Details for: SGK2

Gene ID: 10110

Symbol: SGK2

Ensembl ID: ENSG00000101049

Description: serum/glucocorticoid regulated kinase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1,512
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.77
    Marker Score: 935
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.6
    Marker Score: 1,229
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.23
    Marker Score: 3,296
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.1
    Marker Score: 953
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.07
    Marker Score: 6,894
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,049
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.99
    Marker Score: 261
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2,269
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,269
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3,931
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.89
    Marker Score: 3,176
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.8
    Marker Score: 4,313
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.8
    Marker Score: 2,519
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.8
    Marker Score: 848
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.75
    Marker Score: 745
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 679
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.74
    Marker Score: 3,549
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.71
    Marker Score: 395
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,878
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.69
    Marker Score: 1,728
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.64
    Marker Score: 1,054
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1,115
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.57
    Marker Score: 3,643
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.57
    Marker Score: 2,204
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.54
    Marker Score: 1,784
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.54
    Marker Score: 1,300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.54
    Marker Score: 369
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.53
    Marker Score: 535
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.52
    Marker Score: 102
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.52
    Marker Score: 734
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 133
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7,708
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.48
    Marker Score: 211
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.48
    Marker Score: 113
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 151
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 874
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 205
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.41
    Marker Score: 118
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.41
    Marker Score: 150
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.4
    Marker Score: 97
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.38
    Marker Score: 94
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.38
    Marker Score: 558
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.37
    Marker Score: 178
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.37
    Marker Score: 395
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.36
    Marker Score: 230
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.34
    Marker Score: 7,326
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.34
    Marker Score: 359
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.33
    Marker Score: 124
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.33
    Marker Score: 176
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.33
    Marker Score: 696
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.32
    Marker Score: 3,342
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.31
    Marker Score: 308
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.3
    Marker Score: 720
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.3
    Marker Score: 684
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.29
    Marker Score: 109
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.29
    Marker Score: 286
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.29
    Marker Score: 298
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.28
    Marker Score: 112
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 157
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 67
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.26
    Marker Score: 1,065
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.25
    Marker Score: 64
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.24
    Marker Score: 53
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.24
    Marker Score: 170
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.24
    Marker Score: 371
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.23
    Marker Score: 88
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.23
    Marker Score: 246
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.23
    Marker Score: 662
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.23
    Marker Score: 3,449
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 155
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.23
    Marker Score: 83
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 79
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 349
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.22
    Marker Score: 547
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.22
    Marker Score: 428
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.22
    Marker Score: 137
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.21
    Marker Score: 807

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SGK2 is a constitutively active kinase that is induced by serum and glucocorticoids, hence its name. It is a member of the AGC (Protein Kinase A, Protein Kinase C, and Protein Kinase G) subfamily of serine/threonine kinases. SGK2 exhibits a high degree of tissue specificity, with distinct expression patterns in different cell types. Its kinase activity is mediated by the phosphorylation of serine and threonine residues on target proteins. SGK2 has been shown to interact with various proteins, including transcription factors, ion channels, and transporters, to regulate their activity and function. **Pathways and Functions:** SGK2 is involved in a wide range of cellular processes, including: 1. **Cell growth and proliferation:** SGK2 regulates cell growth and proliferation by phosphorylating and activating key proteins involved in the cell cycle, such as cyclin-dependent kinases and transcription factors. 2. **Ion transport:** SGK2 modulates ion transport across cell membranes, influencing cellular excitability and signaling. It phosphorylates and activates potassium channels, sodium channels, and calcium channels, which in turn regulate cellular excitability and signaling. 3. **Oxidative stress response:** SGK2 has been shown to play a key role in responding to oxidative stress by phosphorylating and activating antioxidant enzymes, such as superoxide dismutase and catalase. 4. **Cellular differentiation:** SGK2 regulates cellular differentiation by phosphorylating and activating transcription factors involved in the differentiation process. 5. **Apoptosis:** SGK2 has been implicated in regulating apoptosis by phosphorylating and activating pro-apoptotic and anti-apoptotic proteins. **Clinical Significance:** SGK2 has been associated with various human diseases, including: 1. **Diabetes:** SGK2 has been implicated in the development of insulin resistance and type 2 diabetes. 2. **Cardiovascular disease:** SGK2 has been shown to play a role in the development of cardiovascular disease by regulating ion transport and oxidative stress. 3. **Cancer:** SGK2 has been implicated in the development and progression of various types of cancer, including breast cancer, lung cancer, and colon cancer. 4. **Neurological disorders:** SGK2 has been associated with neurological disorders, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. In conclusion, SGK2 is a multifunctional kinase enzyme that plays a crucial role in regulating cellular homeostasis and responding to various forms of stress. Its expression and activity are implicated in numerous human diseases, highlighting the need for further research into the molecular mechanisms of SGK2 and its potential therapeutic applications.

Genular Protein ID: 4126703019

Symbol: SGK2_HUMAN

Name: Serine/threonine-protein kinase Sgk2

UniProtKB Accession Codes:

Q9HBY8 Q52PK5 Q5H8Y6 Q5H8Z1 Q5TZR3 Q9UKG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 Rhea 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10548550

Title: Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.

PubMed ID: 10548550

DOI: 10.1042/bj3440189

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12590200

Title: Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms.

PubMed ID: 12590200

DOI: 10.1159/000068699

PubMed ID: 12397388

Title: K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.

PubMed ID: 12397388

DOI: 10.1007/s00424-002-0873-2

PubMed ID: 12634932

Title: Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.

PubMed ID: 12634932

DOI: 10.1007/s00424-002-0982-y

PubMed ID: 12632189

Title: The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.

PubMed ID: 12632189

DOI: 10.1007/s00424-002-0993-8

PubMed ID: 15040001

Title: Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1.

PubMed ID: 15040001

DOI: 10.1002/jcp.10430

PubMed ID: 20511718

Title: The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19.

PubMed ID: 20511718

DOI: 10.1159/000315092

PubMed ID: 21865597

Title: Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.

PubMed ID: 21865597

DOI: 10.1091/mbc.e11-04-0328

PubMed ID: 16460280

Title: Sgk kinases and their role in epithelial transport.

PubMed ID: 16460280

DOI: 10.1146/annurev.physiol.68.040104.131654

PubMed ID: 20919962

Title: Second AKT: the rise of SGK in cancer signalling.

PubMed ID: 20919962

DOI: 10.3109/08977194.2010.518616

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 367
  • Mass: 41175
  • Checksum: E53F1ABE253F648B
  • Sequence:
    • MNSSPAGTPS PQPSRANGNI NLGPSANPNA QPTDFDFLKV IGKGNYGKVL LAKRKSDGAF 
YAVKVLQKKS ILKKKEQSHI MAERSVLLKN VRHPFLVGLR YSFQTPEKLY FVLDYVNGGE 
LFFHLQRERR FLEPRARFYA AEVASAIGYL HSLNIIYRDL KPENILLDCQ GHVVLTDFGL 
CKEGVEPEDT TSTFCGTPEY LAPEVLRKEP YDRAVDWWCL GAVLYEMLHG LPPFYSQDVS 
QMYENILHQP LQIPGGRTVA ACDLLQSLLH KDQRQRLGSK ADFLEIKNHV FFSPINWDDL 
YHKRLTPPFN PNVTGPADLK HFDPEFTQEA VSKSIGCTPD TVASSSGASS AFLGFSYAPE 
DDDILDC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.