Details for: DNM1L
Associated with
Other Information
Genular Protein ID: 2820353759
Symbol: DNM1L_HUMAN
Name: Dynamin-1-like protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9348079
Title: Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p.
PubMed ID: 9348079
PubMed ID: 9731200
Title: Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.
PubMed ID: 9731200
PubMed ID: 9570752
Title: Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1p.
PubMed ID: 9570752
PubMed ID: 10749171
Title: Differential expression of four human dynamin-like protein variants in brain tumors.
PubMed ID: 10749171
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9422767
Title: Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells.
PubMed ID: 9422767
PubMed ID: 9472031
Title: A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells.
PubMed ID: 9472031
PubMed ID: 9786947
Title: A human dynamin-related protein controls the distribution of mitochondria.
PubMed ID: 9786947
PubMed ID: 9915810
Title: Intermolecular and interdomain interactions of a dynamin-related GTP-binding protein, Dnm1p/Vps1p-like protein.
PubMed ID: 9915810
PubMed ID: 11514614
Title: Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells.
PubMed ID: 11514614
PubMed ID: 12499366
Title: Dynamin-like protein 1 is involved in peroxisomal fission.
PubMed ID: 12499366
PubMed ID: 12618434
Title: The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11.
PubMed ID: 12618434
PubMed ID: 15208300
Title: Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1.
PubMed ID: 15208300
PubMed ID: 16874301
Title: A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.
PubMed ID: 16874301
PubMed ID: 16936636
Title: MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology.
PubMed ID: 16936636
PubMed ID: 17015472
Title: Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.
PubMed ID: 17015472
DOI: 10.1128/mcb.02282-05
PubMed ID: 17301055
Title: Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.
PubMed ID: 17301055
PubMed ID: 17553808
Title: Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.
PubMed ID: 17553808
PubMed ID: 17606867
Title: The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division.
PubMed ID: 17606867
PubMed ID: 17460227
Title: A lethal defect of mitochondrial and peroxisomal fission.
PubMed ID: 17460227
DOI: 10.1056/nejmoa064436
PubMed ID: 18695047
Title: CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology.
PubMed ID: 18695047
PubMed ID: 18088087
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18838687
Title: Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.
PubMed ID: 18838687
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19407830
Title: MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission.
PubMed ID: 19407830
PubMed ID: 19638400
Title: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle.
PubMed ID: 19638400
DOI: 10.1096/fj.09-136630
PubMed ID: 19411255
Title: Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis.
PubMed ID: 19411255
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19342591
Title: S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.
PubMed ID: 19342591
PubMed ID: 20688057
Title: Dynamin-like protein 1 at the Golgi complex: A novel component of the sorting/targeting machinery en route to the plasma membrane.
PubMed ID: 20688057
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21508961
Title: MiD49 and MiD51, new components of the mitochondrial fission machinery.
PubMed ID: 21508961
PubMed ID: 21701560
Title: Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission.
PubMed ID: 21701560
PubMed ID: 21822277
Title: RALA and RALBP1 regulate mitochondrial fission at mitosis.
PubMed ID: 21822277
DOI: 10.1038/ncb2310
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22265414
Title: The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.
PubMed ID: 22265414
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23921378
Title: MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.
PubMed ID: 23921378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23283981
Title: Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
PubMed ID: 23283981
PubMed ID: 23792689
Title: A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.
PubMed ID: 23792689
DOI: 10.1038/ncb2791
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24196833
Title: Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
PubMed ID: 24196833
PubMed ID: 26122121
Title: Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.
PubMed ID: 26122121
DOI: 10.1093/brain/awv182
PubMed ID: 23530241
Title: Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.
PubMed ID: 23530241
PubMed ID: 29478834
Title: Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics.
PubMed ID: 29478834
PubMed ID: 32484300
Title: PINK1 phosphorylates Drp1S616 to regulate mitophagy-independent mitochondrial dynamics.
PubMed ID: 32484300
PubMed ID: 33850055
Title: DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.
PubMed ID: 33850055
PubMed ID: 23584531
Title: Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
PubMed ID: 23584531
PubMed ID: 23977156
Title: Functional mapping of human dynamin-1-like GTPase domain based on x-ray structure analyses.
PubMed ID: 23977156
PubMed ID: 29899447
Title: Structural basis of mitochondrial receptor binding and constriction by DRP1.
PubMed ID: 29899447
PubMed ID: 26604000
Title: DNM1L-related mitochondrial fission defect presenting as refractory epilepsy.
PubMed ID: 26604000
PubMed ID: 27145208
Title: A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
PubMed ID: 27145208
DOI: 10.1002/ajmg.a.37721
PubMed ID: 26992161
Title: Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function.
PubMed ID: 26992161
DOI: 10.1002/ajmg.a.37624
PubMed ID: 27301544
Title: DNM1L-related encephalopathy in infancy with Leigh syndrome-like phenotype and suppression-burst.
PubMed ID: 27301544
DOI: 10.1111/cge.12805
PubMed ID: 27328748
Title: Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
PubMed ID: 27328748
DOI: 10.1002/humu.23033
PubMed ID: 28969390
Title: Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effectson mitochondrial fusion and fission.
PubMed ID: 28969390
DOI: 10.1093/brain/awx219
Sequence Information:
- Length: 736
- Mass: 81877
- Checksum: F9521A376B785B71
- Sequence:
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR RPLILQLVHV SQEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG NNKGVSPEPI HLKIFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKSSKVPSAL APASQEPSPA ASAEADGKLI QDSRRETKNV ASGGGGVGDG VQEPTTGNWR GMLKTSKAEE LLAEEKSKPI PIMPASPQKG HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK NIQDSVPKAV MHFLVNHVKD TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL QGASQIIAEI RETHLW
Genular Protein ID: 3884563909
Symbol: B4DYR6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 763
- Mass: 85378
- Checksum: 5981338137BA8A21
- Sequence:
MACREGAGSR RARSNGCRLP RRGRRRGGRR RTVGPGPIHC RGRRALGPRV FRVMEALIPV INKLQDVFNT VGADIIQLPQ IVVVGTQSSG KSSVLESLVG RDLLPRGTGI VTRRPLILQL VHVSQEDKRK TTGEENGVEA EEWGKFLHTK NKLYTDFDEI RQEIENETER ISGNNKGVSP EPIHLKIFSP NVVNLTLVDL PGMTKVPVGD QPKDIELQIR ELILRFISNP NSIILAVTAA NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM DVLMGRVIPV KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR NATGPRPALF VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS NYSTQELLRF PKLHDAIVEV VTCLLRKRLP VTNEMVHNLV AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA VSRDKLIQDS RRETKNVASG GGGAGDGVQE PTTGNWRGML KTSKAEELLA EEKSKPIPIM PASPQKGHAV NLLDVPVPVA RKLSAREQRD CEVIERLIKS YFLIVRKNIQ DSVPKAVMHF LVNHVKDTLQ SELVGQLYKS SLLDDLLTES EDMAQRRKEA TDMLKALQGA SQIIAEIRET HLW
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.