Details for: PPIF

Gene ID: 10105

Symbol: PPIF

Ensembl ID: ENSG00000108179

Description: peptidylprolyl isomerase F

Associated with

  • Apoptotic mitochondrial changes
    (GO:0008637)
  • Cellular response to arsenic-containing substance
    (GO:0071243)
  • Cellular response to calcium ion
    (GO:0071277)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cyclosporin a binding
    (GO:0016018)
  • Cytoplasm
    (GO:0005737)
  • Membrane
    (GO:0016020)
  • Mitochondrial depolarization
    (GO:0051882)
  • Mitochondrial matrix
    (GO:0005759)
  • Mitochondrial outer membrane permeabilization involved in programmed cell death
    (GO:1902686)
  • Mitochondrial permeability transition pore complex
    (GO:0005757)
  • Mitochondrial proton-transporting atp synthase complex
    (GO:0005753)
  • Mitochondrion
    (GO:0005739)
  • Necroptotic process
    (GO:0070266)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of atp-dependent activity
    (GO:0032780)
  • Negative regulation of intrinsic apoptotic signaling pathway
    (GO:2001243)
  • Negative regulation of oxidative phosphorylation
    (GO:0090324)
  • Negative regulation of oxidative phosphorylation uncoupler activity
    (GO:2000276)
  • Negative regulation of release of cytochrome c from mitochondria
    (GO:0090201)
  • Peptidyl-prolyl cis-trans isomerase activity
    (GO:0003755)
  • Protein binding
    (GO:0005515)
  • Protein folding
    (GO:0006457)
  • Protein peptidyl-prolyl isomerization
    (GO:0000413)
  • Regulation of mitochondrial membrane permeability
    (GO:0046902)
  • Regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
    (GO:1902445)
  • Regulation of proton-transporting atpase activity, rotational mechanism
    (GO:0010849)
  • Response to ischemia
    (GO:0002931)
  • Skeletal muscle fiber differentiation
    (GO:0098528)

Other Information

Genular Protein ID: 1260727097

Symbol: PPIF_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial

UniProtKB Accession Codes:

P30405 Q2YDB7 Q5W131

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 69 PDBsum 66 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1744118

Title: The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

PubMed ID: 1744118

DOI: 10.1016/s0021-9258(18)54484-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10406942

Title: Import and processing of heart mitochondrial cyclophilin D.

PubMed ID: 10406942

DOI: 10.1046/j.1432-1327.1999.00490.x

PubMed ID: 19228691

Title: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect.

PubMed ID: 19228691

DOI: 10.1074/jbc.m808750200

PubMed ID: 20676357

Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

PubMed ID: 20676357

DOI: 10.1371/journal.pbio.1000439

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20950273

Title: Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death.

PubMed ID: 20950273

DOI: 10.1042/bj20101431

PubMed ID: 21930693

Title: Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore.

PubMed ID: 21930693

DOI: 10.1074/jbc.m111.243469

PubMed ID: 22726440

Title: p53 opens the mitochondrial permeability transition pore to trigger necrosis.

PubMed ID: 22726440

DOI: 10.1016/j.cell.2012.05.014

PubMed ID: 26387735

Title: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore.

PubMed ID: 26387735

DOI: 10.1016/j.molcel.2015.08.009

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26976564

Title: Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.

PubMed ID: 26976564

DOI: 10.1073/pnas.1602264113

PubMed ID: 15858260

Title: Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 A resolution.

PubMed ID: 15858260

DOI: 10.1107/s0907444905003070

PubMed ID: 18076075

Title: Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution.

PubMed ID: 18076075

DOI: 10.1002/prot.21855

PubMed ID: 21904027

Title: In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.

PubMed ID: 21904027

DOI: 10.1107/s0907444911023249

Sequence Information:

  • Length: 207
  • Mass: 22040
  • Checksum: D7C76F1D4049F16A
  • Sequence:
    • MLALRCGSRW LGLLSVPRSV PLRLPAARAC SKGSGDPSSS SSSGNPLVYL DVDANGKPLG 
RVVLELKADV VPKTAENFRA LCTGEKGFGY KGSTFHRVIP SFMCQAGDFT NHNGTGGKSI 
YGSRFPDENF TLKHVGPGVL SMANAGPNTN GSQFFICTIK TDWLDGKHVV FGHVKEGMDV 
VKKIESFGSK SGRTSKKIVI TDCGQLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.