Details for: ADAM8
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 59.9826
Cell Significance Index: -9.3300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 30.9884
Cell Significance Index: -7.8600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 25.8949
Cell Significance Index: -10.5200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.3905
Cell Significance Index: -10.8800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.5672
Cell Significance Index: -9.3300 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 3.5481
Cell Significance Index: 9.5100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 2.2563
Cell Significance Index: -6.9300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.6266
Cell Significance Index: 189.5600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.4484
Cell Significance Index: -3.1700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.4202
Cell Significance Index: 41.7100 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 1.3210
Cell Significance Index: 22.7000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.2758
Cell Significance Index: 23.5800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.1318
Cell Significance Index: 17.5100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8613
Cell Significance Index: 44.7400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8460
Cell Significance Index: 161.0000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5328
Cell Significance Index: 52.7100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4851
Cell Significance Index: 33.5500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4687
Cell Significance Index: 423.2300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.3471
Cell Significance Index: 5.7200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3201
Cell Significance Index: 2.9500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2887
Cell Significance Index: 46.9600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2822
Cell Significance Index: 6.0100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2594
Cell Significance Index: 28.2200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.2389
Cell Significance Index: -0.6400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1565
Cell Significance Index: 28.2100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1374
Cell Significance Index: 8.2500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1143
Cell Significance Index: 1.5600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1098
Cell Significance Index: 22.0200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0501
Cell Significance Index: 6.1700 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.0451
Cell Significance Index: 0.2800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0332
Cell Significance Index: 11.9200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0328
Cell Significance Index: 3.8700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0326
Cell Significance Index: 0.9400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0136
Cell Significance Index: 9.4300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0119
Cell Significance Index: 6.5200 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0084
Cell Significance Index: 0.1200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0027
Cell Significance Index: -5.1200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0036
Cell Significance Index: -6.5900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0038
Cell Significance Index: -0.1800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0046
Cell Significance Index: -0.1000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0054
Cell Significance Index: -8.3200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0057
Cell Significance Index: -2.5100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0058
Cell Significance Index: -7.8200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0060
Cell Significance Index: -0.1600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0067
Cell Significance Index: -1.3400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0109
Cell Significance Index: -8.2600 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0133
Cell Significance Index: -0.1900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0140
Cell Significance Index: -10.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0148
Cell Significance Index: -10.8300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0161
Cell Significance Index: -10.2100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0165
Cell Significance Index: -10.2900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0172
Cell Significance Index: -0.7800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0187
Cell Significance Index: -10.5500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0234
Cell Significance Index: -10.6200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0282
Cell Significance Index: -8.1200 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.0343
Cell Significance Index: -0.3600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0398
Cell Significance Index: -1.4000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0448
Cell Significance Index: -5.7400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0501
Cell Significance Index: -5.1200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0506
Cell Significance Index: -8.6400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0508
Cell Significance Index: -10.7000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0529
Cell Significance Index: -7.2600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0613
Cell Significance Index: -7.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0652
Cell Significance Index: -9.4800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0668
Cell Significance Index: -2.1400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0724
Cell Significance Index: -9.3600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0758
Cell Significance Index: -5.8200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0781
Cell Significance Index: -4.9200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0855
Cell Significance Index: -8.9000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0914
Cell Significance Index: -4.0500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0920
Cell Significance Index: -2.3000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0940
Cell Significance Index: -2.5200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1028
Cell Significance Index: -6.3000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1045
Cell Significance Index: -7.3900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1046
Cell Significance Index: -2.1700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1062
Cell Significance Index: -6.8500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1086
Cell Significance Index: -7.3100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1091
Cell Significance Index: -4.1300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1215
Cell Significance Index: -4.9800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1324
Cell Significance Index: -3.7000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1331
Cell Significance Index: -6.2100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1350
Cell Significance Index: -8.3000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1412
Cell Significance Index: -10.5200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1422
Cell Significance Index: -7.1900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1451
Cell Significance Index: -7.5600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1451
Cell Significance Index: -11.5000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1573
Cell Significance Index: -4.2200 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.1707
Cell Significance Index: -1.5200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1709
Cell Significance Index: -9.5900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1750
Cell Significance Index: -7.6100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1830
Cell Significance Index: -9.6100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1913
Cell Significance Index: -6.7000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1938
Cell Significance Index: -2.7800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2101
Cell Significance Index: -6.8800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2171
Cell Significance Index: -6.9200 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2442
Cell Significance Index: -4.2100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2482
Cell Significance Index: -6.3800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2517
Cell Significance Index: -6.4300 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.2586
Cell Significance Index: -1.4100 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2591
Cell Significance Index: -3.7900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2362628530
Symbol: ADAM8_HUMAN
Name: Disintegrin and metalloproteinase domain-containing protein 8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9126482
Title: CD156 (human ADAM8): expression, primary amino acid sequence, and gene location.
