Details for: CDH11

Gene ID: 1009

Symbol: CDH11

Ensembl ID: ENSG00000140937

Description: cadherin 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.2352
    Cell Significance Index: -57.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.6904
    Cell Significance Index: -53.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 7.0928
    Cell Significance Index: 398.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.6140
    Cell Significance Index: 101.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.8389
    Cell Significance Index: 169.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.5431
    Cell Significance Index: 134.1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.8473
    Cell Significance Index: 36.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.8386
    Cell Significance Index: 60.6800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.7446
    Cell Significance Index: 16.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4392
    Cell Significance Index: 334.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1607
    Cell Significance Index: 276.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9336
    Cell Significance Index: 387.8800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.8665
    Cell Significance Index: 11.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5566
    Cell Significance Index: 30.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4914
    Cell Significance Index: 100.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4008
    Cell Significance Index: 29.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2613
    Cell Significance Index: 36.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1289
    Cell Significance Index: 404.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0427
    Cell Significance Index: 721.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7700
    Cell Significance Index: 146.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6670
    Cell Significance Index: 19.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4910
    Cell Significance Index: 443.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2783
    Cell Significance Index: 27.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1225
    Cell Significance Index: 7.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1020
    Cell Significance Index: 45.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0651
    Cell Significance Index: 10.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0286
    Cell Significance Index: 53.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0284
    Cell Significance Index: 0.4400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0167
    Cell Significance Index: 0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0110
    Cell Significance Index: 4.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0066
    Cell Significance Index: 0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0033
    Cell Significance Index: 2.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0197
    Cell Significance Index: -2.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0294
    Cell Significance Index: -45.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0367
    Cell Significance Index: -67.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0495
    Cell Significance Index: -1.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0792
    Cell Significance Index: -59.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0827
    Cell Significance Index: -60.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0836
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0916
    Cell Significance Index: -67.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1205
    Cell Significance Index: -67.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1610
    Cell Significance Index: -4.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1660
    Cell Significance Index: -47.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2086
    Cell Significance Index: -22.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2690
    Cell Significance Index: -48.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2710
    Cell Significance Index: -53.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2901
    Cell Significance Index: -13.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3285
    Cell Significance Index: -69.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3831
    Cell Significance Index: -13.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4087
    Cell Significance Index: -69.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4157
    Cell Significance Index: -48.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4398
    Cell Significance Index: -54.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4683
    Cell Significance Index: -60.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4812
    Cell Significance Index: -33.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4824
    Cell Significance Index: -50.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4965
    Cell Significance Index: -30.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5484
    Cell Significance Index: -64.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5490
    Cell Significance Index: -42.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5586
    Cell Significance Index: -57.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6026
    Cell Significance Index: -69.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6346
    Cell Significance Index: -20.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6521
    Cell Significance Index: -21.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6533
    Cell Significance Index: -11.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6633
    Cell Significance Index: -21.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6658
    Cell Significance Index: -47.0900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6732
    Cell Significance Index: -8.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7009
    Cell Significance Index: -45.2200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.7557
    Cell Significance Index: -4.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7712
    Cell Significance Index: -46.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8110
    Cell Significance Index: -60.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8674
    Cell Significance Index: -18.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8724
    Cell Significance Index: -24.3800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8875
    Cell Significance Index: -14.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9136
    Cell Significance Index: -21.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9142
    Cell Significance Index: -57.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9615
    Cell Significance Index: -48.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9660
    Cell Significance Index: -24.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9667
    Cell Significance Index: -25.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9689
    Cell Significance Index: -24.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9799
    Cell Significance Index: -21.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9829
    Cell Significance Index: -51.2000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.9936
    Cell Significance Index: -6.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9970
    Cell Significance Index: -46.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0752
    Cell Significance Index: -21.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1315
    Cell Significance Index: -59.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1629
    Cell Significance Index: -60.4100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.1642
    Cell Significance Index: -16.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1741
    Cell Significance Index: -41.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.2438
    Cell Significance Index: -57.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.3638
    Cell Significance Index: -19.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.3858
    Cell Significance Index: -23.9600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.4031
    Cell Significance Index: -15.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.4228
    Cell Significance Index: -61.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6203
    Cell Significance Index: -59.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.6222
    Cell Significance Index: -47.7800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.6682
    Cell Significance Index: -23.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.7307
    Cell Significance Index: -18.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.7344
    Cell Significance Index: -34.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.8296
    Cell Significance Index: -49.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Cadherin 11 is a type II classical cadherin, characterized by its ability to mediate homophilic and heterophilic cell-cell adhesion. It is a calcium-dependent cell adhesion molecule, which means that it requires calcium ions to bind to its ligands and facilitate cell-cell adhesion. CDH11 is also involved in the regulation of cell-cell junction organization and the modulation of chemical synaptic transmission. Its expression is tightly regulated by various transcriptional and post-transcriptional mechanisms, including microRNA-mediated control. **Pathways and Functions:** CDH11 is involved in multiple cellular processes, including: 1. **Adherens Junction Organization:** CDH11 plays a crucial role in the formation and maintenance of adherens junctions, which are essential for cell-cell adhesion and tissue structure. 2. **Cell Migration:** CDH11 is involved in the regulation of cell migration, particularly in the context of tissue development and repair. 3. **Cell Morphogenesis:** CDH11 is required for the proper morphogenesis of various tissues, including the aortic valve and the corticospinal tract. 4. **Cell Adhesion:** CDH11 mediates cell-cell adhesion via its interaction with other cadherins and catenins. 5. **Synaptic Transmission:** CDH11 is involved in the regulation of chemical synaptic transmission, particularly in the context of glutamatergic synapses. **Clinical Significance:** Dysregulation of CDH11 has been implicated in various diseases, including: 1. **Aortic Valve Disease:** CDH11 mutations have been associated with aortic valve disease, a condition characterized by the abnormal formation of the aortic valve. 2. **Cortical Dysplasia:** CDH11 mutations have been linked to cortical dysplasia, a condition characterized by abnormal brain development. 3. **Neurodevelopmental Disorders:** CDH11 has been implicated in the pathogenesis of neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 4. **Cancer:** CDH11 has been shown to be overexpressed in certain types of cancer, including breast and colon cancer. In conclusion, CDH11 is a complex gene that plays a critical role in various cellular processes, including cell adhesion, migration, and morphogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CDH11 function and its role in human disease.

