Details for: PREB

Gene ID: 10113

Symbol: PREB

Ensembl ID: ENSG00000138073

Description: prolactin regulatory element binding

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.73
    Marker Score: 1,385
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.59
    Marker Score: 2,291
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.35
    Marker Score: 1,688
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.25
    Marker Score: 310
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.12
    Marker Score: 7,185
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.08
    Marker Score: 1,164
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.07
    Marker Score: 4,216
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.02
    Marker Score: 281
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1
    Marker Score: 348
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,697
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,921
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,393
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.91
    Marker Score: 1,210
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,696
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.88
    Marker Score: 750
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.87
    Marker Score: 2,371
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,275
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.86
    Marker Score: 249
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.84
    Marker Score: 368
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,777
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.84
    Marker Score: 5,445
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.83
    Marker Score: 217
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.82
    Marker Score: 875
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.82
    Marker Score: 829
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.81
    Marker Score: 8,126
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.8
    Marker Score: 1,291
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.8
    Marker Score: 600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.78
    Marker Score: 565
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.76
    Marker Score: 2,055
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.75
    Marker Score: 510
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.74
    Marker Score: 369
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.74
    Marker Score: 493
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.74
    Marker Score: 1,677
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.73
    Marker Score: 2,176
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.72
    Marker Score: 396
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.72
    Marker Score: 3,092
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.71
    Marker Score: 391
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.71
    Marker Score: 493
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.7
    Marker Score: 1,823
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.69
    Marker Score: 460
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,875
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.68
    Marker Score: 2,802
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.68
    Marker Score: 720
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.68
    Marker Score: 1,429
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.68
    Marker Score: 5,829
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.67
    Marker Score: 2,589
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.67
    Marker Score: 1,398
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.66
    Marker Score: 739
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.65
    Marker Score: 244
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.65
    Marker Score: 132
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.64
    Marker Score: 280
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.64
    Marker Score: 899
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.63
    Marker Score: 3,024
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.63
    Marker Score: 334
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.63
    Marker Score: 147
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.63
    Marker Score: 1,272
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.62
    Marker Score: 522
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.62
    Marker Score: 177
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.62
    Marker Score: 415
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.62
    Marker Score: 555
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 409
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.62
    Marker Score: 421
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.62
    Marker Score: 3,934
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.62
    Marker Score: 1,464
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.62
    Marker Score: 688
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.61
    Marker Score: 8,156
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.61
    Marker Score: 633
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.6
    Marker Score: 132
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.6
    Marker Score: 153
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.6
    Marker Score: 201
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6
    Marker Score: 1,016
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.6
    Marker Score: 3,627
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9,312
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.6
    Marker Score: 430
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.59
    Marker Score: 946
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.59
    Marker Score: 292
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.59
    Marker Score: 1,390
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.59
    Marker Score: 1,861
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.59
    Marker Score: 1,026
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.59
    Marker Score: 140
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.58
    Marker Score: 390
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.58
    Marker Score: 135
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.58
    Marker Score: 123
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.57
    Marker Score: 201
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.57
    Marker Score: 579
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.56
    Marker Score: 1,006
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.56
    Marker Score: 273

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The PREB gene is a transcription factor that belongs to the basic helix-loop-helix (bHLH) family of proteins. It is characterized by its ability to bind to specific DNA sequences, known as regulatory elements, which are involved in the regulation of gene expression. PREB is highly expressed in various cell types, including pulmonary interstitial fibroblasts, oogonial cells, primordial germ cells, and immune cells such as CD4-positive, alpha-beta memory T cells. The PREB protein is also involved in the regulation of protein modification, transport, and metabolism, highlighting its role in maintaining cellular homeostasis. **Pathways and Functions** PREB is involved in various cellular pathways, including: 1. **Cellular responses to stimuli**: PREB regulates the expression of genes involved in cell growth, differentiation, and survival in response to different cellular stimuli. 2. **Endoplasmic reticulum (ER) stress response**: PREB interacts with the unfolded protein response (UPR) pathway, regulating the expression of chaperone genes that help maintain ER homeostasis. 3. **Vesicle-mediated transport**: PREB is involved in the regulation of Copii-mediated vesicle transport, which is essential for the transport of proteins and lipids between the ER and Golgi apparatus. 4. **Protein binding and modification**: PREB regulates the expression of genes involved in protein modification, including glycosylation, phosphorylation, and ubiquitination. 5. **Immune response**: PREB is expressed in immune cells, where it regulates the expression of genes involved in immune responses, including cytokine production and cell signaling. **Clinical Significance** The PREB gene has been implicated in various diseases, including: 1. **Autoimmune disorders**: PREB has been shown to regulate the expression of genes involved in autoimmune responses, including those involved in rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: PREB has been implicated in the regulation of cancer cell growth and survival, suggesting its potential role in cancer development and progression. 3. **Neurological disorders**: PREB has been shown to regulate the expression of genes involved in neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Reproductive disorders**: PREB has been implicated in the regulation of reproductive processes, including ovulation and fertility. In conclusion, the PREB gene plays a critical role in regulating various cellular processes, including cell growth, differentiation, and survival. Its involvement in multiple biological pathways and its expression in various cell types highlight its potential role in disease development and progression. Further research is needed to fully elucidate the functions and clinical significance of the PREB gene.

