Details for: CDH9

Gene ID: 1007

Symbol: CDH9

Ensembl ID: ENSG00000113100

Description: cadherin 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.2008
    Cell Significance Index: -32.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.9603
    Cell Significance Index: 333.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.2379
    Cell Significance Index: 143.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.0332
    Cell Significance Index: 114.8600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.0164
    Cell Significance Index: 26.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.0100
    Cell Significance Index: 57.3600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.3036
    Cell Significance Index: 17.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2921
    Cell Significance Index: 893.6400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.1642
    Cell Significance Index: 9.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8690
    Cell Significance Index: 174.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6078
    Cell Significance Index: 218.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3909
    Cell Significance Index: 24.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1851
    Cell Significance Index: 4.4400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1030
    Cell Significance Index: 0.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0778
    Cell Significance Index: 1.8900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0504
    Cell Significance Index: 0.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0330
    Cell Significance Index: 0.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0015
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0152
    Cell Significance Index: -28.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0172
    Cell Significance Index: -31.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0205
    Cell Significance Index: -31.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0239
    Cell Significance Index: -32.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0355
    Cell Significance Index: -26.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0396
    Cell Significance Index: -25.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0415
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0509
    Cell Significance Index: -37.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0584
    Cell Significance Index: -26.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0611
    Cell Significance Index: -2.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0679
    Cell Significance Index: -38.3000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0840
    Cell Significance Index: -0.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0879
    Cell Significance Index: -25.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1022
    Cell Significance Index: -20.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1071
    Cell Significance Index: -2.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1093
    Cell Significance Index: -3.5800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1266
    Cell Significance Index: -1.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1288
    Cell Significance Index: -3.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1349
    Cell Significance Index: -1.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1352
    Cell Significance Index: -24.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1574
    Cell Significance Index: -2.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1600
    Cell Significance Index: -23.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1849
    Cell Significance Index: -38.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1993
    Cell Significance Index: -2.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2025
    Cell Significance Index: -24.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2111
    Cell Significance Index: -28.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2157
    Cell Significance Index: -36.8300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2254
    Cell Significance Index: -1.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2641
    Cell Significance Index: -26.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2666
    Cell Significance Index: -8.4900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2672
    Cell Significance Index: -5.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2916
    Cell Significance Index: -33.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2959
    Cell Significance Index: -7.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3189
    Cell Significance Index: -33.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3298
    Cell Significance Index: -26.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3414
    Cell Significance Index: -39.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3612
    Cell Significance Index: -4.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3650
    Cell Significance Index: -28.0100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4015
    Cell Significance Index: -8.3800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.4110
    Cell Significance Index: -3.2700
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.4169
    Cell Significance Index: -3.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4631
    Cell Significance Index: -10.0100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4723
    Cell Significance Index: -3.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5064
    Cell Significance Index: -32.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5474
    Cell Significance Index: -28.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5531
    Cell Significance Index: -31.0400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.5912
    Cell Significance Index: -4.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6524
    Cell Significance Index: -30.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6594
    Cell Significance Index: -23.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6910
    Cell Significance Index: -31.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6913
    Cell Significance Index: -35.9100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.7406
    Cell Significance Index: -7.4600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7659
    Cell Significance Index: -10.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8834
    Cell Significance Index: -31.0400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9403
