Details for: ARL4A

Gene ID: 10124

Symbol: ARL4A

Ensembl ID: ENSG00000122644

Description: ADP ribosylation factor like GTPase 4A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.32
    Marker Score: 5,596
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.29
    Marker Score: 4,581
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.28
    Marker Score: 58,412
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.2
    Marker Score: 3,395
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.18
    Marker Score: 6,836
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2
    Marker Score: 677
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.98
    Marker Score: 9,522
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.94
    Marker Score: 16,689
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.89
    Marker Score: 4,305
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.88
    Marker Score: 3,087
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.84
    Marker Score: 533
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.81
    Marker Score: 6,718
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8
    Marker Score: 7,060
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.78
    Marker Score: 1,749
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.73
    Marker Score: 1,446
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.72
    Marker Score: 11,212
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.71
    Marker Score: 2,887
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.65
    Marker Score: 10,031
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.64
    Marker Score: 14,226
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.59
    Marker Score: 1,814
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.58
    Marker Score: 11,797
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.58
    Marker Score: 15,868
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.57
    Marker Score: 334
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.56
    Marker Score: 12,209
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.56
    Marker Score: 3,040
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.55
    Marker Score: 4,213
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.53
    Marker Score: 484
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.53
    Marker Score: 370
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.47
    Marker Score: 6,320
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.47
    Marker Score: 6,108
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.45
    Marker Score: 983
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.44
    Marker Score: 900
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.43
    Marker Score: 1,521
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.43
    Marker Score: 1,425
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.41
    Marker Score: 47,805
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.38
    Marker Score: 444
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.38
    Marker Score: 1,244
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.37
    Marker Score: 2,613
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.36
    Marker Score: 76,143
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.36
    Marker Score: 407
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.35
    Marker Score: 1,213
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.34
    Marker Score: 664
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.33
    Marker Score: 1,330
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.3
    Marker Score: 852
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.29
    Marker Score: 321
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.29
    Marker Score: 778
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.29
    Marker Score: 1,346
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.27
    Marker Score: 3,568
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.26
    Marker Score: 303
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.26
    Marker Score: 446
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.26
    Marker Score: 528
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.25
    Marker Score: 2,641
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.25
    Marker Score: 936
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.22
    Marker Score: 2,131
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.22
    Marker Score: 1,576
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.22
    Marker Score: 351
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.22
    Marker Score: 712
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.21
    Marker Score: 599
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.2
    Marker Score: 911
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.2
    Marker Score: 600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.2
    Marker Score: 569
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.19
    Marker Score: 5,864
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.19
    Marker Score: 1,214
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.19
    Marker Score: 871
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.19
    Marker Score: 1,290
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.19
    Marker Score: 1,115
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.18
    Marker Score: 723
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.17
    Marker Score: 2,140
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.17
    Marker Score: 1,230
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.17
    Marker Score: 1,173
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.16
    Marker Score: 3,011
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.16
    Marker Score: 2,833
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.16
    Marker Score: 40,213
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.16
    Marker Score: 234
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.16
    Marker Score: 2,827
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.16
    Marker Score: 1,680
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.15
    Marker Score: 2,729
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.15
    Marker Score: 816
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.14
    Marker Score: 729
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.14
    Marker Score: 516
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.13
    Marker Score: 475
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.13
    Marker Score: 271
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.12
    Marker Score: 513
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 524
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.12
    Marker Score: 811
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.12
    Marker Score: 266
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.12
    Marker Score: 746
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17,388
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 1.11
    Marker Score: 551
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.11
    Marker Score: 1,525
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.1
    Marker Score: 905
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.1
    Marker Score: 415
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.1
    Marker Score: 474
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.1
    Marker Score: 3,782
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.1
    Marker Score: 2,297
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.1
    Marker Score: 240
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.08
    Marker Score: 2,272
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.08
    Marker Score: 931
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.08
    Marker Score: 618
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.07
    Marker Score: 309

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARL4A belongs to the ADP-ribosylation factor (ARF) family of GTPases, which are small GTP-binding proteins that play crucial roles in regulating various cellular processes. ARL4A is characterized by its ability to bind to GTP and GDP, facilitating its interaction with other proteins and influencing its activity. The protein is primarily localized to the cytosol, where it participates in vesicle-mediated transport, protein binding, and GTPase activity. **Pathways and Functions:** ARL4A is involved in multiple cellular pathways, including: 1. **Vesicle-mediated transport**: ARL4A regulates the movement of vesicles along actin filaments, facilitating the transport of proteins and lipids between different cellular compartments. 2. **Protein binding**: ARL4A interacts with various proteins, including other ARF family members, to regulate their activity and localization. 3. **GTPase activity**: ARL4A hydrolyzes GTP to GDP, which inactivates the protein and regulates its activity. 4. **Cell differentiation and survival**: ARL4A is involved in the regulation of cell differentiation and survival pathways, particularly in the context of brown fat cell differentiation. **Significantly Expressed Cells:** ARL4A is highly expressed in various cell types, including: 1. **Non-classical monocytes**: ARL4A is involved in the regulation of monocyte function and differentiation. 2. **Endothelial cells**: ARL4A plays a role in maintaining endothelial cell integrity and function. 3. **Alveolar macrophages**: ARL4A is involved in the regulation of macrophage function and survival. 4. **Enterocytes**: ARL4A is involved in the regulation of enterocyte function and differentiation. **Clinical Significance:** Dysregulation of ARL4A has been implicated in various human diseases, including: 1. **Brown fat cell dysfunction**: ARL4A mutations have been associated with brown fat cell dysfunction, leading to impaired thermogenesis and obesity. 2. **Inflammatory diseases**: ARL4A is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in various inflammatory diseases, including atherosclerosis and rheumatoid arthritis. 3. **Cancer**: ARL4A has been implicated in the regulation of cancer cell proliferation and survival, and its dysregulation has been associated with various types of cancer. In conclusion, ARL4A plays a crucial role in maintaining cellular homeostasis and regulating various cellular processes. Further research is needed to fully elucidate the mechanisms underlying ARL4A function and its implications in human diseases.

Genular Protein ID: 58946290

Symbol: ARL4A_HUMAN

Name: ADP-ribosylation factor-like protein 4A

UniProtKB Accession Codes:

P40617 A4D119 P80418 Q49AF5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10462049

Title: ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal.

PubMed ID: 10462049

DOI: 10.1016/s0014-5793(99)00759-0

PubMed ID: 10980193

Title: ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli.

PubMed ID: 10980193

DOI: 10.1074/jbc.m002470200

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 17398095

Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

PubMed ID: 17398095

DOI: 10.1016/j.cub.2007.03.007

Sequence Information:

  • Length: 200
  • Mass: 22615
  • Checksum: 8D93A8C003BD16CF
  • Sequence:
    • MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP TKGFNTEKIK 
VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV DSVDVERMEE AKTELHKITR 
ISENQGVPVL IVANKQDLRN SLSLSEIEKL LAMGELSSST PWHLQPTCAI IGDGLKEGLE 
KLHDMIIKRR KMLRQQKKKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.