Details for: TOM1

Gene ID: 10043

Symbol: TOM1

Ensembl ID: ENSG00000100284

Description: target of myb1 membrane trafficking protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.86
    Marker Score: 104,055
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.77
    Marker Score: 1,208
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.55
    Marker Score: 3,799
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.54
    Marker Score: 6,428
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.43
    Marker Score: 2,778
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.38
    Marker Score: 14,210
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.36
    Marker Score: 2,382
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.33
    Marker Score: 3,126
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3
    Marker Score: 5,092
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19,666
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.22
    Marker Score: 3,047
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.21
    Marker Score: 10,432
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.16
    Marker Score: 1,286
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.15
    Marker Score: 4,087
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.13
    Marker Score: 25,344
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.11
    Marker Score: 2,774
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 343
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.04
    Marker Score: 12,145
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.02
    Marker Score: 2,327
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1
    Marker Score: 373
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,695
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,921
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.99
    Marker Score: 1,011
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,390
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.97
    Marker Score: 4,202
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.97
    Marker Score: 532
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.96
    Marker Score: 35,382
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1,950
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.96
    Marker Score: 15,353
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.95
    Marker Score: 397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.92
    Marker Score: 614
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.92
    Marker Score: 563
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.92
    Marker Score: 1,415
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.91
    Marker Score: 31,051
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,704
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.89
    Marker Score: 745
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.88
    Marker Score: 1,419
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 275
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.86
    Marker Score: 7,418
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.85
    Marker Score: 6,659
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,841
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.85
    Marker Score: 5,521
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.84
    Marker Score: 408
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.84
    Marker Score: 3,235
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.83
    Marker Score: 348
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.83
    Marker Score: 1,475
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.83
    Marker Score: 972
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1,351
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.83
    Marker Score: 51,148
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.83
    Marker Score: 387
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.83
    Marker Score: 12,366
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.83
    Marker Score: 31,392
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.83
    Marker Score: 234
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.83
    Marker Score: 1,677
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.82
    Marker Score: 43,325
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.81
    Marker Score: 20,798
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.81
    Marker Score: 287
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8
    Marker Score: 844
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.8
    Marker Score: 219
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.79
    Marker Score: 4,810
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.78
    Marker Score: 2,452
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.78
    Marker Score: 7,390
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.77
    Marker Score: 2,633
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.76
    Marker Score: 7,194
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.76
    Marker Score: 1,257
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.75
    Marker Score: 913
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.75
    Marker Score: 500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.75
    Marker Score: 238
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.75
    Marker Score: 1,807
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.75
    Marker Score: 236
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.74
    Marker Score: 3,062
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.74
    Marker Score: 297
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,074
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.73
    Marker Score: 3,010
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.72
    Marker Score: 405
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.72
    Marker Score: 184
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.72
    Marker Score: 3,088
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.72
    Marker Score: 248
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.72
    Marker Score: 408
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.71
    Marker Score: 751
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 424
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.71
    Marker Score: 807
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.7
    Marker Score: 1,824
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.7
    Marker Score: 1,527
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.69
    Marker Score: 3,327
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.69
    Marker Score: 575
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.69
    Marker Score: 614
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.69
    Marker Score: 973
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.69
    Marker Score: 741
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.69
    Marker Score: 740
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.69
    Marker Score: 971

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TOM1 is a transmembrane protein that belongs to the TOM (Target of Myb1) family of proteins. It is characterized by its ability to bind to myosin VI, which is a motor protein involved in the regulation of membrane trafficking. TOM1 is also known to interact with other proteins, including ubiquitin and phosphatidylinositol-5-phosphate, which are involved in the regulation of protein degradation and signaling pathways. Its expression is tightly regulated by various transcription factors, including Myb1, which is a transcription factor that regulates the expression of genes involved in cell growth and differentiation. **Pathways and Functions:** TOM1 is involved in several cellular pathways, including: 1. **Autophagosome-lysosome fusion:** TOM1 plays a crucial role in the regulation of autophagosome-lysosome fusion, which is essential for the degradation of cellular waste and the regulation of cellular homeostasis. 2. **Endocytosis:** TOM1 is involved in the regulation of endocytosis, which is the process by which cells internalize external molecules and organelles. 3. **Signal transduction:** TOM1 is involved in the regulation of signal transduction pathways, including those involved in the regulation of immune responses. 4. **Protein degradation:** TOM1 is involved in the regulation of protein degradation, including the ubiquitin-proteasome pathway. **Clinical Significance:** Dysregulation of TOM1 has been implicated in various diseases, including: 1. **Autoimmune disorders:** TOM1 has been shown to play a role in the regulation of immune responses, and its dysregulation may contribute to autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** TOM1 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer, where it may contribute to tumor progression and metastasis. 3. **Neurological disorders:** TOM1 has been implicated in the regulation of neuronal function and may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** TOM1 has been shown to play a role in the regulation of immune responses, and its dysregulation may contribute to infectious diseases, such as tuberculosis and HIV. In conclusion, the TOM1 gene is a key regulator of membrane trafficking and immune response, and its dysregulation may contribute to various diseases. Further research is needed to fully understand the role of TOM1 in human health and disease.

