Details for: ARL4C

Gene ID: 10123

Symbol: ARL4C

Ensembl ID: ENSG00000188042

Description: ADP ribosylation factor like GTPase 4C

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.38
    Marker Score: 9,489
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.2
    Marker Score: 1,380
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.12
    Marker Score: 1,558
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.09
    Marker Score: 9,761
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.88
    Marker Score: 2,699
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.81
    Marker Score: 11,731
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.72
    Marker Score: 1,753
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.67
    Marker Score: 829
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.59
    Marker Score: 25,675
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.58
    Marker Score: 848
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.57
    Marker Score: 2,166
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.54
    Marker Score: 7,412
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.52
    Marker Score: 3,474
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5
    Marker Score: 15,953
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.42
    Marker Score: 2,610
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.41
    Marker Score: 2,143
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.39
    Marker Score: 835
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.36
    Marker Score: 10,129
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.32
    Marker Score: 3,412
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.27
    Marker Score: 5,548
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.23
    Marker Score: 117,992
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.15
    Marker Score: 1,107
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.15
    Marker Score: 2,079
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.1
    Marker Score: 636
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.09
    Marker Score: 1,515
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.09
    Marker Score: 1,832
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.07
    Marker Score: 3,706
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.04
    Marker Score: 7,560
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.97
    Marker Score: 74,734
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.93
    Marker Score: 1,189
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.92
    Marker Score: 28,666
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.88
    Marker Score: 3,221
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.84
    Marker Score: 1,844
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.8
    Marker Score: 774
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.75
    Marker Score: 1,279
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.74
    Marker Score: 3,415
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.71
    Marker Score: 433
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.67
    Marker Score: 2,903
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.65
    Marker Score: 12,646
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.64
    Marker Score: 1,342
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.63
    Marker Score: 8,021
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.62
    Marker Score: 1,183
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.62
    Marker Score: 2,104
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.62
    Marker Score: 18,783
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.6
    Marker Score: 1,215
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6
    Marker Score: 6,196
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.55
    Marker Score: 893
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.55
    Marker Score: 853
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.53
    Marker Score: 895
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.52
    Marker Score: 30,206
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5
    Marker Score: 1,576
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.49
    Marker Score: 339
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.46
    Marker Score: 50,491
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.43
    Marker Score: 1,428
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.37
    Marker Score: 2,598
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.37
    Marker Score: 823
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.36
    Marker Score: 3,536
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.36
    Marker Score: 1,482
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.36
    Marker Score: 1,172
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.33
    Marker Score: 973
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.31
    Marker Score: 1,153
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.29
    Marker Score: 889
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.28
    Marker Score: 1,462
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.27
    Marker Score: 448
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.26
    Marker Score: 1,861
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.26
    Marker Score: 913
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.22
    Marker Score: 45,079
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.21
    Marker Score: 2,151
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.2
    Marker Score: 1,332
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.18
    Marker Score: 1,001
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.16
    Marker Score: 402
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.16
    Marker Score: 394
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.16
    Marker Score: 308
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.16
    Marker Score: 1,181
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.16
    Marker Score: 1,201
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.14
    Marker Score: 2,322
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.14
    Marker Score: 4,676
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.14
    Marker Score: 2,557
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.13
    Marker Score: 1,846
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.13
    Marker Score: 388
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.12
    Marker Score: 4,679
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.1
    Marker Score: 594
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1
    Marker Score: 2,687
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.1
    Marker Score: 499
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.08
    Marker Score: 378
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.07
    Marker Score: 717
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.06
    Marker Score: 1,458
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.04
    Marker Score: 436
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.04
    Marker Score: 8,914
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16,064
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.02
    Marker Score: 218
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.02
    Marker Score: 222
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.02
    Marker Score: 937
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.02
    Marker Score: 798
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.01
    Marker Score: 4,239
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,624
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,849
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.99
    Marker Score: 547
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.99
    Marker Score: 597
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.99
    Marker Score: 230

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** ARL4C is predominantly found in the cytosol and plasma membrane of immune cells, including T cells, natural killer cells, and neurons. 2. **GTPase activity:** ARL4C possesses GTPase activity, which is essential for its function in regulating protein transport and signaling pathways. 3. **Association with membrane trafficking:** ARL4C is involved in endocytic recycling, filopodium formation, and intracellular protein transport, highlighting its role in maintaining cellular homeostasis. 4. **Regulation of cholesterol transport:** ARL4C interacts with nuclear receptors, specifically NR1H2 and NR1H3, which regulate gene expression linked to cholesterol transport and efflux. **Pathways and Functions:** 1. **GTP binding and hydrolysis:** ARL4C's GTPase activity regulates protein transport, membrane trafficking, and signal transduction. 2. **Endocytic recycling:** ARL4C is involved in the recycling of endocytosed proteins, which is essential for maintaining cellular homeostasis. 3. **Filopodium formation:** ARL4C contributes to the formation of filopodia, which are essential for cell migration, adhesion, and signaling. 4. **Signaling by nuclear receptors:** ARL4C interacts with NR1H2 and NR1H3, regulating gene expression linked to cholesterol transport and efflux. 5. **Intracellular protein transport:** ARL4C regulates the transport of proteins between the cytosol and plasma membrane, which is critical for maintaining cellular homeostasis. **Clinical Significance:** 1. **T cell development and function:** ARL4C plays a critical role in T cell development, particularly in the maturation of alpha-beta T cells. 2. **Cytokine secretion:** ARL4C regulates cytokine secretion in T cells, which is essential for the immune response. 3. **Cholesterol transport and efflux:** ARL4C's interaction with NR1H2 and NR1H3 highlights its role in regulating cholesterol transport and efflux, which is crucial for maintaining lipid homeostasis. 4. **Neurological disorders:** ARL4C's involvement in neuronal function and cholesterol transport suggests its potential role in neurological disorders, such as Alzheimer's disease and multiple sclerosis. In conclusion, ARL4C is a multifaceted protein that plays a critical role in regulating immune cell function, particularly in the context of T cell development, cytokine secretion, and cholesterol transport. Further research is necessary to fully elucidate the mechanisms underlying ARL4C's functions and its potential implications for human disease.

Genular Protein ID: 186583715

Symbol: ARL4C_HUMAN

Name: ADP-ribosylation factor-like protein 4C

UniProtKB Accession Codes:

P56559 Q4A519 Q53R10 Q9BVN1 Q9UQ34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 13 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10462049

Title: ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal.

PubMed ID: 10462049

DOI: 10.1016/s0014-5793(99)00759-0

PubMed ID: 15147902

Title: ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export.

PubMed ID: 15147902

DOI: 10.1016/j.febslet.2004.04.048

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17398095

Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

PubMed ID: 17398095

DOI: 10.1016/j.cub.2007.03.007

PubMed ID: 19409876

Title: ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport.

PubMed ID: 19409876

DOI: 10.1016/j.bbrc.2009.04.125

Sequence Information:

  • Length: 192
  • Mass: 21487
  • Checksum: 389BD49CF9E6D10D
  • Sequence:
    • MGNISSNISA FQSLHIVMLG LDSAGKTTVL YRLKFNEFVN TVPTIGFNTE KIKLSNGTAK 
GISCHFWDVG GQEKLRPLWK SYSRCTDGII YVVDSVDVDR LEEAKTELHK VTKFAENQGT 
PLLVIANKQD LPKSLPVAEI EKQLALHELI PATTYHVQPA CAIIGEGLTE GMDKLYEMIL 
KRRKSLKQKK KR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.