Details for: CDH8

Gene ID: 1006

Symbol: CDH8

Ensembl ID: ENSG00000150394

Description: cadherin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.9147
    Cell Significance Index: 397.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.7782
    Cell Significance Index: 211.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.3668
    Cell Significance Index: 165.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.9570
    Cell Significance Index: 112.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5227
    Cell Significance Index: 506.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3649
    Cell Significance Index: 75.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2179
    Cell Significance Index: 795.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.2107
    Cell Significance Index: 1528.9800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.3062
    Cell Significance Index: 16.9400
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.8553
    Cell Significance Index: 6.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5636
    Cell Significance Index: 34.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4596
    Cell Significance Index: 5.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3323
    Cell Significance Index: 7.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2781
    Cell Significance Index: 6.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2637
    Cell Significance Index: 42.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1962
    Cell Significance Index: 37.3400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1598
    Cell Significance Index: 1.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1562
    Cell Significance Index: 70.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1451
    Cell Significance Index: 2.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0113
    Cell Significance Index: -21.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0172
    Cell Significance Index: -31.6800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0207
    Cell Significance Index: -31.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0241
    Cell Significance Index: -32.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0339
    Cell Significance Index: -25.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0471
    Cell Significance Index: -29.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0497
    Cell Significance Index: -37.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0514
    Cell Significance Index: -28.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0623
    Cell Significance Index: -38.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0630
    Cell Significance Index: -1.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0632
    Cell Significance Index: -27.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0635
    Cell Significance Index: -34.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0746
    Cell Significance Index: -4.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0824
    Cell Significance Index: -1.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0826
    Cell Significance Index: -4.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0944
    Cell Significance Index: -17.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0968
    Cell Significance Index: -27.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1082
    Cell Significance Index: -2.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1227
    Cell Significance Index: -24.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1602
    Cell Significance Index: -33.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1840
    Cell Significance Index: -22.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1893
    Cell Significance Index: -27.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1973
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2095
    Cell Significance Index: -35.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2168
    Cell Significance Index: -21.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2229
    Cell Significance Index: -25.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2280
    Cell Significance Index: -24.8000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2374
    Cell Significance Index: -2.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2383
    Cell Significance Index: -32.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2549
    Cell Significance Index: -32.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2595
    Cell Significance Index: -5.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2732
    Cell Significance Index: -35.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2810
    Cell Significance Index: -12.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2854
    Cell Significance Index: -5.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2961
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3244
    Cell Significance Index: -37.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3306
    Cell Significance Index: -34.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3394
    Cell Significance Index: -34.6700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3471
    Cell Significance Index: -4.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3531
    Cell Significance Index: -24.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3559
    Cell Significance Index: -7.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3755
    Cell Significance Index: -7.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3946
    Cell Significance Index: -12.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3988
    Cell Significance Index: -3.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3989
    Cell Significance Index: -30.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4003
    Cell Significance Index: -28.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4276
    Cell Significance Index: -14.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4522
    Cell Significance Index: -13.0300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.4704
    Cell Significance Index: -5.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4791
    Cell Significance Index: -8.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4842
    Cell Significance Index: -27.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4978
    Cell Significance Index: -25.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5492
    Cell Significance Index: -33.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5529
    Cell Significance Index: -29.0300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5690
    Cell Significance Index: -11.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5718
    Cell Significance Index: -25.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5837
    Cell Significance Index: -36.7900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5904
    Cell Significance Index: -7.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6472
    Cell Significance Index: -13.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6742
    Cell Significance Index: -31.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7211
    Cell Significance Index: -15.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7603
    Cell Significance Index: -18.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8030
    Cell Significance Index: -37.4400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.8060
    Cell Significance Index: -9.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8089
    Cell Significance Index: -21.2700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.8245
    Cell Significance Index: -10.9900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.8773
    Cell Significance Index: -9.0200
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.8836
    Cell Significance Index: -6.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9140
    Cell Significance Index: -24.4900
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.9333
    Cell Significance Index: -9.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9554
    Cell Significance Index: -33.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9634
    Cell Significance Index: -35.3700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -1.0127
    Cell Significance Index: -11.5000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0273
    Cell Significance Index: -20.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.0322
    Cell Significance Index: -36.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0360
    Cell Significance Index: -26.6300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.0912
    Cell Significance Index: -11.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.0996
    Cell Significance Index: -29.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1195
    Cell Significance Index: -18.7400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.1241
    Cell Significance Index: -23.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Adhesion:** CDH8 is a calcium-dependent cell adhesion molecule that mediates homophilic and heterophilic interactions between cells, facilitating the formation of adherens junctions. 2. **Synaptic Function:** CDH8 is expressed in synaptic terminals and plays a critical role in regulating synaptic cleft and synaptic membrane structure, thereby influencing synaptic transmission and plasticity. 3. **Cell Morphogenesis:** CDH8 is involved in regulating cell shape and morphology, particularly during neural development and tissue organization. 4. **Regulation of CDH11 Expression:** CDH8 interacts with CDH11, regulating its expression and function, which is essential for maintaining cell-cell adhesion and tissue integrity. **Pathways and Functions:** 1. **Adherens Junction Formation:** CDH8 interacts with other cadherins and catenins to form adherens junctions, which are essential for maintaining tissue integrity and regulating cell-cell adhesion. 2. **Synaptic Organization:** CDH8 regulates synaptic cleft and synaptic membrane structure, influencing synaptic transmission and plasticity. 3. **Cell Morphogenesis:** CDH8 regulates cell shape and morphology, particularly during neural development and tissue organization. 4. **Regulation of CDH11 Expression:** CDH8 interacts with CDH11, regulating its expression and function, which is essential for maintaining cell-cell adhesion and tissue integrity. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in CDH8 expression and function have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cancer:** CDH8 is often downregulated in various types of cancer, including breast, lung, and colon cancer, suggesting its potential as a tumor suppressor gene. 3. **Neurodevelopmental Disorders:** CDH8 is involved in regulating neural development and tissue organization, making it a potential target for therapies in neurodevelopmental disorders, such as autism and intellectual disability. In conclusion, CDH8 is a critical cadherin that plays a significant role in maintaining cell adhesion, synaptic function, and cell morphogenesis. Its dysregulation has been implicated in various neurological and cancer disorders, highlighting the need for further research into the molecular mechanisms underlying its function.

