Details for: CDH11

Gene ID: 1009

Symbol: CDH11

Ensembl ID: ENSG00000140937

Description: cadherin 11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 9.11
    Marker Score: 5148
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.15
    Marker Score: 173961
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.94
    Marker Score: 2745
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.26
    Marker Score: 22906
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.16
    Marker Score: 6075
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.75
    Marker Score: 3170
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.59
    Marker Score: 3567
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.58
    Marker Score: 34005
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.46
    Marker Score: 1852
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.39
    Marker Score: 15573
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.21
    Marker Score: 626
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.12
    Marker Score: 19945
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.11
    Marker Score: 23800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.06
    Marker Score: 4934
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.03
    Marker Score: 3120
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.96
    Marker Score: 509
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.91
    Marker Score: 40673
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17888
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.85
    Marker Score: 4360
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.84
    Marker Score: 4823
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15815
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.83
    Marker Score: 18870
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.78
    Marker Score: 60638
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.71
    Marker Score: 62932
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.69
    Marker Score: 33577
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.67
    Marker Score: 1805
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102608.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.66
    Marker Score: 2784
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1153
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.54
    Marker Score: 1916
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.53
    Marker Score: 1098
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.53
    Marker Score: 912
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.53
    Marker Score: 4356
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.51
    Marker Score: 4102
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.5
    Marker Score: 480
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.49
    Marker Score: 335
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.49
    Marker Score: 1838
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.47
    Marker Score: 727.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.47
    Marker Score: 5991
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167485
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.46
    Marker Score: 6278
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.45
    Marker Score: 918
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.4
    Marker Score: 10755.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.37
    Marker Score: 2114
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.36
    Marker Score: 565
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.35
    Marker Score: 2297
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.33
    Marker Score: 1643.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.32
    Marker Score: 3038
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.31
    Marker Score: 49721.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.24
    Marker Score: 4783
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.21
    Marker Score: 2661.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.19
    Marker Score: 413
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.19
    Marker Score: 667
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.17
    Marker Score: 1626
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.14
    Marker Score: 989
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.14
    Marker Score: 2382
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4781.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.14
    Marker Score: 283
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.13
    Marker Score: 429
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.13
    Marker Score: 283
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.12
    Marker Score: 1189
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.1
    Marker Score: 369
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.1
    Marker Score: 4548
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.08
    Marker Score: 1032
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.07
    Marker Score: 611
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.07
    Marker Score: 1030
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.06
    Marker Score: 615
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.04
    Marker Score: 607
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2113
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251757
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 415
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48002
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.98
    Marker Score: 4523
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15144
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.95
    Marker Score: 1111
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5670
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.94
    Marker Score: 265
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.93
    Marker Score: 428
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5202
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9
    Marker Score: 208
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.9
    Marker Score: 307
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.9
    Marker Score: 13462.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.89
    Marker Score: 757
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.87
    Marker Score: 195
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.87
    Marker Score: 222
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 640.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.81
    Marker Score: 386
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.81
    Marker Score: 12944
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.79
    Marker Score: 304
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.79
    Marker Score: 518
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.79
    Marker Score: 316

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Other Information

**Key characteristics:** * CDH11 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a type II cadherin, which is characterized by a single extracellular domain. * CDH11 is expressed in a variety of cell types, including endothelial cells, smooth muscle cells, and fibroblasts. * It is a key regulator of cell-cell adhesion and tissue morphogenesis. **Pathways and functions:** * CDH11 is involved in the formation of cell-cell junctions, including adherens junctions between endothelial cells and the basement membrane. * It is also involved in the regulation of vascular development, including the formation of blood vessels and the remodeling of the vascular network. * CDH11 is also involved in cell adhesion, cell migration, and cell signaling. **Clinical significance:** * Mutations in the CDH11 gene have been linked to a number of human diseases, including cardiovascular disease, stroke, and cancer. * Inhibition of CDH11 has been shown to inhibit cell adhesion and migration, suggesting that it is a potential therapeutic target for cancer and other diseases that are characterized by abnormal cell adhesion. **Other important points:** * CDH11 is a highly conserved protein, with a similar protein found in other mammals. * It is a key regulator of cardiovascular development, and its expression is upregulated in heart failure and other cardiovascular diseases. * CDH11 is also involved in the regulation of renal development and function.

