Details for: CDH13

Gene ID: 1012

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CDH13

Ensembl ID: ENSG00000140945

Description: cadherin 13

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • sst GABAergic cortical interneuron CL4023017
    CSI 41.89
    rCSI 54%
    PRS 86.08
  • VIP GABAergic cortical interneuron CL4023016
    CSI 41.58
    rCSI 49.67%
    PRS 85.13
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 37.3
    rCSI 46.4%
    PRS 83.05
  • cardiac muscle cell CL0000746
    CSI 35.36
    rCSI 50.74%
    PRS 87.95
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 28.81
    rCSI 48.36%
    PRS 85.25
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 27.1
    rCSI 47.87%
    PRS 84.61
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 23.52
    rCSI 42.74%
    PRS 89.69
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 20.7
    rCSI 44.91%
    PRS 85.16
  • oligodendrocyte precursor cell CL0002453
    CSI 16.05
    rCSI 35.32%
    PRS 79.59
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 13.69
    rCSI 45%
    PRS 85.23
  • regular atrial cardiac myocyte CL0002129
    CSI 13.59
    rCSI 43.74%
    PRS 91.17
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 13.24
    rCSI 32.17%
    PRS 83.19
  • glioblast CL0000030
    CSI 13.16
    rCSI 20.99%
    PRS 88.42
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 13.08
    rCSI 47.06%
    PRS 83.49
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 12.6
    rCSI 47.62%
    PRS 85.31
  • sncg GABAergic cortical interneuron CL4023015
    CSI 11.23
    rCSI 18.06%
    PRS 85.99
  • vascular leptomeningeal cell CL4023051
    CSI 11.17
    rCSI 19.59%
    PRS 92.12
  • cerebral cortex neuron CL0010012
    CSI 10.84
    rCSI 44.15%
    PRS 88.43
  • lung ciliated cell CL1000271
    CSI 10.33
    rCSI 11.95%
    PRS 90.09
  • alveolar type 1 fibroblast cell CL4028004
    CSI 10.17
    rCSI 11.13%
    PRS 95.5
  • capillary endothelial cell CL0002144
    CSI 9.86
    rCSI 18.06%
    PRS 93.5
  • blood vessel endothelial cell CL0000071
    CSI 9.53
    rCSI 19.77%
    PRS 92.95
  • cerebellar granule cell CL0001031
    CSI 9.38
    rCSI 13.79%
    PRS 90.55
  • neural cell CL0002319
    CSI 9.07
    rCSI 34.22%
    PRS 82.85
  • adipocyte CL0000136
    CSI 8.87
    rCSI 11.38%
    PRS 87.85
  • glutamatergic neuron CL0000679
    CSI 8.78
    rCSI 18.05%
    PRS 84.79
  • regular ventricular cardiac myocyte CL0002131
    CSI 8.67
    rCSI 54.18%
    PRS 89.33
  • fibroblast of lung CL0002553
    CSI 8.63
    rCSI 8.03%
    PRS 95.33
  • inhibitory interneuron CL0000498
    CSI 8.48
    rCSI 19.57%
    PRS 87.54
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 8.21
    rCSI 19.64%
    PRS 86.34
  • endothelial cell of placenta CL0009092
    CSI 7.95
    rCSI 39.19%
    PRS 96.09
  • interneuron CL0000099
    CSI 7.93
    rCSI 15.92%
    PRS 90.05
  • GABAergic neuron CL0000617
    CSI 7.63
    rCSI 25.57%
    PRS 83.66
  • retinal blood vessel endothelial cell CL0002585
    CSI 7.42
    rCSI 11.85%
    PRS 95.71
  • mesodermal cell CL0000222
    CSI 7.15
    rCSI 8.58%
    PRS 93.61
  • myoepithelial cell CL0000185
    CSI 7.14
    rCSI 18.06%
    PRS 95.6
  • enteric smooth muscle cell CL0002504
    CSI 7.11
    rCSI 10.15%
    PRS 94.2
  • vascular associated smooth muscle cell CL0000359
    CSI 7.07
    rCSI 22.94%
    PRS 93.02
  • GABAergic amacrine cell CL4030027
    CSI 7.02
    rCSI 24.05%
    PRS 84.09
  • skin fibroblast CL0002620
    CSI 6.62
    rCSI 5.71%
    PRS 93.76
  • astrocyte of the cerebral cortex CL0002605
    CSI 6.41
    rCSI 14.36%
    PRS 85.4
  • ependymal cell CL0000065
    CSI 6.17
    rCSI 12.53%
    PRS 79.96
  • Bergmann glial cell CL0000644
    CSI 6.15
    rCSI 8.41%
    PRS 88.58
  • renal interstitial pericyte CL1001318
