Details for: ARPC2

Gene ID: 10109

Symbol: ARPC2

Ensembl ID: ENSG00000163466

Description: actin related protein 2/3 complex subunit 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.73
    Marker Score: 46,848
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.68
    Marker Score: 13,663
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.31
    Marker Score: 13,614
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.28
    Marker Score: 57,572
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.17
    Marker Score: 3,145
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.09
    Marker Score: 228,628
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.97
    Marker Score: 10,959
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.93
    Marker Score: 4,369
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.87
    Marker Score: 9,443
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.86
    Marker Score: 44,867
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.79
    Marker Score: 3,386
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.77
    Marker Score: 4,553
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.71
    Marker Score: 2,260
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.62
    Marker Score: 191,593
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.62
    Marker Score: 5,325
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.55
    Marker Score: 2,572
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.54
    Marker Score: 3,425
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.54
    Marker Score: 9,924
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.52
    Marker Score: 840
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.51
    Marker Score: 2,059
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.48
    Marker Score: 1,505
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.48
    Marker Score: 2,930
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.46
    Marker Score: 3,039
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.45
    Marker Score: 3,942
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.41
    Marker Score: 8,227
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.39
    Marker Score: 6,065
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.39
    Marker Score: 1,520
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.37
    Marker Score: 14,470
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.31
    Marker Score: 2,810
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.3
    Marker Score: 1,697
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.3
    Marker Score: 5,653
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.28
    Marker Score: 7,990
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.26
    Marker Score: 1,799
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.26
    Marker Score: 3,209
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.23
    Marker Score: 2,443
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.23
    Marker Score: 1,966
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.22
    Marker Score: 25,126
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.19
    Marker Score: 2,517
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.19
    Marker Score: 2,058
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.18
    Marker Score: 2,992
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.18
    Marker Score: 20,737
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.17
    Marker Score: 6,177
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.16
    Marker Score: 2,483
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.16
    Marker Score: 9,380
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.16
    Marker Score: 4,362
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 3.15
    Marker Score: 817
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.15
    Marker Score: 2,387
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.14
    Marker Score: 4,317
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.13
    Marker Score: 3,134
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.12
    Marker Score: 1,536
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.11
    Marker Score: 4,402
  • Cell Name: basal cell (CL0000646)
    Fold Change: 3.07
    Marker Score: 3,958
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.06
    Marker Score: 1,319
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.05
    Marker Score: 3,313
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.03
    Marker Score: 695
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.02
    Marker Score: 2,831
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.02
    Marker Score: 5,521
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.02
    Marker Score: 2,475
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.02
    Marker Score: 799
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3
    Marker Score: 2,494
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.99
    Marker Score: 2,660
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.98
    Marker Score: 1,746
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.98
    Marker Score: 7,711
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.97
    Marker Score: 2,000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.96
    Marker Score: 2,612
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.96
    Marker Score: 1,703
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.95
    Marker Score: 1,954
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.94
    Marker Score: 5,133
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 2.94
    Marker Score: 835
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.94
    Marker Score: 2,016
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.94
    Marker Score: 25,331
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.93
    Marker Score: 3,435
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.93
    Marker Score: 952
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.92
    Marker Score: 38,570
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.92
    Marker Score: 989
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.92
    Marker Score: 21,734
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.91
    Marker Score: 1,251
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.91
    Marker Score: 1,753
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.9
    Marker Score: 828
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.9
    Marker Score: 1,319
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.9
    Marker Score: 2,114
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.9
    Marker Score: 18,538
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.88
    Marker Score: 2,082
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.88
    Marker Score: 747
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.88
    Marker Score: 757
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.86
    Marker Score: 999
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.86
    Marker Score: 3,080
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.85
    Marker Score: 18,213
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.85
    Marker Score: 11,895
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.85
    Marker Score: 2,556
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.85
    Marker Score: 938
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.85
    Marker Score: 7,090
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.84
    Marker Score: 72,840
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.84
    Marker Score: 1,420
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.84
    Marker Score: 1,183
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.84
    Marker Score: 621
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 2.83
    Marker Score: 1,827
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 2.83
    Marker Score: 704
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.82
    Marker Score: 999
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.82
    Marker Score: 613

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARPC2 is a 110-kDa protein that is encoded by the ENSG00000163466 gene. It is a subunit of the Arp2/3 complex, which is a multifunctional protein complex involved in various cellular processes. ARPC2 is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** ARPC2 is involved in several key pathways, including: 1. **Actin filament polymerization:** ARPC2 regulates the assembly of actin filaments, which is crucial for cell motility, cell migration, and phagocytosis. 2. **Arp2/3 complex-mediated actin nucleation:** ARPC2 is a key component of the Arp2/3 complex, which is responsible for nucleating actin filaments from actin monomers. 3. **Actin polymerization-dependent cell motility:** ARPC2 regulates actin polymerization-dependent cell motility, which is essential for cell migration, tissue repair, and immune response. 4. **Phagocytosis:** ARPC2 is involved in phagocytosis, which is the process by which cells engulf and internalize pathogens and debris. 5. **Immune system:** ARPC2 plays a crucial role in the immune system, particularly in the regulation of actin dynamics and phagocytosis in immune cells, such as macrophages and neutrophils. **Clinical Significance:** Dysregulation of ARPC2 has been implicated in various diseases, including: 1. **Immunodeficiency disorders:** ARPC2 mutations have been associated with immunodeficiency disorders, such as chronic granulomatous disease and leukemia. 2. **Cancer:** ARPC2 is overexpressed in various types of cancer, including leukemia, lymphoma, and breast cancer, suggesting its role in tumor progression and metastasis. 3. **Neurological disorders:** ARPC2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates actin dynamics and synaptic plasticity. 4. **Infectious diseases:** ARPC2 plays a crucial role in the regulation of actin dynamics and phagocytosis in immune cells, making it a potential therapeutic target for the treatment of infectious diseases, such as leishmaniasis. In conclusion, ARPC2 is a critical component of the Arp2/3 complex, regulating actin dynamics, cell motility, and immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying its function and its potential as a therapeutic target.

Genular Protein ID: 2037566657

Symbol: ARPC2_HUMAN

Name: Actin-related protein 2/3 complex subunit 2

UniProtKB Accession Codes:

O15144 Q92801 Q9P1D4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 5 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9230079

Title: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.

PubMed ID: 9230079

DOI: 10.1083/jcb.138.2.375

PubMed ID: 8812419

Title: Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13.

PubMed ID: 8812419

DOI: 10.1006/geno.1996.0428

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11741539

Title: Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.

PubMed ID: 11741539

DOI: 10.1016/s1097-2765(01)00393-8

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29925947

Title: Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

PubMed ID: 29925947

DOI: 10.1038/s41586-018-0237-5

PubMed ID: 32128961

Title: WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.

PubMed ID: 32128961

DOI: 10.15252/embr.201949269

Sequence Information:

  • Length: 300
  • Mass: 34333
  • Checksum: 3BA57121BE9A05F2
  • Sequence:
    • MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS 
LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC 
FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV 
FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT 
INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.