NR1H3 | ENSG00000025434 | NCBI 10062

Details for: NR1H3

Gene ID: 10062

Symbol: NR1H3

Ensembl ID: ENSG00000025434

Description: nuclear receptor subfamily 1 group H member 3

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Nr1h2 & nr1h3 regulate gene expression linked to gluconeogenesis
(R-HSA-9632974)
Nr1h2 & nr1h3 regulate gene expression linked to lipogenesis
(R-HSA-9029558)
Nr1h2 & nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose
(R-HSA-9031528)
Nr1h2 & nr1h3 regulate gene expression to control bile acid homeostasis
(R-HSA-9623433)
Nr1h2 & nr1h3 regulate gene expression to limit cholesterol uptake
(R-HSA-9031525)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Nuclear receptor transcription pathway
(R-HSA-383280)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Post-translational protein modification
(R-HSA-597592)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of intracellular receptors
(R-HSA-4090294)
Transport of small molecules
(R-HSA-382551)
Vldlr internalisation and degradation
(R-HSA-8866427)
Apoptotic cell clearance
(GO:0043277)
Cell differentiation
(GO:0030154)
Cellular response to lipopolysaccharide
(GO:0071222)
Cholesterol binding
(GO:0015485)
Cholesterol homeostasis
(GO:0042632)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Hormone-mediated signaling pathway
(GO:0009755)
Intracellular receptor signaling pathway
(GO:0030522)
Lipid homeostasis
(GO:0055088)
Mrna transcription by rna polymerase ii
(GO:0042789)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of lipid transport
(GO:0032369)
Negative regulation of macrophage activation
(GO:0043031)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Negative regulation of pancreatic juice secretion
(GO:0090188)
Negative regulation of pinocytosis
(GO:0048550)
Negative regulation of proteolysis
(GO:0045861)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Negative regulation of secretion of lysosomal enzymes
(GO:0090341)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type ii interferon-mediated signaling pathway
(GO:0060336)
Nuclear receptor activity
(GO:0004879)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylcholine acyl-chain remodeling
(GO:0036151)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of cholesterol transport
(GO:0032376)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of lipid biosynthetic process
(GO:0046889)
Positive regulation of lipoprotein lipase activity
(GO:0051006)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of toll-like receptor 4 signaling pathway
(GO:0034145)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transporter activity
(GO:0032411)
Positive regulation of triglyceride biosynthetic process
(GO:0010867)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Regulation of circadian rhythm
(GO:0042752)
Response to progesterone
(GO:0032570)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sterol homeostasis
(GO:0055092)
Sterol response element binding
(GO:0032810)
Transcription cis-regulatory region binding
(GO:0000976)
Triglyceride homeostasis
(GO:0070328)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Genular Protein ID: 4010277701

Symbol: NR1H3_HUMAN

Name: Oxysterols receptor LXR-alpha

UniProtKB Accession Codes:

Q13133 A8K3J9 D3DQR1 Q8IW13 Q96H87

Database IDs:

Citations:

PubMed ID: 7744246

Title: LXR, a nuclear receptor that defines a distinct retinoid response pathway.

PubMed ID: 7744246

DOI: 10.1101/gad.9.9.1033

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19481530

Title: GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

PubMed ID: 19481530

DOI: 10.1016/j.molcel.2009.05.006

PubMed ID: 25661920

Title: CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase.

PubMed ID: 25661920

DOI: 10.1016/j.jsbmb.2015.02.001

Sequence Information:

Length: 447
Mass: 50396
Checksum: 0D27B237440F8C9C
Sequence:

MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA GGTAGVGLEA 
AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV CGDKASGFHY NVLSCEGCKG 
FFRRSVIKGA HYICHSGGHC PMDTYMRRKC QECRLRKCRQ AGMREECVLS EEQIRLKKLK 
RQEEEQAHAT SLPPRASSPP QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM 
APDPHSREAR QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL 
ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ LNDAEFALLI 
AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD RLMFPRMLMK LVSLRTLSSV 
HSEQVFALRL QDKKLPPLLS EIWDVHE

Genular Protein ID: 879357598

Symbol: B5MBY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B5MBY7

Database IDs:

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

Length: 342
Mass: 38851
Checksum: 538BB583A1D370B0
Sequence:

MPHSAGGTAG VGLEAAEPTA LLTRAEPPSE PTEIRPQKRK KGPAPKMLGN ELCSVCGDKA 
SGFHYNVLSC EGCKGFFRRS VIKGAHYICH SGGHCPMDTY MRRKCQECRL RKCRQAGMRE 
ECVLSEEQIR LKKLKRQEEE QAHATSLPPR ASSPPQILPQ LSPEQLGMIE KLVAAQQQCN 
RRSFSDRLRV TVMLLETSRR YNPGSESITF LKDFSYNRED FAKAGLQVEF INPIFEFSRA 
MNELQLNDAE FALLIAISIF SADRPNVQDQ LQVERLQHTY VEALHAYVSI HHPHDRLMFP 
RMLMKLVSLR TLSSVHSEQV FALRLQDKKL PPLLSEIWDV HE

Genular Protein ID: 2682475464

Symbol: B4DXU5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DXU5

Database IDs:

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

Length: 453
Mass: 51113
Checksum: 819DD0503B4400ED
Sequence:

MQQTSWNPLG GTCKQPPGRT HSAVELWKPG AQDASSQAQG GSSCILREEA RMPHSAGGTA 
GVGLEAAEPT ALLTRAEPPS EPTEIRPQKR KKGPAPKMLG NELCSVCGDK ASGFHYNVLS 
CEGCKGFFRR SVIKGAHYIC HSGGHCPMDT YMRRKCQECR LRKCRQAGMR EECVLSEEQI 
RLKKLKRQEE EQAHATSLPP RASSPPQILP QLSPEQLGMI EKLVAAQQQC NRRSFSDRLR 
VTPWPMAPDP HSREARQQRF AHFTELAIVS VQEIVDFAKQ LPGFLQLSRE DQIALLKTSA 
IEVMLLETSR RYNPGSESIT FLKDFSYNRE DFAKAGLQVE FINPIFEFSR AMNELQLNDA 
EFALLIAISI FSADRPNVQD QLQVERLQHT YVEALHAYVS IHHPHDRLMF PRMLMKLVSL 
RTLSSVHSEQ VFALRLQDKK LPPLLSEIWD VHE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NR1H3

Associated with

Other Information

LXR, a nuclear receptor that defines a distinct retinoid response pathway. PubMed ID: 7744246

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. PubMed ID: 19481530

CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase. PubMed ID: 25661920

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

Database document:

PubMed ID: 7744246

PubMed ID: 14702039

PubMed ID: 16554811

PubMed ID: 15489334

PubMed ID: 19481530

PubMed ID: 25661920

PubMed ID: 16554811

PubMed ID: 16554811