Details for: CDH12

Gene ID: 1010

Symbol: CDH12

Ensembl ID: ENSG00000154162

Description: cadherin 12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.37
    Marker Score: 55559
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 7.03
    Marker Score: 16149
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 5.65
    Marker Score: 2534
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.6
    Marker Score: 189243
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.15
    Marker Score: 1000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.89
    Marker Score: 15533
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.66
    Marker Score: 20390
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.65
    Marker Score: 875
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.62
    Marker Score: 4962.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.62
    Marker Score: 15733
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.58
    Marker Score: 1349
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.52
    Marker Score: 10431
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.52
    Marker Score: 3384
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.49
    Marker Score: 3010
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.44
    Marker Score: 2105
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.43
    Marker Score: 1419
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.41
    Marker Score: 32095
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.33
    Marker Score: 976
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.24
    Marker Score: 906
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.06
    Marker Score: 40961
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2
    Marker Score: 8382.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.99
    Marker Score: 9226
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.98
    Marker Score: 3405
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.96
    Marker Score: 10265
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.92
    Marker Score: 875
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.91
    Marker Score: 733
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.89
    Marker Score: 3182
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.86
    Marker Score: 1404
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.84
    Marker Score: 7116
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.79
    Marker Score: 18448
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.77
    Marker Score: 893
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15062
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.75
    Marker Score: 107622
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.7
    Marker Score: 62814
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.7
    Marker Score: 3458
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.69
    Marker Score: 463
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.66
    Marker Score: 6772
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.63
    Marker Score: 982
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.62
    Marker Score: 2023
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.61
    Marker Score: 2091
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.6
    Marker Score: 15086
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1159
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.58
    Marker Score: 4519
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.45
    Marker Score: 55232
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.34
    Marker Score: 465
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.33
    Marker Score: 421.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.3
    Marker Score: 757
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.28
    Marker Score: 22723
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.28
    Marker Score: 2330
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.24
    Marker Score: 1537
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18490
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.17
    Marker Score: 1811
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.14
    Marker Score: 10810
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4767
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.13
    Marker Score: 1305
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.08
    Marker Score: 1191
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.08
    Marker Score: 1197.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.07
    Marker Score: 725
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.06
    Marker Score: 439
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.05
    Marker Score: 22389
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.05
    Marker Score: 3511
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.05
    Marker Score: 1473
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.03
    Marker Score: 2432
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.01
    Marker Score: 464
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1
    Marker Score: 683
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71731
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47956
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.98
    Marker Score: 14598
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.98
    Marker Score: 2143
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.96
    Marker Score: 573
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.94
    Marker Score: 645
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.93
    Marker Score: 292
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.92
    Marker Score: 2298
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.92
    Marker Score: 1333
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5230
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.89
    Marker Score: 266
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.89
    Marker Score: 432
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.88
    Marker Score: 834
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.87
    Marker Score: 315
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.87
    Marker Score: 797
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.87
    Marker Score: 570
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.86
    Marker Score: 412
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.86
    Marker Score: 3064
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.86
    Marker Score: 251
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.84
    Marker Score: 265
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.83
    Marker Score: 264
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.82
    Marker Score: 303
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.81
    Marker Score: 2776.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.8
    Marker Score: 3354
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.8
    Marker Score: 207

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Other Information

**Key characteristics:** - CDH12 is a transmembrane protein that is expressed in both epithelial and mesenchymal cells. - It is a type of cadherin, a family of cell adhesion molecules that are crucial for the formation and maintenance of tissue integrity. - CDH12 is a homophilic protein, meaning that it binds to other CDH12 molecules. - It is a key component of adherens junctions, which are specialized cell-cell adhesion structures that hold tissues and organs together. - CDH12 is also involved in cell-cell adhesion in non-junctional contexts, such as in the development of the lung and the formation of the cardiovascular system. **Pathways and functions:** - CDH12 is involved in various cellular processes, including cell adhesion, migration, and signaling. - It is crucial for the formation and maintenance of epithelial tissues, such as the lining of the lungs, stomach, and intestines. - In the heart, CDH12 is involved in the development and function of cardiac endothelial cells and the formation of blood-brain barriers. - It is also involved in the development and function of the nervous system, where it is expressed in neurons and glial cells. **Clinical significance:** - Mutations in CDH12 have been linked to several human diseases, including cardiovascular disease, cancer, and developmental disorders. - Targeting CDH12 has emerged as a promising therapeutic approach for these diseases. - Antibodies against CDH12 have been shown to be effective in inhibiting cell adhesion and reducing the symptoms of cancer.

Genular Protein ID: 3278129336

Symbol: CAD12_HUMAN

Name: Cadherin-12

UniProtKB Accession Codes:

P55289 B2RBT1 B7Z2U6 Q86UD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 3 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 7731968

Title: Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene.

PubMed ID: 7731968

DOI: 10.1073/pnas.92.9.3702

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 794
  • Mass: 88332
  • Checksum: 76DF39AB56E7BC2D
  • Sequence:
    • MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ RVKRGWVWNQ 
FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT VFTIDETTGD IHAIRSLDRE 
EKPFYTLRAQ AVDIETRKPL EPESEFIIKV QDINDNEPKF LDGPYVATVP EMSPVGAYVL 
QVKATDADDP TYGNSARVVY SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK 
DMGGQLGGLA GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ 
NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA SNLHLDHRFH 
SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG TIIGAVTAQD LDVGSSAVRY 
FIDWKSDGDS YFTIDGNEGT IATNELLDRE STAQYNFSII ASKVSNPLLT SKVNILINVL 
DVNEFPPEIS VPYETAVCEN AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV 
RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS 
CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK EDIRDNVIHY 
DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL PRQRPPMEDN TDIRDFIHQR 
LQENDVDPTA PPYDSLATYA YEGSGSVAES LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD 
MFGEEESYNP DKVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.