Details for: CDH10

Gene ID: 1008

Symbol: CDH10

Ensembl ID: ENSG00000040731

Description: cadherin 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.1697
    Cell Significance Index: 635.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.7048
    Cell Significance Index: 970.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.6848
    Cell Significance Index: 48.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4536
    Cell Significance Index: 97.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2807
    Cell Significance Index: 78.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0544
    Cell Significance Index: 729.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5245
    Cell Significance Index: 12.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4622
    Cell Significance Index: 7.9200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0085
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0278
    Cell Significance Index: -52.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0316
    Cell Significance Index: -58.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0373
    Cell Significance Index: -57.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0450
    Cell Significance Index: -61.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0636
    Cell Significance Index: -47.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0854
    Cell Significance Index: -64.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0912
    Cell Significance Index: -57.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1046
    Cell Significance Index: -58.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1057
    Cell Significance Index: -66.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1302
    Cell Significance Index: -59.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1713
    Cell Significance Index: -49.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1907
    Cell Significance Index: -2.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2195
    Cell Significance Index: -43.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2657
    Cell Significance Index: -8.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2741
    Cell Significance Index: -5.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2765
    Cell Significance Index: -49.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2940
    Cell Significance Index: -16.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3033
    Cell Significance Index: -63.8900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3081
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3542
    Cell Significance Index: -60.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3729
    Cell Significance Index: -4.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3934
    Cell Significance Index: -57.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4253
    Cell Significance Index: -18.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4326
    Cell Significance Index: -53.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4703
    Cell Significance Index: -54.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4982
    Cell Significance Index: -68.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5287
    Cell Significance Index: -13.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5335
    Cell Significance Index: -14.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5539
    Cell Significance Index: -57.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5607
    Cell Significance Index: -64.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5962
    Cell Significance Index: -6.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6246
    Cell Significance Index: -8.9400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6568
    Cell Significance Index: -8.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7142
    Cell Significance Index: -6.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7658
    Cell Significance Index: -58.7700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8336
    Cell Significance Index: -10.8100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9112
    Cell Significance Index: -11.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9288
    Cell Significance Index: -35.1700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9332
    Cell Significance Index: -13.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9748
    Cell Significance Index: -16.8600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.0058
    Cell Significance Index: -9.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0123
    Cell Significance Index: -32.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0316
    Cell Significance Index: -65.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0388
    Cell Significance Index: -54.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0563
    Cell Significance Index: -26.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0714
    Cell Significance Index: -56.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1096
    Cell Significance Index: -38.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1730
    Cell Significance Index: -54.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1807
    Cell Significance Index: -25.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.2308
    Cell Significance Index: -57.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3908
    Cell Significance Index: -72.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.5496
    Cell Significance Index: -30.5000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.6133
    Cell Significance Index: -33.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.6630
    Cell Significance Index: -41.4700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.7353
    Cell Significance Index: -19.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.7445
    Cell Significance Index: -60.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.7480
    Cell Significance Index: -42.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.7582
    Cell Significance Index: -61.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.7791
    Cell Significance Index: -37.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.9041
    Cell Significance Index: -37.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.9229
    Cell Significance Index: -52.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.9679
    Cell Significance Index: -43.0900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.9783
    Cell Significance Index: -32.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.0000
    Cell Significance Index: -43.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0493
    Cell Significance Index: -60.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.0497
    Cell Significance Index: -58.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.0503
    Cell Significance Index: -64.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -2.1020
    Cell Significance Index: -28.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.1373
    Cell Significance Index: -61.5800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -2.1381
    Cell Significance Index: -26.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.1536
    Cell Significance Index: -56.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -2.1817
    Cell Significance Index: -58.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.1817
    Cell Significance Index: -58.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.2756
    Cell Significance Index: -60.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -2.2973
    Cell Significance Index: -58.5300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.3147
    Cell Significance Index: -47.1000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.3376
    Cell Significance Index: -27.9600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -2.4734
    Cell Significance Index: -32.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -2.4736
    Cell Significance Index: -16.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.4767
    Cell Significance Index: -61.9100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -2.4792
    Cell Significance Index: -61.9200
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -2.4973
    Cell Significance Index: -25.6800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -2.6723
    Cell Significance Index: -35.0000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.6804
    Cell Significance Index: -57.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -2.7018
    Cell Significance Index: -62.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -2.7447
    Cell Significance Index: -66.9700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -2.7589
    Cell Significance Index: -41.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -2.7646
    Cell Significance Index: -43.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -2.8301
    Cell Significance Index: -32.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.9350
    Cell Significance Index: -49.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.9686
    Cell Significance Index: -61.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDH10 is a type of cadherin, specifically a type II transmembrane cadherin, which is characterized by its ability to bind to other cadherins through homophilic interactions. This binding is mediated by the extracellular domain of the cadherin, which contains a cadherin domain and a calcium-binding site. The cytoplasmic domain of CDH10 interacts with catenins, which are cytoskeletal proteins that regulate cell-cell adhesion and cytoskeletal organization. **Pathways and Functions:** CDH10 plays a critical role in maintaining cell-cell adhesion and tissue structure through its interaction with other cadherins and catenins. The cadherin-catenin complex regulates the organization of the actin cytoskeleton, which is essential for cell-cell adhesion and tissue integrity. In addition, CDH10 is involved in synaptic function, particularly in the development and maintenance of GABAergic and glutamatergic synapses. CDH10 has been implicated in several cellular processes, including: 1. Cell-cell adhesion: CDH10 mediates homophilic cell-cell adhesion, which is essential for maintaining tissue structure and preventing cell migration. 2. Synaptic function: CDH10 is involved in the development and maintenance of GABAergic and glutamatergic synapses, which are critical for neuronal communication. 3. Cytoskeletal organization: The cadherin-catenin complex regulates the organization of the actin cytoskeleton, which is essential for cell-cell adhesion and tissue integrity. 4. Cell migration: CDH10 has been shown to regulate cell migration, particularly in the context of tissue development and repair. **Clinical Significance:** CDH10 has been implicated in several diseases and disorders, including: 1. Autism Spectrum Disorder (ASD): CDH10 has been shown to be associated with ASD, particularly in the context of synaptic function and cell-cell adhesion. 2. Schizophrenia: CDH10 has been implicated in schizophrenia, particularly in the context of synaptic dysfunction and cell-cell adhesion. 3. Neurological disorders: CDH10 has been shown to play a role in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, CDH10 is a critical cadherin that plays a key role in maintaining cell-cell adhesion and synaptic function. Its dysregulation has been implicated in several diseases and disorders, highlighting the importance of CDH10 in maintaining tissue structure and neuronal communication. **References:** 1. [Insert references to studies on CDH10 and its role in cell-cell adhesion, synaptic function, and disease] 2. [Insert references to studies on CDH10 and its expression in various tissues and cells] Note: The references provided are fictional and for demonstration purposes only.

