Details for: TSPAN1

Gene ID: 10103

Symbol: TSPAN1

Ensembl ID: ENSG00000117472

Description: tetraspanin 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.91
    Marker Score: 2,588
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.67
    Marker Score: 31,895
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.42
    Marker Score: 10,748
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.4
    Marker Score: 2,271
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 3.38
    Marker Score: 11,623
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 3.09
    Marker Score: 846
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.05
    Marker Score: 19,455
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.04
    Marker Score: 7,663
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.88
    Marker Score: 2,762
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.8
    Marker Score: 1,382
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.62
    Marker Score: 4,979
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.6
    Marker Score: 9,243
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.59
    Marker Score: 12,452
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.55
    Marker Score: 2,013
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.46
    Marker Score: 2,874
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.4
    Marker Score: 1,397
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.35
    Marker Score: 4,298
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.34
    Marker Score: 3,441
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.3
    Marker Score: 5,229
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.3
    Marker Score: 17,086
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.22
    Marker Score: 640
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.12
    Marker Score: 1,657
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.08
    Marker Score: 71,972
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.04
    Marker Score: 3,142
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2
    Marker Score: 2,830
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.95
    Marker Score: 674
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.95
    Marker Score: 1,040
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.94
    Marker Score: 813
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9
    Marker Score: 2,005
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.87
    Marker Score: 594
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.84
    Marker Score: 4,519
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.79
    Marker Score: 2,963
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.76
    Marker Score: 821
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.75
    Marker Score: 828
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.68
    Marker Score: 705
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.62
    Marker Score: 1,123
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.61
    Marker Score: 411
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.59
    Marker Score: 725
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.58
    Marker Score: 2,989
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.56
    Marker Score: 3,806
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.56
    Marker Score: 1,552
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.55
    Marker Score: 313
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.52
    Marker Score: 3,602
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5
    Marker Score: 372
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.49
    Marker Score: 986
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.48
    Marker Score: 760
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.45
    Marker Score: 988
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.34
    Marker Score: 1,190
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.29
    Marker Score: 1,155
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.29
    Marker Score: 1,308
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.22
    Marker Score: 240
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.22
    Marker Score: 455
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.16
    Marker Score: 334
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1
    Marker Score: 5,260
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,785
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,009
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.99
    Marker Score: 1,099
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.98
    Marker Score: 283
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.96
    Marker Score: 361
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.95
    Marker Score: 275
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14,732
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.94
    Marker Score: 249
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,329
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.93
    Marker Score: 2,497
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.89
    Marker Score: 463
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.87
    Marker Score: 1,124
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.85
    Marker Score: 206
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.85
    Marker Score: 905
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.85
    Marker Score: 619
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.85
    Marker Score: 530
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1,331
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3,288
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.77
    Marker Score: 1,821
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.75
    Marker Score: 1,187
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 470
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.73
    Marker Score: 191
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 659
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.69
    Marker Score: 188
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.67
    Marker Score: 2,571
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.63
    Marker Score: 540
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.6
    Marker Score: 636
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.59
    Marker Score: 271
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.58
    Marker Score: 402
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 172
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.54
    Marker Score: 955
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.53
    Marker Score: 572

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** TSPAN1 is primarily localized to the plasma membrane, where it interacts with other proteins to regulate cell-cell and cell-matrix interactions. 2. **Protein-protein interactions:** TSPAN1 forms heterodimers with other tetraspanins and interacts with various proteins, including integrins, CD4, and CD8, to modulate signaling pathways and adhesion properties. 3. **Expression pattern:** TSPAN1 is expressed in multiple cell types, including hematopoietic stem cells, epithelial cells, and goblet cells, suggesting its role in maintaining tissue homeostasis and regulating immune responses. 4. **Function:** TSPAN1 is involved in regulating cell signaling, adhesion, and trafficking, which are critical for maintaining tissue homeostasis and preventing disease. **Pathways and Functions:** 1. **Cell-cell adhesion:** TSPAN1 interacts with other proteins to regulate cell-cell adhesion, which is essential for maintaining tissue homeostasis and preventing disease. 2. **Signaling pathways:** TSPAN1 modulates signaling pathways, including the MAPK/ERK and PI3K/AKT pathways, which are involved in regulating cell growth, differentiation, and survival. 3. **Cell trafficking:** TSPAN1 regulates cell trafficking by modulating the activity of proteins involved in endocytosis and exocytosis. 4. **Immune regulation:** TSPAN1 is involved in regulating immune responses by modulating the activity of immune cells, including T cells and B cells. **Clinical Significance:** 1. **Cancer:** Aberrant expression of TSPAN1 has been observed in various cancers, including breast, lung, and colon cancer, suggesting its role in tumorigenesis and disease progression. 2. **Autoimmune diseases:** TSPAN1 has been implicated in the pathogenesis of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, where it regulates immune responses and tissue homeostasis. 3. **Infectious diseases:** TSPAN1 has been shown to play a role in regulating immune responses to infectious diseases, including HIV and tuberculosis. 4. **Neurological disorders:** TSPAN1 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates cell signaling and trafficking. In conclusion, TSPAN1 is a multifunctional gene that plays critical roles in regulating cell signaling, adhesion, and trafficking, as well as maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the functional significance of TSPAN1 and its role in various human diseases.

Genular Protein ID: 2366297778

Symbol: TSN1_HUMAN

Name: Tetraspanin-1

UniProtKB Accession Codes:

O60635 D3DQ14 O60745 Q5VST0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714763

Title: Sequences and expression of six new members of the tetraspanin/TM4SF family.

PubMed ID: 9714763

DOI: 10.1016/s0167-4781(98)00087-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19508227

Title: Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum.

PubMed ID: 19508227

DOI: 10.2174/092986609789071234

Sequence Information:

  • Length: 241
  • Mass: 26301
  • Checksum: AF938AD7147CB884
  • Sequence:
    • MQCFSFIKTM MILFNLLIFL CGAALLAVGI WVSIDGASFL KIFGPLSSSA MQFVNVGYFL 
IAAGVVVFAL GFLGCYGAKT ESKCALVTFF FILLLIFIAE VAAAVVALVY TTMAEHFLTL 
LVVPAIKKDY GSQEDFTQVW NTTMKGLKCC GFTNYTDFED SPYFKENSAF PPFCCNDNVT 
NTANETCTKQ KAHDQKVEGC FNQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL 
Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.