PQBP1 | ENSG00000102103 | NCBI 10084

Details for: PQBP1

Gene ID: 10084

Symbol: PQBP1

Ensembl ID: ENSG00000102103

Description: polyglutamine binding protein 1

Associated with

Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Activation of innate immune response
(GO:0002218)
Alternative mrna splicing, via spliceosome
(GO:0000380)
Cellular response to exogenous dsrna
(GO:0071360)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Defense response to virus
(GO:0051607)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Innate immune response
(GO:0045087)
Neuronal ribonucleoprotein granule
(GO:0071598)
Neuron projection development
(GO:0031175)
Nuclear body
(GO:0016604)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of defense response to virus by host
(GO:0002230)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of type i interferon production
(GO:0032481)
Protein binding
(GO:0005515)
Regulation of dendrite morphogenesis
(GO:0048814)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of rna splicing
(GO:0043484)
Ribonucleoprotein complex binding
(GO:0043021)
Transcription coactivator activity
(GO:0003713)

Other Information

Proteins

PQBP1_HUMAN

Genular Protein ID: 1419502407

Symbol: PQBP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60828 C9JQA1 Q4VY25 Q4VY26 Q4VY27 Q4VY29 Q4VY30 Q4VY34 Q4VY35 Q4VY36 Q4VY37 Q4VY38 Q9GZP2 Q9GZU4 Q9GZZ4

Database IDs:

Citations:

PubMed ID: 10332029

Title: PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival.

PubMed ID: 10332029

DOI: 10.1093/hmg/8.6.977

PubMed ID: 10198427

Title: Npw38, a novel nuclear protein possessing a WW domain capable of activating basal transcription.

PubMed ID: 10198427

DOI: 10.1093/nar/27.9.1957

PubMed ID: 11163963

Title: Genomic organization and alternative transcripts of the human PQBP-1 gene.

PubMed ID: 11163963

DOI: 10.1016/s0378-1119(00)00437-6

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9875212

Title: Polar amino acid-rich sequences bind to polyglutamine tracts.

PubMed ID: 9875212

DOI: 10.1006/bbrc.1998.9725

PubMed ID: 10873650

Title: PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain.

PubMed ID: 10873650

DOI: 10.1006/bbrc.2000.2992

PubMed ID: 12062018

Title: Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death.

PubMed ID: 12062018

DOI: 10.1016/s0896-6273(02)00697-9

PubMed ID: 14634649

Title: Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation.

PubMed ID: 14634649

DOI: 10.1038/ng1264

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19303059

Title: Polyglutamine tract binding protein-1 is an intrinsically unstructured protein.

PubMed ID: 19303059

DOI: 10.1016/j.bbapap.2009.03.001

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21315190

Title: A novel frame shift mutation in the PQBP1 gene identified in a Tunisian family with X-linked mental retardation.

PubMed ID: 21315190

DOI: 10.1016/j.ejmg.2011.01.010

PubMed ID: 21933836

Title: The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.

PubMed ID: 21933836

DOI: 10.1093/hmg/ddr430

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23512658

Title: PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth.

PubMed ID: 23512658

DOI: 10.1101/gad.212308.112

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26046437

Title: PQBP1 is a proximal sensor of the cGAS-dependent innate response to HIV-1.

PubMed ID: 26046437

DOI: 10.1016/j.cell.2015.04.050

PubMed ID: 27314904

Title: Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD.

PubMed ID: 27314904

DOI: 10.1002/1873-3468.12256

PubMed ID: 28627366

Title: PQBP1, an intrinsically disordered/denatured protein at the crossroad of intellectual disability and neurodegenerative diseases.

PubMed ID: 28627366

DOI: 10.1016/j.neuint.2017.06.005

PubMed ID: 24781215

Title: Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD.

PubMed ID: 24781215

DOI: 10.1038/ncomms4822

PubMed ID: 16740914

Title: Golabi-Ito-Hall syndrome results from a missense mutation in the WW domain of the PQBP1 gene.

PubMed ID: 16740914

DOI: 10.1136/jmg.2005.037556

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 20410308

Title: Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing.

PubMed ID: 20410308

DOI: 10.1074/jbc.m109.084525

PubMed ID: 26637798

Title: Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

PubMed ID: 26637798

DOI: 10.1016/j.neuron.2015.11.009

Sequence Information:

Length: 265
Mass: 30472
Checksum: 98C3BEF18CFF0297
Sequence:

MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC 
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS 
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR 
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF 
QQRPYPSPGA VLRANAEASR TKQQD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PQBP1

Associated with

Other Information

PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival. PubMed ID: 10332029

Npw38, a novel nuclear protein possessing a WW domain capable of activating basal transcription. PubMed ID: 10198427

Genomic organization and alternative transcripts of the human PQBP-1 gene. PubMed ID: 11163963

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Polar amino acid-rich sequences bind to polyglutamine tracts. PubMed ID: 9875212

PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain. PubMed ID: 10873650

Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. PubMed ID: 12062018

Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation. PubMed ID: 14634649

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Polyglutamine tract binding protein-1 is an intrinsically unstructured protein. PubMed ID: 19303059

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

A novel frame shift mutation in the PQBP1 gene identified in a Tunisian family with X-linked mental retardation. PubMed ID: 21315190

The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules. PubMed ID: 21933836

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. PubMed ID: 23512658

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PQBP1 is a proximal sensor of the cGAS-dependent innate response to HIV-1. PubMed ID: 26046437

Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD. PubMed ID: 27314904

PQBP1, an intrinsically disordered/denatured protein at the crossroad of intellectual disability and neurodegenerative diseases. PubMed ID: 28627366

Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD. PubMed ID: 24781215

Golabi-Ito-Hall syndrome results from a missense mutation in the WW domain of the PQBP1 gene. PubMed ID: 16740914

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing. PubMed ID: 20410308

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms. PubMed ID: 26637798