Details for: KIF20A

Gene ID: 10112

Symbol: KIF20A

Ensembl ID: ENSG00000112984

Description: kinesin family member 20A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.88
    Marker Score: 2,704
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.74
    Marker Score: 2,406
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.72
    Marker Score: 3,553
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.34
    Marker Score: 879
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.16
    Marker Score: 1,090
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.13
    Marker Score: 802
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,047
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1
    Marker Score: 1,743
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,280
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.87
    Marker Score: 2,371
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 684
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1,384
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.73
    Marker Score: 777
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 546
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,909
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10,690
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.67
    Marker Score: 355
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.65
    Marker Score: 205
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.61
    Marker Score: 385
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.57
    Marker Score: 430
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.52
    Marker Score: 352
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1,188
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.48
    Marker Score: 637
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.48
    Marker Score: 597
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.47
    Marker Score: 961
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.46
    Marker Score: 363
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.45
    Marker Score: 324
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 184
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.42
    Marker Score: 716
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.42
    Marker Score: 507
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.42
    Marker Score: 321
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.4
    Marker Score: 133
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 194
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 124
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.39
    Marker Score: 1,160
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.39
    Marker Score: 406
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.39
    Marker Score: 281
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.37
    Marker Score: 136
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.37
    Marker Score: 272
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 343
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.35
    Marker Score: 954
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.35
    Marker Score: 819
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 705
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.34
    Marker Score: 179
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 202
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.32
    Marker Score: 91
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.31
    Marker Score: 255
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.3
    Marker Score: 433
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.29
    Marker Score: 143
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.29
    Marker Score: 308
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.28
    Marker Score: 1,094
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.26
    Marker Score: 132
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.26
    Marker Score: 3,487
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.26
    Marker Score: 128
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 123
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.26
    Marker Score: 128
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.25
    Marker Score: 261
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.25
    Marker Score: 153
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 155
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.24
    Marker Score: 83
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.23
    Marker Score: 151
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 159
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 130
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.23
    Marker Score: 165
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 132
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.22
    Marker Score: 123
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.22
    Marker Score: 225
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.21
    Marker Score: 201
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 93
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.21
    Marker Score: 132
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.21
    Marker Score: 249
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.2
    Marker Score: 75
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.2
    Marker Score: 830

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KIF20A is a highly expressed gene, predominantly found in cells of the immune system, including T-helper 17 cells, double negative thymocytes, and kidney interstitial cells. Its expression is also observed in other cell types, such as respiratory basal cells, kidney proximal convoluted tubule epithelial cells, and migratory enteric neural crest cells. The gene encodes a kinesin-like protein, which is characterized by its ability to bind microtubules, undergo ATP-dependent movement, and interact with various proteins, including protein kinases and kinases. **Pathways and Functions:** KIF20A's functions can be broadly categorized into three main domains: immune system regulation, cell cycle progression, and membrane trafficking. In the context of the immune system, KIF20A is involved in adaptive immune system regulation, antigen presentation via MHC class II, and cytokinesis. Its role in cell cycle progression is evident in its involvement in mitotic telophase/cytokinesis, midbody abscission, and spindle formation. Furthermore, KIF20A is implicated in membrane trafficking, including Golgi-to-ER retrograde transport, copi-dependent Golgi-to-ER retrograde traffic, and vesicle-mediated transport. **Clinical Significance:** The clinical significance of KIF20A lies in its potential as a biomarker for various immune-related disorders, such as autoimmune diseases and cancer. Abnormal expression of KIF20A has been linked to several diseases, including multiple sclerosis, rheumatoid arthritis, and leukemia. Additionally, KIF20A's involvement in cell cycle progression and membrane trafficking suggests its potential as a therapeutic target for cancer treatment. Further research is necessary to fully elucidate the clinical significance of KIF20A and its potential applications in human medicine. **Implications for Future Research:** The study of KIF20A offers a wealth of opportunities for future research. Further investigation into its role in immune system regulation, cell cycle progression, and membrane trafficking is necessary to fully understand its functions and implications for human health. Additionally, the development of novel therapeutic strategies targeting KIF20A's functions may provide new avenues for the treatment of immune-related disorders and cancer. As an expert immunologist, it is essential to continue exploring the complexities of KIF20A to unlock its full potential as a biomarker and therapeutic target. **Conclusion:** In conclusion, KIF20A is a multifunctional gene that plays a critical role in various cellular processes, including immune system regulation, cell cycle progression, and membrane trafficking. Its clinical significance lies in its potential as a biomarker for immune-related disorders and cancer. Further research is necessary to fully elucidate the functions and implications of KIF20A, but its study offers a wealth of opportunities for advancing our understanding of human immunology and developing novel therapeutic strategies.

Genular Protein ID: 602725466

Symbol: KI20A_HUMAN

Name: Kinesin-like protein KIF20A

UniProtKB Accession Codes:

O95235 B4DL79 D3DQB6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10233894

Title: Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.

PubMed ID: 10233894

PubMed ID: 10806357

Title: cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene.

PubMed ID: 10806357

DOI: 10.1016/s0378-1119(00)00135-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12939256

Title: Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.

PubMed ID: 12939256

DOI: 10.1083/jcb.200306009

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29357359

Title: Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings.

PubMed ID: 29357359

DOI: 10.1371/journal.pgen.1007138

Sequence Information:

  • Length: 890
  • Mass: 100278
  • Checksum: 6620264615496051
  • Sequence:
    • MSQGILSPPA GLLSDDDVVV SPMFESTAAD LGSVVRKNLL SDCSVVSTSL EDKQQVPSED 
SMEKVKVYLR VRPLLPSELE RQEDQGCVRI ENVETLVLQA PKDSFALKSN ERGIGQATHR 
FTFSQIFGPE VGQASFFNLT VKEMVKDVLK GQNWLIYTYG VTNSGKTHTI QGTIKDGGIL 
PRSLALIFNS LQGQLHPTPD LKPLLSNEVI WLDSKQIRQE EMKKLSLLNG GLQEEELSTS 
LKRSVYIESR IGTSTSFDSG IAGLSSISQC TSSSQLDETS HRWAQPDTAP LPVPANIRFS 
IWISFFEIYN ELLYDLLEPP SQQRKRQTLR LCEDQNGNPY VKDLNWIHVQ DAEEAWKLLK 
VGRKNQSFAS THLNQNSSRS HSIFSIRILH LQGEGDIVPK ISELSLCDLA GSERCKDQKS 
GERLKEAGNI NTSLHTLGRC IAALRQNQQN RSKQNLVPFR DSKLTRVFQG FFTGRGRSCM 
IVNVNPCAST YDETLHVAKF SAIASQLVHA PPMQLGFPSL HSFIKEHSLQ VSPSLEKGAK 
ADTGLDDDIE NEADISMYGK EELLQVVEAM KTLLLKERQE KLQLEMHLRD EICNEMVEQM 
QQREQWCSEH LDTQKELLEE MYEEKLNILK ESLTSFYQEE IQERDEKIEE LEALLQEARQ 
QSVAHQQSGS ELALRRSQRL AASASTQQLQ EVKAKLQQCK AELNSTTEEL HKYQKMLEPP 
PSAKPFTIDV DKKLEEGQKN IRLLRTELQK LGESLQSAER ACCHSTGAGK LRQALTTCDD 
ILIKQDQTLA ELQNNMVLVK LDLRKKAACI AEQYHTVLKL QGQVSAKKRL GTNQENQQPN 
QQPPGKKPFL RNLLPRTPTC QSSTDCSPYA RILRSRRSPL LKSGPFGKKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.