Genular Protein ID: 3387144342

Symbol: CAD10_HUMAN

Name: Cadherin-10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10386616

Title: The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14.

PubMed ID: 10386616

DOI: 10.1016/s0014-5793(99)00672-9

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 788
  • Mass: 88451
  • Checksum: E92908F9C19270B2
  • Sequence:
  • MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH RQKRGWMWNQ 
    FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT LFIIDEKTGD IHATRRIDRE 
    EKAFYTLRAQ AINRRTLRPV EPESEFVIKI HDINDNEPTF PEEIYTASVP EMSVVGTSVV 
    QVTATDADDP SYGNSARVIY SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK 
    DMGGQMGGLS GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK 
    NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA ENTHVDPRFY 
    YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG TIIGTVMARD PDSISSPIRF 
    SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE LSQWHNLTVI AAEINNPKET TRVAVFVRIL 
    DVNDNAPQFA VFYDTFVCEN ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN 
    EDNTARILTR KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA 
    EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI RDNIVSYNDE 
    GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR TPTAPDNTDV RDFINERLKE 
    HDLDPTAPPY DSLATYAYEG NDSIAESLSS LESGTTEGDQ NYDYLREWGP RFNKLAEMYG 
    GGESDKDS

Genular Protein ID: 1021831221

Symbol: X5DNG6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 786
  • Mass: 88239
  • Checksum: 3BE3B1BD6B060377
  • Sequence:
  • MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH RQKRGWMWNQ 
    FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT LFIIDEKTGD IHATRRIDRE 
    EKAFYTLRAQ AINRRTLRPV EPESEFVIKI HDINDNEPTF PEEIYTASVP EMSVVGTSVV 
    QVTATDADDP SYGNSARVIY SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK 
    DMGGQMGGLS GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK 
    NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA ENTHVDPRFY 
    YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG TIIGTVMARD PDSISSPIRF 
    SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE LSQWHNLTVI AAEINNPKET TRVAVFVRIL 
    DVNDNAPQFA VFYDTFVCEN ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN 
    EDNTARILTR KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA 
    EALLLPAGLS TGALIAILLC IIILLVVLFA ALKRQRKKEP LILSKEDIRD NIVSYNDEGG 
    GEEDTQAFDI GTLRNPAAIE EKKLRRDIIP ETLFIPRRTP TAPDNTDVRD FINERLKEHD 
    LDPTAPPYDS LATYAYEGND SIAESLSSLE SGTTEGDQNY DYLREWGPRF NKLAEMYGGG 
    ESDKDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.