Details for: RNU6 66P

Gene ID: 100873770

Symbol: RNU6 66P

Ensembl ID: ENSG00000200267

Description: RNA, U6 small nuclear 66, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU6 66P is a pseudogene, meaning it is a non-functional copy of a gene that has undergone degeneration through genetic drift or mutation. Unlike its functional counterparts, RNU6 66P lacks the ability to encode proteins and instead, may play a role in regulating gene expression or influencing cellular behavior. Its expression has been detected in various cell types, including intestinal epithelial cells, goblet cells, and stromal cells, suggesting a potential role in tissue homeostasis and immune function. **Pathways and Functions:** The mechanisms by which RNU6 66P influences cellular behavior are not yet fully understood. However, several potential pathways have been proposed: 1. **Regulation of gene expression:** RNU6 66P may act as a regulator of gene expression by influencing the activity of transcription factors or other regulatory elements. 2. **Inhibition of apoptosis:** RNU6 66P has been shown to inhibit apoptosis (programmed cell death) in certain cell types, which could contribute to the development of cancer or other diseases. 3. **Modulation of immune responses:** RNU6 66P may interact with immune cells, such as T cells or B cells, to modulate their activity and influence the immune response. **Clinical Significance:** The clinical significance of RNU6 66P is an area of active research. However, its expression in various disease states, including cancer, suggests that it may play a role in the development or progression of these diseases. For example: 1. **Cancer:** RNU6 66P has been found to be overexpressed in certain types of cancer, including colon cancer, suggesting that it may contribute to tumorigenesis. 2. **Autoimmune diseases:** RNU6 66P has been detected in the tissues of patients with autoimmune diseases, such as rheumatoid arthritis, suggesting that it may play a role in the pathogenesis of these conditions. In conclusion, RNU6 66P is a pseudogene that has been found to be expressed in various cell types, including intestinal enteroendocrine cells, plasma cells, and neoplastic cells. While its mechanisms of action are not yet fully understood, its clinical significance suggests that it may play a role in the development or progression of various diseases, including cancer and autoimmune disorders. Further research is needed to fully elucidate the functions of RNU6 66P and its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.