Details for: CERT1

Gene ID: 10087

Symbol: CERT1

Ensembl ID: ENSG00000113163

Description: ceramide transporter 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.22
    Marker Score: 56,091
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.62
    Marker Score: 1,759
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.3
    Marker Score: 2,330
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.46
    Marker Score: 10,290
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.97
    Marker Score: 74,818
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.92
    Marker Score: 14,712
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.88
    Marker Score: 28,155
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.88
    Marker Score: 37,434
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.86
    Marker Score: 1,712
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.84
    Marker Score: 7,123
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.83
    Marker Score: 112,471
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.81
    Marker Score: 16,982
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.78
    Marker Score: 18,349
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.76
    Marker Score: 7,315
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.75
    Marker Score: 64,690
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.72
    Marker Score: 16,389
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.71
    Marker Score: 494
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.71
    Marker Score: 14,702
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.71
    Marker Score: 954
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.71
    Marker Score: 1,885
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.7
    Marker Score: 4,073
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.7
    Marker Score: 1,958
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.66
    Marker Score: 875
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.66
    Marker Score: 35,378
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.66
    Marker Score: 1,107
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.61
    Marker Score: 2,013
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.61
    Marker Score: 2,021
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.61
    Marker Score: 1,726
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.61
    Marker Score: 2,366
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.6
    Marker Score: 1,093
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.59
    Marker Score: 460
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.58
    Marker Score: 945
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.58
    Marker Score: 1,658
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.57
    Marker Score: 460
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.57
    Marker Score: 3,436
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.56
    Marker Score: 6,468
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.56
    Marker Score: 7,206
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.54
    Marker Score: 6,281
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.52
    Marker Score: 1,168
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.5
    Marker Score: 2,308
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.48
    Marker Score: 12,968
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.47
    Marker Score: 425
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.47
    Marker Score: 820
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.46
    Marker Score: 2,813
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.45
    Marker Score: 609
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.44
    Marker Score: 709
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.42
    Marker Score: 1,531
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.42
    Marker Score: 447
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.4
    Marker Score: 695
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.37
    Marker Score: 30,725
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.36
    Marker Score: 1,951
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.35
    Marker Score: 75,652
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.31
    Marker Score: 9,728
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.3
    Marker Score: 485
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.3
    Marker Score: 4,605
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.27
    Marker Score: 1,572
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.26
    Marker Score: 737
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.26
    Marker Score: 42,872
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.26
    Marker Score: 43,634
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.25
    Marker Score: 32,003
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.24
    Marker Score: 1,184
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.22
    Marker Score: 457
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.21
    Marker Score: 413
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.2
    Marker Score: 835
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.18
    Marker Score: 425
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.17
    Marker Score: 1,658
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.17
    Marker Score: 3,337
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.17
    Marker Score: 319
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.16
    Marker Score: 680
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.16
    Marker Score: 424
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.16
    Marker Score: 1,236
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.15
    Marker Score: 1,165
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.15
    Marker Score: 1,022
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.13
    Marker Score: 1,407
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.13
    Marker Score: 259
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.12
    Marker Score: 555
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.12
    Marker Score: 653
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.12
    Marker Score: 413
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.11
    Marker Score: 758
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1,184
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.09
    Marker Score: 473
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.09
    Marker Score: 2,302
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.08
    Marker Score: 920
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.07
    Marker Score: 2,516
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.07
    Marker Score: 6,849
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.06
    Marker Score: 430
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.05
    Marker Score: 363
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.04
    Marker Score: 1,106
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.04
    Marker Score: 448
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.03
    Marker Score: 688
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.03
    Marker Score: 458
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.03
    Marker Score: 2,354
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.03
    Marker Score: 3,668
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.03
    Marker Score: 13,845
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.03
    Marker Score: 703
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.03
    Marker Score: 326
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.03
    Marker Score: 387
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.03
    Marker Score: 11,923
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.02
    Marker Score: 582
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.02
    Marker Score: 1,237