Genular Protein ID: 1440674088

Symbol: TOM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10329004

Title: TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM.

PubMed ID: 10329004

DOI: 10.1006/geno.1998.5739

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14563850

Title: Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.

PubMed ID: 14563850

DOI: 10.1074/jbc.m306740200

PubMed ID: 14613930

Title: Endofin recruits TOM1 to endosomes.

PubMed ID: 14613930

DOI: 10.1074/jbc.m311228200

PubMed ID: 15047686

Title: Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.

PubMed ID: 15047686

DOI: 10.1074/jbc.m400059200

PubMed ID: 15657082

Title: Endofin recruits clathrin to early endosomes via TOM1.

PubMed ID: 15657082

DOI: 10.1242/jcs.01628

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23023224

Title: Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.

PubMed ID: 23023224

DOI: 10.1038/ncb2589

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25588840

Title: TOM1 is a PI5P effector involved in the regulation of endosomal maturation.

PubMed ID: 25588840

DOI: 10.1242/jcs.166314

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10985773

Title: Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes.

PubMed ID: 10985773

DOI: 10.1021/bi0013546

PubMed ID: 16199040

Title: Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.

PubMed ID: 16199040

DOI: 10.1016/j.febslet.2005.08.076

PubMed ID: 26320582

Title: Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.

PubMed ID: 26320582

DOI: 10.1016/j.str.2015.07.017

PubMed ID: 26977434

Title: Structure of the GAT domain of the endosomal adapter protein Tom1.

PubMed ID: 26977434

DOI: 10.1016/j.dib.2016.02.042

PubMed ID: 31371777

Title: Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering.

PubMed ID: 31371777

DOI: 10.1038/s41467-019-11481-6

PubMed ID: 31263572

Title: Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.

PubMed ID: 31263572

DOI: 10.1038/s41525-019-0088-5

Sequence Information:

  • Length: 492
  • Mass: 53818
  • Checksum: C7D77B5669476242
  • Sequence:
  • MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA LRAVKKRIVG 
    NKNFHEVMLA LTVLETCVKN CGHRFHVLVA SQDFVESVLV RTILPKNNPP TIVHDKVLNL 
    IQSWADAFRS SPDLTGVVTI YEDLRRKGLE FPMTDLDMLS PIHTPQRTVF NSETQSGQDS 
    VGTDSSQQED SGQHAAPLPA PPILSGDTPI APTPEQIGKL RSELEMVSGN VRVMSEMLTE 
    LVPTQAEPAD LELLQELNRT CRAMQQRVLE LIPQIANEQL TEELLIVNDN LNNVFLRHER 
    FERFRTGQTT KAPSEAEPAA DLIDMGPDPA ATGNLSSQLA GMNLGSSSVR AGLQSLEASG 
    RLEDEFDMFA LTRGSSLADQ RKEVKYEAPQ ATDGLAGALD ARQQSTGAIP VTQACLMEDI 
    EQWLSTDVGN DAEEPKGVTS EEFDKFLEER AKAADRLPNL SSPSAEGPPG PPSGPAPRKK 
    TQEKDDDMLF AL

Genular Protein ID: 3985177214

Symbol: B3KUF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 229
  • Mass: 24740
  • Checksum: 1DE3B62A95C5399C
  • Sequence:
  • MQQRVLELIP QIANEQLTEE LLIVNDNLNN VFLRHERFER FRTGQTTKAP SEAEPAADLI 
    DMGPDPAATG NLSSQLAGMN LGSSSVRAGL QSLEASGRLE DGFDMFALTR GSSLADQRKE 
    VKYEAPQATD GLAGALDARQ QSTGAIPVTQ ACLMEDIEQW LSTDVGNDAE EPKGVTSEEF 
    DKFLEERAKA ADRLPNLSSP SAEGPPGPPS GPAPRKKTQE KDDDMLFAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.