Details for: CDH7

Gene ID: 1005

Symbol: CDH7

Ensembl ID: ENSG00000081138

Description: cadherin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.9359
    Cell Significance Index: -17.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.0877
    Cell Significance Index: -17.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 6.2799
    Cell Significance Index: 107.6200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.6105
    Cell Significance Index: 57.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3867
    Cell Significance Index: -17.3100
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.1753
    Cell Significance Index: 47.5400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.4508
    Cell Significance Index: 25.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.3539
    Cell Significance Index: 104.1200
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.3119
    Cell Significance Index: 25.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.1417
    Cell Significance Index: 81.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7543
    Cell Significance Index: 92.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6850
    Cell Significance Index: 103.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6592
    Cell Significance Index: 41.4800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.6203
    Cell Significance Index: 9.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5212
    Cell Significance Index: 85.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4508
    Cell Significance Index: 50.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7659
    Cell Significance Index: 153.6300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.6745
    Cell Significance Index: 7.6600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.6688
    Cell Significance Index: 5.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6257
    Cell Significance Index: 15.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4750
    Cell Significance Index: 90.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3749
    Cell Significance Index: 259.3100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.3722
    Cell Significance Index: 1.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3520
    Cell Significance Index: 34.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2845
    Cell Significance Index: 256.9100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1820
    Cell Significance Index: 2.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1458
    Cell Significance Index: 23.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0794
    Cell Significance Index: 149.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0780
    Cell Significance Index: 8.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0718
    Cell Significance Index: 10.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0678
    Cell Significance Index: 1.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0439
    Cell Significance Index: 15.7300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0182
    Cell Significance Index: 0.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0033
    Cell Significance Index: 0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0091
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0182
    Cell Significance Index: -0.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0186
    Cell Significance Index: -11.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0201
    Cell Significance Index: -0.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0221
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0242
    Cell Significance Index: -18.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0259
    Cell Significance Index: -0.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0272
    Cell Significance Index: -15.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0273
    Cell Significance Index: -17.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0295
    Cell Significance Index: -13.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0312
    Cell Significance Index: -17.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0374
    Cell Significance Index: -0.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0379
    Cell Significance Index: -1.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0444
    Cell Significance Index: -12.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0591
    Cell Significance Index: -10.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0630
    Cell Significance Index: -1.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0718
    Cell Significance Index: -4.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0728
    Cell Significance Index: -13.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0760
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0778
    Cell Significance Index: -16.3800
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0791
    Cell Significance Index: -0.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0792
    Cell Significance Index: -15.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0892
    Cell Significance Index: -11.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0896
    Cell Significance Index: -5.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0942
    Cell Significance Index: -5.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0955
    Cell Significance Index: -2.0700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1017
    Cell Significance Index: -0.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1098
    Cell Significance Index: -13.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1152
    Cell Significance Index: -3.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1185
    Cell Significance Index: -16.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1210
    Cell Significance Index: -2.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1279
    Cell Significance Index: -14.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1378
    Cell Significance Index: -4.3900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1443
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1459
    Cell Significance Index: -16.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1642
    Cell Significance Index: -7.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1677
    Cell Significance Index: -17.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1813
    Cell Significance Index: -3.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1836
    Cell Significance Index: -1.7400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1843
    Cell Significance Index: -2.1500
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.2078
    Cell Significance Index: -1.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2142
    Cell Significance Index: -6.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2330
    Cell Significance Index: -17.8800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2383
    Cell Significance Index: -2.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2451
    Cell Significance Index: -16.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2544
    Cell Significance Index: -8.3300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.2587
    Cell Significance Index: -2.6600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2588
    Cell Significance Index: -6.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2607
    Cell Significance Index: -3.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2636
    Cell Significance Index: -13.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2667
    Cell Significance Index: -1.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2764
    Cell Significance Index: -3.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2872
    Cell Significance Index: -8.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2941
    Cell Significance Index: -15.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3014
    Cell Significance Index: -5.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3015
    Cell Significance Index: -6.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3080
    Cell Significance Index: -6.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3186
    Cell Significance Index: -11.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3260
    Cell Significance Index: -15.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3295
    Cell Significance Index: -3.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3329
    Cell Significance Index: -15.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3364
    Cell Significance Index: -9.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** CDH7 is a type I transmembrane protein consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. 2. **Function:** CDH7 mediates homophilic cell adhesion, which is essential for the organization and morphogenesis of tissues. 3. **Expression:** CDH7 is highly expressed in various cell types, including granule cells, neurons, macroglial cells, and epithelial cells. 4. **Signaling:** CDH7 interacts with the cadherin-catenin complex, which is a key signaling platform for cell-cell communication. **Pathways and Functions:** CDH7 is involved in several key pathways, including: 1. **Adherens Junction Organization:** CDH7 regulates the organization and formation of adherens junctions, which are critical for tissue structure and function. 2. **Cell-Cell Adhesion:** CDH7 mediates homophilic cell adhesion, which is essential for cell-cell communication and tissue morphogenesis. 3. **Calcium-Dependent Cell-Cell Adhesion:** CDH7 requires calcium ions to mediate cell-cell adhesion, highlighting the importance of calcium homeostasis in this process. 4. **Catenin Complex:** CDH7 interacts with the cadherin-catenin complex, which is a key signaling platform for cell-cell communication. **Clinical Significance:** Dysregulation of CDH7 has been implicated in several diseases, including: 1. **Cancer:** CDH7 has been found to be downregulated in several types of cancer, including lung, breast, and colon cancer. 2. **Neurological Disorders:** CDH7 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Developmental Abnormalities:** CDH7 is required for proper tissue morphogenesis, and its dysregulation can lead to developmental abnormalities. In conclusion, CDH7 is a critical gene involved in cell-cell adhesion and communication. Its dysregulation can have significant implications for human health, highlighting the importance of further research into the functions and dysregulation of this gene.