    CSI 6.13
    rCSI 16.88%
    PRS 92.9
  • neural crest cell CL0011012
    CSI 6.03
    rCSI 4.77%
    PRS 89.52
  • smooth muscle cell CL0000192
    CSI 5.97
    rCSI 14.24%
    PRS 89.93
  • retina horizontal cell CL0000745
    CSI 5.92
    rCSI 9.02%
    PRS 91.78
  • cardiac blood vessel endothelial cell CL0010006
    CSI 5.91
    rCSI 41.81%
    PRS 89.59
  • Schwann cell CL0002573
    CSI 5.71
    rCSI 16.23%
    PRS 91.38
  • hepatic stellate cell CL0000632
    CSI 5.69
    rCSI 21.32%
    PRS 91.54
  • endocardial cell CL0002350
    CSI 5.68
    rCSI 27.19%
    PRS 91.53
  • cardiac neuron CL0010022
    CSI 5.58
    rCSI 17.86%
    PRS 93.36
  • contractile cell CL0000183
    CSI 5.53
    rCSI 16.32%
    PRS 94.3
  • basal cell CL0000646
    CSI 5.41
    rCSI 7.23%
    PRS 91.86
  • H2 horizontal cell CL0004218
    CSI 5.35
    rCSI 26.59%
    PRS 89.88
  • fibroblast of cardiac tissue CL0002548
    CSI 5.28
    rCSI 25.28%
    PRS 95.06
  • cardiac endothelial cell CL0010008
    CSI 5.24
    rCSI 21.13%
    PRS 94.82
  • amacrine cell CL0000561
    CSI 5.21
    rCSI 15.1%
    PRS 87.9
  • corneal epithelial cell CL0000575
    CSI 4.68
    rCSI 13.38%
    PRS 94.88
  • peripheral nervous system neuron CL2000032
    CSI 4.61
    rCSI 6.28%
    PRS 89.31
  • serotonergic neuron CL0000850
    CSI 4.23
    rCSI 18.91%
    PRS 82.26
  • melanocyte CL0000148
    CSI 4.18
    rCSI 3.09%
    PRS 92.05
  • keratinocyte CL0000312
    CSI 4.07
    rCSI 3.41%
    PRS 93.88
  • conjunctival epithelial cell CL1000432
    CSI 4.05
    rCSI 6.19%
    PRS 93.29
  • fast muscle cell CL0000190
    CSI 4.02
    rCSI 15.72%
    PRS 88.28
  • endothelial cell of vascular tree CL0002139
    CSI 3.68
    rCSI 20.09%
    PRS 90.97
  • dopaminergic neuron CL0000700
    CSI 3.63
    rCSI 20.51%
    PRS 85.98
  • tracheobronchial smooth muscle cell CL0019019
    CSI 3.6
    rCSI 6.34%
    PRS 96.06
  • microcirculation associated smooth muscle cell CL0008035
    CSI 3.47
    rCSI 10.04%
    PRS 93.69
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 3.46
    rCSI 20.39%
    PRS 85.51
  • stromal cell CL0000499
    CSI 3.17
    rCSI 8.9%
    PRS 91.37
  • cerebral cortex endothelial cell CL1001602
    CSI 3.09
    rCSI 5.34%
    PRS 90.74
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 2.97
    rCSI 9.16%
    PRS 94.99
  • central nervous system neuron CL2000029
    CSI 2.85
    rCSI 20.93%
    PRS 88.52
  • mesenchymal cell CL0008019
    CSI 2.71
    rCSI 6.87%
    PRS 90.94
  • epicardial adipocyte CL1000309
    CSI 2.69
    rCSI 8.75%
    PRS 92.14
  • starburst amacrine cell CL0004232
    CSI 2.62
    rCSI 22.08%
    PRS 82.55
  • neural progenitor cell CL0011020
    CSI 2.57
    rCSI 11.3%
    PRS 85.33
  • chondrocyte CL0000138
    CSI 2.51
    rCSI 3.99%
    PRS 91.03
  • alveolar adventitial fibroblast CL4028006
    CSI 2.3
    rCSI 3.63%
    PRS 95.04
  • skeletal muscle satellite stem cell CL0008011
    CSI 2.07
    rCSI 9.25%
    PRS 97.77
  • L6b glutamatergic cortical neuron CL4023038
    CSI 2.07
    rCSI 6.48%
    PRS 86.14
  • mesangial cell CL0000650
    CSI 1.89
    rCSI 7.71%
    PRS 97.39
  • skeletal muscle satellite cell CL0000594
    CSI 1.82
    rCSI 5.32%
    PRS 97.16
  • cell of skeletal muscle CL0000188
    CSI 1.79
    rCSI 19.48%
    PRS 92.31
  • enteroglial cell CL4040002
    CSI 1.66
    rCSI 8.71%
    PRS 94.2
  • parietal epithelial cell CL1000452
    CSI 1.47
    rCSI 3.93%
    PRS 90.72
  • endothelial cell of uterus CL0009095
    CSI 1.2
    rCSI 8.77%
    PRS 97.29
  • retinal ganglion cell CL0000740
    CSI 1.18
    rCSI 2.61%
    PRS 86.52
  • blood vessel smooth muscle cell CL0019018
    CSI 0.91
    rCSI 7.4%
    PRS 93.17
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.77
    rCSI 2.42%
    PRS 87.75

