Details for: MIR4483

Gene ID: 100616162

Symbol: MIR4483

Ensembl ID: ENSG00000283656

Description: microRNA 4483

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR4483 is a microRNA, a class of small, non-coding RNAs that regulate gene expression post-transcriptionally by binding to complementary sequences on target messenger RNA (mRNA). MicroRNAs are known to play crucial roles in various biological processes, including development, differentiation, and disease. MIR4483 is a member of the microRNA family and has been identified as a novel regulator of gene expression in the intestinal epithelium. **Pathways and Functions:** MIR4483 is involved in several key pathways that regulate intestinal homeostasis and function. These include: 1. **Wnt/β-catenin signaling pathway:** MIR4483 has been shown to modulate the Wnt/β-catenin signaling pathway, which is critical for intestinal stem cell maintenance and differentiation. 2. **Notch signaling pathway:** MIR4483 also regulates the Notch signaling pathway, which is involved in cell fate decisions, differentiation, and proliferation in the intestinal epithelium. 3. **Epithelial-to-mesenchymal transition (EMT):** MIR4483 has been implicated in the regulation of EMT, a process that involves the transformation of epithelial cells into mesenchymal cells, which is essential for tissue repair and regeneration. 4. **Apoptosis:** MIR4483 has been shown to regulate apoptosis, or programmed cell death, in the intestinal epithelium, which is critical for maintaining tissue homeostasis. **Clinical Significance:** The dysregulation of MIR4483 has been implicated in several intestinal diseases, including: 1. **Inflammatory bowel disease (IBD):** MIR4483 has been shown to be downregulated in IBD patients, suggesting its potential role as a biomarker for disease diagnosis and prognosis. 2. **Colorectal cancer:** MIR4483 has been implicated in the regulation of cell proliferation and apoptosis in colorectal cancer, suggesting its potential as a therapeutic target. 3. **Gastrointestinal motility disorders:** MIR4483 has been shown to regulate intestinal motility, suggesting its potential role in the pathogenesis of gastrointestinal motility disorders. In conclusion, MIR4483 is a novel player in intestinal homeostasis and disease. Further studies are needed to fully elucidate the functions of MIR4483 and its potential therapeutic applications in intestinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.