Details for: ACTR1A

Gene ID: 10121

Symbol: ACTR1A

Ensembl ID: ENSG00000138107

Description: actin related protein 1A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.88
    Marker Score: 7,855
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.74
    Marker Score: 1,952
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.63
    Marker Score: 786
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.52
    Marker Score: 510
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.38
    Marker Score: 1,482
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.37
    Marker Score: 442
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.35
    Marker Score: 1,954
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.32
    Marker Score: 621
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.3
    Marker Score: 1,377
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.27
    Marker Score: 1,194
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.26
    Marker Score: 2,562
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.25
    Marker Score: 392
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.25
    Marker Score: 1,769
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.24
    Marker Score: 10,658
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12,716
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.21
    Marker Score: 721
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2
    Marker Score: 4,735
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.2
    Marker Score: 2,816
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18,415
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.17
    Marker Score: 643
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.16
    Marker Score: 5,020
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.16
    Marker Score: 1,169
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.16
    Marker Score: 328
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.14
    Marker Score: 63,749
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.14
    Marker Score: 3,098
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.13
    Marker Score: 1,504
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.13
    Marker Score: 770
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.13
    Marker Score: 2,198
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.12
    Marker Score: 1,911
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.12
    Marker Score: 2,344
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.12
    Marker Score: 13,016
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.11
    Marker Score: 11,202
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.11
    Marker Score: 927
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1
    Marker Score: 7,009
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.09
    Marker Score: 689
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.09
    Marker Score: 9,346
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.08
    Marker Score: 786
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.07
    Marker Score: 1,148
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.06
    Marker Score: 1,126
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.05
    Marker Score: 1,265
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.05
    Marker Score: 990
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.04
    Marker Score: 6,334
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.03
    Marker Score: 1,595
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.03
    Marker Score: 549
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63,256
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.02
    Marker Score: 3,962
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.02
    Marker Score: 2,397
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.01
    Marker Score: 1,221
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.01
    Marker Score: 1,489
  • Cell Name: neuron (CL0000540)
    Fold Change: 1
    Marker Score: 4,091
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1
    Marker Score: 402
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1
    Marker Score: 2,714
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,604
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,827
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.99
    Marker Score: 659
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.99
    Marker Score: 491
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.98
    Marker Score: 2,501
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.98
    Marker Score: 888
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.98
    Marker Score: 616
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,372
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.98
    Marker Score: 233
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.97
    Marker Score: 1,173
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.97
    Marker Score: 338
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.96
    Marker Score: 2,183
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.96
    Marker Score: 236
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.95
    Marker Score: 1,018
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.95
    Marker Score: 521
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.94
    Marker Score: 3,858
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.94
    Marker Score: 8,934
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.94
    Marker Score: 5,574
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.94
    Marker Score: 24,020
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.94
    Marker Score: 626
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.94
    Marker Score: 4,330
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.94
    Marker Score: 883
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,378
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.93
    Marker Score: 1,172
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.93
    Marker Score: 1,483
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.93
    Marker Score: 2,322
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.93
    Marker Score: 935
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.92
    Marker Score: 3,559
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.92
    Marker Score: 823
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.92
    Marker Score: 186
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.92
    Marker Score: 1,511
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.92
    Marker Score: 1,109
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.92
    Marker Score: 374
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.91
    Marker Score: 259
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.91
    Marker Score: 335
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.91
    Marker Score: 835
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.91
    Marker Score: 33,440
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.9
    Marker Score: 1,393
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9
    Marker Score: 5,882
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.9
    Marker Score: 316
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.9
    Marker Score: 320
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.9
    Marker Score: 441
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9
    Marker Score: 9,101
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.9
    Marker Score: 8,429
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.89
    Marker Score: 471
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.89
    Marker Score: 480

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular localization**: ACTR1A is predominantly localized to the cytoskeleton, where it interacts with other proteins to maintain cellular structure and organization. 2. **Expression pattern**: ACTR1A is expressed in a wide range of cell types, including immune cells, neurons, and epithelial cells. 3. **Homology**: ACTR1A shares high sequence homology with other actin-related proteins, such as ARP2/3 and ARP5, which are involved in actin polymerization and depolymerization. 4. **Regulation**: ACTR1A is regulated by various post-translational modifications, including phosphorylation and ubiquitination, which modulate its activity and interactions. **Pathways and Functions** 1. **Immune function**: ACTR1A plays a crucial role in the regulation of immune cell function, including the activation and differentiation of T cells and the production of cytokines. 2. **Cell cycle regulation**: ACTR1A is involved in the regulation of the cell cycle, particularly during the G2/M phase, where it interacts with proteins such as Plk1 and Aurora kinase. 3. **Protein trafficking**: ACTR1A is involved in the regulation of protein trafficking, including the transport of proteins to the Golgi apparatus and the endoplasmic reticulum. 4. **Cytoskeletal organization**: ACTR1A contributes to the organization and dynamics of the cytoskeleton, which is essential for cell shape, movement, and division. **Clinical Significance** 1. **Immunodeficiency**: Dysregulation of ACTR1A has been implicated in various immunodeficiency disorders, including autoimmune diseases and cancer. 2. **Neurological disorders**: ACTR1A has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer**: ACTR1A has been identified as a potential oncogene, with its expression levels correlated with tumor progression and metastasis. 4. **Neurodevelopmental disorders**: ACTR1A has been implicated in neurodevelopmental disorders, including autism and schizophrenia. In conclusion, ACTR1A is a multifunctional protein that plays a critical role in various cellular processes, including immune function, cell cycle regulation, and protein trafficking. Its dysregulation has been implicated in various diseases, including immunodeficiency, neurological disorders, cancer, and neurodevelopmental disorders. Further research is necessary to fully elucidate the mechanisms by which ACTR1A regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3872590517

Symbol: ACTZ_HUMAN

Name: Alpha-centractin

UniProtKB Accession Codes:

P61163 B2R6B0 P42024

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 11 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7696711

Title: Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.

PubMed ID: 7696711

DOI: 10.1091/mbc.5.12.1301

PubMed ID: 1528266

Title: A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility.

PubMed ID: 1528266

DOI: 10.1038/359244a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22327364

Title: Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.

PubMed ID: 22327364

DOI: 10.1038/ncb2440

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28394342

Title: Regulation of spindle integrity and mitotic fidelity by BCCIP.

PubMed ID: 28394342

DOI: 10.1038/onc.2017.92

Sequence Information:

  • Length: 376
  • Mass: 42614
  • Checksum: 4A978E7AB3739436
  • Sequence:
    • MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG ALEGDIFIGP 
KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPRKN 
RERAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI 
MRIDIAGRDV SRFLRLYLRK EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ 
YYLPDGSTIE IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL 
SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL DTFKKMWVSK 
KEYEEDGARS IHRKTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.