance Index: -5.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2313
    Cell Significance Index: -29.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2391
    Cell Significance Index: -5.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2450
    Cell Significance Index: -8.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2484
    Cell Significance Index: -28.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2777
    Cell Significance Index: -16.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2867
    Cell Significance Index: -15.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3287
    Cell Significance Index: -25.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3599
    Cell Significance Index: -28.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3943
    Cell Significance Index: -11.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4011
    Cell Significance Index: -29.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4104
    Cell Significance Index: -8.5900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.4262
    Cell Significance Index: -1.6100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4394
    Cell Significance Index: -9.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4526
    Cell Significance Index: -27.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4558
    Cell Significance Index: -30.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4664
    Cell Significance Index: -16.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4742
    Cell Significance Index: -12.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4748
    Cell Significance Index: -10.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4919
    Cell Significance Index: -25.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5226
    Cell Significance Index: -11.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5808
    Cell Significance Index: -27.0800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5847
    Cell Significance Index: -7.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5988
    Cell Significance Index: -12.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6036
    Cell Significance Index: -17.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6221
    Cell Significance Index: -29.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6484
    Cell Significance Index: -9.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7411
    Cell Significance Index: -27.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7694
    Cell Significance Index: -15.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8048
    Cell Significance Index: -17.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8274
    Cell Significance Index: -16.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8374
    Cell Significance Index: -22.0200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.8789
    Cell Significance Index: -10.7000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.8949
    Cell Significance Index: -12.7300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.9051
    Cell Significance Index: -12.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9101
    Cell Significance Index: -25.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9113
    Cell Significance Index: -19.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9495
    Cell Significance Index: -12.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9545
    Cell Significance Index: -25.9800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.9582
    Cell Significance Index: -15.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.9601
    Cell Significance Index: -23.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9602
    Cell Significance Index: -39.3400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.9707
    Cell Significance Index: -13.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9773
    Cell Significance Index: -24.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0002
    Cell Significance Index: -16.7400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.0075
    Cell Significance Index: -20.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.0164
    Cell Significance Index: -9.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Unique Structure:** CDH6 possesses a distinct cytoplasmic domain, which is different from other cadherins. This unique structure is thought to be responsible for its specific interactions with catenins and other proteins. 2. **Cell-Specific Expression:** CDH6 is expressed in a range of cell types, including epithelial cells, neural crest cells, and neurons. This cell-specific expression pattern suggests that CDH6 plays distinct roles in different tissues and developmental processes. 3. **Homophilic and Heterophilic Interactions:** CDH6 can form homophilic and heterophilic interactions with other cadherins and catenins, which are essential for cell-cell adhesion and signaling. 4. **Calcium-Dependent:** CDH6 is calcium-dependent, which is a characteristic shared with other cadherins. This calcium-dependent mechanism is crucial for the regulation of cell-cell adhesion and signaling. **Pathways and Functions:** 1. **Adherens Junction Formation:** CDH6 plays a critical role in the formation and maintenance of adherens junctions, which are essential for cell-cell adhesion and tissue integrity. 2. **Cell Signaling:** CDH6 is involved in cell signaling pathways, including the Notch signaling pathway, which is crucial for development and tissue homeostasis. 3. **Cell Morphogenesis:** CDH6 is essential for cell morphogenesis, which is the process of cell shape and organization during development. 4. **Neurological Functions:** CDH6 is expressed in neurons and is involved in the formation of synaptic junctions and the regulation of neuronal signaling. **Clinical Significance:** 1. **Cancer Association:** CDH6 has been implicated in various cancers, including breast, lung, and colon cancer. Mutations in the CDH6 gene have been associated with cancer progression and metastasis. 2. **Neurological Disorders:** CDH6 has been linked to neurological disorders, including autism spectrum disorder and schizophrenia. CDH6 mutations have been found in individuals with these conditions. 3. **Developmental Delays:** CDH6 has been associated with developmental delays and intellectual disability in individuals with mutations in the CDH6 gene. 4. **Therapeutic Potential:** CDH6 is a potential target for therapeutic interventions in cancer and neurological disorders. Understanding the mechanisms of CDH6 in cell adhesion and signaling can lead to the development of novel therapeutic strategies. In conclusion, the CDH6 gene is a critical component of the cadherin superfamily, playing a vital role in cell-cell adhesion, signaling, and development. Its unique characteristics and functions make it an essential molecule for understanding various diseases and developing novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms of CDH6 and its clinical significance.

Genular Protein ID: 62915032

Symbol: CADH6_HUMAN

Name: Cadherin-6

UniProtKB Accession Codes:

P55285 A8K5H5 Q9BWS0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7743525

Title: Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells.

PubMed ID: 7743525

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 790
  • Mass: 88309
  • Checksum: C175004FC8A61100
  • Sequence:
    • MRTYRYFLLL FWVGQPYPTL STPLSKRTSG FPAKKRALEL SGNSKNELNR SKRSWMWNQF 
FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL FIINENTGDI QATKRLDREE 
KPVYILRAQA INRRTGRPVE PESEFIIKIH DINDNEPIFT KEVYTATVPE MSDVGTFVVQ 
VTATDADDPT YGNSAKVVYS ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQVVIQAKD 
MGGQMGGLSG TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN 
AEIEYSITDG EGLDMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS NPYVEPRFLY 
LGPFKDSATV RIVVEDVDEP PVFSKLAYIL QIREDAQINT TIGSVTAQDP DAARNPVKYS 
VDRHTDMDRI FNIDSGNGSI FTSKLLDRET LLWHNITVIA TEINNPKQSS RVPLYIKVLD 
VNDNAPEFAE FYETFVCEKA KADQLIQTLH AVDKDDPYSG HQFSFSLAPE AASGSNFTIQ 
DNKDNTAGIL TRKNGYNRHE MSTYLLPVVI SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC 
HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE DIRDNIVSYN 
DEGGGEEDTQ AFDIGTLRNP EAIEDNKLRR DIVPEALFLP RRTPTARDNT DVRDFINQRL 
KENDTDPTAP PYDSLATYAY EGTGSVADSL SSLESVTTDA DQDYDYLSDW GPRFKKLADM 
YGGVDSDKDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.