Details for: TRIM10

Gene ID: 10107

Symbol: TRIM10

Ensembl ID: ENSG00000204613

Description: tripartite motif containing 10

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1,520
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.11
    Marker Score: 3,642
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.97
    Marker Score: 2,200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 1.54
    Marker Score: 770
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,649
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 706
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 804
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.04
    Marker Score: 995
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 705
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,333
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.87
    Marker Score: 351
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,186
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.67
    Marker Score: 428
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.63
    Marker Score: 312
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 499
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1,352
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 216
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.5
    Marker Score: 313
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 439
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.42
    Marker Score: 318
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4
    Marker Score: 288
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 203
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.29
    Marker Score: 163
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.29
    Marker Score: 179
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.28
    Marker Score: 120
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.24
    Marker Score: 233
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 116
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.19
    Marker Score: 202
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 387
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.18
    Marker Score: 72
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 154
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.16
    Marker Score: 49
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.16
    Marker Score: 239
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.15
    Marker Score: 159
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.14
    Marker Score: 53
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 80
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.09
    Marker Score: 452
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.08
    Marker Score: 271
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.07
    Marker Score: 227
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 220
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.06
    Marker Score: 71
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.05
    Marker Score: 127
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.04
    Marker Score: 18

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIM10 is a 264-amino acid protein containing three domains: a RING finger domain, a B-box domain, and a coiled-coil domain. The RING finger domain is responsible for the ubiquitin ligase activity, while the B-box domain facilitates protein-protein interactions. The coiled-coil domain is thought to play a role in protein dimerization and oligomerization. TRIM10's expression is tightly regulated, with significant upregulation in response to viral infections and inflammation. **Pathways and Functions:** TRIM10's primary function is the negative regulation of viral entry into host cells, thereby inhibiting the replication of pathogens. This is achieved through its ubiquitin ligase activity, which targets viral proteins for degradation. TRIM10 also modulates cytokine signaling pathways, including interferon gamma (IFN-γ) and interferon (IFN) signaling, which are essential for initiating an effective immune response. Furthermore, TRIM10 regulates erythrocyte differentiation and erythropoiesis, highlighting its role in maintaining hematopoiesis. The protein's ability to bind to zinc ions and other molecules underscores its versatility in interacting with various cellular components. **Clinical Significance:** Dysregulation of TRIM10 has been implicated in various immune-related disorders, including viral infections, autoimmune diseases, and cancer. For instance, reduced TRIM10 expression has been observed in patients with HIV-1 infection, where it contributes to the pathogenesis of the disease. Additionally, TRIM10's role in regulating cytokine signaling pathways makes it a potential therapeutic target for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Furthermore, TRIM10's involvement in erythropoiesis highlights its potential as a biomarker for anemia and other hematological disorders. In conclusion, TRIM10 is a multifunctional protein that plays a critical role in regulating the immune response, particularly in the context of viral infections and inflammation. Its dysregulation has been implicated in various immune-related disorders, underscoring the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2474194468

Symbol: TRI10_HUMAN

Name: Tripartite motif-containing protein 10

UniProtKB Accession Codes:

Q9UDY6 A6NF84 Q5SRJ5 Q5SRK8 Q86Z08 Q96QB6 Q9C023 Q9C024

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 EPD 1 Ensembl 16 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9271628

Title: Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions.

PubMed ID: 9271628

DOI: 10.1007/s002510050292

PubMed ID: 11331580

Title: The tripartite motif family identifies cell compartments.

PubMed ID: 11331580

DOI: 10.1093/emboj/20.9.2140

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33811647

Title: TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction.

PubMed ID: 33811647

DOI: 10.1002/eji.202049073

Sequence Information:

  • Length: 481
  • Mass: 55037
  • Checksum: 49A1A11F391F5F98
  • Sequence:
    • MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD LEESPTCPLC 
KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ EHGEKIYFFC EDDEMQLCVV 
CREAGEHATH TMRFLEDAAA PYREQIHKCL KCLRKEREEI QEIQSRENKR MQVLLTQVST 
KRQQVISEFA HLRKFLEEQQ SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE 
EKNERPAREL LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK 
LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR ATCVLAHTGI 
TGGRHTWVVS IDLAHGGSCT VGVVSEDVQR KGELRLRPEE GVWAVRLAWG FVSALGSFPT 
RLTLKEQPRQ VRVSLDYEVG WVTFTNAVTR EPIYTFTASF TRKVIPFFGL WGRGSSFSLS 
S

Genular Protein ID: 3283381518

Symbol: A0A1U9X8M5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1U9X8M5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 DNASU 1 EMBL 3 ExpressionAtlas 1 GO 2 Gene3D 3 GenomeRNAi 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 Pfam 3 RefSeq 1 SMART 3 SMR 1 SUPFAM 3 VEuPathDB 1

Sequence Information:

  • Length: 395
  • Mass: 45252
  • Checksum: EDEFCB7027B6C15D
  • Sequence:
    • MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD LEESPTCPLC 
KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ EHGEKIYFFC EDDEMQLCVV 
CREAGEHATH TMRFLEDAAA PYREQIHKCL KCLRKEREEI QEIQSRENKR MQVLLTQVST 
KRQQVISEFA HLRKFLEEQQ SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE 
EKNERPAREL LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK 
LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR ATCVLAHTGI 
TGGRHTWVWM ARVPGDSGCC QFCSPPSVLG TEVAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.