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CERT1 is a type II transmembrane protein that exhibits a START (Sphingolipid Activation Regulatory Transducer) domain, which is characteristic of ceramide transporters. The protein is primarily expressed in cells involved in immune responses, such as monocytes, macrophages, and neurons. CERT1 has been shown to interact with other proteins involved in lipid metabolism, including sphingosine kinase and sphingomyelin synthase. The gene is highly expressed in various tissues, including the heart, brain, and immune cells. **Pathways and Functions:** CERT1 is involved in several cellular pathways, including: 1. **Ceramide Metabolic Process:** CERT1 regulates ceramide levels by facilitating its transport between the ER and Golgi apparatus, as well as intermembrane transfer. 2. **Immune Response:** CERT1 plays a critical role in regulating immune responses, particularly in cells involved in immune cell activation and differentiation. 3. **Lipid Homeostasis:** CERT1 helps maintain lipid homeostasis by regulating ceramide levels, which is essential for cellular function and survival. 4. **Sphingolipid Metabolism:** CERT1 is involved in the metabolism of sphingolipids, including ceramide, sphingosine, and sphingomyelin. **Clinical Significance:** Dysregulation of CERT1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** CERT1 has been shown to play a role in regulating immune responses, and its dysregulation may contribute to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cardiovascular Disease:** CERT1 has been implicated in the regulation of lipid homeostasis, and its dysregulation may contribute to cardiovascular disease, including atherosclerosis and cardiac dysfunction. 3. **Neurological Disorders:** CERT1 has been shown to play a role in regulating immune responses in the brain, and its dysregulation may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CERT1 is a critical gene that regulates ceramide levels and lipid homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of CERT1 in maintaining cellular function and preventing disease.

Genular Protein ID: 3589358786

Symbol: CERT_HUMAN

Name: START domain-containing protein 11

UniProtKB Accession Codes:

Q9Y5P4 A8K7S2 B3KUB7 Q53YV1 Q53YV2 Q96Q85 Q96Q88 Q9H2S7 Q9H2S8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 16 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 27 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 1 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10212244

Title: Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen.

PubMed ID: 10212244

DOI: 10.1074/jbc.274.18.12642

PubMed ID: 11007769

Title: Goodpasture antigen-binding protein, the kinase that phosphorylates the Goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis.

PubMed ID: 11007769

DOI: 10.1074/jbc.m002769200

PubMed ID: 14685229

Title: Molecular machinery for non-vesicular trafficking of ceramide.

PubMed ID: 14685229

DOI: 10.1038/nature02188

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16895911

Title: Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT.

PubMed ID: 16895911

DOI: 10.1074/jbc.m605032200

PubMed ID: 17591919

Title: Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein.

PubMed ID: 17591919

DOI: 10.1083/jcb.200612017

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19005213

Title: Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.

PubMed ID: 19005213

DOI: 10.1091/mbc.e08-07-0669

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25533962

Title: Large-scale discovery of novel genetic causes of developmental disorders.

PubMed ID: 25533962

DOI: 10.1038/nature14135

PubMed ID: 29858488

Title: Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.

PubMed ID: 29858488

DOI: 10.15252/embr.201745453

PubMed ID: 18184806

Title: Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.

PubMed ID: 18184806

DOI: 10.1073/pnas.0709191105

PubMed ID: 20036255

Title: Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer.

PubMed ID: 20036255

DOI: 10.1016/j.jmb.2009.12.029

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

Sequence Information:

  • Length: 624
  • Mass: 70835
  • Checksum: A125162492AC5A0E
  • Sequence:
    • MSDNQSWNSS GSEEDPETES GPPVERCGVL SKWTNYIHGW QDRWVVLKNN ALSYYKSEDE 
TEYGCRGSIC LSKAVITPHD FDECRFDISV NDSVWYLRAQ DPDHRQQWID AIEQHKTESG 
YGSESSLRRH GSMVSLVSGA SGYSATSTSS FKKGHSLREK LAEMETFRDI LCRQVDTLQK 
YFDACADAVS KDELQRDKVV EDDEDDFPTT RSDGDFLHST NGNKEKLFPH VTPKGINGID 
FKGEAITFKA TTAGILATLS HCIELMVKRE DSWQKRLDKE TEKKRRTEEA YKNAMTELKK 
KSHFGGPDYE EGPNSLINEE EFFDAVEAAL DRQDKIEEQS QSEKVRLHWP TSLPSGDAFS 
SVGTHRFVQK PYSRSSSMSS IDLVSASDDV HRFSSQVEEM VQNHMTYSLQ DVGGDANWQL 
VVEEGEMKVY RREVEENGIV LDPLKATHAV KGVTGHEVCN YFWNVDVRND WETTIENFHV 
VETLADNAII IYQTHKRVWP ASQRDVLYLS VIRKIPALTE NDPETWIVCN FSVDHDSAPL 
NNRCVRAKIN VAMICQTLVS PPEGNQEISR DNILCKITYV ANVNPGGWAP ASVLRAVAKR 
EYPKFLKRFT SYVQEKTAGK PILF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.