Details for: PPIF

Gene ID: 10105

Symbol: PPIF

Ensembl ID: ENSG00000108179

Description: peptidylprolyl isomerase F

Associated with

  • Apoptotic mitochondrial changes
    (GO:0008637)
  • Cellular response to arsenic-containing substance
    (GO:0071243)
  • Cellular response to calcium ion
    (GO:0071277)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cyclosporin a binding
    (GO:0016018)
  • Cytoplasm
    (GO:0005737)
  • Membrane
    (GO:0016020)
  • Mitochondrial depolarization
    (GO:0051882)
  • Mitochondrial matrix
    (GO:0005759)
  • Mitochondrial outer membrane permeabilization involved in programmed cell death
    (GO:1902686)
  • Mitochondrial permeability transition pore complex
    (GO:0005757)
  • Mitochondrial proton-transporting atp synthase complex
    (GO:0005753)
  • Mitochondrion
    (GO:0005739)
  • Necroptotic process
    (GO:0070266)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of atp-dependent activity
    (GO:0032780)
  • Negative regulation of intrinsic apoptotic signaling pathway
    (GO:2001243)
  • Negative regulation of oxidative phosphorylation
    (GO:0090324)
  • Negative regulation of oxidative phosphorylation uncoupler activity
    (GO:2000276)
  • Negative regulation of release of cytochrome c from mitochondria
    (GO:0090201)
  • Peptidyl-prolyl cis-trans isomerase activity
    (GO:0003755)
  • Protein binding
    (GO:0005515)
  • Protein folding
    (GO:0006457)
  • Protein peptidyl-prolyl isomerization
    (GO:0000413)
  • Regulation of mitochondrial membrane permeability
    (GO:0046902)
  • Regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
    (GO:1902445)
  • Regulation of proton-transporting atpase activity, rotational mechanism
    (GO:0010849)
  • Response to ischemia
    (GO:0002931)
  • Skeletal muscle fiber differentiation
    (GO:0098528)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.55
    Marker Score: 45,215
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.07
    Marker Score: 3,609
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.88
    Marker Score: 11,141
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.73
    Marker Score: 10,523
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.69
    Marker Score: 10,803
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.51
    Marker Score: 5,848
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.5
    Marker Score: 1,019
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.49
    Marker Score: 83,495
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.49
    Marker Score: 6,106
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.47
    Marker Score: 5,444
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.44
    Marker Score: 474
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.43
    Marker Score: 5,616
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.39
    Marker Score: 2,045
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.36
    Marker Score: 3,221
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.31
    Marker Score: 534
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3
    Marker Score: 44,220
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.28
    Marker Score: 12,886
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.28
    Marker Score: 3,481
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.25
    Marker Score: 6,121
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.22
    Marker Score: 1,284
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.21
    Marker Score: 3,240
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.19
    Marker Score: 2,318
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.18
    Marker Score: 1,963
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.18
    Marker Score: 1,934
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.17
    Marker Score: 826
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.12
    Marker Score: 2,900
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.08
    Marker Score: 1,557
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.08
    Marker Score: 8,436
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2,190
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.07
    Marker Score: 806
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16,514
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.05
    Marker Score: 372
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.04
    Marker Score: 1,108
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.02
    Marker Score: 1,170
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.02
    Marker Score: 6,535
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.02
    Marker Score: 35,289
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.02
    Marker Score: 3,191
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.02
    Marker Score: 1,034
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.01
    Marker Score: 1,053
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.01
    Marker Score: 638
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1
    Marker Score: 2,498
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,685
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,908
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Marker Score: 824
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.99
    Marker Score: 2,080
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,388
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.98
    Marker Score: 977
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.98
    Marker Score: 487
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.97
    Marker Score: 1,293
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.97
    Marker Score: 535
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.97
    Marker Score: 1,025
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.97
    Marker Score: 478
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.94
    Marker Score: 889
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.93
    Marker Score: 2,111
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.93
    Marker Score: 218
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.93
    Marker Score: 677
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.92
    Marker Score: 979
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,222
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.91
    Marker Score: 977
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9
    Marker Score: 1,705
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,694
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.9
    Marker Score: 7,743
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.89
    Marker Score: 617
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.88
    Marker Score: 221
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.87
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.85
    Marker Score: 1,783
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 513
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.85
    Marker Score: 904
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.85
    Marker Score: 1,199
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.84
    Marker Score: 900
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.84
    Marker Score: 316
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.84
    Marker Score: 3,488
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.83
    Marker Score: 477
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.83
    Marker Score: 1,038
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.82
    Marker Score: 2,073
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.79
    Marker Score: 225
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.79
    Marker Score: 753
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.78
    Marker Score: 521
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.78
    Marker Score: 809
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.77
    Marker Score: 441
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.77
    Marker Score: 1,004
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.77
    Marker Score: 2,274
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.77
    Marker Score: 523
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.77
    Marker Score: 897
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.76
    Marker Score: 162
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.76
    Marker Score: 516
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.76
    Marker Score: 820
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.75
    Marker Score: 19,159
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.74
    Marker Score: 509
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.74
    Marker Score: 466
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.74
    Marker Score: 1,806
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PPIF is a mitochondrial protein that belongs to the peptidyl-prolyl cis-trans isomerase family. It is characterized by its ability to catalyze the cis-trans isomerization of peptidyl-prolyl bonds, which is essential for protein folding and stability. PPIF is predominantly expressed in mitochondria, where it regulates mitochondrial membrane permeability and plays a role in the regulation of ATP-dependent activities. Its expression is also observed in various cell types, including immune cells, where it may contribute to immune regulation and response to stress signals. **Pathways and Functions** PPIF is involved in several cellular pathways, including: 1. **Apoptotic mitochondrial changes**: PPIF regulates mitochondrial membrane permeability, which is a critical step in the intrinsic apoptotic pathway. 2. **Cellular response to arsenic-containing substance**: PPIF is involved in the regulation of mitochondrial function and response to oxidative stress caused by arsenic exposure. 3. **Regulation of mitochondrial membrane permeability**: PPIF regulates the opening of the mitochondrial permeability transition pore (mPTP), which is crucial for programmed cell death. 4. **Negative regulation of apoptotic process**: PPIF inhibits the release of cytochrome c from mitochondria, which is a key step in the intrinsic apoptotic pathway. 5. **Regulation of oxidative phosphorylation**: PPIF regulates the activity of ATP synthase, which is essential for oxidative phosphorylation. **Clinical Significance** PPIF has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: PPIF has been shown to play a role in the regulation of immune responses and the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: PPIF has been implicated in cancer progression and metastasis, where it regulates mitochondrial function and response to stress signals. 3. **Neurodegenerative diseases**: PPIF has been shown to be involved in the regulation of mitochondrial function in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: PPIF has been implicated in the regulation of immune responses to infections, such as tuberculosis and malaria. In conclusion, PPIF is a critical protein that regulates various cellular processes, including protein folding, mitochondrial membrane permeability, and response to stress signals. Its clinical significance lies in its involvement in immune-related disorders, including autoimmune diseases, cancer, neurodegenerative diseases, and infectious diseases. Further research is needed to fully understand the role of PPIF in human health and disease.

