Details for: RASGRP1
Associated with
Other Information
Genular Protein ID: 3520043057
Symbol: GRP1_HUMAN
Name: RAS guanyl-releasing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9789079
Title: A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.
PubMed ID: 9789079
PubMed ID: 10087292
Title: RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.
PubMed ID: 10087292
PubMed ID: 17878389
Title: Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus.
PubMed ID: 17878389
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10807788
Title: RasGRP links T-cell receptor signaling to Ras.
PubMed ID: 10807788
PubMed ID: 11257115
Title: Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.
PubMed ID: 11257115
PubMed ID: 11919165
Title: Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP.
PubMed ID: 11919165
PubMed ID: 12839994
Title: Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.
PubMed ID: 12839994
DOI: 10.1093/emboj/cdg316
PubMed ID: 12782630
Title: Exchange factors of the RasGRP family mediate Ras activation in the Golgi.
PubMed ID: 12782630
PubMed ID: 12845332
Title: Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.
PubMed ID: 12845332
DOI: 10.1038/nature01806
PubMed ID: 15060167
Title: Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.
PubMed ID: 15060167
PubMed ID: 15184873
Title: Inverted signaling hierarchy between RAS and RAC in T-lymphocytes.
PubMed ID: 15184873
PubMed ID: 15657177
Title: Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.
PubMed ID: 15657177
PubMed ID: 15899849
Title: A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
PubMed ID: 15899849
PubMed ID: 17658605
Title: SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.
PubMed ID: 17658605
PubMed ID: 19933860
Title: RasGRP1 is required for human NK cell function.
PubMed ID: 19933860
PubMed ID: 27776107
Title: RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.
PubMed ID: 27776107
DOI: 10.1038/ni.3575
PubMed ID: 23908768
Title: Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
PubMed ID: 23908768
DOI: 10.7554/elife.00813
PubMed ID: 28822832
Title: Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1.
PubMed ID: 28822832
PubMed ID: 29155103
Title: RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease.
PubMed ID: 29155103
Sequence Information:
- Length: 797
- Mass: 90402
- Checksum: 8ACDCF0F715ABAA9
- Sequence:
MGTLGKAREA PRKPSHGCRA ASKARLEAKP ANSPFPSHPS LAHITQFRMM VSLGHLAKGA SLDDLIDSCI QSFDADGNLC RSNQLLQVML TMHRIVISSA ELLQKVITLY KDALAKNSPG LCLKICYFVR YWITEFWVMF KMDASLTDTM EEFQELVKAK GEELHCRLID TTQINARDWS RKLTQRIKSN TSKKRKVSLL FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE NPTMERSIAL CNGISQWVQL MVLSRPTPQL RAEVFIKFIQ VAQKLHQLQN FNTLMAVIGG LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSSRNYDNY RRAYGECTDF KIPILGVHLK DLISLYEAMP DYLEDGKVNV HKLLALYNHI SELVQLQEVA PPLEANKDLV HLLTLSLDLY YTEDEIYELS YAREPRNHRA PPLTPSKPPV VVDWASGVSP KPDPKTISKH VQRMVDSVFK NYDHDQDGYI SQEEFEKIAA SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF PHNFQETTYL KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRAKNPVA PTENNTSVGP VSNLCSLGAK DLLHAPEEGP FTFPNGEAVE HGEESKDRTI MLMGVSSQKI SLRLKRAVAH KATQTESQPW IGSEGPSGPF VLSSPRKTAQ DTLYVLPSPT SPCPSPVLVR KRAFVKWENK DSLIKSKEEL RHLRLPTYQE LEQEINTLKA DNDALKIQLK YAQKKIESLQ LEKSNHVLAQ MEQGDCS
Genular Protein ID: 3974905832
Symbol: B2RA89_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 797
- Mass: 90403
- Checksum: 5C16AFD979F0920B
- Sequence:
MGTLGKAREA PRKPSHGCRA ASKARLEAKP ANSPFPSHPS LAHITQFRMM VSLGHLAKGA SLDDLIDSCI QSFDADGNLC RSNQLLQVML TMHRIVISSA ELLQKVITLY KDALAKNSPG LCLKICYFVR YWITEFWVMF KMDASLTDTM EEFQELVKAK GEELHCRLID TTQINARDWS RKLTQRIKSN TSKKRKVSLL FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE NPTMERSIAL CNGISQWVQL MVLSRPTPQL RAEVFIKFIQ VAQKLHQLQN FNTLMAVIGG LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSSRNYDNY RRAYGECTDF KIPILGVHLK DLISLYEAMP DYLEDGKVNV HKLLALYNHI SELVQLQEVA PPLEANKDLV HLLTLSLDLY YTEDEIYELS YAREPRNHRA PPLTPSKPPV VVDWASGVSP KPDPKTISKH VQRMVDSVFK NYDHDQDGYI SQEEFEKIAA SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF PHNFQETTYL KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRAKNPVA PTENNTSVGP VSNLCSLGAK DLLHAPEEGP FTFPNGEAVE HGEESKDRTI MLMGVSSQKI SLRLKRAVAH KATQTESQPW IGSEGPSGPF VLSSPRETAQ DTLYVLPSPT SPCPSPVLVR KRAFVKWENK DSLIKSKEEL RHLRLPTYQE LEQEINTLKA DNDALKIQLK YAQKKIESLQ LEKSNHVLAQ MEQGDCS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.