Genular Protein ID: 1341869962

Symbol: CADH7_HUMAN

Name: Cadherin-7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10995570

Title: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7.

PubMed ID: 10995570

DOI: 10.1006/geno.2000.6305

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 785
  • Mass: 87086
  • Checksum: 3C504CD1C620F4BC
  • Sequence:
  • MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 
    MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 
    RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 
    DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 
    GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 
    IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 
    TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 
    LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 
    EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 
    ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGV AQTCNAEAYV 
    LPAGLSTGAL IAILACVLTL LVLILLIVTM RRRKKEPLIF DEERDIRENI VRYDDEGGGE 
    EDTEAFDMAA LRNLNVIRDT KTRRDVTPEI QFLSRPAFKS IPDNVIFREF IWERLKEADV 
    DPGAPPYDSL QTYAFEGNGS VAESLSSLDS ISSNSDQNYD YLSDWGPRFK RLADMYGTGQ 
    ESLYS

Genular Protein ID: 1616761570

Symbol: F5H5X9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 630
  • Mass: 69244
  • Checksum: 5EABE084BE10DFFF
  • Sequence:
  • MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 
    MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 
    RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 
    DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 
    GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 
    IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 
    TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 
    LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 
    EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 
    ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGV AQTCNAEAYV 
    LPAGLSTGAL IAILACVLTL LGRYCFQGLL

Genular Protein ID: 939933635

Symbol: Q8IY78_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 630
  • Mass: 69218
  • Checksum: 1EB6FD87A21A61D3
  • Sequence:
  • MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 
    MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 
    RAQALDRLTN EPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 
    DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 
    GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 
    IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 
    TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 
    LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 
    EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 
    ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTSTLTI RVCDCDADGV AQTCNAEAYV 
    LPAGLSTGAL IAILACVLTL LGRYCFQGLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.