Genular Protein ID: 4203403793

Symbol: CAD11_HUMAN

Name: Cadherin-11

UniProtKB Accession Codes:

P55287 A8K5D6 A8MZC8 B7WP28 Q15065 Q15066 Q9UQ93 Q9UQ94

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 8163513

Title: Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.

PubMed ID: 8163513

DOI: 10.1016/s0021-9258(17)32685-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 2059658

Title: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

PubMed ID: 2059658

DOI: 10.1091/mbc.2.4.261

PubMed ID: 15026324

Title: USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.

PubMed ID: 15026324

DOI: 10.1158/0008-5472.can-03-2827

PubMed ID: 28988429

Title: Homozygous indel mutation in CDH11 as the probable cause of Elsahy-Waters syndrome.

PubMed ID: 28988429

DOI: 10.1002/ajmg.a.38495

PubMed ID: 29271567

Title: Elsahy-Waters syndrome is caused by biallelic mutations in CDH11.

PubMed ID: 29271567

DOI: 10.1002/ajmg.a.38568

PubMed ID: 33811546

Title: Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome.

PubMed ID: 33811546

DOI: 10.1007/s00439-021-02274-3

Sequence Information:

  • Length: 796
  • Mass: 87965
  • Checksum: E17090EC95C59936
  • Sequence:
    • MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR SKRGWVWNQF 
FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE 
RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HETYHANVPE RSNVGTSVIQ 
VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD 
MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 
GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA NVHIDPKFIS 
NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS 
IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNITVFA AEIHNRHQEA KVPVAIRVLD 
VNDNAPKFAA PYEGFICESD QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN 
FTVRDNRDNT AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV FEEEDVRENI 
ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY QYMPRPGLRP APNSVDVDDF 
INTRIQEADN DPTAPPYDSI QIYGYEGRGS VAGSLSSLES ATTDSDLDYD YLQNWGPRFK 
KLADLYGSKD TFDDDS

Genular Protein ID: 3744897371

Symbol: H3BUU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BUU9

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DrugBank 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 670
  • Mass: 73793
  • Checksum: F8CBF4E3BD77712D
  • Sequence:
    • MAQAVDRDTN RPLEPPSEFI VKVQDINDNP PEFLHETYHA NVPERSNVGT SVIQVTASDA 
DDPTYGNSAK LVYSILEGQP YFSVEAQTGI IRTALPNMDR EAKEEYHVVI QAKDMGGHMG 
GLSGTTKVTI TLTDVNDNPP KFPQSVYQMS VSEAAVPGEE VGRVKAKDPD IGENGLVTYN 
IVDGDGMESF EITTDYETQE GVIKLKKPVD FETKRAYSLK VEAANVHIDP KFISNGPFKD 
TVTVKISVED ADEPPMFLAP SYIHEVQENA AAGTVVGRVH AKDPDAANSP IRYSIDRHTD 
LDRFFTINPE DGFIKTTKPL DREETAWLNI TVFAAEIHNR HQEAKVPVAI RVLDVNDNAP 
KFAAPYEGFI CESDQTKPLS NQPIVTISAD DKDDTANGPR FIFSLPPEII HNPNFTVRDN 
RDNTAGVYAR RGGFSRQKQD LYLLPIVISD GGIPPMSSTN TLTIKVCGCD VNGALLSCNA 
EAYILNAGLS TGALIAILAC IVILLVIVVL FVTLRRQKKE PLIVFEEEDV RENIITYDDE 
GGGEEDTEAF DIATLQNPDG INGFIPRKDI KPEYQYMPRP GLRPAPNSVD VDDFINTRIQ 
EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESATTDSD LDYDYLQNWG PRFKKLADLY 
GSKDTFDDDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.