Details for: TOM1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.86
Marker Score: 104,055 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.77
Marker Score: 1,208 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.55
Marker Score: 3,799 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.54
Marker Score: 6,428 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.43
Marker Score: 2,778 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.38
Marker Score: 14,210 - Cell Name: germ cell (CL0000586)
Fold Change: 1.36
Marker Score: 2,382 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.33
Marker Score: 3,126 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.3
Marker Score: 5,092 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.26
Marker Score: 19,666 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.22
Marker Score: 3,047 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.21
Marker Score: 10,432 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.16
Marker Score: 1,286 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.15
Marker Score: 4,087 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.13
Marker Score: 25,344 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.11
Marker Score: 2,774 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.06
Marker Score: 343 - Cell Name: blood cell (CL0000081)
Fold Change: 1.04
Marker Score: 12,145 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.02
Marker Score: 2,327 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1
Marker Score: 373 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,695 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,921 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.99
Marker Score: 1,011 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,390 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.97
Marker Score: 4,202 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.97
Marker Score: 532 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.96
Marker Score: 35,382 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.96
Marker Score: 1,950 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.96
Marker Score: 15,353 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.95
Marker Score: 397 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,398 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 482 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 437 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.92
Marker Score: 614 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.92
Marker Score: 563 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.92
Marker Score: 1,415 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.91
Marker Score: 31,051 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,704 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.89
Marker Score: 745 - Cell Name: pneumocyte (CL0000322)
Fold Change: 0.88
Marker Score: 1,419 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.88
Marker Score: 275 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,293 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.86
Marker Score: 7,418 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.85
Marker Score: 6,659 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4,841 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.85
Marker Score: 5,521 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.84
Marker Score: 408 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.84
Marker Score: 3,235 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.83
Marker Score: 348 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.83
Marker Score: 1,475 - Cell Name: club cell (CL0000158)
Fold Change: 0.83
Marker Score: 972 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.83
Marker Score: 1,351 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.83
Marker Score: 51,148 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.83
Marker Score: 387 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.83
Marker Score: 12,366 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.83
Marker Score: 31,392 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.83
Marker Score: 234 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.83
Marker Score: 1,677 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.82
Marker Score: 43,325 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 621 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.81
Marker Score: 20,798 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.81
Marker Score: 287 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.8
Marker Score: 844 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.8
Marker Score: 219 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.79
Marker Score: 4,810 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 317 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.78
Marker Score: 2,452 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.78
Marker Score: 7,390 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.77
Marker Score: 2,633 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.76
Marker Score: 7,194 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.76
Marker Score: 1,257 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.75
Marker Score: 913 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.75
Marker Score: 500 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.75
Marker Score: 238 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.75
Marker Score: 1,807 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.75
Marker Score: 236 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.74
Marker Score: 3,062 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.74
Marker Score: 297 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.73
Marker Score: 465 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3,074 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 376 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.73
Marker Score: 3,010 - Cell Name: fat cell (CL0000136)
Fold Change: 0.72
Marker Score: 405 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.72
Marker Score: 184 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.72
Marker Score: 3,088 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.72
Marker Score: 248 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.72
Marker Score: 408 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.71
Marker Score: 751 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.71
Marker Score: 424 - Cell Name: lung macrophage (CL1001603)
Fold Change: 0.71
Marker Score: 807 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.7
Marker Score: 1,824 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.7
Marker Score: 1,527 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.69
Marker Score: 3,327 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.69
Marker Score: 575 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.69
Marker Score: 614 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.69
Marker Score: 973 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.69
Marker Score: 741 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.69
Marker Score: 740 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.69
Marker Score: 971
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1440674088
Symbol: TOM1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10329004
Title: TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM.
PubMed ID: 10329004
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14563850
Title: Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.
PubMed ID: 14563850
PubMed ID: 14613930
PubMed ID: 15047686
Title: Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.
PubMed ID: 15047686
PubMed ID: 15657082
Title: Endofin recruits clathrin to early endosomes via TOM1.
PubMed ID: 15657082
DOI: 10.1242/jcs.01628
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23023224
Title: Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.
PubMed ID: 23023224
DOI: 10.1038/ncb2589
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25588840
Title: TOM1 is a PI5P effector involved in the regulation of endosomal maturation.
PubMed ID: 25588840
DOI: 10.1242/jcs.166314
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 10985773
Title: Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes.
PubMed ID: 10985773
DOI: 10.1021/bi0013546
PubMed ID: 16199040
Title: Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.
PubMed ID: 16199040
PubMed ID: 26320582
Title: Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.
PubMed ID: 26320582
PubMed ID: 26977434
Title: Structure of the GAT domain of the endosomal adapter protein Tom1.
PubMed ID: 26977434
PubMed ID: 31371777
Title: Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering.
PubMed ID: 31371777
PubMed ID: 31263572
Title: Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.
PubMed ID: 31263572
Sequence Information:
- Length: 492
- Mass: 53818
- Checksum: C7D77B5669476242
- Sequence:
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA LRAVKKRIVG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA SQDFVESVLV RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVTI YEDLRRKGLE FPMTDLDMLS PIHTPQRTVF NSETQSGQDS VGTDSSQQED SGQHAAPLPA PPILSGDTPI APTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQAEPAD LELLQELNRT CRAMQQRVLE LIPQIANEQL TEELLIVNDN LNNVFLRHER FERFRTGQTT KAPSEAEPAA DLIDMGPDPA ATGNLSSQLA GMNLGSSSVR AGLQSLEASG RLEDEFDMFA LTRGSSLADQ RKEVKYEAPQ ATDGLAGALD ARQQSTGAIP VTQACLMEDI EQWLSTDVGN DAEEPKGVTS EEFDKFLEER AKAADRLPNL SSPSAEGPPG PPSGPAPRKK TQEKDDDMLF AL
Genular Protein ID: 3985177214
Symbol: B3KUF5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 229
- Mass: 24740
- Checksum: 1DE3B62A95C5399C
- Sequence:
MQQRVLELIP QIANEQLTEE LLIVNDNLNN VFLRHERFER FRTGQTTKAP SEAEPAADLI DMGPDPAATG NLSSQLAGMN LGSSSVRAGL QSLEASGRLE DGFDMFALTR GSSLADQRKE VKYEAPQATD GLAGALDARQ QSTGAIPVTQ ACLMEDIEQW LSTDVGNDAE EPKGVTSEEF DKFLEERAKA ADRLPNLSSP SAEGPPGPPS GPAPRKKTQE KDDDMLFAL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.