Genular Protein ID: 4002086803

Symbol: PREB_HUMAN

Name: Prolactin regulatory element-binding protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10920239

Title: Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome.

PubMed ID: 10920239

DOI: 10.1007/s003350010142

PubMed ID: 12735795

Title: The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12.

PubMed ID: 12735795

DOI: 10.1186/1471-2164-4-18

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25202031

Title: Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export.

PubMed ID: 25202031

DOI: 10.1083/jcb.201312062

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27170179

Title: Dual function of cTAGE5 in collagen export from the endoplasmic reticulum.

PubMed ID: 27170179

DOI: 10.1091/mbc.e16-03-0180

PubMed ID: 28442536

Title: TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.

PubMed ID: 28442536

DOI: 10.1083/jcb.201703084

Sequence Information:

  • Length: 417
  • Mass: 45468
  • Checksum: 7FD490A641202D19
  • Sequence:
  • MGRRRAPELY RAPFPLYALQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGRLSAS 
    LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ QGNKAEKAGS KEQGPRQRKG 
    AAPAEKKCGA ETQHEGLELR VENLQAVQTD FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV 
    WKVPSLEKVL EFKAHEGEIE DLALGPDGKL VTVGRDLKAS VWQKDQLVTQ LHWQENGPTF 
    SSTPYRYQAC RFGQVPDQPA GLRLFTVQIP HKRLRQPPPC YLTAWDGSNF LPLRTKSCGH 
    EVVSCLDVSE SGTFLGLGTV TGSVAIYIAF SLQCLYYVRE AHGIVVTDVA FLPEKGRGPE 
    LLGSHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG LIIVTILLLQ SAFPGFL

Genular Protein ID: 3140749999

Symbol: B5MC98_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 359
  • Mass: 38940
  • Checksum: F34D9518422A1218
  • Sequence:
  • MGRRRAPELY RAPFPLYALQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGRLSAS 
    LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ QGNKAEKAGS KEQGPRQRKG 
    AAPAEKKCGA ETQHEGLELR VENLQAVQTD FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV 
    WKVPSLEKVL EFKAHEGEIE DLALGPDGKL VTVGRDLKAS VWQKDQLVTQ LHWQENGPTF 
    SSTPYRYQAC SESGTFLGLG TVTGSVAIYI AFSLQCLYYV REAHGIVVTD VAFLPEKGRG 
    PELLGSHETA LFSVAVDSRC QLHLLPSRRS VPVWLLLLLC VGLIIVTILL LQSAFPGFL

Genular Protein ID: 2402244949

Symbol: Q05DB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 345
  • Mass: 37831
  • Checksum: FCB1F13455B3769B
  • Sequence:
  • MNLALAGDIL AAGQDAHCQL LRFQAHQQQG NKAEKAGSKE QGPRQRKGAA PAEKKCGAET 
    QHEGLELRVE NLQAVQTDFS SDPLQKVVCF NHDNTLLATG GTDGYVRVWK VPSLEKVLEF 
    KAHEGEIEDL ALGPDGKLVT VGRDLKASVW QKDQLVTQLH WQENGPTFSS TPYRYQACRF 
    GQVPDQPAGL RLFTVQIPHK RLRQPPPCYL TAWDGSNFLP LRTKSCGHEV VSCLDVSESG 
    TFLGLGTVTG SVAIYIAFSL QCLYYVREAH GIVVTDVAFL PEKGRGPELL GSHETALFSV 
    AVDSRCQLHL LPSRRSVPVW LLLLLCVGLI IVTILLLQSA FPGFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.