Details for: ACTR1B

Gene ID: 10120

Symbol: ACTR1B

Ensembl ID: ENSG00000115073

Description: actin related protein 1B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.63
    Marker Score: 2,849
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2,036
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10,935
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 76,980
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.2
    Marker Score: 11,423
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.19
    Marker Score: 497
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.15
    Marker Score: 1,292
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1
    Marker Score: 4,755
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.1
    Marker Score: 10,323
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.07
    Marker Score: 2,177
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.06
    Marker Score: 356
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38,264
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1
    Marker Score: 6,403
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,649
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,874
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.99
    Marker Score: 3,668
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,385
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.98
    Marker Score: 1,054
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.98
    Marker Score: 2,658
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.96
    Marker Score: 1,031
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.96
    Marker Score: 19,102
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.95
    Marker Score: 525
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.95
    Marker Score: 2,242
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.94
    Marker Score: 3,852
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,391
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.94
    Marker Score: 627
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.94
    Marker Score: 883
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.93
    Marker Score: 238
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.93
    Marker Score: 877
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.92
    Marker Score: 1,921
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 430
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,688
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.89
    Marker Score: 244
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.89
    Marker Score: 944
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13,926
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.89
    Marker Score: 594
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,055
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.88
    Marker Score: 3,753
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.86
    Marker Score: 8,650
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.85
    Marker Score: 1,935
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.84
    Marker Score: 1,435
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.83
    Marker Score: 1,971
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.82
    Marker Score: 852
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.82
    Marker Score: 2,259
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 254
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.81
    Marker Score: 3,130
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.81
    Marker Score: 2,782
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.81
    Marker Score: 1,705
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.8
    Marker Score: 327
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.8
    Marker Score: 426
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.8
    Marker Score: 1,000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.79
    Marker Score: 5,161
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.79
    Marker Score: 797
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.79
    Marker Score: 10,415
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.79
    Marker Score: 712
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.79
    Marker Score: 1,113
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.78
    Marker Score: 3,756
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.78
    Marker Score: 942
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.78
    Marker Score: 1,239
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.78
    Marker Score: 186
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.78
    Marker Score: 8,760
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.78
    Marker Score: 3,215
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.77
    Marker Score: 3,039
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.77
    Marker Score: 560
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.77
    Marker Score: 690
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.77
    Marker Score: 453
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.77
    Marker Score: 40,715
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.77
    Marker Score: 6,669
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.77
    Marker Score: 267
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.76
    Marker Score: 1,366
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.76
    Marker Score: 555
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.76
    Marker Score: 1,521
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.76
    Marker Score: 1,429
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.76
    Marker Score: 570
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.76
    Marker Score: 358
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.75
    Marker Score: 28,627
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.75
    Marker Score: 711
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.75
    Marker Score: 314
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.75
    Marker Score: 215
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.74
    Marker Score: 351
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.74
    Marker Score: 255
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.73
    Marker Score: 1,078
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.73
    Marker Score: 7,190
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.72
    Marker Score: 170
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.72
    Marker Score: 455
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.72
    Marker Score: 874
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.72
    Marker Score: 2,282
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.72
    Marker Score: 191
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.72
    Marker Score: 183
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.72
    Marker Score: 189
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.72
    Marker Score: 300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.71
    Marker Score: 4,239
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.71
    Marker Score: 349

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** ACTR1B is expressed in germ cells, neurons, and immune cells, including neutrophils and decidual cells. 2. **Protein structure:** The ACTR1B protein is a member of the actin-related protein family, which plays a crucial role in cytoskeleton dynamics and protein binding. 3. **Signaling pathways:** ACTR1B is implicated in various signaling pathways, including the adaptive immune system, ATP binding, and centrosome regulation. 4. **Cellular functions:** The protein is involved in cytoskeleton organization, protein binding, and antigen presentation, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Adaptive immune system:** ACTR1B is involved in the regulation of immune responses, including antigen presentation and cytokine signaling. 2. **Cytoskeleton dynamics:** The protein plays a crucial role in maintaining cytoskeleton organization, which is essential for cell migration, division, and signaling. 3. **Centrosome regulation:** ACTR1B is implicated in centrosome function, which is critical for maintaining cell polarity and regulating cellular processes. 4. **Protein binding:** The protein binds to various proteins, including actin-related proteins, which are essential for cytoskeleton dynamics and cellular signaling. 5. **Antigen presentation:** ACTR1B is involved in the regulation of antigen presentation, which is critical for initiating immune responses. **Clinical Significance:** 1. **Neurological disorders:** Dysregulation of ACTR1B has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. 2. **Immune-mediated conditions:** ACTR1B may contribute to the development of immune-mediated conditions, including autoimmune diseases and allergies. 3. **Cancer:** The protein's involvement in antigen presentation and cytoskeleton dynamics makes it a potential target for cancer therapy. 4. **Reproductive disorders:** ACTR1B is expressed in decidual cells, which are essential for maintaining pregnancy. Dysregulation of the protein may contribute to reproductive disorders, including miscarriage and infertility. In conclusion, the ACTR1B gene is a complex and multifaceted molecule that plays a critical role in both the adaptive and innate immune systems, as well as neural function. Further research is necessary to fully elucidate the mechanisms by which ACTR1B regulates cellular processes and to explore its potential therapeutic applications.

Genular Protein ID: 784186492

Symbol: ACTY_HUMAN

Name: Beta-centractin

UniProtKB Accession Codes:

P42025 D3DVH2 Q53SK5 Q9BRB7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7696711

Title: Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.

PubMed ID: 7696711

DOI: 10.1091/mbc.5.12.1301

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 376
  • Mass: 42293
  • Checksum: 24C24ECEE18B83BD
  • Sequence:
    • MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG ALEGDLFIGP 
KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPSKN 
REKAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI 
MRVDIAGRDV SRYLRLLLRK EGVDFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ 
YTLPDGSTLD VGPARFRAPE LLFQPDLVGD ESEGLHEVVA FAIHKSDMDL RRTLFANIVL 
SGGSTLFKGF GDRLLSEVKK LAPKDIKIKI SAPQERLYST WIGGSILASL DTFKKMWVSK 
KEYEEDGSRA IHRKTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.