CDH11 | ENSG00000140937 | NCBI 1009

Details for: CDH11

Gene ID: 1009

Symbol: CDH11

Ensembl ID: ENSG00000140937

Description: cadherin 11

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cdh11 homotypic and heterotypic interactions
(R-HSA-9833576)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 function
(R-HSA-9762292)
Regulation of cdh11 gene transcription
(R-HSA-9762293)
Regulation of cdh11 mrna translation by micrornas
(R-HSA-9759811)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Adherens junction
(GO:0005912)
Adherens junction organization
(GO:0034332)
Aortic valve formation
(GO:0003189)
Cadherin binding
(GO:0045296)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium ion binding
(GO:0005509)
Catenin complex
(GO:0016342)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell junction assembly
(GO:0007043)
Cell adhesion
(GO:0007155)
Cell migration
(GO:0016477)
Cell morphogenesis
(GO:0000902)
Corticospinal tract morphogenesis
(GO:0021957)
Cytoplasm
(GO:0005737)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Focal adhesion assembly
(GO:0048041)
Glutamatergic synapse
(GO:0098978)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Modulation of chemical synaptic transmission
(GO:0050804)
Multicellular organism development
(GO:0007275)
Negative regulation of cell migration
(GO:0030336)
Ossification
(GO:0001503)
Plasma membrane
(GO:0005886)
Schaffer collateral - ca1 synapse
(GO:0098685)
Skeletal system development
(GO:0001501)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: endocardial cell (CL0002350)
Fold Change: 9.11
Marker Score: 5,148
Cell Name: Purkinje cell (CL0000121)
Fold Change: 5.15
Marker Score: 173,961
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 4.94
Marker Score: 2,745
Cell Name: stellate neuron (CL0000122)
Fold Change: 4.26
Marker Score: 22,906
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.16
Marker Score: 6,075
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.75
Marker Score: 3,170
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.59
Marker Score: 3,567
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.58
Marker Score: 34,005
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 2.46
Marker Score: 1,852
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.39
Marker Score: 15,573
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.21
Marker Score: 626
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.12
Marker Score: 19,945
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.11
Marker Score: 23,800
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.06
Marker Score: 4,934
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.03
Marker Score: 3,120
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.96
Marker Score: 509
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.91
Marker Score: 40,673
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.88
Marker Score: 17,888
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.85
Marker Score: 4,360
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.84
Marker Score: 4,823
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.84
Marker Score: 15,815
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.83
Marker Score: 18,870
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.78
Marker Score: 60,638
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.71
Marker Score: 62,932
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.69
Marker Score: 33,577
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.67
Marker Score: 1,805
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.67
Marker Score: 102,609
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.66
Marker Score: 2,784
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1,153
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.54
Marker Score: 1,916
Cell Name: theca cell (CL0000503)
Fold Change: 1.53
Marker Score: 1,098
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.53
Marker Score: 912
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.53
Marker Score: 4,356
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.51
Marker Score: 4,102
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.5
Marker Score: 480
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.49
Marker Score: 335
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.49
Marker Score: 1,838
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.47
Marker Score: 728
Cell Name: neuron (CL0000540)
Fold Change: 1.47
Marker Score: 5,991
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,485
Cell Name: decidual cell (CL2000002)
Fold Change: 1.46
Marker Score: 6,278
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.45
Marker Score: 918
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.4
Marker Score: 10,756
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.37
Marker Score: 2,114
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.36
Marker Score: 565
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.35
Marker Score: 2,297
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.33
Marker Score: 1,644
Cell Name: macroglial cell (CL0000126)
Fold Change: 1.32
Marker Score: 3,038
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.31
Marker Score: 49,722
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.24
Marker Score: 4,783
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.21
Marker Score: 2,662
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.19
Marker Score: 413
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.19
Marker Score: 667
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.17
Marker Score: 1,626
Cell Name: astrocyte (CL0000127)
Fold Change: 1.14
Marker Score: 989
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.14
Marker Score: 2,382
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4,782
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.14
Marker Score: 283
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.13
Marker Score: 429
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.13
Marker Score: 283
Cell Name: Unknown (CL0002371)
Fold Change: 1.12
Marker Score: 1,189
Cell Name: bipolar neuron (CL0000103)
Fold Change: 1.1
Marker Score: 369
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.1
Marker Score: 4,548
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.08
Marker Score: 1,032
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.07
Marker Score: 611
Cell Name: fibroblast (CL0000057)
Fold Change: 1.07
Marker Score: 1,030
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.06
Marker Score: 615
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.04
Marker Score: 607
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.04
Marker Score: 2,113
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,757
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1
Marker Score: 415
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,777
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,002
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,404
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.98
Marker Score: 4,523
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.97
Marker Score: 15,144
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412
Cell Name: stromal cell (CL0000499)
Fold Change: 0.95
Marker Score: 1,111
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.94
Marker Score: 5,670
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.94
Marker Score: 265
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.93
Marker Score: 428
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5,202
Cell Name: keratocyte (CL0002363)
Fold Change: 0.9
Marker Score: 208
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.9
Marker Score: 307
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.9
Marker Score: 13,463
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.89
Marker Score: 757
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.87
Marker Score: 195
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.87
Marker Score: 222
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,275
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.84
Marker Score: 641
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 325
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.81
Marker Score: 386
Cell Name: lactocyte (CL0002325)
Fold Change: 0.81
Marker Score: 12,944
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.79
Marker Score: 304
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.79
Marker Score: 518
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.79
Marker Score: 316

