Details for: CDH7

Gene ID: 1005

Symbol: CDH7

Ensembl ID: ENSG00000081138

Description: cadherin 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.79
    Marker Score: 36099
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.72
    Marker Score: 24788
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.29
    Marker Score: 7565
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.15
    Marker Score: 999
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.82
    Marker Score: 15128
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.45
    Marker Score: 1739
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.94
    Marker Score: 2339.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.79
    Marker Score: 750
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.7
    Marker Score: 13009
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.68
    Marker Score: 753
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.62
    Marker Score: 32201
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.58
    Marker Score: 2997
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.54
    Marker Score: 422
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56273
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.51
    Marker Score: 6147
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.48
    Marker Score: 91212
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.48
    Marker Score: 13906
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.32
    Marker Score: 3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.31
    Marker Score: 12486
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.25
    Marker Score: 726
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.16
    Marker Score: 2364
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.16
    Marker Score: 696
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.14
    Marker Score: 11467.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.13
    Marker Score: 514.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.12
    Marker Score: 2323.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.11
    Marker Score: 11419
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.1
    Marker Score: 41710
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.07
    Marker Score: 1816.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.07
    Marker Score: 1007
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 705
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.02
    Marker Score: 1228
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 416.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.95
    Marker Score: 4415
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.95
    Marker Score: 1936
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.93
    Marker Score: 1440
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.93
    Marker Score: 428.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.87
    Marker Score: 1819
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.84
    Marker Score: 3472
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.8
    Marker Score: 848
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.79
    Marker Score: 1102
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12045
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.76
    Marker Score: 3175
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.72
    Marker Score: 406
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.72
    Marker Score: 227
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.69
    Marker Score: 865
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 429.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.62
    Marker Score: 4116
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.62
    Marker Score: 204
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.62
    Marker Score: 1010
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 393
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.54
    Marker Score: 156
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.54
    Marker Score: 282
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.48
    Marker Score: 532
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 230
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.48
    Marker Score: 4138
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.45
    Marker Score: 1880
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.45
    Marker Score: 498
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 407
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.41
    Marker Score: 1515
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.4
    Marker Score: 423
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.4
    Marker Score: 161
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.37
    Marker Score: 691
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.36
    Marker Score: 274
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.35
    Marker Score: 105
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 144
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 303
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 140
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.31
    Marker Score: 2022
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.31
    Marker Score: 538
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.29
    Marker Score: 207
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 306
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 147
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 151
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.24
    Marker Score: 134

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Other Information

**Key characteristics:** * CDH7 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a member of the cadherin family of cell adhesion molecules. * CDH7 is expressed in a variety of tissues, including the brain, kidney, lung, and skin. * It is a key molecule in cell-cell adhesion and tissue morphogenesis. **Pathways and functions:** * CDH7 is involved in cell-cell adhesion through its interaction with cadherins, which are other cell adhesion molecules. * It is a key component of adherens junctions, which are strong cell-cell adhesion complexes found in epithelial tissues. * CDH7 also plays a role in cell migration, cell signaling, and tissue morphogenesis. **Clinical significance:** * Mutations in CDH7 are associated with several human diseases, including autism, schizophrenia, and cancer. * Targeting CDH7 has been investigated as a therapeutic strategy for these diseases. * A dysfunction of CDH7 has been linked to the development of liver disease and other health conditions. **Conclusion:** CDH7 is a critical cell adhesion molecule that plays a crucial role in cell-cell adhesion and tissue organization. Its mutations are associated with several human diseases, highlighting its importance in human health.

Genular Protein ID: 1341869962

Symbol: CADH7_HUMAN

Name: Cadherin-7

UniProtKB Accession Codes:

Q9ULB5 Q9H157

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10995570

Title: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7.

PubMed ID: 10995570

DOI: 10.1006/geno.2000.6305

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 785
  • Mass: 87086
  • Checksum: 3C504CD1C620F4BC
  • Sequence:
    • MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 
MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 
RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 
DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 
GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 
IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 
TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 
LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 
EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 
ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGV AQTCNAEAYV 
LPAGLSTGAL IAILACVLTL LVLILLIVTM RRRKKEPLIF DEERDIRENI VRYDDEGGGE 
EDTEAFDMAA LRNLNVIRDT KTRRDVTPEI QFLSRPAFKS IPDNVIFREF IWERLKEADV 
DPGAPPYDSL QTYAFEGNGS VAESLSSLDS ISSNSDQNYD YLSDWGPRFK RLADMYGTGQ 
ESLYS

Genular Protein ID: 1616761570

Symbol: F5H5X9_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H5X9

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 630
  • Mass: 69244
  • Checksum: 5EABE084BE10DFFF
  • Sequence:
    • MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 
MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 
RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 
DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 
GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 
IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 
TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 
LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 
EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 
ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGV AQTCNAEAYV 
LPAGLSTGAL IAILACVLTL LGRYCFQGLL

Genular Protein ID: 939933635

Symbol: Q8IY78_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IY78

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 630
  • Mass: 69218
  • Checksum: 1EB6FD87A21A61D3
  • Sequence:
    • MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 
MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 
RAQALDRLTN EPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 
DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 
GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 
IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 
TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 
LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 
EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 
ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTSTLTI RVCDCDADGV AQTCNAEAYV 
LPAGLSTGAL IAILACVLTL LGRYCFQGLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.