Details for: CTDSP2

Gene ID: 10106

Symbol: CTDSP2

Ensembl ID: ENSG00000175215

Description: CTD small phosphatase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.61
    Marker Score: 2,855
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.47
    Marker Score: 1,695
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4
    Marker Score: 3,188
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.38
    Marker Score: 1,478
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.38
    Marker Score: 29,507
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.37
    Marker Score: 1,423
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.36
    Marker Score: 929
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.36
    Marker Score: 1,465
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.36
    Marker Score: 8,817
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.34
    Marker Score: 17,664
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.31
    Marker Score: 1,394
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3
    Marker Score: 1,370
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.27
    Marker Score: 2,686
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.24
    Marker Score: 389
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.24
    Marker Score: 780
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.23
    Marker Score: 6,021
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.22
    Marker Score: 1,958
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.22
    Marker Score: 2,430
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.21
    Marker Score: 8,989
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.21
    Marker Score: 1,746
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.21
    Marker Score: 2,266
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2
    Marker Score: 13,515
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.17
    Marker Score: 3,053
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.17
    Marker Score: 679
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.16
    Marker Score: 1,503
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.16
    Marker Score: 71,497
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.16
    Marker Score: 7,573
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.15
    Marker Score: 658
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.15
    Marker Score: 332
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.15
    Marker Score: 1,228
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.15
    Marker Score: 2,895
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.14
    Marker Score: 4,936
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.14
    Marker Score: 9,823
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.14
    Marker Score: 10,834
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17,804
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.14
    Marker Score: 1,751
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.14
    Marker Score: 11,428
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.13
    Marker Score: 280
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.13
    Marker Score: 3,076
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.11
    Marker Score: 2,618
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.11
    Marker Score: 609
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.1
    Marker Score: 254
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.1
    Marker Score: 384
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.09
    Marker Score: 2,569
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.09
    Marker Score: 309
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.08
    Marker Score: 36,861
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.08
    Marker Score: 1,328
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.07
    Marker Score: 1,581
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.06
    Marker Score: 4,081
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.05
    Marker Score: 492
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.05
    Marker Score: 5,515
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.05
    Marker Score: 235
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.04
    Marker Score: 1,661
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.04
    Marker Score: 2,652
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.04
    Marker Score: 1,122
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.04
    Marker Score: 1,217
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.04
    Marker Score: 3,836
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.04
    Marker Score: 57,898
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.03
    Marker Score: 4,061
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.03
    Marker Score: 1,085
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.03
    Marker Score: 966
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.02
    Marker Score: 363
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.02
    Marker Score: 911
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.02
    Marker Score: 1,954
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.01
    Marker Score: 954
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1
    Marker Score: 15,000
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1
    Marker Score: 951
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,605
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.99
    Marker Score: 1,055
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.99
    Marker Score: 224
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,828
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.99
    Marker Score: 15,874
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.99
    Marker Score: 251
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.98
    Marker Score: 588
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.98
    Marker Score: 5,832
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.98
    Marker Score: 655
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.98
    Marker Score: 2,441
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.98
    Marker Score: 772
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,371
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.98
    Marker Score: 233
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.97
    Marker Score: 569
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.97
    Marker Score: 1,328
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.96
    Marker Score: 640
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.96
    Marker Score: 224
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.95
    Marker Score: 819
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.95
    Marker Score: 524
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.95
    Marker Score: 2,550
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.95
    Marker Score: 1,465
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.94
    Marker Score: 849
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.94
    Marker Score: 617
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,379
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.94
    Marker Score: 904
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.94
    Marker Score: 2,938
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.92
    Marker Score: 376
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.92
    Marker Score: 616
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.92
    Marker Score: 931
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.91
    Marker Score: 840
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** CTDSP2 is highly expressed in various cell types, including luminal epithelial cells of the mammary gland, vascular leptomeningeal cells, and skeletal muscle satellite stem cells. 2. **Function:** CTDSP2 functions as a phosphatase that specifically dephosphorylates the CTD of RNAP II, thereby regulating transcriptional elongation and cell cycle progression. 3. **Cellular Localization:** CTDSP2 is primarily localized to the nucleoplasm, where it interacts with RNAP II and other transcriptional regulators. 4. **Pathway Involvement:** CTDSP2 is involved in several key pathways, including the unfolded protein response (UPR), the regulation of transcription by RNAP II, and the negative regulation of protein phosphorylation. **Pathways and Functions:** 1. **Unfolded Protein Response (UPR):** CTDSP2 interacts with XBP1(s), a transcription factor involved in the UPR, to regulate the expression of chaperone genes that maintain protein homeostasis. 2. **Regulation of Transcription by RNAP II:** CTDSP2 dephosphorylates the CTD of RNAP II, thereby regulating transcriptional elongation and gene expression. 3. **Negative Regulation of Protein Phosphorylation:** CTDSP2 can also dephosphorylate and regulate the activity of protein kinases involved in cell signaling pathways. 4. **Cell Cycle Regulation:** CTDSP2 is involved in the negative regulation of the G1/S transition of the cell cycle, thereby controlling cell proliferation and survival. **Clinical Significance:** 1. **Cancer Association:** Loss or mutation of CTDSP2 has been implicated in various types of cancer, including breast, lung, and colon cancer, where it contributes to aberrant gene expression and tumorigenesis. 2. **Neurological Disorders:** CTDSP2 has also been implicated in neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS), where its dysregulation can contribute to protein misfolding and aggregation. 3. **Other Diseases:** CTDSP2 has also been implicated in other diseases, including inflammatory disorders, where its dysregulation can contribute to the aberrant expression of genes involved in inflammation and immune response. In conclusion, CTDSP2 is a critical gene involved in the regulation of cellular stress responses, protein phosphorylation, and transcriptional control. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully understand the role of CTDSP2 in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 2050190506

Symbol: CTDS2_HUMAN

Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

UniProtKB Accession Codes:

O14595 A8K5H4 Q53ZR2 Q6NZY3 Q9UEX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DEPOD 1 DIP 1 DNASU 1 DisGeNET 1 EC 3 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9315096

Title: Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas.

PubMed ID: 9315096

DOI: 10.1038/sj.onc.1201294

PubMed ID: 12721286

Title: A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.

PubMed ID: 12721286

DOI: 10.1074/jbc.m301791200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15681389

Title: Small CTD phosphatases function in silencing neuronal gene expression.

PubMed ID: 15681389

DOI: 10.1126/science.1100801

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18058037

Title: Structural genomics of protein phosphatases.

PubMed ID: 18058037

DOI: 10.1007/s10969-007-9036-1

Sequence Information:

  • Length: 271
  • Mass: 30664
  • Checksum: E4FA4A1657F2B03F
  • Sequence:
    • MEHGSIITQA RREDALVLTK QGLVSKSSPK KPRGRNIFKA LFCCFRAQHV GQSSSSTELA 
AYKEEANTIA KSDLLQCLQY QFYQIPGTCL LPEVTEEDQG RICVVIDLDE TLVHSSFKPI 
NNADFIVPIE IEGTTHQVYV LKRPYVDEFL RRMGELFECV LFTASLAKYA DPVTDLLDRC 
GVFRARLFRE SCVFHQGCYV KDLSRLGRDL RKTLILDNSP ASYIFHPENA VPVQSWFDDM 
ADTELLNLIP IFEELSGAED VYTSLGQLRA P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.