Details for: CDH11

Gene ID: 1009

Symbol: CDH11

Ensembl ID: ENSG00000140937

Description: cadherin 11

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 9.11
    Marker Score: 5,148
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.15
    Marker Score: 173,961
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.94
    Marker Score: 2,745
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.26
    Marker Score: 22,906
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.16
    Marker Score: 6,075
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.75
    Marker Score: 3,170
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.59
    Marker Score: 3,567
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.58
    Marker Score: 34,005
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.46
    Marker Score: 1,852
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.39
    Marker Score: 15,573
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.21
    Marker Score: 626
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.12
    Marker Score: 19,945
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.11
    Marker Score: 23,800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.06
    Marker Score: 4,934
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.03
    Marker Score: 3,120
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.96
    Marker Score: 509
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.91
    Marker Score: 40,673
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17,888
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.85
    Marker Score: 4,360
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.84
    Marker Score: 4,823
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15,815
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.83
    Marker Score: 18,870
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.78
    Marker Score: 60,638
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.71
    Marker Score: 62,932
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.69
    Marker Score: 33,577
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.67
    Marker Score: 1,805
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102,609
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.66
    Marker Score: 2,784
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,153
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.54
    Marker Score: 1,916
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.53
    Marker Score: 1,098
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.53
    Marker Score: 912
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.53
    Marker Score: 4,356
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.51
    Marker Score: 4,102
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.5
    Marker Score: 480
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.49
    Marker Score: 335
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.49
    Marker Score: 1,838
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.47
    Marker Score: 728
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.47
    Marker Score: 5,991
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,485
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.46
    Marker Score: 6,278
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.45
    Marker Score: 918
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.4
    Marker Score: 10,756
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.37
    Marker Score: 2,114
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.36
    Marker Score: 565
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.35
    Marker Score: 2,297
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.33
    Marker Score: 1,644
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.32
    Marker Score: 3,038
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.31
    Marker Score: 49,722
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.24
    Marker Score: 4,783
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.21
    Marker Score: 2,662
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.19
    Marker Score: 413
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.19
    Marker Score: 667
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.17
    Marker Score: 1,626
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.14
    Marker Score: 989
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.14
    Marker Score: 2,382
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,782
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.14
    Marker Score: 283
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.13
    Marker Score: 429
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.13
    Marker Score: 283
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.12
    Marker Score: 1,189
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.1
    Marker Score: 369
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.1
    Marker Score: 4,548
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.08
    Marker Score: 1,032
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.07
    Marker Score: 611
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.07
    Marker Score: 1,030
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.06
    Marker Score: 615
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.04
    Marker Score: 607
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2,113
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,757
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 415
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,002
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.98
    Marker Score: 4,523
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15,144
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.95
    Marker Score: 1,111
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5,670
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.94
    Marker Score: 265
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.93
    Marker Score: 428
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,202
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9
    Marker Score: 208
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.9
    Marker Score: 307
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.9
    Marker Score: 13,463
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.89
    Marker Score: 757
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.87
    Marker Score: 195
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.87
    Marker Score: 222
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,275
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 641
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.81
    Marker Score: 386
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.81
    Marker Score: 12,944
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.79
    Marker Score: 304
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.79
    Marker Score: 518
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.79
    Marker Score: 316

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Cadherin 11 is a type II classical cadherin, characterized by its ability to mediate homophilic and heterophilic cell-cell adhesion. It is a calcium-dependent cell adhesion molecule, which means that it requires calcium ions to bind to its ligands and facilitate cell-cell adhesion. CDH11 is also involved in the regulation of cell-cell junction organization and the modulation of chemical synaptic transmission. Its expression is tightly regulated by various transcriptional and post-transcriptional mechanisms, including microRNA-mediated control. **Pathways and Functions:** CDH11 is involved in multiple cellular processes, including: 1. **Adherens Junction Organization:** CDH11 plays a crucial role in the formation and maintenance of adherens junctions, which are essential for cell-cell adhesion and tissue structure. 2. **Cell Migration:** CDH11 is involved in the regulation of cell migration, particularly in the context of tissue development and repair. 3. **Cell Morphogenesis:** CDH11 is required for the proper morphogenesis of various tissues, including the aortic valve and the corticospinal tract. 4. **Cell Adhesion:** CDH11 mediates cell-cell adhesion via its interaction with other cadherins and catenins. 5. **Synaptic Transmission:** CDH11 is involved in the regulation of chemical synaptic transmission, particularly in the context of glutamatergic synapses. **Clinical Significance:** Dysregulation of CDH11 has been implicated in various diseases, including: 1. **Aortic Valve Disease:** CDH11 mutations have been associated with aortic valve disease, a condition characterized by the abnormal formation of the aortic valve. 2. **Cortical Dysplasia:** CDH11 mutations have been linked to cortical dysplasia, a condition characterized by abnormal brain development. 3. **Neurodevelopmental Disorders:** CDH11 has been implicated in the pathogenesis of neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 4. **Cancer:** CDH11 has been shown to be overexpressed in certain types of cancer, including breast and colon cancer. In conclusion, CDH11 is a complex gene that plays a critical role in various cellular processes, including cell adhesion, migration, and morphogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CDH11 function and its role in human disease.

