Details for: CDH12

Gene ID: 1010

Symbol: CDH12

Ensembl ID: ENSG00000154162

Description: cadherin 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 114.5211
    Cell Significance Index: -46.5300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 13.6315
    Cell Significance Index: 141.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2160
    Cell Significance Index: -20.1700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 6.6160
    Cell Significance Index: 88.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.4118
    Cell Significance Index: 140.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.9113
    Cell Significance Index: 185.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.3611
    Cell Significance Index: 192.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.2573
    Cell Significance Index: 121.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.7232
    Cell Significance Index: 1335.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9903
    Cell Significance Index: 599.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.8239
    Cell Significance Index: 177.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.3937
    Cell Significance Index: 160.9500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.3606
    Cell Significance Index: 24.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5937
    Cell Significance Index: 89.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2369
    Cell Significance Index: 39.6200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2360
    Cell Significance Index: 15.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7944
    Cell Significance Index: 9.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6553
    Cell Significance Index: 11.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4843
    Cell Significance Index: 70.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4502
    Cell Significance Index: 89.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2979
    Cell Significance Index: 18.3100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2943
    Cell Significance Index: 3.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2818
    Cell Significance Index: 36.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2776
    Cell Significance Index: 52.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2629
    Cell Significance Index: 357.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2623
    Cell Significance Index: 6.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2525
    Cell Significance Index: 388.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2330
    Cell Significance Index: 438.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2242
    Cell Significance Index: 413.4100
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.1963
    Cell Significance Index: 2.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0219
    Cell Significance Index: 13.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0276
    Cell Significance Index: -24.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0480
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0514
    Cell Significance Index: -38.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0632
    Cell Significance Index: -28.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0719
    Cell Significance Index: -31.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0725
    Cell Significance Index: -53.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0730
    Cell Significance Index: -55.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0876
    Cell Significance Index: -49.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0912
    Cell Significance Index: -56.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0976
    Cell Significance Index: -2.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1040
    Cell Significance Index: -56.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1234
    Cell Significance Index: -2.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1411
    Cell Significance Index: -2.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1602
    Cell Significance Index: -46.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1655
    Cell Significance Index: -10.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1726
    Cell Significance Index: -1.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1796
    Cell Significance Index: -29.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1857
    Cell Significance Index: -2.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1934
    Cell Significance Index: -34.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2365
    Cell Significance Index: -40.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2510
    Cell Significance Index: -52.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3028
    Cell Significance Index: -32.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3320
    Cell Significance Index: -8.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3436
    Cell Significance Index: -42.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3761
    Cell Significance Index: -13.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3869
    Cell Significance Index: -49.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3935
    Cell Significance Index: -38.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3992
    Cell Significance Index: -27.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4026
    Cell Significance Index: -11.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4123
    Cell Significance Index: -56.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4127
    Cell Significance Index: -48.0900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4194
    Cell Significance Index: -3.9900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4223
    Cell Significance Index: -5.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4371
    Cell Significance Index: -14.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4517
    Cell Significance Index: -13.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4717
    Cell Significance Index: -54.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4723
    Cell Significance Index: -28.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4731
    Cell Significance Index: -49.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4847
    Cell Significance Index: -49.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5589
    Cell Significance Index: -11.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5970
    Cell Significance Index: -42.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6581
    Cell Significance Index: -20.9600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6630
    Cell Significance Index: -7.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6858
    Cell Significance Index: -51.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7268
    Cell Significance Index: -31.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7427
    Cell Significance Index: -16.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7656
    Cell Significance Index: -58.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7889
    Cell Significance Index: -41.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7988
    Cell Significance Index: -16.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8109
    Cell Significance Index: -38.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8380
    Cell Significance Index: -37.9900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8698
    Cell Significance Index: -11.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8852
    Cell Significance Index: -20.4500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8878
    Cell Significance Index: -18.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9708
    Cell Significance Index: -34.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9914
    Cell Significance Index: -26.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9977
    Cell Significance Index: -51.8300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0024
    Cell Significance Index: -14.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.0528
    Cell Significance Index: -9.9800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.0787
    Cell Significance Index: -21.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1640
    Cell Significance Index: -54.2700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.2103
    Cell Significance Index: -9.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2315
    Cell Significance Index: -30.7200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.2424
    Cell Significance Index: -39.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.3512
    Cell Significance Index: -36.0800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.3764
    Cell Significance Index: -16.4600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.3933
    Cell Significance Index: -10.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4366
    Cell Significance Index: -49.9200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -1.4367
    Cell Significance Index: -16.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDH12 is a type of transmembrane cadherin, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain of CDH12 is characterized by a unique structure, featuring a short cytoplasmic tail and a calcium-binding site. This calcium-binding site is essential for the formation of homophilic adhesion complexes, which are critical for cell-cell adhesion and signaling. CDH12 is also known to interact with other cadherins, such as E-cadherin and N-cadherin, to form complex adhesion complexes. **Pathways and Functions:** CDH12 is involved in several key pathways, including: 1. **Cell-cell adhesion**: CDH12 plays a crucial role in establishing and maintaining cell-cell adhesion, which is essential for tissue architecture and immune function. 2. **Catenin complex**: CDH12 interacts with the catenin complex, a group of proteins that regulate cell-cell adhesion and signaling. 3. **Calcium-dependent signaling**: The calcium-binding site in CDH12 is essential for calcium-dependent signaling, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. 4. **Morphogenesis**: CDH12 is involved in the regulation of cell shape and morphology, which is critical for tissue development and immune function. **Clinical Significance:** CDH12 has been implicated in various diseases, including: 1. **Immune disorders**: CDH12 has been shown to play a role in the development of immune disorders, such as autoimmune diseases and inflammatory disorders. 2. **Cancer**: CDH12 has been found to be overexpressed in certain types of cancer, including breast cancer and colon cancer. 3. **Neurological disorders**: CDH12 has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CDH12 is a critical gene involved in cell-cell adhesion, signaling, and morphogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and significance of this gene.

Genular Protein ID: 3278129336

Symbol: CAD12_HUMAN

Name: Cadherin-12

UniProtKB Accession Codes:

P55289 B2RBT1 B7Z2U6 Q86UD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 3 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 7731968

Title: Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene.

PubMed ID: 7731968

DOI: 10.1073/pnas.92.9.3702

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 794
  • Mass: 88332
  • Checksum: 76DF39AB56E7BC2D
  • Sequence:
    • MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ RVKRGWVWNQ 
FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT VFTIDETTGD IHAIRSLDRE 
EKPFYTLRAQ AVDIETRKPL EPESEFIIKV QDINDNEPKF LDGPYVATVP EMSPVGAYVL 
QVKATDADDP TYGNSARVVY SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK 
DMGGQLGGLA GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ 
NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA SNLHLDHRFH 
SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG TIIGAVTAQD LDVGSSAVRY 
FIDWKSDGDS YFTIDGNEGT IATNELLDRE STAQYNFSII ASKVSNPLLT SKVNILINVL 
DVNEFPPEIS VPYETAVCEN AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV 
RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS 
CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK EDIRDNVIHY 
DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL PRQRPPMEDN TDIRDFIHQR 
LQENDVDPTA PPYDSLATYA YEGSGSVAES LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD 
MFGEEESYNP DKVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.