ACTR2 | ENSG00000138071 | NCBI 10097

Details for: ACTR2

Gene ID: 10097

Symbol: ACTR2

Ensembl ID: ENSG00000138071

Description: actin related protein 2

Associated with

Axon guidance
(R-HSA-422475)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Membrane trafficking
(R-HSA-199991)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Actin cap
(GO:0030478)
Actin cytoskeleton
(GO:0015629)
Actin filament binding
(GO:0051015)
Arp2/3 complex-mediated actin nucleation
(GO:0034314)
Arp2/3 protein complex
(GO:0005885)
Asymmetric cell division
(GO:0008356)
Atp binding
(GO:0005524)
Azurophil granule lumen
(GO:0035578)
Cell projection
(GO:0042995)
Cellular response to type ii interferon
(GO:0071346)
Cilium assembly
(GO:0060271)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Cytosolic transport
(GO:0016482)
Establishment or maintenance of cell polarity
(GO:0007163)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Focal adhesion
(GO:0005925)
Meiotic chromosome movement towards spindle pole
(GO:0016344)
Meiotic cytokinesis
(GO:0033206)
Membrane
(GO:0016020)
Nucleus
(GO:0005634)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of double-strand break repair via nonhomologous end joining
(GO:2001032)
Site of double-strand break
(GO:0035861)
Spindle localization
(GO:0051653)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Actin-related protein 2

Genular Protein ID: 3546912276

Symbol: ARP2_HUMAN

Name: Actin-related protein 2

UniProtKB Accession Codes:

P61160 B2RCP5 D6W5F4 E9PF41 O15142 Q96C82

Database IDs:

Citations:

PubMed ID: 9230079

Title: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.

PubMed ID: 9230079

DOI: 10.1083/jcb.138.2.375

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9000076

Title: Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.

PubMed ID: 9000076

DOI: 10.1038/385265a0

PubMed ID: 11741539

Title: Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.

PubMed ID: 11741539

DOI: 10.1016/s1097-2765(01)00393-8

PubMed ID: 17220302

Title: A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription.

PubMed ID: 17220302

DOI: 10.1074/jbc.m607596200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29058690

Title: Advillin acts upstream of phospholipase C 1 in steroid-resistant nephrotic syndrome.

PubMed ID: 29058690

DOI: 10.1172/jci94138

PubMed ID: 29925947

Title: Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

PubMed ID: 29925947

DOI: 10.1038/s41586-018-0237-5

Sequence Information:

Length: 394
Mass: 44761
Checksum: 1BFA6B442ED1A797
Sequence:

MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI EIKDLMVGDE 
ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI DTRNCKILLT EPPMNPTKNR 
EKIVEVMFET YQFSGVYVAI QAVLTLYAQG LLTGVVVDSG DGVTHICPVY EGFSLPHLTR 
RLDIAGRDIT RYLIKLLLLR GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL 
VESYTLPDGR IIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRSEFYKH 
IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR KHMVFLGGAV 
LADIMKDKDN FWMTRQEYQE KGVRVLEKLG VTVR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACTR2

Associated with

Other Information

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. PubMed ID: 9230079

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. PubMed ID: 9000076

Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. PubMed ID: 11741539

A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. PubMed ID: 17220302

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Advillin acts upstream of phospholipase C 1 in steroid-resistant nephrotic syndrome. PubMed ID: 29058690

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. PubMed ID: 29925947