SAE1 | ENSG00000142230 | NCBI 10055

Details for: SAE1

Gene ID: 10055

Symbol: SAE1

Ensembl ID: ENSG00000142230

Description: SUMO1 activating enzyme subunit 1

Associated with

Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Processing and activation of sumo
(R-HSA-3215018)
Sumo is conjugated to e1 (uba2:sae1)
(R-HSA-3065676)
Sumo is transferred from e1 to e2 (ube2i, ubc9)
(R-HSA-3065678)
Sumoylation
(R-HSA-2990846)
Atp-dependent protein binding
(GO:0043008)
Cytoplasm
(GO:0005737)
Enzyme activator activity
(GO:0008047)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of protein sumoylation
(GO:0033235)
Positive regulation of protein targeting to mitochondrion
(GO:1903955)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein sumoylation
(GO:0016925)
Protein ubiquitination
(GO:0016567)
Small protein activating enzyme binding
(GO:0044388)
Sumo activating enzyme activity
(GO:0019948)
Sumo activating enzyme complex
(GO:0031510)
Ubiquitin activating enzyme activity
(GO:0004839)

Other Information

Proteins

SUMO-activating enzyme subunit 1

Genular Protein ID: 2546153082

Symbol: SAE1_HUMAN

Name: SUMO-activating enzyme subunit 1

UniProtKB Accession Codes:

Q9UBE0 B2RDP5 B3KMQ2 F5GXX7 G3XAK6 O95717 Q9P020

Database IDs:

Citations:

PubMed ID: 9920803

Title: In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2.

PubMed ID: 9920803

DOI: 10.1006/bbrc.1998.9995

PubMed ID: 10217437

Title: Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.

PubMed ID: 10217437

DOI: 10.1016/s0014-5793(99)00367-1

PubMed ID: 10187858

Title: Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1.

PubMed ID: 10187858

DOI: 10.1074/jbc.274.15.10618

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11481243

Title: Expression and regulation of the mammalian SUMO-1 E1 enzyme.

PubMed ID: 11481243

DOI: 10.1096/fj.00-0818fje

PubMed ID: 11451954

Title: Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

PubMed ID: 11451954

DOI: 10.1074/jbc.m104214200

PubMed ID: 16620772

Title: A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.

PubMed ID: 16620772

DOI: 10.1016/j.abb.2006.03.002

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 15660128

Title: Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.

PubMed ID: 15660128

DOI: 10.1038/sj.emboj.7600552

PubMed ID: 20164921

Title: Active site remodelling accompanies thioester bond formation in the SUMO E1.

PubMed ID: 20164921

DOI: 10.1038/nature08765

Sequence Information:

Length: 346
Mass: 38450
Checksum: E2B10A69FF2ED746
Sequence:

MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE IAKNLILAGV 
KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ NLNPMVDVKV DTEDIEKKPE 
SFFTQFDAVC LTCCSRDVIV KVDQICHKNS IKFFTGDVFG YHGYTFANLG EHEFVEEKTK 
VAKVSQGVED GPDTKRAKLD SSETTMVKKK VVFCPVKEAL EVDWSSEKAK AALKRTTSDY 
FLLQVLLKFR TDKGRDPSSD TYEEDSELLL QIRNDVLDSL GISPDLLPED FVRYCFSEMA 
PVCAVVGGIL AQEIVKALSQ RDPPHNNFFF FDGMKGNGIV ECLGPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SAE1

Associated with

Other Information

In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. PubMed ID: 9920803

Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. PubMed ID: 10217437

Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. PubMed ID: 10187858

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression and regulation of the mammalian SUMO-1 E1 enzyme. PubMed ID: 11481243

Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. PubMed ID: 11451954

A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. PubMed ID: 16620772

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. PubMed ID: 25489052

Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. PubMed ID: 15660128

Active site remodelling accompanies thioester bond formation in the SUMO E1. PubMed ID: 20164921