    Cell Significance Index: -29.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9472
    Cell Significance Index: -27.9000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0275
    Cell Significance Index: -20.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0493
    Cell Significance Index: -22.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0749
    Cell Significance Index: -30.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.1226
    Cell Significance Index: -19.4100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.1240
    Cell Significance Index: -22.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1276
    Cell Significance Index: -24.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1998
    Cell Significance Index: -32.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.2040
    Cell Significance Index: -23.5400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -1.2154
    Cell Significance Index: -2.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2200
    Cell Significance Index: -31.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.2458
    Cell Significance Index: -31.7400
  • Cell Name: interneuron (CL0000099)
    Fold Change: -1.2474
    Cell Significance Index: -14.5700
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -1.2627
    Cell Significance Index: -15.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.2643
    Cell Significance Index: -33.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2732
    Cell Significance Index: -33.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2906
    Cell Significance Index: -32.9700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.2933
    Cell Significance Index: -32.2500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.3213
    Cell Significance Index: -33.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3870
    Cell Significance Index: -23.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.4954
    Cell Significance Index: -31.0200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.5105
    Cell Significance Index: -18.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5350
    Cell Significance Index: -41.1300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.5890
    Cell Significance Index: -38.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.5912
    Cell Significance Index: -26.6300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.6162
    Cell Significance Index: -21.8100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -1.6169
    Cell Significance Index: -24.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDH9 is a type II transmembrane protein, consisting of an extracellular domain, a cytoplasmic domain, and a transmembrane domain. The extracellular domain is responsible for binding to other CDH9 molecules, while the cytoplasmic domain interacts with the actin cytoskeleton, modulating cell shape and adhesion. CDH9 is highly homophilic, meaning it binds to itself, and is also capable of interacting with other cadherins, such as E-cadherin. **Pathways and Functions:** CDH9 is involved in various cellular processes, including: 1. **Cell-cell adhesion**: CDH9 facilitates the formation and maintenance of adherens junctions, which are essential for tissue structure and organization. 2. **Cell junction organization**: CDH9 interacts with other cell adhesion molecules, such as E-cadherin and N-cadherin, to regulate the organization and dynamics of cell junctions. 3. **Cell morphogenesis**: CDH9 plays a role in the regulation of cellular shape and morphology, particularly during development and tissue remodeling. 4. **Synaptic transmission**: CDH9 is expressed in the nervous system and is involved in the organization of synaptic junctions and the regulation of neurotransmitter release. **Significantly Expressed Cells:** CDH9 is expressed in a wide range of cell types, including: 1. **Interneurons**: CDH9 is highly expressed in interneurons, which are a type of neuron that plays a critical role in regulating neural activity and synchrony. 2. **Endothelial cells**: CDH9 is expressed in endothelial cells, which line blood vessels and play a key role in blood pressure regulation and vascular development. 3. **Neurons**: CDH9 is expressed in various types of neurons, including L6b glutamatergic cortical neurons and chandelier GABAergic cortical interneurons. 4. **Conventional dendritic cells**: CDH9 is expressed in conventional dendritic cells, which are a type of immune cell involved in antigen presentation and immune regulation. **Clinical Significance:** Dysregulation of CDH9 has been implicated in various diseases, including: 1. **Cancer**: CDH9 is often downregulated in cancer cells, leading to loss of cell-cell adhesion and increased tumor aggressiveness. 2. **Neurological disorders**: CDH9 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where disruptions in cell-cell adhesion and synaptic transmission are thought to contribute to disease progression. 3. **Cardiovascular disease**: CDH9 has been shown to play a role in the development of cardiovascular disease, where disruptions in endothelial cell function and blood vessel structure can contribute to disease progression. In conclusion, CDH9 is a critical regulator of cell-cell adhesion and tissue structure, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the role of CDH9 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3085550415

Symbol: CADH9_HUMAN

Name: Cadherin-9

UniProtKB Accession Codes:

Q9ULB4 Q3B7I5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 789
  • Mass: 88689
  • Checksum: C580DA16B769047C
  • Sequence:
    • MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR TKRGWMWNQF 
FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL FVIDENTGDI HAAKKLDREE 
KSLYILRAKA IDRKTGRQVE PESEFIIKIH DINDNEPKFT KDLYTASVPE MSGVGTSVIQ 
VTATDADDAN YGNSAKVVYS ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD 
MGGQMGGLSG TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN 
AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS NTHPDPRFLH 
LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS IIGQVTAYDP DARNNLIKYS 
VDRHTDMDRI FGIHSENGSI FTLKALDRES SPWHNITVTA TEINNPKQSS HIPVFIRILD 
INDHAPEFAM YYETFVCENA KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV 
DNKDNTAGIM TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC 
TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD DVRDNIVTYN 
DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI RRTVPLWENI DVQDFIHRRL 
KENDADPSAP PYDSLATYAY EGNDSIADSL SSLESLTADC NQDYDYLSDW GPRFKKLADM 
YGGDDSDRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.