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CDH13](/details-gene/1012) (Cadherin-13), also known as H-Cadherin or T-Cadherin, is a member of the cadherin superfamily of calcium-dependent cell-cell adhesion molecules. Unlike classical cadherins, [CDH13](/details-gene/1012) lacks a transmembrane domain and is instead anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor ([Link](https://doi.org/10.1006/bbrc.2000.3465)). This structural feature suggests a unique role in cell signaling and adhesion. **Overall**, expression data reveals that [CDH13](/details-gene/1012) is a highly significant gene in the central nervous system, showing prominent expression in various subtypes of GABAergic cortical interneurons, such as [sst GABAergic cortical interneuron](/details-cell/CL4023017) and [VIP GABAergic cortical interneuron](/details-cell/CL4023016). It is also highly expressed in [cardiac muscle cell](/details-cell/CL0000746). Functionally, it is involved in adherens junction organization, cell migration, and acts as a receptor for lipoproteins, including adiponectin and low-density lipoprotein (LDL) particles. Clinically, loss of [CDH13](/details-gene/1012) expression, often via promoter hypermethylation, is associated with various cancers, where it is suggested to function as a tumor suppressor ([Link](https://omim.org/entry/601364)). ## Cellular Roles and Expression Landscape The expression profile of [CDH13](/details-gene/1012) highlights its primary importance in neural and cardiac tissues. **Overall**, the gene shows its highest significance in several classes of inhibitory neurons within the cerebral cortex, including [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 41.89), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 41.58), and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 37.30). This strong and specific expression pattern suggests a crucial role in the formation, specification, or maintenance of inhibitory circuits in the brain. The gene is also significantly expressed in glutamatergic excitatory neurons, such as [L2/3 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030059), and in glial precursors like [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) and [oligodendrocyte precursor cell](/details-cell/CL0002453), indicating a broader function in CNS development and homeostasis. Outside of the nervous system, [CDH13](/details-gene/1012) demonstrates a notably high significance in [cardiac muscle cell](/details-cell/CL0000746) (CSI: 35.36), consistent with its role in maintaining the structural integrity of heart tissue through cell-cell adhesion. The specificity of its expression profile is underscored by the absence of hematopoietic, endothelial, or epithelial cell types from the top-expressed list, suggesting a specialized function confined primarily to neuronal and muscle tissues. ## Pathways and Molecular Function The molecular functions attributed to [CDH13](/details-gene/1012) align with its observed expression pattern. Its core role in cell adhesion is supported by annotations for '[Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules](/details-go/GO:0016339)' and its participation in '[Adherens junctions interactions](/details-reactome/R-HSA-418990)'. This function is critical for maintaining tissue architecture in both the brain and heart. Beyond its structural role, [CDH13](/details-gene/1012) is implicated in cell signaling and regulation. It is known to negatively regulate cell proliferation ([GO:0008285](/details-go/GO:0008285)), a function that has been demonstrated in cancer studies where its loss promotes tumor growth ([Link](https://doi.org/10.1038/nm0796-776), [Link](https://doi.org/10.1007/s004390050790)). Uniquely for a cadherin, [CDH13](/details-gene/1012) functions as a receptor for lipoproteins, evidenced by its binding to adiponectin ([GO:0055100](/details-go/GO:0055100)) and low-density lipoprotein particles ([GO:0030169](/details-go/GO:0030169)) ([Link](https://doi.org/10.1016/s0014-5793(97)01562-7)). This dual functionality suggests it may act as a signaling platform on the cell surface, integrating mechanical cues from cell adhesion with metabolic signals from circulating lipoproteins, thereby influencing processes like [cell migration](/details-go/GO:0016477) and [angiogenesis](/details-go/GO:0002040). ## Research Directions The established role of [CDH13](/details-gene/1012) as a tumor suppressor in multiple cancers contrasts with its high expression in specific healthy tissues, presenting key research questions about its context-dependent regulation and function. ### Proposed Hypotheses: 1. Given its highly specific and significant expression in distinct subtypes of GABAergic interneurons, [CDH13](/details-gene/1012) may play a critical role in mediating the synaptic specificity and connectivity of inhibitory circuits in the cortex. Its loss or dysfunction could disrupt the excitatory-inhibitory balance, potentially contributing to neurological disorders such as epilepsy or schizophrenia. 2. In [cardiac muscle cell](/details-cell/CL0000746), the dual function of [CDH13](/details-gene/1012) as both an adhesion molecule and a lipoprotein receptor suggests it acts as a mechanometabolic sensor. We hypothesize that [CDH13](/details-gene/1012) integrates signals from mechanical stress (via cell-cell junctions) and metabolic status (via LDL/adiponectin binding) to regulate cardiac myocyte growth and survival, and its dysregulation could be a factor in cardiometabolic diseases. ### Experimental Approach: To test the first hypothesis regarding the role of [CDH13](/details-gene/1012) in cortical inhibitory circuits, a conditional knockout mouse model could be employed. By crossing a floxed-[CDH13](/details-gene/1012) mouse line with a Pvalb-Cre or Sst-Cre driver line, the gene can be selectively deleted in parvalbumin- or somatostatin-positive interneurons, respectively. The resulting phenotype can be analyzed using a combination of techniques: *in vivo* two-photon imaging to assess structural plasticity of dendritic spines and axonal boutons, patch-clamp electrophysiology to measure the frequency and amplitude of inhibitory postsynaptic currents (IPSCs) in connected pyramidal neurons, and behavioral assays to assess cognitive functions dependent on cortical inhibition. ### Therapeutic Potential: As [CDH13](/details-gene/1012) is frequently silenced in cancers such as breast and lung carcinoma and functions as a negative growth regulator, it is a compelling target for therapeutic reactivation rather than inhibition ([Link](https://doi.org/10.1038/nm0796-776)). Since its inactivation is often due to epigenetic silencing via promoter hypermethylation, a potential therapeutic strategy could involve the use of demethylating agents (e.g., decitabine) to restore its expression in tumor cells. This approach could resensitize cancer cells to growth-inhibitory signals, potentially synergizing with conventional chemotherapy or immunotherapy. However, the widespread expression of [CDH13](/details-gene/1012) in the CNS and heart necessitates careful consideration of off-target effects and targeted delivery systems for such therapies.

