Details for: ADAM8

Gene ID: 101

Symbol: ADAM8

Ensembl ID: ENSG00000151651

Description: ADAM metallopeptidase domain 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.9826
    Cell Significance Index: -9.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.9884
    Cell Significance Index: -7.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.8949
    Cell Significance Index: -10.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3905
    Cell Significance Index: -10.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.5672
    Cell Significance Index: -9.3300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.5481
    Cell Significance Index: 9.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2563
    Cell Significance Index: -6.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6266
    Cell Significance Index: 189.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4484
    Cell Significance Index: -3.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4202
    Cell Significance Index: 41.7100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.3210
    Cell Significance Index: 22.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2758
    Cell Significance Index: 23.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.1318
    Cell Significance Index: 17.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8613
    Cell Significance Index: 44.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8460
    Cell Significance Index: 161.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5328
    Cell Significance Index: 52.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4851
    Cell Significance Index: 33.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4687
    Cell Significance Index: 423.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3471
    Cell Significance Index: 5.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3201
    Cell Significance Index: 2.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2887
    Cell Significance Index: 46.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2822
    Cell Significance Index: 6.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2594
    Cell Significance Index: 28.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.2389
    Cell Significance Index: -0.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1565
    Cell Significance Index: 28.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1374
    Cell Significance Index: 8.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1143
    Cell Significance Index: 1.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1098
    Cell Significance Index: 22.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0501
    Cell Significance Index: 6.1700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0451
    Cell Significance Index: 0.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0332
    Cell Significance Index: 11.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0328
    Cell Significance Index: 3.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0326
    Cell Significance Index: 0.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0136
    Cell Significance Index: 9.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0119
    Cell Significance Index: 6.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0084
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0038
    Cell Significance Index: -0.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0046
    Cell Significance Index: -0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0057
    Cell Significance Index: -2.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0067
    Cell Significance Index: -1.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0148
    Cell Significance Index: -10.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0165
    Cell Significance Index: -10.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0172
    Cell Significance Index: -0.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0187
    Cell Significance Index: -10.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0234
    Cell Significance Index: -10.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0282
    Cell Significance Index: -8.1200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0343
    Cell Significance Index: -0.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0398
    Cell Significance Index: -1.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0448
    Cell Significance Index: -5.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0501
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0506
    Cell Significance Index: -8.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0508
    Cell Significance Index: -10.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0529
    Cell Significance Index: -7.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0613
    Cell Significance Index: -7.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0652
    Cell Significance Index: -9.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0668
    Cell Significance Index: -2.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0724
    Cell Significance Index: -9.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0758
    Cell Significance Index: -5.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0781
    Cell Significance Index: -4.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0855
    Cell Significance Index: -8.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0914
    Cell Significance Index: -4.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0920
    Cell Significance Index: -2.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0940
    Cell Significance Index: -2.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1028
    Cell Significance Index: -6.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1045
    Cell Significance Index: -7.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1046
    Cell Significance Index: -2.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1062
    Cell Significance Index: -6.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1086
    Cell Significance Index: -7.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1091
    Cell Significance Index: -4.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1215
    Cell Significance Index: -4.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1324
    Cell Significance Index: -3.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1331
    Cell Significance Index: -6.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1350
    Cell Significance Index: -8.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1412
    Cell Significance Index: -10.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1422
    Cell Significance Index: -7.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1451
    Cell Significance Index: -7.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1451
    Cell Significance Index: -11.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1573
    Cell Significance Index: -4.2200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1707
    Cell Significance Index: -1.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1709
    Cell Significance Index: -9.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1750
    Cell Significance Index: -7.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1830
    Cell Significance Index: -9.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1913
    Cell Significance Index: -6.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1938
    Cell Significance Index: -2.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2101
    Cell Significance Index: -6.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2171
    Cell Significance Index: -6.9200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2442
    Cell Significance Index: -4.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2482
    Cell Significance Index: -6.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2517
    Cell Significance Index: -6.4300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2586
    Cell Significance Index: -1.4100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2591
    Cell Significance Index: -3.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ADAM8 is characterized by the presence of a metalloprotease domain, which is responsible for its enzymatic activity. The protein is also known to interact with various ligands, including integrins, chemokines, and cytokines, which modulate its activity and regulate its interactions with other cells. ADAM8 is expressed in a variety of cell types, including immune cells, neurons, and epithelial cells, suggesting its involvement in multiple biological processes. The protein is also known to be involved in the regulation of cell-cell adhesion, migration, and signaling pathways. **Pathways and Functions** ADAM8 is involved in various signaling pathways, including: 1. **Canonical NF-κB signaling pathway**: ADAM8 is known to interact with components of the NF-κB signaling pathway, which regulates the expression of genes involved in inflammation and immune response. 2. **Alpha9-beta1 integrin-adam8 complex**: ADAM8 interacts with the alpha9-beta1 integrin, which is involved in cell adhesion and migration. 3. **Angiogenesis**: ADAM8 is involved in the regulation of angiogenesis, the process of new blood vessel formation, which is critical for wound healing and tumor growth. 4. **Cell-cell adhesion**: ADAM8 is involved in the regulation of cell-cell adhesion, which is critical for the proper functioning of tissues and organs. 5. **Inflammatory response**: ADAM8 is involved in the regulation of the inflammatory response, which is critical for the defense against pathogens and injury. The functions of ADAM8 include: 1. **Cell migration**: ADAM8 is involved in the regulation of cell migration, which is critical for the proper functioning of tissues and organs. 2. **Protein processing**: ADAM8 is involved in the cleavage and processing of proteins at the cell surface, which regulates various cellular processes. 3. **Cell signaling**: ADAM8 is involved in the regulation of cell signaling pathways, which are critical for the proper functioning of cells and tissues. **Clinical Significance** ADAM8 has been implicated in various diseases, including: 1. **Inflammatory disorders**: ADAM8 has been implicated in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis and asthma. 2. **Cancer**: ADAM8 has been implicated in the progression of various cancers, including breast, lung, and colon cancer. 3. **Neurological disorders**: ADAM8 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: ADAM8 has been implicated in the pathogenesis of infectious diseases, such as HIV and tuberculosis. Overall, ADAM8 is a multifunctional protein that plays a critical role in various biological processes, including inflammation, immune response, and cell migration. Its dysregulation has been implicated in various diseases, highlighting the potential of ADAM8 as a therapeutic target for the treatment of these diseases.

