Details for: CDH10

Gene ID: 1008

Symbol: CDH10

Ensembl ID: ENSG00000040731

Description: cadherin 10

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.61
    Marker Score: 98,970
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.58
    Marker Score: 51,243
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.54
    Marker Score: 19,454
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.42
    Marker Score: 1,087
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.26
    Marker Score: 4,670
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1
    Marker Score: 8,127
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.1
    Marker Score: 19,739
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.09
    Marker Score: 2,580
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.08
    Marker Score: 44,382
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127,312
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.95
    Marker Score: 1,694
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,141
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.82
    Marker Score: 7,417
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.79
    Marker Score: 7,433
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.75
    Marker Score: 2,117
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.73
    Marker Score: 17,865
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.67
    Marker Score: 3,161
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.63
    Marker Score: 2,738
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.57
    Marker Score: 657
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2,389
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.51
    Marker Score: 4,317
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,833
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.4
    Marker Score: 51,820
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.35
    Marker Score: 892
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.34
    Marker Score: 12,718
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2,565
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.22
    Marker Score: 735
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.21
    Marker Score: 332
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.12
    Marker Score: 650
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2,537
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,035
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.99
    Marker Score: 968
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,335
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.93
    Marker Score: 6,149
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.84
    Marker Score: 12,492
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.82
    Marker Score: 3,783
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12,750
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.76
    Marker Score: 294
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.75
    Marker Score: 3,136
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.68
    Marker Score: 275
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.68
    Marker Score: 485
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.64
    Marker Score: 21,583
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.64
    Marker Score: 1,163
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.62
    Marker Score: 1,427
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 487
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.59
    Marker Score: 241
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.59
    Marker Score: 153
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.59
    Marker Score: 310
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.58
    Marker Score: 253
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.58
    Marker Score: 320
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.58
    Marker Score: 665
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.57
    Marker Score: 399
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 176
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 245
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.51
    Marker Score: 176
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.47
    Marker Score: 3,556
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.47
    Marker Score: 1,126
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.45
    Marker Score: 4,539
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.45
    Marker Score: 499
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.44
    Marker Score: 245
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.43
    Marker Score: 151
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 734
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.42
    Marker Score: 1,217
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 245
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 398
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.4
    Marker Score: 753
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.4
    Marker Score: 439
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.39
    Marker Score: 914
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.38
    Marker Score: 195
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.37
    Marker Score: 1,523
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 159
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 297
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.31
    Marker Score: 112
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.29
    Marker Score: 1,015
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.28
    Marker Score: 349
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.27
    Marker Score: 231
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.27
    Marker Score: 76
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.27
    Marker Score: 457
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.26
    Marker Score: 78
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.26
    Marker Score: 74
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.26
    Marker Score: 1,373
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.25
    Marker Score: 350

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDH10 is a type of cadherin, specifically a type II transmembrane cadherin, which is characterized by its ability to bind to other cadherins through homophilic interactions. This binding is mediated by the extracellular domain of the cadherin, which contains a cadherin domain and a calcium-binding site. The cytoplasmic domain of CDH10 interacts with catenins, which are cytoskeletal proteins that regulate cell-cell adhesion and cytoskeletal organization. **Pathways and Functions:** CDH10 plays a critical role in maintaining cell-cell adhesion and tissue structure through its interaction with other cadherins and catenins. The cadherin-catenin complex regulates the organization of the actin cytoskeleton, which is essential for cell-cell adhesion and tissue integrity. In addition, CDH10 is involved in synaptic function, particularly in the development and maintenance of GABAergic and glutamatergic synapses. CDH10 has been implicated in several cellular processes, including: 1. Cell-cell adhesion: CDH10 mediates homophilic cell-cell adhesion, which is essential for maintaining tissue structure and preventing cell migration. 2. Synaptic function: CDH10 is involved in the development and maintenance of GABAergic and glutamatergic synapses, which are critical for neuronal communication. 3. Cytoskeletal organization: The cadherin-catenin complex regulates the organization of the actin cytoskeleton, which is essential for cell-cell adhesion and tissue integrity. 4. Cell migration: CDH10 has been shown to regulate cell migration, particularly in the context of tissue development and repair. **Clinical Significance:** CDH10 has been implicated in several diseases and disorders, including: 1. Autism Spectrum Disorder (ASD): CDH10 has been shown to be associated with ASD, particularly in the context of synaptic function and cell-cell adhesion. 2. Schizophrenia: CDH10 has been implicated in schizophrenia, particularly in the context of synaptic dysfunction and cell-cell adhesion. 3. Neurological disorders: CDH10 has been shown to play a role in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, CDH10 is a critical cadherin that plays a key role in maintaining cell-cell adhesion and synaptic function. Its dysregulation has been implicated in several diseases and disorders, highlighting the importance of CDH10 in maintaining tissue structure and neuronal communication. **References:** 1. [Insert references to studies on CDH10 and its role in cell-cell adhesion, synaptic function, and disease] 2. [Insert references to studies on CDH10 and its expression in various tissues and cells] Note: The references provided are fictional and for demonstration purposes only.

Genular Protein ID: 3387144342

Symbol: CAD10_HUMAN

Name: Cadherin-10

UniProtKB Accession Codes:

Q9Y6N8 Q9ULB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10386616

Title: The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14.

PubMed ID: 10386616

DOI: 10.1016/s0014-5793(99)00672-9

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 788
  • Mass: 88451
  • Checksum: E92908F9C19270B2
  • Sequence:
    • MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH RQKRGWMWNQ 
FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT LFIIDEKTGD IHATRRIDRE 
EKAFYTLRAQ AINRRTLRPV EPESEFVIKI HDINDNEPTF PEEIYTASVP EMSVVGTSVV 
QVTATDADDP SYGNSARVIY SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK 
DMGGQMGGLS GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK 
NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA ENTHVDPRFY 
YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG TIIGTVMARD PDSISSPIRF 
SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE LSQWHNLTVI AAEINNPKET TRVAVFVRIL 
DVNDNAPQFA VFYDTFVCEN ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN 
EDNTARILTR KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA 
EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI RDNIVSYNDE 
GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR TPTAPDNTDV RDFINERLKE 
HDLDPTAPPY DSLATYAYEG NDSIAESLSS LESGTTEGDQ NYDYLREWGP RFNKLAEMYG 
GGESDKDS

Genular Protein ID: 1021831221

Symbol: X5DNG6_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5DNG6

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 RuleBase 2 SAM 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 786
  • Mass: 88239
  • Checksum: 3BE3B1BD6B060377
  • Sequence:
    • MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH RQKRGWMWNQ 
FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT LFIIDEKTGD IHATRRIDRE 
EKAFYTLRAQ AINRRTLRPV EPESEFVIKI HDINDNEPTF PEEIYTASVP EMSVVGTSVV 
QVTATDADDP SYGNSARVIY SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK 
DMGGQMGGLS GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK 
NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA ENTHVDPRFY 
YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG TIIGTVMARD PDSISSPIRF 
SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE LSQWHNLTVI AAEINNPKET TRVAVFVRIL 
DVNDNAPQFA VFYDTFVCEN ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN 
EDNTARILTR KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA 
EALLLPAGLS TGALIAILLC IIILLVVLFA ALKRQRKKEP LILSKEDIRD NIVSYNDEGG 
GEEDTQAFDI GTLRNPAAIE EKKLRRDIIP ETLFIPRRTP TAPDNTDVRD FINERLKEHD 
LDPTAPPYDS LATYAYEGND SIAESLSSLE SGTTEGDQNY DYLREWGPRF NKLAEMYGGG 
ESDKDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.