PubMed ID: 9126482
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15574124
Title: FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation.
PubMed ID: 15574124
DOI: 10.1042/bc20040506
PubMed ID: 22684055
Title: Structure of human ADAM-8 catalytic domain complexed with batimastat.
PubMed ID: 22684055
Sequence Information:
- Length: 824
- Mass: 88771
- Checksum: CE3D31330E153DB8
- Sequence:
MRGLGLWLLG AMMLPAIAPS RPWALMEQYE VVLPWRLPGP RVRRALPSHL GLHPERVSYV LGATGHNFTL HLRKNRDLLG SGYTETYTAA NGSEVTEQPR GQDHCFYQGH VEGYPDSAAS LSTCAGLRGF FQVGSDLHLI EPLDEGGEGG RHAVYQAEHL LQTAGTCGVS DDSLGSLLGP RTAAVFRPRP GDSLPSRETR YVELYVVVDN AEFQMLGSEA AVRHRVLEVV NHVDKLYQKL NFRVVLVGLE IWNSQDRFHV SPDPSVTLEN LLTWQARQRT RRHLHDNVQL ITGVDFTGTT VGFARVSAMC SHSSGAVNQD HSKNPVGVAC TMAHEMGHNL GMDHDENVQG CRCQERFEAG RCIMAGSIGS SFPRMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK ASRYRADMCG VLQCKGGQQP LGRAICIVDV CHALTTEDGT AYEPVPEGTR CGPEKVCWKG RCQDLHVYRS SNCSAQCHNH GVCNHKQECH CHAGWAPPHC AKLLTEVHAA SGSLPVFVVV VLVLLAVVLV TLAGIIVYRK ARSRILSRNV APKTTMGRSN PLFHQAASRV PAKGGAPAPS RGPQELVPTT HPGQPARHPA SSVALKRPPP APPVTVSSPP FPVPVYTRQA PKQVIKPTFA PPVPPVKPGA GAANPGPAEG AVGPKVALKP PIQRKQGAGA PTAP
Genular Protein ID: 3663900655
Symbol: Q14C66_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 824
- Mass: 88707
- Checksum: C1BDEF3317DA2B4F
- Sequence:
MRGLGLWLLG AMMLPAIAPS RPWALMEQYE VVLPRRLPGP RVRRALPSHL GLHPERVSYV LGATGHNFTL HLRKNRDLLG SGYTETYTAA NGSEVTEQPR GQDHCFYQGH VEGYPDSAAS LSTCAGLRGF FQVGSDLHLI EPLDEGGEGG RHAVYQAEHL LQTAGTCGVS DDSLGSLLGP RTAAVFRPRP GDSLPSRETR YVELYVVVDN AEFQMLGSEA AVRHRVLEVV NHVDKLYQKL NFRVVLVGLE IWNSQDRFHV SPDPSVTLEN LLTWQARQRT RRHLHDNVQL ITGVDFTGTT VGFARVSAMC SHSSGAVNQD HSKNPVGVAC TMAHEMGHNL GMDHDENVQG CRCQERFEAG RCIMAGSIGS SFPRMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK ASRYRADMCG VLQCKGGQQP LGRAICIVDV CHALTTEDGT AYEPVPEGTR CGPEKVCWKG RCQDLHVYRS SNCSAQCHNH GVCNHKQECH CHAGWAPPHC AKLLTEVHAA SGSLPVLVVV VLVLLAVVLV TLAGIIVYRK ARSRILSRNV APKTTMGRSN PLFHQAASRV PAKGGAPAPS RGPQELVPTT HPGQPARHPA SSVALKRPPP APPVTVSSPP FPVPVYTRQA PKQVIKPTFA PPVPPVKPGA GAANPGPAEG AVGPKVALKP PIQRKQGAGA PTAP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.