Details for: FEM1B

Gene ID: 10116

Symbol: FEM1B

Ensembl ID: ENSG00000169018

Description: fem-1 homolog B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11,662
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.35
    Marker Score: 82,878
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.31
    Marker Score: 6,459
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.29
    Marker Score: 1,356
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.25
    Marker Score: 2,648
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.25
    Marker Score: 5,196
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.21
    Marker Score: 11,477
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.17
    Marker Score: 4,539
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.15
    Marker Score: 1,697
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.09
    Marker Score: 1,168
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.09
    Marker Score: 41,283
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.08
    Marker Score: 1,672
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.04
    Marker Score: 710
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.04
    Marker Score: 1,818
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.04
    Marker Score: 10,707
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.03
    Marker Score: 1,832
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 16,020
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.01
    Marker Score: 504
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,695
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,919
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Marker Score: 4,019
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.98
    Marker Score: 2,420
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.98
    Marker Score: 1,129
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,389
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.97
    Marker Score: 14,532
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.97
    Marker Score: 19,284
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.97
    Marker Score: 327
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.95
    Marker Score: 8,938
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.95
    Marker Score: 35,042
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,393
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.93
    Marker Score: 851
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.92
    Marker Score: 995
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.91
    Marker Score: 6,999
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.9
    Marker Score: 711
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,696
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9
    Marker Score: 30,458
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.88
    Marker Score: 7,625
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.87
    Marker Score: 3,606
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4,764
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.83
    Marker Score: 934
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.82
    Marker Score: 854
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.82
    Marker Score: 549
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.82
    Marker Score: 554
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.81
    Marker Score: 448
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.81
    Marker Score: 3,763
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.81
    Marker Score: 1,973
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.8
    Marker Score: 1,038
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.8
    Marker Score: 1,752
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.79
    Marker Score: 664
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.79
    Marker Score: 228
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.78
    Marker Score: 1,781
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.77
    Marker Score: 4,560
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.77
    Marker Score: 483
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.76
    Marker Score: 174
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.75
    Marker Score: 168
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.74
    Marker Score: 424
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.74
    Marker Score: 502
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.73
    Marker Score: 253
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,007
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.71
    Marker Score: 7,159
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.71
    Marker Score: 710
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.71
    Marker Score: 750
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7
    Marker Score: 24,096
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.69
    Marker Score: 7,825
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.69
    Marker Score: 971
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.69
    Marker Score: 170
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.69
    Marker Score: 655
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.68
    Marker Score: 220
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.68
    Marker Score: 454
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.68
    Marker Score: 4,440
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.68
    Marker Score: 4,144
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.68
    Marker Score: 2,343
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.67
    Marker Score: 2,592
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.67
    Marker Score: 4,959
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.67
    Marker Score: 311
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 439
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.66
    Marker Score: 223
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.66
    Marker Score: 270
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 603
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.66
    Marker Score: 1,760
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.66
    Marker Score: 167
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.65
    Marker Score: 1,644
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.65
    Marker Score: 5,643
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.65
    Marker Score: 714
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1,311
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.63
    Marker Score: 637
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.63
    Marker Score: 1,278
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.63
    Marker Score: 1,711
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.63
    Marker Score: 442
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.63
    Marker Score: 1,474