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** Cadherin 11 is a type II classical cadherin, characterized by its ability to mediate homophilic and heterophilic cell-cell adhesion. It is a calcium-dependent cell adhesion molecule, which means that it requires calcium ions to bind to its ligands and facilitate cell-cell adhesion. CDH11 is also involved in the regulation of cell-cell junction organization and the modulation of chemical synaptic transmission. Its expression is tightly regulated by various transcriptional and post-transcriptional mechanisms, including microRNA-mediated control. **Pathways and Functions:** CDH11 is involved in multiple cellular processes, including: 1. **Adherens Junction Organization:** CDH11 plays a crucial role in the formation and maintenance of adherens junctions, which are essential for cell-cell adhesion and tissue structure. 2. **Cell Migration:** CDH11 is involved in the regulation of cell migration, particularly in the context of tissue development and repair. 3. **Cell Morphogenesis:** CDH11 is required for the proper morphogenesis of various tissues, including the aortic valve and the corticospinal tract. 4. **Cell Adhesion:** CDH11 mediates cell-cell adhesion via its interaction with other cadherins and catenins. 5. **Synaptic Transmission:** CDH11 is involved in the regulation of chemical synaptic transmission, particularly in the context of glutamatergic synapses. **Clinical Significance:** Dysregulation of CDH11 has been implicated in various diseases, including: 1. **Aortic Valve Disease:** CDH11 mutations have been associated with aortic valve disease, a condition characterized by the abnormal formation of the aortic valve. 2. **Cortical Dysplasia:** CDH11 mutations have been linked to cortical dysplasia, a condition characterized by abnormal brain development. 3. **Neurodevelopmental Disorders:** CDH11 has been implicated in the pathogenesis of neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 4. **Cancer:** CDH11 has been shown to be overexpressed in certain types of cancer, including breast and colon cancer. In conclusion, CDH11 is a complex gene that plays a critical role in various cellular processes, including cell adhesion, migration, and morphogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CDH11 function and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cadherin-11
H3BUU9_HUMAN

Genular Protein ID: 4203403793

Symbol: CAD11_HUMAN

Name: Cadherin-11

UniProtKB Accession Codes:

P55287 A8K5D6 A8MZC8 B7WP28 Q15065 Q15066 Q9UQ93 Q9UQ94

Database IDs:

Citations:

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 8163513

Title: Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.

PubMed ID: 8163513

DOI: 10.1016/s0021-9258(17)32685-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

PubMed ID: 15026324

Title: USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.

