Details for: RAD50
Associated with
Other Information
Genular Protein ID: 231470592
Symbol: RAD50_HUMAN
Name: DNA repair protein RAD50
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8756642
Title: Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair.
PubMed ID: 8756642
PubMed ID: 10415333
Title: Molecular cloning and characterization of splice variants of human RAD50 gene.
PubMed ID: 10415333
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9590181
Title: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
PubMed ID: 9590181
PubMed ID: 9705271
Title: Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
PubMed ID: 9705271
PubMed ID: 9651580
Title: The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.
PubMed ID: 9651580
PubMed ID: 10426999
Title: Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
PubMed ID: 10426999
PubMed ID: 10783165
Title: BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
PubMed ID: 10783165
PubMed ID: 10839544
Title: Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.
PubMed ID: 10839544
DOI: 10.1038/35013083
PubMed ID: 10888888
Title: Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
PubMed ID: 10888888
DOI: 10.1038/77139
PubMed ID: 11096100
Title: RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G2/M checkpoint control.
PubMed ID: 11096100
PubMed ID: 11741547
Title: Human Rad50/Mre11 is a flexible complex that can tether DNA ends.
PubMed ID: 11741547
PubMed ID: 12124628
Title: Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
PubMed ID: 12124628
DOI: 10.1038/nature00863
PubMed ID: 12384589
Title: DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.
PubMed ID: 12384589
DOI: 10.1093/nar/gkf574
PubMed ID: 15456891
Title: Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
PubMed ID: 15456891
PubMed ID: 15064416
Title: Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
PubMed ID: 15064416
PubMed ID: 15723659
Title: Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.
PubMed ID: 15723659
PubMed ID: 15916964
Title: ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
PubMed ID: 15916964
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19409520
Title: Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
PubMed ID: 19409520
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20943970
Title: Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.
PubMed ID: 20943970
DOI: 10.1128/jvi.01506-10
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26215093
Title: MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.
PubMed ID: 26215093
DOI: 10.1038/ncomms8744
PubMed ID: 27568553
Title: MRNIP/C5orf45 interacts with the MRN complex and contributes to the DNA damage response.
PubMed ID: 27568553
PubMed ID: 14684699
Title: Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility.
PubMed ID: 14684699
Sequence Information:
- Length: 1312
- Mass: 153892
- Checksum: 1F208C3817FC41FC
- Sequence:
MSRIEKMSIL GVRSFGIEDK DKQIITFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GELIAVQRSM VCTQKSKKTE FKTLEGVITR TKHGEKVSLS SKCAEIDREM ISSLGVSKAV LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF SATRYIKALE TLRQVRQTQG QKVKEYQMEL KYLKQYKEKA CEIRDQITSK EAQLTSSKEI VKSYENELDP LKNRLKEIEH NLSKIMKLDN EIKALDSRKK QMEKDNSELE EKMEKVFQGT DEQLNDLYHN HQRTVREKER KLVDCHRELE KLNKESRLLN QEKSELLVEQ GRLQLQADRH QEHIRARDSL IQSLATQLEL DGFERGPFSE RQIKNFHKLV RERQEGEAKT ANQLMNDFAE KETLKQKQID EIRDKKTGLG RIIELKSEIL SKKQNELKNV KYELQQLEGS SDRILELDQE LIKAERELSK AEKNSNVETL KMEVISLQNE KADLDRTLRK LDQEMEQLNH HTTTRTQMEM LTKDKADKDE QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE LASSEQNKNH INNELKRKEE QLSSYEDKLF DVCGSQDFES DLDRLKEEIE KSSKQRAMLA GATAVYSQFI TQLTDENQSC CPVCQRVFQT EAELQEVISD LQSKLRLAPD KLKSTESELK KKEKRRDEML GLVPMRQSII DLKEKEIPEL RNKLQNVNRD IQRLKNDIEE QETLLGTIMP EEESAKVCLT DVTIMERFQM ELKDVERKIA QQAAKLQGID LDRTVQQVNQ EKQEKQHKLD TVSSKIELNR KLIQDQQEQI QHLKSTTNEL KSEKLQISTN LQRRQQLEEQ TVELSTEVQS LYREIKDAKE QVSPLETTLE KFQQEKEELI NKKNTSNKIA QDKLNDIKEK VKNIHGYMKD IENYIQDGKD DYKKQKETEL NKVIAQLSEC EKHKEKINED MRLMRQDIDT QKIQERWLQD NLTLRKRNEE LKEVEEERKQ HLKEMGQMQV LQMKSEHQKL EENIDNIKRN HNLALGRQKG YEEEIIHFKK ELREPQFRDA EEKYREMMIV MRTTELVNKD LDIYYKTLDQ AIMKFHSMKM EEINKIIRDL WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR CSAGQKVLAS LIIRLALAET FCLNCGIIAL DEPTTNLDRE NIESLAHALV EIIKSRSQQR NFQLLVITHD EDFVELLGRS EYVEKFYRIK KNIDQCSEIV KCSVSSLGFN VH
Genular Protein ID: 3902154380
Symbol: A5D6Y3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 110
- Mass: 12259
- Checksum: B25CD5B6ED40C592
- Sequence:
MSRIEKMSIL GVRSFGIEDK DKQIITFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GELIAVQRSM VCTQKSKKKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.