Details for: RAD50

Gene ID: 10111

Symbol: RAD50

Ensembl ID: ENSG00000113522

Description: RAD50 double strand break repair protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.11
    Marker Score: 5,431
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.92
    Marker Score: 28,648
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.89
    Marker Score: 37,531
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.86
    Marker Score: 68,638
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.83
    Marker Score: 69,582
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.8
    Marker Score: 16,919
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.77
    Marker Score: 13,561
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.75
    Marker Score: 6,767
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.74
    Marker Score: 106,982
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7
    Marker Score: 660
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.69
    Marker Score: 16,031
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.67
    Marker Score: 14,329
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.64
    Marker Score: 6,808
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.63
    Marker Score: 2,337
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.57
    Marker Score: 17,644
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.54
    Marker Score: 32,877
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.54
    Marker Score: 645
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.49
    Marker Score: 2,293
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.47
    Marker Score: 5,439
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.44
    Marker Score: 14,850
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.43
    Marker Score: 12,420
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.39
    Marker Score: 5,465
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.37
    Marker Score: 932
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.36
    Marker Score: 1,176
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.33
    Marker Score: 3,264
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.32
    Marker Score: 697
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.29
    Marker Score: 22,945
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.28
    Marker Score: 984
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.27
    Marker Score: 5,180
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.26
    Marker Score: 43,489
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.24
    Marker Score: 5,350
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.24
    Marker Score: 5,152
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.24
    Marker Score: 1,422
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.23
    Marker Score: 1,396
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.22
    Marker Score: 302
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.22
    Marker Score: 601
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.17
    Marker Score: 710
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.17
    Marker Score: 4,787
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.17
    Marker Score: 337
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.14
    Marker Score: 1,435
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.14
    Marker Score: 10,006
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.14
    Marker Score: 760
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.13
    Marker Score: 359
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.13
    Marker Score: 308
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.12
    Marker Score: 323
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.12
    Marker Score: 990
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.11
    Marker Score: 1,188
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.1
    Marker Score: 2,073
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.05
    Marker Score: 891
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.03
    Marker Score: 776
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.03
    Marker Score: 717
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.02
    Marker Score: 568
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1
    Marker Score: 1,647
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1
    Marker Score: 1,700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1
    Marker Score: 2,394
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,696
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,920
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.99
    Marker Score: 252
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.98
    Marker Score: 1,306
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.97
    Marker Score: 1,843
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.96
    Marker Score: 363
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.96
    Marker Score: 226
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.96
    Marker Score: 2,622
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.95
    Marker Score: 835
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.94
    Marker Score: 663
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.93
    Marker Score: 263
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.92
    Marker Score: 271
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.92
    Marker Score: 1,028
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.91
    Marker Score: 293
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.9
    Marker Score: 288
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.89
    Marker Score: 6,978
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,440
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.88
    Marker Score: 29,849
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.88
    Marker Score: 1,411
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.87
    Marker Score: 171
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.87
    Marker Score: 488
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.87
    Marker Score: 1,046
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,241
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.86
    Marker Score: 481
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.86
    Marker Score: 1,066
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.86
    Marker Score: 909
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,864
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.85
    Marker Score: 440
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.85
    Marker Score: 1,350
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.84
    Marker Score: 909
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.84
    Marker Score: 596
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.84
    Marker Score: 337
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.84
    Marker Score: 220
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.83
    Marker Score: 720
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.83
    Marker Score: 1,687
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.83
    Marker Score: 583
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.82
    Marker Score: 542
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.82
    Marker Score: 1,487
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 794

