ARPC2 | ENSG00000163466 | NCBI 10109

Details for: ARPC2

Gene ID: 10109

Symbol: ARPC2

Ensembl ID: ENSG00000163466

Description: actin related protein 2/3 complex subunit 2

Associated with

Axon guidance
(R-HSA-422475)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Membrane trafficking
(R-HSA-199991)
Nervous system development
(R-HSA-9675108)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Actin cytoskeleton
(GO:0015629)
Actin filament binding
(GO:0051015)
Actin filament polymerization
(GO:0030041)
Actin polymerization-dependent cell motility
(GO:0070358)
Arp2/3 complex-mediated actin nucleation
(GO:0034314)
Arp2/3 protein complex
(GO:0005885)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Glutamatergic synapse
(GO:0098978)
Lamellipodium
(GO:0030027)
Muscle cell projection membrane
(GO:0036195)
Neuron projection
(GO:0043005)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Protein binding
(GO:0005515)
Site of double-strand break
(GO:0035861)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Actin-related protein 2/3 complex subunit 2

Genular Protein ID: 2037566657

Symbol: ARPC2_HUMAN

Name: Actin-related protein 2/3 complex subunit 2

UniProtKB Accession Codes:

O15144 Q92801 Q9P1D4

Database IDs:

Citations:

PubMed ID: 9230079

Title: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.

PubMed ID: 9230079

DOI: 10.1083/jcb.138.2.375

PubMed ID: 8812419

Title: Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13.

PubMed ID: 8812419

DOI: 10.1006/geno.1996.0428

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11741539

Title: Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.

PubMed ID: 11741539

DOI: 10.1016/s1097-2765(01)00393-8

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29925947

Title: Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

PubMed ID: 29925947

DOI: 10.1038/s41586-018-0237-5

PubMed ID: 32128961

Title: WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.

PubMed ID: 32128961

DOI: 10.15252/embr.201949269

Sequence Information:

Length: 300
Mass: 34333
Checksum: 3BA57121BE9A05F2
Sequence:

MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS 
LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC 
FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV 
FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT 
INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARPC2

Associated with

Other Information

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. PubMed ID: 9230079

Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. PubMed ID: 8812419

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. PubMed ID: 11741539

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. PubMed ID: 29925947

WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis. PubMed ID: 32128961