ARPC4 | ENSG00000241553 | NCBI 10093

Details for: ARPC4

Gene ID: 10093

Symbol: ARPC4

Ensembl ID: ENSG00000241553

Description: actin related protein 2/3 complex subunit 4

Associated with

Axon guidance
(R-HSA-422475)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Membrane trafficking
(R-HSA-199991)
Nervous system development
(R-HSA-9675108)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Actin filament binding
(GO:0051015)
Actin filament polymerization
(GO:0030041)
Actin nucleation
(GO:0045010)
Arp2/3 complex-mediated actin nucleation
(GO:0034314)
Arp2/3 protein complex
(GO:0005885)
Cell projection
(GO:0042995)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Nucleus
(GO:0005634)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Site of double-strand break
(GO:0035861)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Actin-related protein 2/3 complex subunit 4

Genular Protein ID: 3898614481

Symbol: ARPC4_HUMAN

Name: Actin-related protein 2/3 complex subunit 4

UniProtKB Accession Codes:

P59998 C9JWM7 E7ETI0 F6TTL5 O15509 Q6P0W5 Q96QJ3

Database IDs:

Citations:

PubMed ID: 9359840

Title: Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.

PubMed ID: 9359840

DOI: 10.1042/bj3280105

PubMed ID: 9230079

Title: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.

PubMed ID: 9230079

DOI: 10.1083/jcb.138.2.375

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11741539

Title: Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.

PubMed ID: 11741539

DOI: 10.1016/s1097-2765(01)00393-8

PubMed ID: 29925947

Title: Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

PubMed ID: 29925947

DOI: 10.1038/s41586-018-0237-5

PubMed ID: 35047857

Title: A recurrent, de novo pathogenic variant in ARPC4 disrupts actin filament formation and causes microcephaly and speech delay.

PubMed ID: 35047857

DOI: 10.1016/j.xhgg.2021.100072

Sequence Information:

Length: 168
Mass: 19667
Checksum: 273CCB230AC703DF
Sequence:

MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK 
VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN 
FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARPC4

Associated with

Other Information

Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. PubMed ID: 9359840

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. PubMed ID: 9230079

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. PubMed ID: 11741539

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. PubMed ID: 29925947

A recurrent, de novo pathogenic variant in ARPC4 disrupts actin filament formation and causes microcephaly and speech delay. PubMed ID: 35047857