Genular Protein ID: 2362628530

Symbol: ADAM8_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 8

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9126482

Title: CD156 (human ADAM8): expression, primary amino acid sequence, and gene location.

PubMed ID: 9126482

DOI: 10.1006/geno.1997.4607

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15574124

Title: FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation.

PubMed ID: 15574124

DOI: 10.1042/bc20040506

PubMed ID: 22684055

Title: Structure of human ADAM-8 catalytic domain complexed with batimastat.

PubMed ID: 22684055

DOI: 10.1107/s1744309112015618

Sequence Information:

  • Length: 824
  • Mass: 88771
  • Checksum: CE3D31330E153DB8
  • Sequence:
  • MRGLGLWLLG AMMLPAIAPS RPWALMEQYE VVLPWRLPGP RVRRALPSHL GLHPERVSYV 
    LGATGHNFTL HLRKNRDLLG SGYTETYTAA NGSEVTEQPR GQDHCFYQGH VEGYPDSAAS 
    LSTCAGLRGF FQVGSDLHLI EPLDEGGEGG RHAVYQAEHL LQTAGTCGVS DDSLGSLLGP 
    RTAAVFRPRP GDSLPSRETR YVELYVVVDN AEFQMLGSEA AVRHRVLEVV NHVDKLYQKL 
    NFRVVLVGLE IWNSQDRFHV SPDPSVTLEN LLTWQARQRT RRHLHDNVQL ITGVDFTGTT 
    VGFARVSAMC SHSSGAVNQD HSKNPVGVAC TMAHEMGHNL GMDHDENVQG CRCQERFEAG 
    RCIMAGSIGS SFPRMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE 
    QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD 
    GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK 
    ASRYRADMCG VLQCKGGQQP LGRAICIVDV CHALTTEDGT AYEPVPEGTR CGPEKVCWKG 
    RCQDLHVYRS SNCSAQCHNH GVCNHKQECH CHAGWAPPHC AKLLTEVHAA SGSLPVFVVV 
    VLVLLAVVLV TLAGIIVYRK ARSRILSRNV APKTTMGRSN PLFHQAASRV PAKGGAPAPS 
    RGPQELVPTT HPGQPARHPA SSVALKRPPP APPVTVSSPP FPVPVYTRQA PKQVIKPTFA 
    PPVPPVKPGA GAANPGPAEG AVGPKVALKP PIQRKQGAGA PTAP

Genular Protein ID: 3663900655

Symbol: Q14C66_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 824
  • Mass: 88707
  • Checksum: C1BDEF3317DA2B4F
  • Sequence:
  • MRGLGLWLLG AMMLPAIAPS RPWALMEQYE VVLPRRLPGP RVRRALPSHL GLHPERVSYV 
    LGATGHNFTL HLRKNRDLLG SGYTETYTAA NGSEVTEQPR GQDHCFYQGH VEGYPDSAAS 
    LSTCAGLRGF FQVGSDLHLI EPLDEGGEGG RHAVYQAEHL LQTAGTCGVS DDSLGSLLGP 
    RTAAVFRPRP GDSLPSRETR YVELYVVVDN AEFQMLGSEA AVRHRVLEVV NHVDKLYQKL 
    NFRVVLVGLE IWNSQDRFHV SPDPSVTLEN LLTWQARQRT RRHLHDNVQL ITGVDFTGTT 
    VGFARVSAMC SHSSGAVNQD HSKNPVGVAC TMAHEMGHNL GMDHDENVQG CRCQERFEAG 
    RCIMAGSIGS SFPRMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE 
    QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD 
    GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK 
    ASRYRADMCG VLQCKGGQQP LGRAICIVDV CHALTTEDGT AYEPVPEGTR CGPEKVCWKG 
    RCQDLHVYRS SNCSAQCHNH GVCNHKQECH CHAGWAPPHC AKLLTEVHAA SGSLPVLVVV 
    VLVLLAVVLV TLAGIIVYRK ARSRILSRNV APKTTMGRSN PLFHQAASRV PAKGGAPAPS 
    RGPQELVPTT HPGQPARHPA SSVALKRPPP APPVTVSSPP FPVPVYTRQA PKQVIKPTFA 
    PPVPPVKPGA GAANPGPAEG AVGPKVALKP PIQRKQGAGA PTAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.