PubMed ID: 15026324

DOI: 10.1158/0008-5472.can-03-2827

PubMed ID: 28988429

Title: Homozygous indel mutation in CDH11 as the probable cause of Elsahy-Waters syndrome.

PubMed ID: 28988429

DOI: 10.1002/ajmg.a.38495

PubMed ID: 29271567

Title: Elsahy-Waters syndrome is caused by biallelic mutations in CDH11.

PubMed ID: 29271567

DOI: 10.1002/ajmg.a.38568

PubMed ID: 33811546

Title: Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome.

PubMed ID: 33811546

DOI: 10.1007/s00439-021-02274-3

Sequence Information:

Length: 796
Mass: 87965
Checksum: E17090EC95C59936
Sequence:

MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR SKRGWVWNQF 
FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE 
RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HETYHANVPE RSNVGTSVIQ 
VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD 
MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 
GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA NVHIDPKFIS 
NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS 
IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNITVFA AEIHNRHQEA KVPVAIRVLD 
VNDNAPKFAA PYEGFICESD QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN 
FTVRDNRDNT AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV FEEEDVRENI 
ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY QYMPRPGLRP APNSVDVDDF 
INTRIQEADN DPTAPPYDSI QIYGYEGRGS VAGSLSSLES ATTDSDLDYD YLQNWGPRFK 
KLADLYGSKD TFDDDS

Genular Protein ID: 3744897371

Symbol: H3BUU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BUU9

Database IDs:

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

Length: 670
Mass: 73793
Checksum: F8CBF4E3BD77712D
Sequence:

MAQAVDRDTN RPLEPPSEFI VKVQDINDNP PEFLHETYHA NVPERSNVGT SVIQVTASDA 
DDPTYGNSAK LVYSILEGQP YFSVEAQTGI IRTALPNMDR EAKEEYHVVI QAKDMGGHMG 
GLSGTTKVTI TLTDVNDNPP KFPQSVYQMS VSEAAVPGEE VGRVKAKDPD IGENGLVTYN 
IVDGDGMESF EITTDYETQE GVIKLKKPVD FETKRAYSLK VEAANVHIDP KFISNGPFKD 
TVTVKISVED ADEPPMFLAP SYIHEVQENA AAGTVVGRVH AKDPDAANSP IRYSIDRHTD 
LDRFFTINPE DGFIKTTKPL DREETAWLNI TVFAAEIHNR HQEAKVPVAI RVLDVNDNAP 
KFAAPYEGFI CESDQTKPLS NQPIVTISAD DKDDTANGPR FIFSLPPEII HNPNFTVRDN 
RDNTAGVYAR RGGFSRQKQD LYLLPIVISD GGIPPMSSTN TLTIKVCGCD VNGALLSCNA 
EAYILNAGLS TGALIAILAC IVILLVIVVL FVTLRRQKKE PLIVFEEEDV RENIITYDDE 
GGGEEDTEAF DIATLQNPDG INGFIPRKDI KPEYQYMPRP GLRPAPNSVD VDDFINTRIQ 
EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESATTDSD LDYDYLQNWG PRFKKLADLY 
GSKDTFDDDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDH11

Associated with

Cells (max top 100)

Other Information

Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. PubMed ID: 7982033

Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. PubMed ID: 8163513

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. PubMed ID: 2059658

USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. PubMed ID: 15026324

Homozygous indel mutation in CDH11 as the probable cause of Elsahy-Waters syndrome. PubMed ID: 28988429

Elsahy-Waters syndrome is caused by biallelic mutations in CDH11. PubMed ID: 29271567

Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome. PubMed ID: 33811546

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

Database document:

PubMed ID: 7982033

PubMed ID: 8163513

PubMed ID: 14702039

PubMed ID: 15616553

PubMed ID: 2059658

PubMed ID: 15026324

PubMed ID: 28988429

PubMed ID: 29271567

PubMed ID: 33811546

PubMed ID: 15616553