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAD50 is a 245-kDa protein that belongs to the phosphoinositide 3-kinase-related kinase (PIKK) family. It is characterized by its ability to bind to DNA, specifically to single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA), and to interact with other proteins involved in DNA repair. RAD50 is highly conserved across species, suggesting its essential role in maintaining genome stability. It is also known to interact with various proteins, including BRCA2, BRCA1, and PALB2, which are involved in the HRR pathway. **Pathways and Functions** RAD50 is involved in several key pathways that ensure genome stability and maintain cellular homeostasis. These include: 1. **Homologous Recombination Repair (HRR)**: RAD50 is a critical component of the MRN complex, which is responsible for repairing DNA double-strand breaks through homologous recombination. 2. **Non-Homologous End Joining (NHEJ)**: RAD50 also interacts with proteins involved in NHEJ, a pathway that repairs DNA double-strand breaks through non-homologous end joining. 3. **Cell Cycle Checkpoints**: RAD50 is involved in cell cycle checkpoints, which ensure that cells with damaged DNA do not progress to mitosis. 4. **DNA Damage Response**: RAD50 is part of the DNA damage response, which is a complex network of pathways that respond to DNA damage and maintain genome stability. **Clinical Significance** RAD50 is involved in several human diseases, including: 1. **Breast Cancer**: Mutations in RAD50 have been associated with breast cancer, highlighting its role in maintaining genome stability. 2. **Cancer Therapy Resistance**: RAD50 is also involved in cancer therapy resistance, as mutations in RAD50 can lead to resistance to chemotherapy and radiation therapy. 3. **Neurological Disorders**: RAD50 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where DNA damage and genome instability play a critical role. 4. **Genetic Disorders**: RAD50 is also involved in genetic disorders, such as Fanconi anemia, which is characterized by congenital abnormalities and increased risk of cancer. In conclusion, RAD50 is a critical protein involved in maintaining genome stability and ensuring cellular homeostasis. Its dysregulation has been implicated in several human diseases, highlighting the importance of this protein in human health and disease. Further research on RAD50 and its role in DNA repair pathways is essential for understanding the molecular mechanisms underlying these diseases and developing effective therapeutic strategies.

Genular Protein ID: 231470592

Symbol: RAD50_HUMAN

Name: DNA repair protein RAD50

UniProtKB Accession Codes:

Q92878 B9EGF5 O43254 Q6GMT7 Q6P5X3 Q9UP86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 20 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8756642

Title: Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair.

PubMed ID: 8756642

DOI: 10.1128/mcb.16.9.4832

PubMed ID: 10415333

Title: Molecular cloning and characterization of splice variants of human RAD50 gene.

PubMed ID: 10415333

DOI: 10.1016/s0378-1119(99)00215-2

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9590181

Title: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.

PubMed ID: 9590181

DOI: 10.1016/s0092-8674(00)81175-7

PubMed ID: 9705271

Title: Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.

PubMed ID: 9705271

DOI: 10.1074/jbc.273.34.21447

PubMed ID: 9651580

Title: The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.

PubMed ID: 9651580

DOI: 10.1016/s1097-2765(00)80097-0

PubMed ID: 10426999

Title: Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.

PubMed ID: 10426999

DOI: 10.1126/science.285.5428.747

PubMed ID: 10783165

Title: BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

PubMed ID: 10783165

PubMed ID: 10839544

Title: Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.

PubMed ID: 10839544

DOI: 10.1038/35013083

PubMed ID: 10888888

Title: Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.

PubMed ID: 10888888

DOI: 10.1038/77139

PubMed ID: 11096100

Title: RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G2/M checkpoint control.

PubMed ID: 11096100

DOI: 10.1074/jbc.m008893200

PubMed ID: 11741547

Title: Human Rad50/Mre11 is a flexible complex that can tether DNA ends.

PubMed ID: 11741547

DOI: 10.1016/s1097-2765(01)00381-1

PubMed ID: 12124628

Title: Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.

PubMed ID: 12124628

DOI: 10.1038/nature00863

PubMed ID: 12384589

Title: DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

PubMed ID: 12384589

DOI: 10.1093/nar/gkf574

PubMed ID: 15456891

Title: Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

PubMed ID: 15456891

DOI: 10.1128/mcb.24.20.9207-9220.2004

PubMed ID: 15064416

Title: Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.

PubMed ID: 15064416

DOI: 10.1126/science.1091496

PubMed ID: 15723659

Title: Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

PubMed ID: 15723659

DOI: 10.1111/j.1349-7006.2005.00019.x

PubMed ID: 15916964

Title: ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.