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FEM1B is a protein-coding gene that is significantly expressed in various cell types, including neurons, epithelial cells, and muscle cells. The gene has been associated with several cellular processes, including apoptosis, protein regulation, and developmental morphogenesis. FEM1B is also involved in the regulation of ubiquitin-protein transferase activity and the c-end degron rule pathway, which plays a crucial role in protein degradation. **Pathways and Functions:** The FEM1B gene is involved in several key pathways, including: 1. **Apoptotic process:** FEM1B is involved in regulating the extrinsic apoptotic signaling pathway via death domain receptors, which is essential for inducing programmed cell death. 2. **Branching involved in prostate gland morphogenesis:** FEM1B is expressed in prostate gland development and is involved in regulating epithelial cell maturation, which is crucial for the development of the prostate gland. 3. **Cul2-ring ubiquitin ligase complex:** FEM1B interacts with the Cul2-ring ubiquitin ligase complex, which is involved in regulating protein degradation and ubiquitination. 4. **Protein binding and ubiquitination:** FEM1B is involved in binding and ubiquitinating proteins, which is essential for regulating protein degradation and cellular processes. **Clinical Significance:** The FEM1B gene has been associated with various diseases and disorders, including: 1. **Prostate cancer:** FEM1B is overexpressed in prostate cancer cells and is involved in regulating epithelial cell maturation, which is crucial for prostate gland development. 2. **Neurological disorders:** FEM1B is involved in regulating apoptosis and protein regulation in neurons, which is essential for maintaining neuronal health and function. 3. **Muscle disorders:** FEM1B is expressed in muscle cells and is involved in regulating protein degradation and ubiquitination, which is essential for maintaining muscle function and integrity. In conclusion, FEM1B is a novel gene that plays a crucial role in regulating cellular processes, including apoptosis, protein regulation, and developmental morphogenesis. Further research is needed to fully understand the function of FEM1B and its clinical significance in various diseases and disorders. **Recommendations:** 1. Further research is needed to understand the specific mechanisms by which FEM1B regulates cellular processes. 2. The development of specific inhibitors or modulators of FEM1B could provide new therapeutic strategies for treating diseases and disorders associated with FEM1B dysfunction. 3. The analysis of FEM1B expression in various cell types and tissues could provide insights into its role in maintaining cellular homeostasis and regulating developmental processes. By further elucidating the function of FEM1B, we can gain a deeper understanding of its role in regulating cellular processes and developing new therapeutic strategies for treating diseases and disorders associated with FEM1B dysfunction.

Genular Protein ID: 424890564

Symbol: FEM1B_HUMAN

Name: FEM1-beta

UniProtKB Accession Codes:

Q9UK73 O43146

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 3 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10542291

Title: F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.

PubMed ID: 10542291

DOI: 10.1074/jbc.274.45.32461

PubMed ID: 10623617

Title: Sequence, organization, and expression of the human FEM1B gene.

PubMed ID: 10623617

DOI: 10.1006/bbrc.1999.1942

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11559703

Title: The Caenorhabditis elegans sex-determining protein fem-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis.

PubMed ID: 11559703

DOI: 10.1074/jbc.m105880200

PubMed ID: 15601820

Title: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

PubMed ID: 15601820

DOI: 10.1101/gad.1252404

PubMed ID: 19330022

Title: Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.

PubMed ID: 19330022

DOI: 10.1038/onc.2009.58

PubMed ID: 24076122

Title: Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1.

PubMed ID: 24076122

DOI: 10.1016/j.bbrc.2013.09.090

PubMed ID: 28118078

Title: FEM1 proteins are ancient regulators of SLBP degradation.

PubMed ID: 28118078

DOI: 10.1080/15384101.2017.1284715

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 33398170

Title: Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron.

PubMed ID: 33398170

DOI: 10.1038/s41589-020-00703-4

PubMed ID: 33398168

Title: Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase.

PubMed ID: 33398168

DOI: 10.1038/s41589-020-00704-3

Sequence Information:

  • Length: 627
  • Mass: 70264
  • Checksum: 85DA943663A988C1
  • Sequence:
    • MEGLAGYVYK AASEGKVLTL AALLLNRSES DIRYLLGYVS QQGGQRSTPL IIAARNGHAK 
VVRLLLEHYR VQTQQTGTVR FDGYVIDGAT ALWCAAGAGH FEVVKLLVSH GANVNHTTVT 
NSTPLRAACF DGRLDIVKYL VENNANISIA NKYDNTCLMI AAYKGHTDVV RYLLEQRADP 
NAKAHCGATA LHFAAEAGHI DIVKELIKWR AAIVVNGHGM TPLKVAAESC KADVVELLLS 
HADCDRRSRI EALELLGASF ANDRENYDII KTYHYLYLAM LERFQDGDNI LEKEVLPPIH 
AYGNRTECRN PQELESIRQD RDALHMEGLI VRERILGADN IDVSHPIIYR GAVYADNMEF 
EQCIKLWLHA LHLRQKGNRN THKDLLRFAQ VFSQMIHLNE TVKAPDIECV LRCSVLEIEQ 
SMNRVKNISD ADVHNAMDNY ECNLYTFLYL VCISTKTQCS EEDQCKINKQ IYNLIHLDPR 
TREGFTLLHL AVNSNTPVDD FHTNDVCSFP NALVTKLLLD CGAEVNAVDN EGNSALHIIV 
QYNRPISDFL TLHSIIISLV EAGAHTDMTN KQNKTPLDKS TTGVSEILLK TQMKMSLKCL 
AARAVRANDI NYQDQIPRTL EEFVGFH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.