Genular Protein ID: 4066201777

Symbol: CADH8_HUMAN

Name: Cadherin-8

UniProtKB Accession Codes:

P55286 B3KWC1 Q14DC6 Q9ULB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

Sequence Information:

  • Length: 799
  • Mass: 88253
  • Checksum: 9B119B86039C6A0A
  • Sequence:
    • MPERLAEMLL DLWTPLIILW ITLPPCIYMA PMNQSQVLMS GSPLELNSLG EEQRILNRSK 
RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL SGDGAGTIFQ INDVTGDIHA 
IKRLDREEKA EYTLTAQAVD WETSKPLEPP SEFIIKVQDI NDNAPEFLNG PYHATVPEMS 
ILGTSVTNVT ATDADDPVYG NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY 
LVVIQAKDMG GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS YTLKVEAANV 
HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV HENAALNSVI GQVTARDPDI 
TSSPIRFSID RHTDLERQFN INADDGKITL ATPLDRELSV WHNITIIATE IRNHSQISRV 
PVAIKVLDVN DNAPEFASEY EAFLCENGKP GQVIQTVSAM DKDDPKNGHY FLYSLLPEMV 
NNPNFTIKKN EDNSLSILAK HNGFNRQKQE VYLLPIIISD SGNPPLSSTS TLTIRVCGCS 
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE PLIIKDDEDV 
RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI KPDLQFMPRQ GLAPVPNGVD 
VDEFINVRLH EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESTTSDSD QNFDYLSDWG 
PRFKRLGELY SVGESDKET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.