PubMed ID: 15916964

DOI: 10.1016/j.molcel.2005.04.015

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19409520

Title: Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.

PubMed ID: 19409520

DOI: 10.1016/j.ajhg.2009.04.010

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20943970

Title: Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.

PubMed ID: 20943970

DOI: 10.1128/jvi.01506-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26215093

Title: MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.

PubMed ID: 26215093

DOI: 10.1038/ncomms8744

PubMed ID: 27568553

Title: MRNIP/C5orf45 interacts with the MRN complex and contributes to the DNA damage response.

PubMed ID: 27568553

DOI: 10.1016/j.celrep.2016.07.087

PubMed ID: 14684699

Title: Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility.

PubMed ID: 14684699

DOI: 10.1136/jmg.40.12.e131

Sequence Information:

  • Length: 1312
  • Mass: 153892
  • Checksum: 1F208C3817FC41FC
  • Sequence:
    • MSRIEKMSIL GVRSFGIEDK DKQIITFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG 
TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GELIAVQRSM VCTQKSKKTE FKTLEGVITR 
TKHGEKVSLS SKCAEIDREM ISSLGVSKAV LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF 
SATRYIKALE TLRQVRQTQG QKVKEYQMEL KYLKQYKEKA CEIRDQITSK EAQLTSSKEI 
VKSYENELDP LKNRLKEIEH NLSKIMKLDN EIKALDSRKK QMEKDNSELE EKMEKVFQGT 
DEQLNDLYHN HQRTVREKER KLVDCHRELE KLNKESRLLN QEKSELLVEQ GRLQLQADRH 
QEHIRARDSL IQSLATQLEL DGFERGPFSE RQIKNFHKLV RERQEGEAKT ANQLMNDFAE 
KETLKQKQID EIRDKKTGLG RIIELKSEIL SKKQNELKNV KYELQQLEGS SDRILELDQE 
LIKAERELSK AEKNSNVETL KMEVISLQNE KADLDRTLRK LDQEMEQLNH HTTTRTQMEM 
LTKDKADKDE QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE 
LASSEQNKNH INNELKRKEE QLSSYEDKLF DVCGSQDFES DLDRLKEEIE KSSKQRAMLA 
GATAVYSQFI TQLTDENQSC CPVCQRVFQT EAELQEVISD LQSKLRLAPD KLKSTESELK 
KKEKRRDEML GLVPMRQSII DLKEKEIPEL RNKLQNVNRD IQRLKNDIEE QETLLGTIMP 
EEESAKVCLT DVTIMERFQM ELKDVERKIA QQAAKLQGID LDRTVQQVNQ EKQEKQHKLD 
TVSSKIELNR KLIQDQQEQI QHLKSTTNEL KSEKLQISTN LQRRQQLEEQ TVELSTEVQS 
LYREIKDAKE QVSPLETTLE KFQQEKEELI NKKNTSNKIA QDKLNDIKEK VKNIHGYMKD 
IENYIQDGKD DYKKQKETEL NKVIAQLSEC EKHKEKINED MRLMRQDIDT QKIQERWLQD 
NLTLRKRNEE LKEVEEERKQ HLKEMGQMQV LQMKSEHQKL EENIDNIKRN HNLALGRQKG 
YEEEIIHFKK ELREPQFRDA EEKYREMMIV MRTTELVNKD LDIYYKTLDQ AIMKFHSMKM 
EEINKIIRDL WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR 
CSAGQKVLAS LIIRLALAET FCLNCGIIAL DEPTTNLDRE NIESLAHALV EIIKSRSQQR 
NFQLLVITHD EDFVELLGRS EYVEKFYRIK KNIDQCSEIV KCSVSSLGFN VH

Genular Protein ID: 3902154380

Symbol: A5D6Y3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5D6Y3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 110
  • Mass: 12259
  • Checksum: B25CD5B6ED40C592
  • Sequence:
    • MSRIEKMSIL GVRSFGIEDK DKQIITFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG 
TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GELIAVQRSM VCTQKSKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.