Details for: IL18BP

Gene ID: 10068

Symbol: IL18BP

Ensembl ID: ENSG00000137496

Description: interleukin 18 binding protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,729
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,132
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,275
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.86
    Marker Score: 583
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,244
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.76
    Marker Score: 748
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 665
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 546
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.58
    Marker Score: 1,485
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1,109
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.54
    Marker Score: 464
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.51
    Marker Score: 1,430
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.51
    Marker Score: 986
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.47
    Marker Score: 469
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7,247
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.46
    Marker Score: 199
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.45
    Marker Score: 895
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 370
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.4
    Marker Score: 163
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 757
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.38
    Marker Score: 989
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.37
    Marker Score: 170
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.37
    Marker Score: 533
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.36
    Marker Score: 390
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.35
    Marker Score: 85
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.35
    Marker Score: 2,252
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.35
    Marker Score: 307
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.35
    Marker Score: 241
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 811
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.34
    Marker Score: 259
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.32
    Marker Score: 327
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 84
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 208
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.31
    Marker Score: 989
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.3
    Marker Score: 272
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.3
    Marker Score: 300
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.3
    Marker Score: 289
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.3
    Marker Score: 412
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.3
    Marker Score: 300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.3
    Marker Score: 829
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.29
    Marker Score: 3,422
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.29
    Marker Score: 480
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.29
    Marker Score: 424
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.28
    Marker Score: 411
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.27
    Marker Score: 242
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.27
    Marker Score: 486
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.26
    Marker Score: 255
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.26
    Marker Score: 293
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.25
    Marker Score: 1,545
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 142
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.25
    Marker Score: 2,449
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.24
    Marker Score: 1,042
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.24
    Marker Score: 586
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.24
    Marker Score: 47
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.23
    Marker Score: 456
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 96
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.22
    Marker Score: 67
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.22
    Marker Score: 136
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.22
    Marker Score: 61
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.22
    Marker Score: 12,328
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.22
    Marker Score: 11,520
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 103
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 346
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 128
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 114
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.21
    Marker Score: 43
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.21
    Marker Score: 240
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.21
    Marker Score: 46
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 197
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2
    Marker Score: 112
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2
    Marker Score: 47
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.2
    Marker Score: 218
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 192
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.2
    Marker Score: 45

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL18BP is a protein that belongs to the interleukin-18 binding protein family. It is primarily expressed in the brain, intestinal epithelium, and other tissues, where it plays a crucial role in regulating immune responses. IL18BP is known to bind to IL-18 with high affinity, thereby inhibiting its pro-inflammatory effects. This binding also prevents IL-18 from interacting with its receptor, which is essential for the activation of downstream signaling pathways. **Pathways and Functions:** IL18BP modulates immune responses through several key pathways, including: 1. **Cytokine signaling in the immune system**: IL18BP regulates the signaling pathways of IL-18, which is a potent pro-inflammatory cytokine. By binding to IL-18, IL18BP prevents its interaction with its receptor, thereby reducing the production of pro-inflammatory cytokines and attenuating the inflammatory response. 2. **Receptor antagonist activity**: IL18BP acts as a receptor antagonist, competing with IL-18 for binding to its receptor. This competition prevents the activation of downstream signaling pathways, which are essential for the production of pro-inflammatory cytokines and the initiation of an immune response. 3. **Response to lipopolysaccharide**: IL18BP has been shown to regulate the response to lipopolysaccharide (LPS), a potent stimulator of the immune system. By binding to IL-18, IL18BP reduces the production of pro-inflammatory cytokines and attenuates the inflammatory response. 4. **T-helper 1 type immune response**: IL18BP has been shown to regulate the T-helper 1 (Th1) type immune response, which is characterized by the production of pro-inflammatory cytokines. By binding to IL-18, IL18BP reduces the production of Th1 cytokines and attenuates the inflammatory response. **Clinical Significance:** IL18BP has been implicated in various diseases, including: 1. **Inflammatory bowel disease (IBD)**: IL18BP has been shown to regulate the inflammatory response in IBD, a chronic inflammatory disease of the gut. 2. **Multiple sclerosis (MS)**: IL18BP has been implicated in the pathogenesis of MS, a chronic inflammatory disease of the central nervous system. 3. **Rheumatoid arthritis (RA)**: IL18BP has been shown to regulate the inflammatory response in RA, a chronic inflammatory disease of the joints. 4. **Sepsis**: IL18BP has been implicated in the pathogenesis of sepsis, a life-threatening condition characterized by an overwhelming inflammatory response. In conclusion, IL18BP is a crucial regulator of the immune system, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which IL18BP regulates immune responses and to develop therapeutic strategies that target this protein in the treatment of diseases characterized by excessive inflammation.

Genular Protein ID: 2486443930

Symbol: I18BP_HUMAN

Name: Interleukin-18-binding protein

UniProtKB Accession Codes:

O95998 B3KUZ0 B7WPK4 O95993 O96027 Q9NZA9 Q9UBR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 12 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10023777

Title: Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.

PubMed ID: 10023777

DOI: 10.1016/s1074-7613(00)80013-8

PubMed ID: 10094485

Title: Cloning and expression of interleukin-18 binding protein.

PubMed ID: 10094485

DOI: 10.1016/s0014-5793(99)00148-9

PubMed ID: 10329540

Title: Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus.

PubMed ID: 10329540

DOI: 10.1006/viro.1999.9676

PubMed ID: 10655506

Title: Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18.

PubMed ID: 10655506

DOI: 10.1073/pnas.97.3.1190

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 31213488

Title: Inherited IL-18BP deficiency in human fulminant viral hepatitis.

PubMed ID: 31213488

DOI: 10.1084/jem.20190669

Sequence Information:

  • Length: 194
  • Mass: 21099
  • Checksum: 5E520D6E46AFA843
  • Sequence:
    • MTMRHNWTPD LSPLWVLLLC AHVVTLLVRA TPVSQTTTAA TASVRSTKDP CPSQPPVFPA 
AKQCPALEVT WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL PGRLWEGSTS 
RERGSTGTQL CKALVLEQLT PALHSTNFSC VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ 
EALPSSHSSP QQQG

Genular Protein ID: 2146389607

Symbol: G3V1C5_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V1C5 A0A024R5M6

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 3 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 199
  • Mass: 21930
  • Checksum: 97C24049FBD830BF
  • Sequence:
    • MTMRHNWTPD LSPLWVLLLC AHVVTLLVRA TPVSQTTTAA TASVRSTKDP CPSQPPVFPA 
AKQCPALEVT WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL PGRLWEGSTS 
RERGSTGTQL CKALVLEQLT PALHSTNFSC VLVDPEQVVQ RHVVLAQLWV RSPRRGLQEQ 
EELCFHMWGG KGGLCQSSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.