Genular Protein ID: 1950201510

Symbol: CAD13_HUMAN

Name: Cadherin-13

UniProtKB Accession Codes:

P55290 A8W476 A8W477 B7Z590 C9JRI6 J3KN62 Q6GTW4 Q8TBX3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7982033

Title: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.

PubMed ID: 7982033

DOI: 10.3109/15419069409014199

PubMed ID: 8673923

Title: H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer.

PubMed ID: 8673923

DOI: 10.1038/nm0796-776

PubMed ID: 9737784

Title: The H-cadherin (CDH13) gene is inactivated in human lung cancer.

PubMed ID: 9737784

DOI: 10.1007/s004390050790

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9468307

Title: Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin.

PubMed ID: 9468307

DOI: 10.1016/s0014-5793(97)01562-7

PubMed ID: 10737605

Title: Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells.

PubMed ID: 10737605

DOI: 10.1046/j.1471-4159.2000.0741489.x

PubMed ID: 11027617

Title: The glycosyl phosphatidylinositol anchor of human T-cadherin binds lipoproteins.

PubMed ID: 11027617

DOI: 10.1006/bbrc.2000.3465

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17566972

Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.

PubMed ID: 17566972

DOI: 10.1002/pmic.200700068

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21220648

Title: Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.

PubMed ID: 21220648

DOI: 10.1001/archneurol.2010.351

Sequence Information:

