Details for: CDH10

Gene ID: 1008

Symbol: CDH10

Ensembl ID: ENSG00000040731

Description: cadherin 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.61
    Marker Score: 98970
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.58
    Marker Score: 51243
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.54
    Marker Score: 19454
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.42
    Marker Score: 1087
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.26
    Marker Score: 4670
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1
    Marker Score: 8127
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.1
    Marker Score: 19739
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.09
    Marker Score: 2580
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.08
    Marker Score: 44382
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127312
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.95
    Marker Score: 1694
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16141
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.82
    Marker Score: 7417
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.79
    Marker Score: 7433
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.75
    Marker Score: 2117
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.73
    Marker Score: 17865
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.67
    Marker Score: 3161
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.63
    Marker Score: 2738
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.57
    Marker Score: 657
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2389
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.51
    Marker Score: 4317
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169833
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.4
    Marker Score: 51820
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.35
    Marker Score: 891.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.34
    Marker Score: 12718
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2565
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.22
    Marker Score: 735
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.21
    Marker Score: 332
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.12
    Marker Score: 650
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48035
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.99
    Marker Score: 968
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.93
    Marker Score: 6149
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.84
    Marker Score: 12492
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.82
    Marker Score: 3783
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12750
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.76
    Marker Score: 294
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.75
    Marker Score: 3136
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.68
    Marker Score: 275
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.68
    Marker Score: 485
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.64
    Marker Score: 21583
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.64
    Marker Score: 1163
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.62
    Marker Score: 1427
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 487
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.59
    Marker Score: 241
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.59
    Marker Score: 153
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.59
    Marker Score: 310
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.58
    Marker Score: 253
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.58
    Marker Score: 320
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.58
    Marker Score: 665
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.57
    Marker Score: 399
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 176
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 245
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.51
    Marker Score: 176
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.47
    Marker Score: 3556
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.47
    Marker Score: 1125.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.45
    Marker Score: 4539
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.45
    Marker Score: 499
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.44
    Marker Score: 245
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.43
    Marker Score: 151
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 734
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.42
    Marker Score: 1217
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 245
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 398
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.4
    Marker Score: 753
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.4
    Marker Score: 439
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.39
    Marker Score: 914
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.38
    Marker Score: 195
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.37
    Marker Score: 1523
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 159
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 297
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.31
    Marker Score: 112
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.29
    Marker Score: 1015
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.28
    Marker Score: 349
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.27
    Marker Score: 231
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.27
    Marker Score: 76
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.27
    Marker Score: 457
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.26
    Marker Score: 78
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.26
    Marker Score: 74
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.26
    Marker Score: 1373
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.25
    Marker Score: 350

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Other Information

**Key characteristics:** * CDH10 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a type of cadherin that is expressed in adherens junctions, which are cell-cell contacts that hold tissues together. * CDH10 is a highly conserved protein, with a similar sequence in mammals, birds, and reptiles. * It is a key component of the adherens junction complex, which is responsible for the assembly and maintenance of tissue junctions. **Pathways and functions:** * CDH10 is involved in a variety of cellular processes, including cell adhesion, migration, and signaling. * It is important for the formation and maintenance of neural tissue. * It is involved in the organization of adherens junctions, which are essential for cell-cell communication and tissue integrity. * CDH10 is also involved in the regulation of neuronal differentiation and survival. **Clinical significance:** * Mutations in CDH10 have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * These mutations can disrupt the assembly and function of adherens junctions, leading to the formation of abnormal tissue connections and the development of neurological symptoms. * Targeting CDH10 has been investigated as a potential therapeutic strategy for these disorders. **Additional information:** * CDH10 is a member of the cadherin family of cell adhesion molecules. Cadherins are a large family of proteins that are involved in cell-cell adhesion, migration, and signaling. * CDH10 is a transmembrane protein that is expressed on the surface of endothelial cells, neurons, and astrocytes. * It is a highly dynamic protein that undergoes changes in expression and localization in response to a variety of stimuli.

Genular Protein ID: 3387144342

Symbol: CAD10_HUMAN

Name: Cadherin-10

UniProtKB Accession Codes:

Q9Y6N8 Q9ULB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10386616

Title: The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14.

PubMed ID: 10386616

DOI: 10.1016/s0014-5793(99)00672-9

PubMed ID: 10861224

Title: Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

PubMed ID: 10861224

DOI: 10.1042/0264-6021:3490159

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 788
  • Mass: 88451
  • Checksum: E92908F9C19270B2
  • Sequence:
    • MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH RQKRGWMWNQ 
FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT LFIIDEKTGD IHATRRIDRE 
EKAFYTLRAQ AINRRTLRPV EPESEFVIKI HDINDNEPTF PEEIYTASVP EMSVVGTSVV 
QVTATDADDP SYGNSARVIY SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK 
DMGGQMGGLS GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK 
NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA ENTHVDPRFY 
YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG TIIGTVMARD PDSISSPIRF 
SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE LSQWHNLTVI AAEINNPKET TRVAVFVRIL 
DVNDNAPQFA VFYDTFVCEN ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN 
EDNTARILTR KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA 
EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI RDNIVSYNDE 
GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR TPTAPDNTDV RDFINERLKE 
HDLDPTAPPY DSLATYAYEG NDSIAESLSS LESGTTEGDQ NYDYLREWGP RFNKLAEMYG 
GGESDKDS

Genular Protein ID: 1021831221

Symbol: X5DNG6_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5DNG6

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 RuleBase 2 SAM 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 786
  • Mass: 88239
  • Checksum: 3BE3B1BD6B060377
  • Sequence:
    • MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH RQKRGWMWNQ 
FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT LFIIDEKTGD IHATRRIDRE 
EKAFYTLRAQ AINRRTLRPV EPESEFVIKI HDINDNEPTF PEEIYTASVP EMSVVGTSVV 
QVTATDADDP SYGNSARVIY SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK 
DMGGQMGGLS GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK 
NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA ENTHVDPRFY 
YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG TIIGTVMARD PDSISSPIRF 
SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE LSQWHNLTVI AAEINNPKET TRVAVFVRIL 
DVNDNAPQFA VFYDTFVCEN ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN 
EDNTARILTR KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA 
EALLLPAGLS TGALIAILLC IIILLVVLFA ALKRQRKKEP LILSKEDIRD NIVSYNDEGG 
GEEDTQAFDI GTLRNPAAIE EKKLRRDIIP ETLFIPRRTP TAPDNTDVRD FINERLKEHD 
LDPTAPPYDS LATYAYEGND SIAESLSSLE SGTTEGDQNY DYLREWGPRF NKLAEMYGGG 
ESDKDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.