Genular Protein ID: 4203403793

Symbol: CAD11_HUMAN

Name: Cadherin-11

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 8163513

Title: Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.

PubMed ID: 8163513

DOI: 10.1016/s0021-9258(17)32685-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

PubMed ID: 15026324

Title: USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.

PubMed ID: 15026324

DOI: 10.1158/0008-5472.can-03-2827

PubMed ID: 28988429

Title: Homozygous indel mutation in CDH11 as the probable cause of Elsahy-Waters syndrome.

PubMed ID: 28988429

DOI: 10.1002/ajmg.a.38495

PubMed ID: 29271567

Title: Elsahy-Waters syndrome is caused by biallelic mutations in CDH11.

PubMed ID: 29271567

DOI: 10.1002/ajmg.a.38568

PubMed ID: 33811546

Title: Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome.

PubMed ID: 33811546

DOI: 10.1007/s00439-021-02274-3

Sequence Information:

  • Length: 796
  • Mass: 87965
  • Checksum: E17090EC95C59936
  • Sequence:
  • MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR SKRGWVWNQF 
    FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE 
    RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HETYHANVPE RSNVGTSVIQ 
    VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD 
    MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 
    GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA NVHIDPKFIS 
    NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS 
    IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNITVFA AEIHNRHQEA KVPVAIRVLD 
    VNDNAPKFAA PYEGFICESD QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN 
    FTVRDNRDNT AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 
    LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV FEEEDVRENI 
    ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY QYMPRPGLRP APNSVDVDDF 
    INTRIQEADN DPTAPPYDSI QIYGYEGRGS VAGSLSSLES ATTDSDLDYD YLQNWGPRFK 
    KLADLYGSKD TFDDDS

Genular Protein ID: 3744897371

Symbol: H3BUU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 670
  • Mass: 73793
  • Checksum: F8CBF4E3BD77712D
  • Sequence:
  • MAQAVDRDTN RPLEPPSEFI VKVQDINDNP PEFLHETYHA NVPERSNVGT SVIQVTASDA 
    DDPTYGNSAK LVYSILEGQP YFSVEAQTGI IRTALPNMDR EAKEEYHVVI QAKDMGGHMG 
    GLSGTTKVTI TLTDVNDNPP KFPQSVYQMS VSEAAVPGEE VGRVKAKDPD IGENGLVTYN 
    IVDGDGMESF EITTDYETQE GVIKLKKPVD FETKRAYSLK VEAANVHIDP KFISNGPFKD 
    TVTVKISVED ADEPPMFLAP SYIHEVQENA AAGTVVGRVH AKDPDAANSP IRYSIDRHTD 
    LDRFFTINPE DGFIKTTKPL DREETAWLNI TVFAAEIHNR HQEAKVPVAI RVLDVNDNAP 
    KFAAPYEGFI CESDQTKPLS NQPIVTISAD DKDDTANGPR FIFSLPPEII HNPNFTVRDN 
    RDNTAGVYAR RGGFSRQKQD LYLLPIVISD GGIPPMSSTN TLTIKVCGCD VNGALLSCNA 
    EAYILNAGLS TGALIAILAC IVILLVIVVL FVTLRRQKKE PLIVFEEEDV RENIITYDDE 
    GGGEEDTEAF DIATLQNPDG INGFIPRKDI KPEYQYMPRP GLRPAPNSVD VDDFINTRIQ 
    EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESATTDSD LDYDYLQNWG PRFKKLADLY 
    GSKDTFDDDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.