  • Length: 713
  • Mass: 78287
  • Checksum: CEB662D77824CB60
  • Sequence:
    • MQPRTPLVLC VLLSQVLLLT SAEDLDCTPG FQQKVFHINQ PAEFIEDQSI LNLTFSDCKG 
NDKLRYEVSS PYFKVNSDGG LVALRNITAV GKTLFVHART PHAEDMAELV IVGGKDIQGS 
LQDIFKFART SPVPRQKRSI VVSPILIPEN QRQPFPRDVG KVVDSDRPER SKFRLTGKGV 
DQEPKGIFRI NENTGSVSVT RTLDREVIAV YQLFVETTDV NGKTLEGPVP LEVIVIDQND 
NRPIFREGPY IGHVMEGSPT GTTVMRMTAF DADDPATDNA LLRYNIRQQT PDKPSPNMFY 
IDPEKGDIVT VVSPALLDRE TLENPKYELI IEAQDMAGLD VGLTGTATAT IMIDDKNDHS 
PKFTKKEFQA TVEEGAVGVI VNLTVEDKDD PTTGAWRAAY TIINGNPGQS FEIHTNPQTN 
EGMLSVVKPL DYEISAFHTL LIKVENEDPL VPDVSYGPSS TATVHITVLD VNEGPVFYPD 
PMMVTRQEDL SVGSVLLTVN ATDPDSLQHQ TIRYSVYKDP AGWLNINPIN GTVDTTAVLD 
RESPFVDNSV YTALFLAIDS GNPPATGTGT LLITLEDVND NAPFIYPTVA EVCDDAKNLS 
VVILGASDKD LHPNTDPFKF EIHKQAVPDK VWKISKINNT HALVSLLQNL NKANYNLPIM 
VTDSGKPPMT NITDLRVQVC SCRNSKVDCN AAGALRFSLP SVLLLSLFSL ACL

Genular Protein ID: 60758181

Symbol: B7Z9B1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9B1

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 11 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 760
  • Mass: 83408
  • Checksum: 65D9C11190FCBF5C
  • Sequence:
    • MKTPPGASSR TKCSRELRSF CAFSCPRAKQ PTCTAWFPQQ EHPSENGPQM PGRDSPAAST 
MQVLLLTSAE DLDCTPGFQQ KVFHINQPAE FIEDQSILNL TFSDCKGNDK LRYEVSSPYF 
KVNSDGGLVA LRNITAVGKT LFVHARTPHA EDMAELVIVG GKDIQGSLQD IFKFARTSPV 
PRQKRSIVVS PILIPENQRQ PFPRDVGKVV DSDRPERSKF RLTGKGVDQE PKGIFRINEN 
TGSVSVTRTL DREVIAVYQL FVETTDVNGK TLEGPVPLEV IVIDQNDNRP IFREGPYIGH 
VMEGSPTGTT VMRMTAFDAD DPATDNALLR YNIRQQTPDK PSPNMFYIDP EKGDIVTVVS 
PALLDRETLE NPKYELIIEA QDMAGLDFGL TGTATATIMI DDKNDHSPKF TKKEFQATVE 
EGAVGVIVNL TVEDKDDPTT GAWRAAYTII NGNPGQSFEI HTNPQTNEGM LSVVKPLDYE 
ISAFHTLLIK VENEDPLVPD VSYGPSSTAT VHITVLDVNE GPVFYPDPMM VTRQEDLSVG 
SVLLTVNATD PDSLQHQTIR YSVYKDPAGW LNINPINGTV DTTAVLDRES PFVDNSVYTA 
LFLAIDSGNP PATGTGTLLI TLEDVNDNAP FIYPTVAEVC DDAKNLSVVI LGASDKDLHP 
NTDPFKFEIH KQAVPDKVWK ISKINNTHAL VSLLQSLNKA NYNLPIMVTD SGKPPMTNIT 
DLRVQVCSCR NSKVDCNAAG ALRFSLPSVL LLSLFSLACL

Genular Protein ID: 3019639236

Symbol: B7Z3H7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3H7

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 11 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 459
  • Mass: 49951
  • Checksum: 2EF090EA0143C77C
  • Sequence:
    • MEGSPTGTTV MRMTAFDADD PATDNALLRY NIRQQTPDKP SPNMFYIDPE KGDIVTVVSP 
ALLDRETPEN PKYELIIEAQ DMAGLDVGLT GTATATIMID DKNDHSPKFT KKEFQATVEE 
GAVGVIVNLT VEDKDDPTTG AWRAAYTIIN GNPGQSFEIH TNPQTNEGML SVVKPLDYEI 
SAFHTLLIKV ENEDPLVPDV SYGPSSTATV HITVLDVNEG PVFYPDPMMV TRQEDLSVGS 
VLLTVNATDP DSLQHQTIRY SVYKDPAGWL NINPINGTVD TTAVLDRESP FVDNSVYTAL 
FLAIDSGNPP ATGTGTLLIT LEDVNDNAPF IYPTVAEVCD DAKNLSVVIL GASDKDLHPN 
TDPFKFEIHK QAVPDKVWKI SKINNTHALV SLLQNLNKAN YNLPIMVTDS GKPPMTNITD 
LRVQVCSCRN SKVDCNAAGA LRFSLPSVLL LSLFSLACL