Genular Protein ID: 1260727097

Symbol: PPIF_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial

UniProtKB Accession Codes:

P30405 Q2YDB7 Q5W131

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 69 PDBsum 66 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1744118

Title: The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

PubMed ID: 1744118

DOI: 10.1016/s0021-9258(18)54484-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10406942

Title: Import and processing of heart mitochondrial cyclophilin D.

PubMed ID: 10406942

DOI: 10.1046/j.1432-1327.1999.00490.x

PubMed ID: 19228691

Title: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect.

PubMed ID: 19228691

DOI: 10.1074/jbc.m808750200

PubMed ID: 20676357

Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

PubMed ID: 20676357

DOI: 10.1371/journal.pbio.1000439

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20950273

Title: Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death.

PubMed ID: 20950273

DOI: 10.1042/bj20101431

PubMed ID: 21930693

Title: Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore.

PubMed ID: 21930693

DOI: 10.1074/jbc.m111.243469

PubMed ID: 22726440

Title: p53 opens the mitochondrial permeability transition pore to trigger necrosis.

PubMed ID: 22726440

DOI: 10.1016/j.cell.2012.05.014

PubMed ID: 26387735

Title: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore.

PubMed ID: 26387735

DOI: 10.1016/j.molcel.2015.08.009

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26976564

Title: Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.

PubMed ID: 26976564

DOI: 10.1073/pnas.1602264113

PubMed ID: 15858260

Title: Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 A resolution.

PubMed ID: 15858260

DOI: 10.1107/s0907444905003070

PubMed ID: 18076075

Title: Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution.

PubMed ID: 18076075

DOI: 10.1002/prot.21855

PubMed ID: 21904027

Title: In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.

PubMed ID: 21904027

DOI: 10.1107/s0907444911023249

Sequence Information:

  • Length: 207
  • Mass: 22040
  • Checksum: D7C76F1D4049F16A
  • Sequence:
    • MLALRCGSRW LGLLSVPRSV PLRLPAARAC SKGSGDPSSS SSSGNPLVYL DVDANGKPLG 
RVVLELKADV VPKTAENFRA LCTGEKGFGY KGSTFHRVIP SFMCQAGDFT NHNGTGGKSI 
YGSRFPDENF TLKHVGPGVL SMANAGPNTN GSQFFICTIK TDWLDGKHVV FGHVKEGMDV 
VKKIESFGSK SGRTSKKIVI TDCGQLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.