Gene CDH9 - ENSG00000113100 | NCBI Gene ID: 1007

Details for: CDH9

Gene ID: 1007

Symbol: CDH9

Ensembl ID: ENSG00000113100

Description: cadherin 9

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Adherens junction
(GO:0005912)
Adherens junction organization
(GO:0034332)
Cadherin binding
(GO:0045296)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium ion binding
(GO:0005509)
Catenin complex
(GO:0016342)
Cell-cell adhesion
(GO:0098609)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell junction assembly
(GO:0007043)
Cell morphogenesis
(GO:0000902)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Molecular_function
(GO:0003674)
Multicellular organism development
(GO:0007275)
Plasma membrane
(GO:0005886)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Synapse assembly
(GO:0007416)
Synaptic membrane adhesion
(GO:0099560)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: interneuron (CL0000099)
Fold Change: 4.96
Marker Score: 2263
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.14
Marker Score: 3159
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.79
Marker Score: 55549
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.74
Marker Score: 21040
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.48
Marker Score: 7065
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.33
Marker Score: 9651
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.16
Marker Score: 79747
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.84
Marker Score: 3487.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.84
Marker Score: 15773.5
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.83
Marker Score: 1264.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.8
Marker Score: 16935
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.66
Marker Score: 63146
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.33
Marker Score: 4470
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.33
Marker Score: 12639
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 1.29
Marker Score: 1232
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.26
Marker Score: 759
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.25
Marker Score: 2532
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.19
Marker Score: 2803
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.18
Marker Score: 4916
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.18
Marker Score: 4178
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.17
Marker Score: 740
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.14
Marker Score: 69969
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.1
Marker Score: 16437
Cell Name: macrophage (CL0000235)
Fold Change: 1.06
Marker Score: 1181
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71794
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48019
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5346
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.91
Marker Score: 697
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: neuron (CL0000540)
Fold Change: 0.84
Marker Score: 3433
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.83
Marker Score: 12937
Cell Name: goblet cell (CL0000160)
Fold Change: 0.82
Marker Score: 5460
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.82
Marker Score: 1371
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.82
Marker Score: 3155
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.69
Marker Score: 832
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.68
Marker Score: 326
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 475
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.58
Marker Score: 409
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.56
Marker Score: 265
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.55
Marker Score: 254
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.54
Marker Score: 243
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.54
Marker Score: 173
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.52
Marker Score: 596
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.52
Marker Score: 555.5
Cell Name: granule cell (CL0000120)
Fold Change: 0.49
Marker Score: 3731.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.47
Marker Score: 500
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 274
Cell Name: podocyte (CL0000653)
Fold Change: 0.45
Marker Score: 167
Cell Name: B cell (CL0000236)
Fold Change: 0.45
Marker Score: 430
Cell Name: mast cell (CL0000097)
Fold Change: 0.45
Marker Score: 259
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.42
Marker Score: 2222.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.41
Marker Score: 8819
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.4
Marker Score: 125
Cell Name: astrocyte (CL0000127)
Fold Change: 0.39
Marker Score: 340
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.38
Marker Score: 99
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.37
Marker Score: 163
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.36
Marker Score: 701
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.36
Marker Score: 580
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.36
Marker Score: 3681.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.36
Marker Score: 550
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.35
Marker Score: 133
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.34
Marker Score: 224
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.33
Marker Score: 3302
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.32
Marker Score: 135
Cell Name: stromal cell (CL0000499)
Fold Change: 0.32
Marker Score: 378
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.32
Marker Score: 112
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.3
Marker Score: 503
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.28
Marker Score: 101
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.28
Marker Score: 182
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.26
Marker Score: 371
Cell Name: leukocyte (CL0000738)
Fold Change: 0.26
Marker Score: 150
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.26
Marker Score: 56.5
Cell Name: keratocyte (CL0002363)
Fold Change: 0.25
Marker Score: 57.5
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.24
Marker Score: 1105
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.24
Marker Score: 56
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.24
Marker Score: 60.5
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.23
Marker Score: 233
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.23
Marker Score: 284
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.22
Marker Score: 59
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.22
Marker Score: 57.5
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.22
Marker Score: 58.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.22
Marker Score: 333
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.22
Marker Score: 205
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.21
Marker Score: 73
Cell Name: glial cell (CL0000125)
Fold Change: 0.21
Marker Score: 235.5
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.21
Marker Score: 114
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.21
Marker Score: 70
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.21
Marker Score: 122
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.21
Marker Score: 58.5
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.21
Marker Score: 430
Cell Name: plasma cell (CL0000786)
Fold Change: 0.21
Marker Score: 232
Cell Name: neutrophil (CL0000775)
Fold Change: 0.21
Marker Score: 125

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**Key characteristics:** - CDH9 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a type of cadherin, a family of cell adhesion molecules that are characterized by their ability to mediate cell-cell adhesion. - CDH9 is a transmembrane protein that is expressed in a variety of cell types, including neurons, endothelial cells, and cardiac cells. - It is a key component of the adherens junction, a specialized cell adhesion mechanism that facilitates cell-cell interactions in tissues such as the brain and the cardiovascular system. **Pathways and functions:** - CDH9 is involved in cell-cell adhesion through the adherens junction. - The adherens junction is a complex network of adhesion molecules that holds cells together and allows them to adhere to each other. - It is essential for many cellular processes, including tissue morphogenesis, neuronal development, and blood vessel formation. - Mutations in CDH9 have been linked to several human diseases, including autism and schizophrenia. **Clinical significance:** - CDH9 is a promising target for cancer immunotherapy. - Inhibition of CDH9 has been shown to inhibit cell adhesion and migration, leading to cell death. - This makes CDH9 a potential therapeutic target for a variety of cancers, including breast cancer, lung cancer, and colon cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cadherin-9

Genular Protein ID: 3085550415

Symbol: CADH9_HUMAN

Name: Cadherin-9

UniProtKB Accession Codes:

Q9ULB4 Q3B7I5

Database IDs:

Citations:

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 789
Mass: 88689
Checksum: C580DA16B769047C
Sequence:

MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR TKRGWMWNQF 
FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL FVIDENTGDI HAAKKLDREE 
KSLYILRAKA IDRKTGRQVE PESEFIIKIH DINDNEPKFT KDLYTASVPE MSGVGTSVIQ 
VTATDADDAN YGNSAKVVYS ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD 
MGGQMGGLSG TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN 
AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS NTHPDPRFLH 
LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS IIGQVTAYDP DARNNLIKYS 
VDRHTDMDRI FGIHSENGSI FTLKALDRES SPWHNITVTA TEINNPKQSS HIPVFIRILD 
INDHAPEFAM YYETFVCENA KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV 
DNKDNTAGIM TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC 
TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD DVRDNIVTYN 
DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI RRTVPLWENI DVQDFIHRRL 
KENDADPSAP PYDSLATYAY EGNDSIADSL SSLESLTADC NQDYDYLSDW GPRFKKLADM 
YGGDDSDRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.