Genular Protein ID: 4203403793

Symbol: CAD11_HUMAN

Name: Cadherin-11

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 8163513

Title: Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.

PubMed ID: 8163513

DOI: 10.1016/s0021-9258(17)32685-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

PubMed ID: 15026324

Title: USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.

PubMed ID: 15026324

DOI: 10.1158/0008-5472.can-03-2827

PubMed ID: 28988429

Title: Homozygous indel mutation in CDH11 as the probable cause of Elsahy-Waters syndrome.

PubMed ID: 28988429

DOI: 10.1002/ajmg.a.38495

PubMed ID: 29271567

Title: Elsahy-Waters syndrome is caused by biallelic mutations in CDH11.

PubMed ID: 29271567

DOI: 10.1002/ajmg.a.38568

PubMed ID: 33811546

Title: Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome.

PubMed ID: 33811546

DOI: 10.1007/s00439-021-02274-3

Sequence Information:

  • Length: 796
  • Mass: 87965
  • Checksum: E17090EC95C59936
  • Sequence:
  • MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR SKRGWVWNQF 
    FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE 
    RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HETYHANVPE RSNVGTSVIQ 
    VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD 
    MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 
    GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA NVHIDPKFIS 
    NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS 
    IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNITVFA AEIHNRHQEA KVPVAIRVLD 
    VNDNAPKFAA PYEGFICESD QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN 
    FTVRDNRDNT AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 
    LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV FEEEDVRENI 
    ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY QYMPRPGLRP APNSVDVDDF 
    INTRIQEADN DPTAPPYDSI QIYGYEGRGS VAGSLSSLES ATTDSDLDYD YLQNWGPRFK 
    KLADLYGSKD TFDDDS

Genular Protein ID: 3744897371

Symbol: H3BUU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 670
  • Mass: 73793
  • Checksum: F8CBF4E3BD77712D
  • Sequence:
  • MAQAVDRDTN RPLEPPSEFI VKVQDINDNP PEFLHETYHA NVPERSNVGT SVIQVTASDA 
    DDPTYGNSAK LVYSILEGQP YFSVEAQTGI IRTALPNMDR EAKEEYHVVI QAKDMGGHMG 
    GLSGTTKVTI TLTDVNDNPP KFPQSVYQMS VSEAAVPGEE VGRVKAKDPD IGENGLVTYN 
    IVDGDGMESF EITTDYETQE GVIKLKKPVD FETKRAYSLK VEAANVHIDP KFISNGPFKD 
    TVTVKISVED ADEPPMFLAP SYIHEVQENA AAGTVVGRVH AKDPDAANSP IRYSIDRHTD 
    LDRFFTINPE DGFIKTTKPL DREETAWLNI TVFAAEIHNR HQEAKVPVAI RVLDVNDNAP 
    KFAAPYEGFI CESDQTKPLS NQPIVTISAD DKDDTANGPR FIFSLPPEII HNPNFTVRDN 
    RDNTAGVYAR RGGFSRQKQD LYLLPIVISD GGIPPMSSTN TLTIKVCGCD VNGALLSCNA 
    EAYILNAGLS TGALIAILAC IVILLVIVVL FVTLRRQKKE PLIVFEEEDV RENIITYDDE 
    GGGEEDTEAF DIATLQNPDG INGFIPRKDI KPEYQYMPRP GLRPAPNSVD VDDFINTRIQ 
    EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESATTDSD LDYDYLQNWG PRFKKLADLY 
    GSKDTFDDDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.