Details for: DNAL4

Gene ID: 10126

Symbol: DNAL4

Ensembl ID: ENSG00000100246

Description: dynein axonemal light chain 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 3.6
    Marker Score: 5,174
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.27
    Marker Score: 1,817
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.69
    Marker Score: 495
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.17
    Marker Score: 10,180
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.14
    Marker Score: 1,112
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.13
    Marker Score: 620
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.04
    Marker Score: 36,196
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,768
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,991
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15,518
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.92
    Marker Score: 1,741
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.91
    Marker Score: 609
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,199
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,719
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 356
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.89
    Marker Score: 3,286
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,262
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.86
    Marker Score: 3,576
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.82
    Marker Score: 235
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.78
    Marker Score: 3,077
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.77
    Marker Score: 812
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.72
    Marker Score: 1,468
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.72
    Marker Score: 1,502
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.69
    Marker Score: 733
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.69
    Marker Score: 161
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.67
    Marker Score: 191
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.67
    Marker Score: 722
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.67
    Marker Score: 839
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2,761
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.66
    Marker Score: 6,592
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.65
    Marker Score: 679
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.63
    Marker Score: 702
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.62
    Marker Score: 1,019
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.62
    Marker Score: 1,678
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.62
    Marker Score: 297
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.61
    Marker Score: 326
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.61
    Marker Score: 1,437
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.6
    Marker Score: 285
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1,124
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.58
    Marker Score: 858
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.57
    Marker Score: 3,735
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.57
    Marker Score: 260
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.57
    Marker Score: 813
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.56
    Marker Score: 353
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.54
    Marker Score: 2,342
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.54
    Marker Score: 254
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.53
    Marker Score: 497
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.53
    Marker Score: 894
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.52
    Marker Score: 6,919
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.52
    Marker Score: 225
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.51
    Marker Score: 633
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.51
    Marker Score: 521
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.51
    Marker Score: 131
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.51
    Marker Score: 906
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.5
    Marker Score: 299
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.5
    Marker Score: 98
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.49
    Marker Score: 1,039
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.49
    Marker Score: 156
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.47
    Marker Score: 444
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.47
    Marker Score: 757
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.47
    Marker Score: 503
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.47
    Marker Score: 1,793
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.46
    Marker Score: 1,042
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.45
    Marker Score: 235
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.45
    Marker Score: 285
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.44
    Marker Score: 1,056
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.44
    Marker Score: 149
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 285
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.43
    Marker Score: 1,748
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.43
    Marker Score: 309
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 203
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.42
    Marker Score: 170
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.42
    Marker Score: 3,635
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.42
    Marker Score: 2,500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.42
    Marker Score: 669
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.42
    Marker Score: 4,682
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.41
    Marker Score: 235
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.41
    Marker Score: 212
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.41
    Marker Score: 494
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.4
    Marker Score: 669
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 167
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 106
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.4
    Marker Score: 377
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 381
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.39
    Marker Score: 158
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.39
    Marker Score: 915
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.38
    Marker Score: 2,480
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.38
    Marker Score: 1,988

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dynein Complex Association:** DNAL4 is a key component of the dynein complex, which is a heterotetrameric protein that interacts with microtubules to facilitate retrograde transport. 2. **Microtubule Motility:** The dynein complex, in which DNAL4 is embedded, exhibits microtubule motor activity, enabling the movement of vesicles and organelles along microtubules. 3. **Cellular Expression:** DNAL4 is significantly expressed in various cell types, including respiratory basal cells, pulmonary interstitial fibroblasts, tracheobronchial smooth muscle cells, and cardiac muscle myoblasts. 4. **Signaling Pathways:** DNAL4 is involved in signaling pathways, including retrograde neurotrophin signaling, signaling by ntrk1 (trka), and signaling by receptor tyrosine kinases. **Pathways and Functions:** 1. **Retrograde Neurotrophin Signaling:** DNAL4 is involved in retrograde neurotrophin signaling, a process that enables the transport of neurotrophic factors from the periphery to the central nervous system. 2. **Microtubule-Based Movement:** The dynein complex, in which DNAL4 is embedded, facilitates microtubule-based movement, enabling the transport of vesicles and organelles along microtubules. 3. **Signaling by Receptor Tyrosine Kinases:** DNAL4 is involved in signaling by receptor tyrosine kinases, a process that enables the transmission of signals from the cell surface to the interior of the cell. 4. **Cellular Transport:** DNAL4 plays a crucial role in cellular transport, enabling the movement of vesicles and organelles along microtubules. **Clinical Significance:** 1. **Respiratory Diseases:** DNAL4's involvement in respiratory cells makes it an attractive target for the treatment of respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Neurological Disorders:** DNAL4's role in retrograde neurotrophin signaling and signaling by receptor tyrosine kinases makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Diseases:** DNAL4's involvement in cardiac muscle cells makes it an attractive target for the treatment of cardiovascular diseases, such as heart failure and cardiac arrhythmias. In conclusion, DNAL4 is a gene that plays a multifaceted role in various cellular processes, including microtubule-based movement, signaling, and cellular transport. Further research is necessary to fully understand the functions of DNAL4 and its potential therapeutic applications in immune and non-immune diseases.

Genular Protein ID: 1352386649

Symbol: DNAL4_HUMAN

Name: Dynein axonemal light chain 4

UniProtKB Accession Codes:

O96015 Q6FGB2 Q6FGD0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25098561

Title: Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.

PubMed ID: 25098561

DOI: 10.1007/s00439-014-1475-8

Sequence Information:

  • Length: 105
  • Mass: 12009
  • Checksum: D0AE8929DEB2AC06
  • Sequence:
    • MGETEGKKDE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN ESAAKMIKET 
MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC VWKCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.